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Protein

BarH-like 1 homeobox protein

Gene

BARHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi178 – 237HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 1 homeobox protein
Gene namesi
Name:BARHL1
ORF Names:FKSG31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000125492.9
HGNCiHGNC:953 BARHL1
MIMi605211 gene
neXtProtiNX_Q9BZE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125492
PharmGKBiPA25257

Polymorphism and mutation databases

BioMutaiBARHL1
DMDMi29336920

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488261 – 327BarH-like 1 homeobox proteinAdd BLAST327

Proteomic databases

PaxDbiQ9BZE3
PRIDEiQ9BZE3
ProteomicsDBi79821

PTM databases

iPTMnetiQ9BZE3
PhosphoSitePlusiQ9BZE3

Expressioni

Gene expression databases

BgeeiENSG00000125492
CleanExiHS_BARHL1
GenevisibleiQ9BZE3 HS

Organism-specific databases

HPAiHPA004809

Interactioni

Protein-protein interaction databases

BioGridi121195, 3 interactors
IntActiQ9BZE3, 1 interactor
STRINGi9606.ENSP00000263610

Structurei

3D structure databases

ProteinModelPortaliQ9BZE3
SMRiQ9BZE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000231533
HOVERGENiHBG050663
InParanoidiQ9BZE3
KOiK09360
OMAiSDSEYKG
OrthoDBiEOG091G13SM
PhylomeDBiQ9BZE3
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BZE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSNGFGID SILSHRAGSP ALPKGDPLLG DCRSPLELSP RSESSSDCSS
60 70 80 90 100
PASPGRDCLE TGTPRPGGAS GPGLDSHLQP GQLSAPAQSR TVTSSFLIRD
110 120 130 140 150
ILADCKPLAA CAPYSSSGQP AAPEPGGRLA AKAAEDFRDK LDKSGSNASS
160 170 180 190 200
DSEYKVKEEG DREISSSRDS PPVRLKKPRK ARTAFTDHQL AQLERSFERQ
210 220 230 240 250
KYLSVQDRME LAASLNLTDT QVKTWYQNRR TKWKRQTAVG LELLAEAGNY
260 270 280 290 300
SALQRMFPSP YFYPQSLVSN LDPGAALYLY RGPSAPPPAL QRPLVPRILI
310 320
HGLQGASEPP PPLPPLAGVL PRAAQPR
Length:327
Mass (Da):35,074
Last modified:June 1, 2001 - v1
Checksum:i5BFCE201BC6359D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325688 mRNA Translation: AAG50279.1
AF321618 mRNA Translation: AAK52674.1
AK054797 mRNA Translation: BAB70807.1
AL354735 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88005.1
BC136956 mRNA Translation: AAI36957.1
BC136969 mRNA Translation: AAI36970.1
AJ237816 Genomic DNA Translation: CAB92439.1
CCDSiCCDS6950.1
RefSeqiNP_064448.1, NM_020064.3
UniGeneiHs.283809

Genome annotation databases

EnsembliENST00000263610; ENSP00000263610; ENSG00000125492
ENST00000542090; ENSP00000444704; ENSG00000125492
GeneIDi56751
KEGGihsa:56751
UCSCiuc004cbp.2 human

Similar proteinsi

Entry informationi

Entry nameiBARH1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE3
Secondary accession number(s): Q5T6V2, Q9NY88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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