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UniProtKB - Q9BZF3 (OSBL6_HUMAN)

Protein

Oxysterol-binding protein-related protein 6

Gene

OSBPL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Weakly binds 25-hydroxycholesterol.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-192105 Synthesis of bile acids and bile salts

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 6
Short name:
ORP-6
Short name:
OSBP-related protein 6
Gene namesi
Name:OSBPL6
Synonyms:ORP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000079156.16
HGNCiHGNC:16388 OSBPL6
MIMi606734 gene
neXtProtiNX_Q9BZF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi114880
OpenTargetsiENSG00000079156
PharmGKBiPA32830

Polymorphism and mutation databases

BioMutaiOSBPL6
DMDMi20139133

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001003752 – 934Oxysterol-binding protein-related protein 6Add BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BZF3
MaxQBiQ9BZF3
PaxDbiQ9BZF3
PeptideAtlasiQ9BZF3
PRIDEiQ9BZF3
ProteomicsDBi79831
79832 [Q9BZF3-2]
79833 [Q9BZF3-3]
79834 [Q9BZF3-4]
79835 [Q9BZF3-5]

PTM databases

iPTMnetiQ9BZF3
PhosphoSitePlusiQ9BZF3

Expressioni

Tissue specificityi

Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).

Developmental stagei

Expressed in fetal brain and lung.1 Publication

Gene expression databases

BgeeiENSG00000079156 Expressed in 184 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_OSBPL6
GenevisibleiQ9BZF3 HS

Organism-specific databases

HPAiHPA032131

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G43EBI-2372709,EBI-6248094From Human immunodeficiency virus 1.

Protein-protein interaction databases

BioGridi125381, 51 interactors
ELMiQ9BZF3
IntActiQ9BZF3, 7 interactors
MINTiQ9BZF3
STRINGi9606.ENSP00000376293

Structurei

3D structure databases

ProteinModelPortaliQ9BZF3
SMRiQ9BZF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 181PHPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231072
HOVERGENiHBG058934
InParanoidiQ9BZF3
KOiK20463
OMAiFVKGNYW
OrthoDBiEOG091G0DJB
PhylomeDBiQ9BZF3
TreeFamiTF320922

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 2 hits
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BZF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS 
        60         70         80         90        100
VSRQLLEPEP VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP 
       110        120        130        140        150
LKGWHKRFFV LDNGMLKYSK APLDIQKGKV HGSIDVGLSV MSIKKKARRI 
       160        170        180        190        200
DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR LYRQNEIVRS PRDASFHIFP 
       210        220        230        240        250
STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT CTTGQSKVAA 
       260        270        280        290        300
WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN 
       310        320        330        340        350
CVDISKKDKR VTRRWRTKSV SKDTKIQLQV PFSATMSPVR LHSSNPNLCA 
       360        370        380        390        400
DIEFQTPPSH LTDPLESSTD YTKLQEEFCL IAQKVHSLLK SAFNSIAIEK 
       410        420        430        440        450
EKLKQMVSEQ DHSKGHSTQM ARLRQSLSQA LNQNAELRSR LNRIHSESII 
       460        470        480        490        500
CDQVVSVNII PSPDEAGEQI HVSLPLSQQV ANESRLSMSE SVSEFFDAQE 
       510        520        530        540        550
VLLSASSSEN EASDDESYIS DVSDNISEDN TSVADNISRQ ILNGELTGGA 
       560        570        580        590        600
FRNGRRACLP APCPDTSNIN LWNILRNNIG KDLSKVSMPV ELNEPLNTLQ 
       610        620        630        640        650
HLCEEMEYSE LLDKASETDD PYERMVLVAA FAVSGYCSTY FRAGSKPFNP 
       660        670        680        690        700
VLGETYECIR EDKGFRFFSE QVSHHPPISA CHCESKNFVF WQDIRWKNKF 
       710        720        730        740        750
WGKSMEILPV GTLNVMLPKY GDYYVWNKVT TCIHNILSGR RWIEHYGEVT 
       760        770        780        790        800
IRNTKSSVCI CKLTFVKVNY WNSNMNEVQG VVIDQEGKAV YRLFGKWHEG 
       810        820        830        840        850
LYCGVAPSAK CIWRPGSMPT NYELYYGFTR FAIELNELDP VLKDLLPPTD 
       860        870        880        890        900
ARFRPDQRFL EEGNLEAAAS EKQRVEELQR SRRRYMEENN LEHIPKFFKK 
       910        920        930 
VIDANQREAW VSNDTYWELR KDPGFSKVDS PVLW
Length:934
Mass (Da):106,306
Last modified:June 1, 2001 - v1
Checksum:iD20F90EA34C81497
GO
Isoform 2 (identifier: Q9BZF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-466: Missing.

