UniProtKB - Q9BZF3 (OSBL6_HUMAN)
Protein
Oxysterol-binding protein-related protein 6
Gene
OSBPL6
Organism
Homo sapiens (Human)
Status
Functioni
Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193).By similarity2 Publications
GO - Molecular functioni
- cholesterol binding Source: GO_Central
- lipid binding Source: GO_Central
- sterol binding Source: GO_Central
- sterol transporter activity Source: GO_Central
GO - Biological processi
- bile acid biosynthetic process Source: Reactome
- regulation of cholesterol transport Source: UniProtKB
Keywordsi
Biological process | Lipid transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BZF3 |
Reactomei | R-HSA-192105, Synthesis of bile acids and bile salts |
Names & Taxonomyi
Protein namesi | Recommended name: Oxysterol-binding protein-related protein 6Short name: ORP-6 Short name: OSBP-related protein 6 |
Gene namesi | Name:OSBPL6 Synonyms:ORP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000079156.16 |
HGNCi | HGNC:16388, OSBPL6 |
MIMi | 606734, gene |
neXtProti | NX_Q9BZF3 |
Subcellular locationi
Cytosol
- cytosol 2 Publications
Endoplasmic reticulum
- Endoplasmic reticulum membrane 3 Publications; Peripheral membrane protein Curated
Plasma membrane
- Cell membrane 2 Publications; Peripheral membrane protein Curated
Nucleus
- Nucleus envelope 1 Publication
Endosome
- Endosome membrane 1 Publication; Peripheral membrane protein Curated
Note: Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum.By similarity
Cytosol
- cytosol Source: BHF-UCL
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
- perinuclear endoplasmic reticulum Source: BHF-UCL
Endosome
- early endosome membrane Source: UniProtKB
Nucleus
- nuclear membrane Source: BHF-UCL
Plasma Membrane
- plasma membrane Source: BHF-UCL
Other locations
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 114880 |
OpenTargetsi | ENSG00000079156 |
PharmGKBi | PA32830 |
Miscellaneous databases
Pharosi | Q9BZF3, Tbio |
Polymorphism and mutation databases
BioMutai | OSBPL6 |
DMDMi | 20139133 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000100375 | 2 – 934 | Oxysterol-binding protein-related protein 6Add BLAST | 933 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Modified residuei | 190 | PhosphoserineCombined sources | 1 | |
Modified residuei | 290 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BZF3 |
jPOSTi | Q9BZF3 |
MassIVEi | Q9BZF3 |
MaxQBi | Q9BZF3 |
PaxDbi | Q9BZF3 |
PeptideAtlasi | Q9BZF3 |
PRIDEi | Q9BZF3 |
ProteomicsDBi | 69974 79831 [Q9BZF3-1] 79832 [Q9BZF3-2] 79833 [Q9BZF3-3] 79834 [Q9BZF3-4] 79835 [Q9BZF3-5] |
PTM databases
iPTMneti | Q9BZF3 |
PhosphoSitePlusi | Q9BZF3 |
Expressioni
Tissue specificityi
Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).
Developmental stagei
Expressed in fetal brain and lung.1 Publication
Inductioni
By acetylated low-density lipoprotein.1 Publication
Gene expression databases
Bgeei | ENSG00000079156, Expressed in bronchial epithelial cell and 199 other tissues |
Genevisiblei | Q9BZF3, HS |
Organism-specific databases
HPAi | ENSG00000079156, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with OSBPL3 (By similarity).
