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Protein

Nucleolar GTP-binding protein 1

Gene

GTPBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 182GTPPROSITE-ProRule annotation8
Nucleotide bindingi221 – 225GTPPROSITE-ProRule annotation5
Nucleotide bindingi289 – 292GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GTPase activity Source: HGNC
  • GTP binding Source: HGNC
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 1
Alternative name(s):
Chronic renal failure gene protein
GTP-binding protein NGB
Gene namesi
Name:GTPBP4
Synonyms:CRFG, NOG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107937.18
HGNCiHGNC:21535 GTPBP4
neXtProtiNX_Q9BZE4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23560
OpenTargetsiENSG00000107937
PharmGKBiPA134922009

Polymorphism and mutation databases

BioMutaiGTPBP4
DMDMi17368711

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001950232 – 634Nucleolar GTP-binding protein 1Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei103N6-acetyllysine; alternateCombined sources1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei122PhosphoserineCombined sources1
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei468PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei522N6-acetyllysineCombined sources1
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei558PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BZE4
MaxQBiQ9BZE4
PaxDbiQ9BZE4
PeptideAtlasiQ9BZE4
PRIDEiQ9BZE4
ProteomicsDBi79822

2D gel databases

SWISS-2DPAGEiQ9BZE4

PTM databases

iPTMnetiQ9BZE4
PhosphoSitePlusiQ9BZE4
SwissPalmiQ9BZE4

Expressioni

Gene expression databases

BgeeiENSG00000107937 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_GTPBP4
ExpressionAtlasiQ9BZE4 baseline and differential
GenevisibleiQ9BZE4 HS

Organism-specific databases

HPAiHPA039618
HPA056468

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NF2P352409EBI-1056249,EBI-1014472

Protein-protein interaction databases

BioGridi117104, 148 interactors
IntActiQ9BZE4, 42 interactors
MINTiQ9BZE4
STRINGi9606.ENSP00000354040

Structurei

3D structure databases

ProteinModelPortaliQ9BZE4
SMRiQ9BZE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 340OBG-type GPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1490 Eukaryota
COG1084 LUCA
GeneTreeiENSGT00390000018475
HOGENOMiHOG000164071
HOVERGENiHBG052642
InParanoidiQ9BZE4
KOiK06943
OMAiSAIMYFM
OrthoDBiEOG091G0476
PhylomeDBiQ9BZE4
TreeFamiTF300430

Family and domain databases

InterProiView protein in InterPro
IPR031167 G_OBG
IPR006073 GTP_binding_domain
IPR024926 NOG1
IPR010674 NOG1_Rossman_fold_dom
IPR012973 NOG_C
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PANTHERiPTHR11702:SF4 PTHR11702:SF4, 1 hit
PfamiView protein in Pfam
PF06858 NOG1, 1 hit
PF08155 NOGCT, 1 hit
PIRSFiPIRSF038919 NOG1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK
60 70 80 90 100
VKFTQQNYHD RLSQILTDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN
110 120 130 140 150
IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTV IKRQKQSLEY
160 170 180 190 200
LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF
210 220 230 240 250
TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA
260 270 280 290 300
VLYVMDLSEQ CGHGLREQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS
310 320 330 340 350
EDDQKIFTDL QSEGFPVIET STLTEEGVIK VKTEACDRLL AHRVETKMKG
360 370 380 390 400
NKVNEVLNRL HLAIPTRRDD KERPPFIPEG VVARRKRMET EESRKKRERD
410 420 430 440 450
LELEMGDDYI LDLQKYWDLM NLSEKHDKIP EIWEGHNIAD YIDPAIMKKL
460 470 480 490 500
EELEKEEELR TAAGEYDSVS ESEDEEMLEI RQLAKQIREK KKLKILESKE
510 520 530 540 550
KNTQGPRMPR TAKKVQRTVL EKEMRSLGVD MDDKDDAHYA VQARRSRSIT
560 570 580 590 600
RKRKREDSAP PSSVARSGSC SRTPRDVSGL RDVKMVKKAK TMMKNAQKKM
610 620 630
NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR
Length:634
Mass (Da):73,964
Last modified:January 23, 2007 - v3
Checksum:i0A05E65E65D6DB62
GO
Isoform 2 (identifier: Q9BZE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):68,273
Checksum:i185E3546E24D4BE8
GO
Isoform 3 (identifier: Q9BZE4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Note: No experimental confirmation available.
Show »
Length:518
Mass (Da):60,051
Checksum:i7F5B0AADB755446E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T3R7Q5T3R7_HUMAN
Nucleolar GTP-binding protein 1
GTPBP4
140Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti593Missing in AAD09830 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068801525R → H1 PublicationCorresponds to variant dbSNP:rs3207775Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561461 – 116Missing in isoform 3. CuratedAdd BLAST116
Alternative sequenceiVSP_0561471 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120334 mRNA Translation: AAD09830.1
AF325353 mRNA Translation: AAK13444.1
AK001548 mRNA Translation: BAG50937.1
AK001552 mRNA Translation: BAA91752.1
AK301721 mRNA Translation: BAH13539.1
AK302219 mRNA Translation: BAG63575.1
AC022536 Genomic DNA No translation available.
AL359878 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86526.1
BC038975 mRNA Translation: AAH38975.1
CCDSiCCDS31132.1 [Q9BZE4-1]
RefSeqiNP_036473.2, NM_012341.2 [Q9BZE4-1]
UniGeneiHs.215766