Show »
Length:898
Mass (Da):102,293
Checksum:iFDCF238AFD0D0B79
GO
Isoform 3 (identifier: Q9BZF3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQ → MHQLSLIRGNRGR
     329-329: Q → QEGPPAKGQFSTTRRRQRLAAAVATT

Show »
Length:938
Mass (Da):106,864
Checksum:i275936D5B48740FF
GO
Isoform 4 (identifier: Q9BZF3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-328: Missing.

Show »
Length:903
Mass (Da):102,635
Checksum:i612100E10BD6C501
GO
Isoform 5 (identifier: Q9BZF3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-329: Q → QEGPPAKGQFSTTRRRQRLAAAVATT

Show »
Length:959
Mass (Da):108,959
Checksum:iD0D688B86FECA73D
GO
Isoform 6 (identifier: Q9BZF3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-328: Missing.
     431-466: Missing.
     541-575: ILNGELTGGAFRNGRRACLPAPCPDTSNINLWNIL → SMHHLSFQVVLSTCQIATRRLNEQAFPLPRHPHPC
     576-934: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):56,951
Checksum:iDF8ED83EB1DC131D
GO

Sequence cautioni

The sequence BAB55223 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92135 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319S → G in BAB55223 (PubMed:14702039).Curated1
Sequence conflicti350A → V in BAG62123 (PubMed:14702039).Curated1
Sequence conflicti487S → P in BAC04248 (PubMed:14702039).Curated1
Sequence conflicti714N → S in BAB55223 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05766353R → Q. Corresponds to variant dbSNP:rs35032920Ensembl.1
Natural variantiVAR_05355058P → L. Corresponds to variant dbSNP:rs34874235Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365591 – 34MSSDE…RDSRQ → MHQLSLIRGNRGR in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_036560298 – 328Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_036561329Q → QEGPPAKGQFSTTRRRQRLA AAVATT in isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_010013431 – 466Missing in isoform 2 and isoform 6. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_054430541 – 575ILNGE…LWNIL → SMHHLSFQVVLSTCQIATRR LNEQAFPLPRHPHPC in isoform 6. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_054431576 – 934Missing in isoform 6. 1 PublicationAdd BLAST359

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323728 mRNA Translation: AAG53409.1
AF392448 mRNA Translation: AAL40661.1
AF462443 mRNA Translation: AAP97711.1
AK027600 mRNA Translation: BAB55223.1 Different initiation.
AK093902 mRNA Translation: BAC04248.1
AK300389 mRNA Translation: BAG62123.1
AB208898 mRNA Translation: BAD92135.1 Different initiation.
AC009948 Genomic DNA Translation: AAX88881.1
AC011743 Genomic DNA Translation: AAY15090.1
AC011238 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11040.1
CH471058 Genomic DNA Translation: EAX11041.1
CH471058 Genomic DNA Translation: EAX11042.1
CH471058 Genomic DNA Translation: EAX11043.1
BC052259 mRNA Translation: AAH52259.1
CCDSiCCDS2277.1 [Q9BZF3-1]
CCDS2278.1 [Q9BZF3-3]
CCDS56150.1 [Q9BZF3-5]
CCDS56151.1 [Q9BZF3-2]
CCDS56152.1 [Q9BZF3-4]
RefSeqiNP_001188409.1, NM_001201480.1 [Q9BZF3-5]
NP_001188410.1, NM_001201481.1 [Q9BZF3-4]
NP_001188411.1, NM_001201482.1 [Q9BZF3-2]
NP_115912.1, NM_032523.3 [Q9BZF3-1]
NP_665682.1, NM_145739.2 [Q9BZF3-3]
XP_016858755.1, XM_017003266.1 [Q9BZF3-5]
XP_016858756.1, XM_017003267.1 [Q9BZF3-5]
XP_016858759.1, XM_017003270.1 [Q9BZF3-4]
XP_016858760.1, XM_017003271.1 [Q9BZF3-2]
UniGeneiHs.318775

