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UniProtKB - Q9BZF2 (OSBL7_HUMAN)
Protein
Oxysterol-binding protein-related protein 7
Gene
OSBPL7
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cholesterol binding Source: BHF-UCL
- sterol binding Source: GO_Central
- sterol transporter activity Source: GO_Central
GO - Biological processi
- bile acid biosynthetic process Source: Reactome
- cellular response to cholesterol Source: BHF-UCL
- positive regulation of proteasomal protein catabolic process Source: BHF-UCL
- regulation of autophagy Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Lipid transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BZF2 |
Reactomei | R-HSA-192105, Synthesis of bile acids and bile salts |
SignaLinki | Q9BZF2 |
Names & Taxonomyi
Protein namesi | Recommended name: Oxysterol-binding protein-related protein 7Short name: ORP-7 Short name: OSBP-related protein 7 |
Gene namesi | Name:OSBPL7 Synonyms:ORP7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16387, OSBPL7 |
MIMi | 606735, gene |
neXtProti | NX_Q9BZF2 |
VEuPathDBi | HostDB:ENSG00000006025 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication
Cytoplasm and Cytosol
- cytosol 1 Publication
Cytosol
- cytosol Source: BHF-UCL
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- perinuclear endoplasmic reticulum Source: BHF-UCL
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: BHF-UCL
Other locations
- autophagosome Source: BHF-UCL
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 114881 |
OpenTargetsi | ENSG00000006025 |
PharmGKBi | PA32831 |
Miscellaneous databases
Pharosi | Q9BZF2, Tbio |
Genetic variation databases
BioMutai | OSBPL7 |
DMDMi | 20139132 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100377 | 1 – 842 | Oxysterol-binding protein-related protein 7Add BLAST | 842 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 171 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 217 | PhosphoserineCombined sources | 1 | |
Modified residuei | 226 | PhosphoserineCombined sources | 1 | |
Modified residuei | 256 | PhosphoserineCombined sources | 1 | |
Modified residuei | 272 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BZF2 |
jPOSTi | Q9BZF2 |
MassIVEi | Q9BZF2 |
MaxQBi | Q9BZF2 |
PaxDbi | Q9BZF2 |
PeptideAtlasi | Q9BZF2 |
PRIDEi | Q9BZF2 |
ProteomicsDBi | 79830 [Q9BZF2-1] |
PTM databases
iPTMneti | Q9BZF2 |
MetOSitei | Q9BZF2 |
PhosphoSitePlusi | Q9BZF2 |
Expressioni
Tissue specificityi
Expressed in epithelium of small and large intestines (at protein level). Expressed in stomach, duodenum, jejunum, ascending colon, spleen, thymus, lymph node, trachea and leukocytes.1 Publication
Developmental stagei
Expressed in fetal lung and thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000006025, Expressed in fundus of stomach and 176 other tissues |
ExpressionAtlasi | Q9BZF2, baseline and differential |
Genevisiblei | Q9BZF2, HS |
Organism-specific databases
HPAi | ENSG00000006025, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125382, 15 interactors |
ELMi | Q9BZF2 |
IntActi | Q9BZF2, 1 interactor |
STRINGi | 9606.ENSP00000007414 |
Miscellaneous databases
RNActi | Q9BZF2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 142 | PHPROSITE-ProRule annotationAdd BLAST | 96 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 330 – 369 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 28 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 339 – 369 | Polar residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the OSBP family.Curated