By similarityBinary interactionsi
Q9BZF3
With | #Exp. | IntAct |
---|---|---|
ORF [Q9Q2G4] from Human immunodeficiency virus 1. | 3 | EBI-2372709,EBI-6248094 |
Protein-protein interaction databases
BioGRIDi | 125381, 53 interactors |
ELMi | Q9BZF3 |
IntActi | Q9BZF3, 27 interactors |
MINTi | Q9BZF3 |
STRINGi | 9606.ENSP00000376293 |
Miscellaneous databases
RNActi | Q9BZF3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 86 – 181 | PHPROSITE-ProRule annotationAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the OSBP family.Curated
Phylogenomic databases
eggNOGi | KOG1737, Eukaryota |
GeneTreei | ENSGT00940000156791 |
HOGENOMi | CLU_007105_4_1_1 |
InParanoidi | Q9BZF3 |
OMAi | SESIICE |
OrthoDBi | 542090at2759 |
PhylomeDBi | Q9BZF3 |
TreeFami | TF320922 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037239, OSBP_sf IPR000648, Oxysterol-bd IPR018494, Oxysterol-bd_CS IPR011993, PH-like_dom_sf IPR041680, PH_8 IPR001849, PH_domain |
PANTHERi | PTHR10972, PTHR10972, 1 hit |
Pfami | View protein in Pfam PF01237, Oxysterol_BP, 1 hit PF15409, PH_8, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF144000, SSF144000, 1 hit |
PROSITEi | View protein in PROSITE PS01013, OSBP, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (6)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9BZF3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS
60 70 80 90 100
VSRQLLEPEP VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP
110 120 130 140 150
LKGWHKRFFV LDNGMLKYSK APLDIQKGKV HGSIDVGLSV MSIKKKARRI
160 170 180 190 200
DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR LYRQNEIVRS PRDASFHIFP
210 220 230 240 250
STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT CTTGQSKVAA
260 270 280 290 300
WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN
310 320 330 340 350
CVDISKKDKR VTRRWRTKSV SKDTKIQLQV PFSATMSPVR LHSSNPNLCA
360 370 380 390 400
DIEFQTPPSH LTDPLESSTD YTKLQEEFCL IAQKVHSLLK SAFNSIAIEK
410 420 430 440 450
EKLKQMVSEQ DHSKGHSTQM ARLRQSLSQA LNQNAELRSR LNRIHSESII
460 470 480 490 500
CDQVVSVNII PSPDEAGEQI HVSLPLSQQV ANESRLSMSE SVSEFFDAQE
510 520 530 540 550
VLLSASSSEN EASDDESYIS DVSDNISEDN TSVADNISRQ ILNGELTGGA
560 570 580 590 600
FRNGRRACLP APCPDTSNIN LWNILRNNIG KDLSKVSMPV ELNEPLNTLQ
610 620 630 640 650
HLCEEMEYSE LLDKASETDD PYERMVLVAA FAVSGYCSTY FRAGSKPFNP
660 670 680 690 700
VLGETYECIR EDKGFRFFSE QVSHHPPISA CHCESKNFVF WQDIRWKNKF
710 720 730 740 750
WGKSMEILPV GTLNVMLPKY GDYYVWNKVT TCIHNILSGR RWIEHYGEVT
760 770 780 790 800
IRNTKSSVCI CKLTFVKVNY WNSNMNEVQG VVIDQEGKAV YRLFGKWHEG
810 820 830 840 850
LYCGVAPSAK CIWRPGSMPT NYELYYGFTR FAIELNELDP VLKDLLPPTD
860 870 880 890 900
ARFRPDQRFL EEGNLEAAAS EKQRVEELQR SRRRYMEENN LEHIPKFFKK
910 920 930
VIDANQREAW VSNDTYWELR KDPGFSKVDS PVLW
Sequence cautioni
The sequence BAB55223 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92135 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 319 | S → G in BAB55223 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 350 | A → V in BAG62123 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 487 | S → P in BAC04248 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 714 | N → S in BAB55223 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057663 | 53 | R → Q. Corresponds to variant dbSNP:rs35032920Ensembl. | 1 | |