Genome annotation databases

EnsembliENST00000190611; ENSP00000190611; ENSG00000079156 [Q9BZF3-1]
ENST00000315022; ENSP00000318723; ENSG00000079156 [Q9BZF3-3]
ENST00000357080; ENSP00000349591; ENSG00000079156 [Q9BZF3-6]
ENST00000359685; ENSP00000352713; ENSG00000079156 [Q9BZF3-2]
ENST00000392505; ENSP00000376293; ENSG00000079156 [Q9BZF3-5]
ENST00000409045; ENSP00000387248; ENSG00000079156 [Q9BZF3-4]
ENST00000409631; ENSP00000386885; ENSG00000079156 [Q9BZF3-2]
GeneIDi114880
KEGGihsa:114880
UCSCiuc002ulw.4 human [Q9BZF3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323728 mRNA Translation: AAG53409.1
AF392448 mRNA Translation: AAL40661.1
AF462443 mRNA Translation: AAP97711.1
AK027600 mRNA Translation: BAB55223.1 Different initiation.
AK093902 mRNA Translation: BAC04248.1
AK300389 mRNA Translation: BAG62123.1
AB208898 mRNA Translation: BAD92135.1 Different initiation.
AC009948 Genomic DNA Translation: AAX88881.1
AC011743 Genomic DNA Translation: AAY15090.1
AC011238 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11040.1
CH471058 Genomic DNA Translation: EAX11041.1
CH471058 Genomic DNA Translation: EAX11042.1
CH471058 Genomic DNA Translation: EAX11043.1
BC052259 mRNA Translation: AAH52259.1
CCDSiCCDS2277.1 [Q9BZF3-1]
CCDS2278.1 [Q9BZF3-3]
CCDS56150.1 [Q9BZF3-5]
CCDS56151.1 [Q9BZF3-2]
CCDS56152.1 [Q9BZF3-4]
RefSeqiNP_001188409.1, NM_001201480.1 [Q9BZF3-5]
NP_001188410.1, NM_001201481.1 [Q9BZF3-4]
NP_001188411.1, NM_001201482.1 [Q9BZF3-2]
NP_115912.1, NM_032523.3 [Q9BZF3-1]
NP_665682.1, NM_145739.2 [Q9BZF3-3]
XP_016858755.1, XM_017003266.1 [Q9BZF3-5]
XP_016858756.1, XM_017003267.1 [Q9BZF3-5]
XP_016858759.1, XM_017003270.1 [Q9BZF3-4]
XP_016858760.1, XM_017003271.1 [Q9BZF3-2]
UniGeneiHs.318775

3D structure databases

ProteinModelPortaliQ9BZF3
SMRiQ9BZF3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125381, 51 interactors
ELMiQ9BZF3
IntActiQ9BZF3, 7 interactors
MINTiQ9BZF3
STRINGi9606.ENSP00000376293

PTM databases

iPTMnetiQ9BZF3
PhosphoSitePlusiQ9BZF3

Polymorphism and mutation databases

BioMutaiOSBPL6
DMDMi20139133

Proteomic databases

EPDiQ9BZF3
MaxQBiQ9BZF3
PaxDbiQ9BZF3
PeptideAtlasiQ9BZF3
PRIDEiQ9BZF3
ProteomicsDBi79831
79832 [Q9BZF3-2]
79833 [Q9BZF3-3]
79834 [Q9BZF3-4]
79835 [Q9BZF3-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000190611; ENSP00000190611; ENSG00000079156 [Q9BZF3-1]
ENST00000315022; ENSP00000318723; ENSG00000079156 [Q9BZF3-3]
ENST00000357080; ENSP00000349591; ENSG00000079156 [Q9BZF3-6]
ENST00000359685; ENSP00000352713; ENSG00000079156 [Q9BZF3-2]
ENST00000392505; ENSP00000376293; ENSG00000079156 [Q9BZF3-5]
ENST00000409045; ENSP00000387248; ENSG00000079156 [Q9BZF3-4]
ENST00000409631; ENSP00000386885; ENSG00000079156 [Q9BZF3-2]
GeneIDi114880
KEGGihsa:114880
UCSCiuc002ulw.4 human [Q9BZF3-1]

Organism-specific databases

CTDi114880
DisGeNETi114880
EuPathDBiHostDB:ENSG00000079156.16
GeneCardsiOSBPL6
HGNCiHGNC:16388 OSBPL6
HPAiHPA032131
MIMi606734 gene
neXtProtiNX_Q9BZF3
OpenTargetsiENSG00000079156
PharmGKBiPA32830
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231072
HOVERGENiHBG058934
InParanoidiQ9BZF3
KOiK20463
OMAiFVKGNYW
OrthoDBiEOG091G0DJB
PhylomeDBiQ9BZF3
TreeFamiTF320922

Enzyme and pathway databases

ReactomeiR-HSA-192105 Synthesis of bile acids and bile salts

Miscellaneous databases

ChiTaRSiOSBPL6 human
GenomeRNAii114880
PROiPR:Q9BZF3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079156 Expressed in 184 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_OSBPL6
GenevisibleiQ9BZF3 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 2 hits
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL6_HUMAN
AccessioniPrimary (citable) accession number: Q9BZF3
Secondary accession number(s): B4DTW1
, C4AMC0, C4AME4, D3DPF6, D3DPF7, Q4ZG68, Q53T68, Q59H61, Q7Z4Q1, Q86V84, Q8N9T0, Q96SR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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