Phylogenomic databases
eggNOGi | KOG1737, Eukaryota |
GeneTreei | ENSGT00940000157439 |
HOGENOMi | CLU_007105_4_1_1 |
InParanoidi | Q9BZF2 |
OMAi | SWVTQLR |
OrthoDBi | 542090at2759 |
PhylomeDBi | Q9BZF2 |
TreeFami | TF320922 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037239, OSBP_sf IPR000648, Oxysterol-bd IPR018494, Oxysterol-bd_CS IPR011993, PH-like_dom_sf IPR041680, PH_8 IPR001849, PH_domain |
PANTHERi | PTHR10972, PTHR10972, 1 hit |
Pfami | View protein in Pfam PF01237, Oxysterol_BP, 1 hit PF15409, PH_8, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF144000, SSF144000, 1 hit |
PROSITEi | View protein in PROSITE PS01013, OSBP, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BZF2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFQERDPPF LPESAQSSKP SSAQQASELW EVVEEPRVRL GTEGVMPERQ
60 70 80 90 100
EGHLLKKRKW PLKGWHKRYF VLEDGILHYA TTRQDITKGK LHGSIDVRLS
110 120 130 140 150
VMSINKKAQR IDLDTEDNIY HLKIKSQDLF QSWVAQLRAH RLAHRLDMPR
160 170 180 190 200
GSLPSTAHRK VPGAQLPTAA TASALPGLGP REKVSSWLRD SDGLDRCSHE
210 220 230 240 250
LSECQGKLQE LHRLLQSLES LHRIPSAPVI PTHQASVTTE RPKKGKRTSR
260 270 280 290 300
MWCTQSFAKD DTIGRVGRLH GSVPNLSRYL ESRDSSGTRG LPPTDYAHLQ
310 320 330 340 350
RSFWALAQKV HSSLSSVLAA LTMERDQLRD MHQGSELSRM GVSEASTGQR
360 370 380 390 400
RLHSLSTSSD TTADSFSSLN PEEQEALYMK GRELTPQLSQ TSILSLADSH
410 420 430 440 450
TEFFDACEVL LSASSSENEG SEEEESCTSE ITTSLSEEML DLRGAERCQK
460 470 480 490 500
GGCVPGRPMG PPRRRCLPAA SGPGADVSLW NILRNNIGKD LSKVSMPVQL
510 520 530 540 550
NEPLNTLQRL CEELEYSSLL DQASRIADPC ERMVYIAAFA VSAYSSTYHR
560 570 580 590 600
AGCKPFNPVL GETYECERPD RGFRFISEQV SHHPPISACH AESENFAFWQ
610 620 630 640 650
DMKWKNKFWG KSLEIVPVGT VNVSLPRFGD HFEWNKVTSC IHNVLSGQRW
660 670 680 690 700
IEHYGEVLIR NTQDSSCHCK ITFCKAKYWS SNVHEVQGAV LSRSGRVLHR
710 720 730 740 750
LFGKWHEGLY RGPTPGGQCI WKPNSMPPDH ERNFGFTQFA LELNELTAEL
760 770 780 790 800
KRSLPSTDTR LRPDQRYLEE GNIQAAEAQK RRIEQLQRDR RKVMEENNIV
810 820 830 840
HQARFFRRQT DSSGKEWWVT NNTYWRLRAE PGYGNMDGAV LW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QLK7 | J3QLK7_HUMAN | Oxysterol-binding protein-related p... | OSBPL7 | 420 | Annotation score: | ||
J3QSC2 | J3QSC2_HUMAN | Oxysterol-binding protein-related p... | OSBPL7 | 19 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060080 | 148 | M → I. Corresponds to variant dbSNP:rs8076196Ensembl. | 1 | |
Natural variantiVAR_053551 | 156 | T → I. Corresponds to variant dbSNP:rs35437144Ensembl. | 1 | |
Natural variantiVAR_060081 | 169 | A → E. Corresponds to variant dbSNP:rs8071195Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057227 | 343 – 357 | SEAST…HSLST → RPGGQGDWCGERASS in isoform 2. 2 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_057228 | 358 – 842 | Missing in isoform 2. 2 PublicationsAdd BLAST | 485 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF323729 mRNA Translation: AAG53410.1 AK289523 mRNA Translation: BAF82212.1 AC003665 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94800.1 CH471109 Genomic DNA Translation: EAW94801.1 CH471109 Genomic DNA Translation: EAW94802.1 CH471109 Genomic DNA Translation: EAW94803.1 BC028010 mRNA Translation: AAH28010.1 BC065482 mRNA Translation: AAH65482.1 |
CCDSi | CCDS11515.1 [Q9BZF2-1] |
RefSeqi | NP_665741.1, NM_145798.2 [Q9BZF2-1] |
Genome annotation databases
Ensembli | ENST00000007414.8; ENSP00000007414.3; ENSG00000006025.12 ENST00000392507.7; ENSP00000376295.3; ENSG00000006025.12 ENST00000613735.4; ENSP00000479827.1; ENSG00000006025.12 [Q9BZF2-2] |
