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Protein

Ras-related protein Rab-34

Gene

RAB34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 66GTPBy similarity8
Nucleotide bindingi107 – 111GTPBy similarity5
Nucleotide bindingi166 – 169GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: ParkinsonsUK-UCL
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation Source: UniProtKB
  • cell projection organization Source: UniProtKB-KW
  • Golgi to plasma membrane protein transport Source: UniProtKB
  • lysosome localization Source: UniProtKB
  • phagosome-lysosome fusion Source: UniProtKB
  • phagosome maturation Source: UniProtKB
  • positive regulation of smoothened signaling pathway Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34
Alternative name(s):
Ras-related protein Rab-39
Ras-related protein Rah
Gene namesi
Name:RAB34
Synonyms:RAB39, RAH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000109113.17
HGNCiHGNC:16519 RAB34
MIMi610917 gene
neXtProtiNX_Q9BZG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83871
OpenTargetsiENSG00000109113
PharmGKBiPA34126

Polymorphism and mutation databases

BioMutaiPROCA1
DMDMi20139693

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212431 – 259Ras-related protein Rab-34Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Lipidationi257S-geranylgeranyl cysteineSequence analysis1
Lipidationi258S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9BZG1
MaxQBiQ9BZG1
PaxDbiQ9BZG1
PeptideAtlasiQ9BZG1
PRIDEiQ9BZG1
ProteomicsDBi79837
79838 [Q9BZG1-2]

PTM databases

iPTMnetiQ9BZG1
PhosphoSitePlusiQ9BZG1

Expressioni

Gene expression databases

BgeeiENSG00000109113
CleanExiHS_RAB34
HS_RAB39
ExpressionAtlasiQ9BZG1 baseline and differential
GenevisibleiQ9BZG1 HS

Organism-specific databases

HPAiHPA021366

Interactioni

Subunit structurei

Interacts with RILP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CA8P352193EBI-2856739,EBI-718700

GO - Molecular functioni

  • GTP-dependent protein binding Source: ParkinsonsUK-UCL
  • Ral GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123784, 18 interactors
IntActiQ9BZG1, 12 interactors
MINTiQ9BZG1
STRINGi9606.ENSP00000410403

Structurei

3D structure databases

ProteinModelPortaliQ9BZG1
SMRiQ9BZG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233970
HOVERGENiHBG106693
InParanoidiQ9BZG1
KOiK07921
PhylomeDBiQ9BZG1

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF
60 70 80 90 100
KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGIP
110 120 130 140 150
FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHTKQWLADA
160 170 180 190 200
LKENDPSSVL LFLVGSKKDL STPAQYALME KDALQVAQEM KAEYWAVSSL
210 220 230 240 250
TGENVREFFF RVAALTFEAN VLAELEKSGA RRIGDVVRIN SDDSNLYLTA

SKKKPTCCP
Length:259
Mass (Da):29,044
Last modified:June 1, 2001 - v1
Checksum:i6D38A6F090F9802D
GO
Isoform 2 (identifier: Q9BZG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-171: Missing.

Show »
Length:251
Mass (Da):28,230
Checksum:i8022E7023BC5137B
GO
Isoform NARR (identifier: P0DI83-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DI83.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:198
Mass (Da):21,118
GO
Isoform 4 (identifier: Q9BZG1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-72: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):26,673
Checksum:i8AD7BEDE6338BB85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10D → Y in BAG65412 (PubMed:14702039).Curated1
Sequence conflicti55V → I in BAC11141 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015097197V → L. Corresponds to variant dbSNP:rs12125Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04473451 – 72Missing in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_010142164 – 171Missing in isoform 2. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322067 mRNA Translation: AAK09397.1
AJ277106 mRNA Translation: CAC81760.1
BT006702 mRNA Translation: AAP35348.1
AK027312 mRNA Translation: BAB55034.1
AK074689 mRNA Translation: BAC11141.1
AK304633 mRNA Translation: BAG65412.1
AC010761 Genomic DNA No translation available.
BC016841 mRNA Translation: AAH16841.1
BC091510 mRNA Translation: AAH91510.1
CCDSiCCDS11240.1 [Q9BZG1-1]
CCDS45636.1 [Q9BZG1-2]
CCDS58536.1 [Q9BZG1-4]
RefSeqiNP_001138414.1, NM_001144942.1 [Q9BZG1-2]
NP_001243205.1, NM_001256276.1 [Q9BZG1-4]
NP_001243206.1, NM_001256277.1 [Q9BZG1-1]
NP_001243207.1, NM_001256278.1
NP_114140.4, NM_031934.5 [Q9BZG1-1]
UniGeneiHs.301853

Genome annotation databases

EnsembliENST00000301043; ENSP00000301043; ENSG00000109113 [Q9BZG1-1]
ENST00000395245; ENSP00000378666; ENSG00000109113 [Q9BZG1-1]
ENST00000415040; ENSP00000410279; ENSG00000109113 [Q9BZG1-4]
ENST00000436730; ENSP00000404180; ENSG00000109113 [Q9BZG1-1]
ENST00000450529; ENSP00000391048; ENSG00000109113 [Q9BZG1-2]
GeneIDi83871
KEGGihsa:83871
UCSCiuc002hce.3 human [Q9BZG1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRAB34_HUMAN
AccessioniPrimary (citable) accession number: Q9BZG1
Secondary accession number(s): B4E3A0
, E9PEJ9, Q5BJE6, Q8NCJ8, Q96AR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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