Genome annotation databases

EnsembliENST00000360803; ENSP00000354040; ENSG00000107937 [Q9BZE4-1]
GeneIDi23560
KEGGihsa:23560
UCSCiuc001ift.4 human [Q9BZE4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120334 mRNA Translation: AAD09830.1
AF325353 mRNA Translation: AAK13444.1
AK001548 mRNA Translation: BAG50937.1
AK001552 mRNA Translation: BAA91752.1
AK301721 mRNA Translation: BAH13539.1
AK302219 mRNA Translation: BAG63575.1
AC022536 Genomic DNA No translation available.
AL359878 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86526.1
BC038975 mRNA Translation: AAH38975.1
CCDSiCCDS31132.1 [Q9BZE4-1]
RefSeqiNP_036473.2, NM_012341.2 [Q9BZE4-1]
UniGeneiHs.215766

3D structure databases

ProteinModelPortaliQ9BZE4
SMRiQ9BZE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117104, 148 interactors
IntActiQ9BZE4, 42 interactors
MINTiQ9BZE4
STRINGi9606.ENSP00000354040

PTM databases

iPTMnetiQ9BZE4
PhosphoSitePlusiQ9BZE4
SwissPalmiQ9BZE4

Polymorphism and mutation databases

BioMutaiGTPBP4
DMDMi17368711

2D gel databases

SWISS-2DPAGEiQ9BZE4

Proteomic databases

EPDiQ9BZE4
MaxQBiQ9BZE4
PaxDbiQ9BZE4
PeptideAtlasiQ9BZE4
PRIDEiQ9BZE4
ProteomicsDBi79822

Protocols and materials databases

DNASUi23560
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360803; ENSP00000354040; ENSG00000107937 [Q9BZE4-1]
GeneIDi23560
KEGGihsa:23560
UCSCiuc001ift.4 human [Q9BZE4-1]

Organism-specific databases

CTDi23560
DisGeNETi23560
EuPathDBiHostDB:ENSG00000107937.18
GeneCardsiGTPBP4
HGNCiHGNC:21535 GTPBP4
HPAiHPA039618
HPA056468
neXtProtiNX_Q9BZE4
OpenTargetsiENSG00000107937
PharmGKBiPA134922009
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1490 Eukaryota
COG1084 LUCA
GeneTreeiENSGT00390000018475
HOGENOMiHOG000164071
HOVERGENiHBG052642
InParanoidiQ9BZE4
KOiK06943
OMAiSAIMYFM
OrthoDBiEOG091G0476
PhylomeDBiQ9BZE4
TreeFamiTF300430

Miscellaneous databases

ChiTaRSiGTPBP4 human
GeneWikiiGTPBP4
GenomeRNAii23560
PROiPR:Q9BZE4

Gene expression databases

BgeeiENSG00000107937 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_GTPBP4
ExpressionAtlasiQ9BZE4 baseline and differential
GenevisibleiQ9BZE4 HS

Family and domain databases

InterProiView protein in InterPro
IPR031167 G_OBG
IPR006073 GTP_binding_domain
IPR024926 NOG1
IPR010674 NOG1_Rossman_fold_dom
IPR012973 NOG_C
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PANTHERiPTHR11702:SF4 PTHR11702:SF4, 1 hit
PfamiView protein in Pfam
PF06858 NOG1, 1 hit
PF08155 NOGCT, 1 hit
PIRSFiPIRSF038919 NOG1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOG1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE4
Secondary accession number(s): B3KMC5
, B4DY13, B7Z7A3, O95446, Q5T3R8, Q9NVJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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