GeneIDi | 114881 |
KEGGi | hsa:114881 |
MANE-Selecti | ENST00000007414.8; ENSP00000007414.3; NM_145798.3; NP_665741.1 |
UCSCi | uc002ilx.2, human [Q9BZF2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF323729 mRNA Translation: AAG53410.1 AK289523 mRNA Translation: BAF82212.1 AC003665 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94800.1 CH471109 Genomic DNA Translation: EAW94801.1 CH471109 Genomic DNA Translation: EAW94802.1 CH471109 Genomic DNA Translation: EAW94803.1 BC028010 mRNA Translation: AAH28010.1 BC065482 mRNA Translation: AAH65482.1 |
CCDSi | CCDS11515.1 [Q9BZF2-1] |
RefSeqi | NP_665741.1, NM_145798.2 [Q9BZF2-1] |
3D structure databases
AlphaFoldDBi | Q9BZF2 |
SMRi | Q9BZF2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125382, 15 interactors |
ELMi | Q9BZF2 |
IntActi | Q9BZF2, 1 interactor |
STRINGi | 9606.ENSP00000007414 |
PTM databases
iPTMneti | Q9BZF2 |
MetOSitei | Q9BZF2 |
PhosphoSitePlusi | Q9BZF2 |
Genetic variation databases
BioMutai | OSBPL7 |
DMDMi | 20139132 |
Proteomic databases
EPDi | Q9BZF2 |
jPOSTi | Q9BZF2 |
MassIVEi | Q9BZF2 |
MaxQBi | Q9BZF2 |
PaxDbi | Q9BZF2 |
PeptideAtlasi | Q9BZF2 |
PRIDEi | Q9BZF2 |
ProteomicsDBi | 79830 [Q9BZF2-1] |
Protocols and materials databases
Antibodypediai | 30177, 47 antibodies from 19 providers |
DNASUi | 114881 |
Genome annotation databases
Ensembli | ENST00000007414.8; ENSP00000007414.3; ENSG00000006025.12 ENST00000392507.7; ENSP00000376295.3; ENSG00000006025.12 ENST00000613735.4; ENSP00000479827.1; ENSG00000006025.12 [Q9BZF2-2] |
GeneIDi | 114881 |
KEGGi | hsa:114881 |
MANE-Selecti | ENST00000007414.8; ENSP00000007414.3; NM_145798.3; NP_665741.1 |
UCSCi | uc002ilx.2, human [Q9BZF2-1] |
Organism-specific databases
CTDi | 114881 |
DisGeNETi | 114881 |
GeneCardsi | OSBPL7 |
HGNCi | HGNC:16387, OSBPL7 |
HPAi | ENSG00000006025, Low tissue specificity |
MIMi | 606735, gene |
neXtProti | NX_Q9BZF2 |
OpenTargetsi | ENSG00000006025 |
PharmGKBi | PA32831 |
VEuPathDBi | HostDB:ENSG00000006025 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1737, Eukaryota |
GeneTreei | ENSGT00940000157439 |
HOGENOMi | CLU_007105_4_1_1 |
InParanoidi | Q9BZF2 |
OMAi | SWVTQLR |
OrthoDBi | 542090at2759 |
PhylomeDBi | Q9BZF2 |
TreeFami | TF320922 |
Enzyme and pathway databases
PathwayCommonsi | Q9BZF2 |
Reactomei | R-HSA-192105, Synthesis of bile acids and bile salts |
SignaLinki | Q9BZF2 |
Miscellaneous databases
BioGRID-ORCSi | 114881, 18 hits in 1077 CRISPR screens |
ChiTaRSi | OSBPL7, human |
GenomeRNAii | 114881 |
Pharosi | Q9BZF2, Tbio |
PROi | PR:Q9BZF2 |
RNActi | Q9BZF2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000006025, Expressed in fundus of stomach and 176 other tissues |
ExpressionAtlasi | Q9BZF2, baseline and differential |
Genevisiblei | Q9BZF2, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037239, OSBP_sf IPR000648, Oxysterol-bd IPR018494, Oxysterol-bd_CS IPR011993, PH-like_dom_sf IPR041680, PH_8 IPR001849, PH_domain |
PANTHERi | PTHR10972, PTHR10972, 1 hit |
Pfami | View protein in Pfam PF01237, Oxysterol_BP, 1 hit PF15409, PH_8, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF144000, SSF144000, 1 hit |
PROSITEi | View protein in PROSITE PS01013, OSBP, 1 hit PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OSBL7_HUMAN | |
Accessioni | Q9BZF2Primary (citable) accession number: Q9BZF2 Secondary accession number(s): D3DTT6, Q6PIV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families