Natural variantiVAR_053550 | 58 | P → L. Corresponds to variant dbSNP:rs34874235Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036559 | 1 – 34 | MSSDE…RDSRQ → MHQLSLIRGNRGR in isoform 3. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_036560 | 298 – 328 | Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_036561 | 329 | Q → QEGPPAKGQFSTTRRRQRLA AAVATT in isoform 3 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_010013 | 431 – 466 | Missing in isoform 2 and isoform 6. 2 PublicationsAdd BLAST | 36 | |
Alternative sequenceiVSP_054430 | 541 – 575 | ILNGE…LWNIL → SMHHLSFQVVLSTCQIATRR LNEQAFPLPRHPHPC in isoform 6. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_054431 | 576 – 934 | Missing in isoform 6. 1 PublicationAdd BLAST | 359 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000190611; ENSP00000190611; ENSG00000079156 [Q9BZF3-1] ENST00000315022; ENSP00000318723; ENSG00000079156 [Q9BZF3-3] ENST00000357080; ENSP00000349591; ENSG00000079156 [Q9BZF3-6] ENST00000359685; ENSP00000352713; ENSG00000079156 [Q9BZF3-2] ENST00000392505; ENSP00000376293; ENSG00000079156 [Q9BZF3-5] ENST00000409045; ENSP00000387248; ENSG00000079156 [Q9BZF3-4] ENST00000409631; ENSP00000386885; ENSG00000079156 [Q9BZF3-2] |
GeneIDi | 114880 |
KEGGi | hsa:114880 |
UCSCi | uc002ulw.4, human [Q9BZF3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q9BZF3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125381, 53 interactors |
ELMi | Q9BZF3 |
IntActi | Q9BZF3, 27 interactors |
MINTi | Q9BZF3 |
STRINGi | 9606.ENSP00000376293 |
PTM databases
iPTMneti | Q9BZF3 |
PhosphoSitePlusi | Q9BZF3 |
Polymorphism and mutation databases
BioMutai | OSBPL6 |
DMDMi | 20139133 |
Proteomic databases
EPDi | Q9BZF3 |
jPOSTi | Q9BZF3 |
MassIVEi | Q9BZF3 |
MaxQBi | Q9BZF3 |
PaxDbi | Q9BZF3 |
PeptideAtlasi | Q9BZF3 |
PRIDEi | Q9BZF3 |
ProteomicsDBi | 69974 79831 [Q9BZF3-1] 79832 [Q9BZF3-2] 79833 [Q9BZF3-3] 79834 [Q9BZF3-4] 79835 [Q9BZF3-5] |
Protocols and materials databases
Antibodypediai | 33930, 124 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 114880 |
DisGeNETi | 114880 |
EuPathDBi | HostDB:ENSG00000079156.16 |
GeneCardsi | OSBPL6 |
HGNCi | HGNC:16388, OSBPL6 |
HPAi | ENSG00000079156, Tissue enhanced (skeletal) |
MIMi | 606734, gene |
neXtProti | NX_Q9BZF3 |
OpenTargetsi | ENSG00000079156 |
PharmGKBi | PA32830 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1737, Eukaryota |
GeneTreei | ENSGT00940000156791 |
HOGENOMi | CLU_007105_4_1_1 |
InParanoidi | Q9BZF3 |
OMAi | SESIICE |
OrthoDBi | 542090at2759 |
PhylomeDBi | Q9BZF3 |
TreeFami | TF320922 |
Enzyme and pathway databases
PathwayCommonsi | Q9BZF3 |
Reactomei | R-HSA-192105, Synthesis of bile acids and bile salts |
Miscellaneous databases
BioGRID-ORCSi | 114880, 4 hits in 850 CRISPR screens |
ChiTaRSi | OSBPL6, human |
GenomeRNAii | 114880 |
Pharosi | Q9BZF3, Tbio |
PROi | PR:Q9BZF3 |
RNActi | Q9BZF3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079156, Expressed in bronchial epithelial cell and 199 other tissues |
Genevisiblei | Q9BZF3, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037239, OSBP_sf IPR000648, Oxysterol-bd IPR018494, Oxysterol-bd_CS IPR011993, PH-like_dom_sf IPR041680, PH_8 IPR001849, PH_domain |
PANTHERi | PTHR10972, PTHR10972, 1 hit |
Pfami | View protein in Pfam PF01237, Oxysterol_BP, 1 hit PF15409, PH_8, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF144000, SSF144000, 1 hit |
PROSITEi | View protein in PROSITE PS01013, OSBP, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OSBL6_HUMAN | |
Accessioni | Q9BZF3Primary (citable) accession number: Q9BZF3 Secondary accession number(s): B4DTW1 Q96SR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations