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Protein

39S ribosomal protein L37, mitochondrial

Gene

MRPL37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L37, mitochondrial
Short name:
L37mt
Short name:
MRP-L37
Alternative name(s):
39S ribosomal protein L2, mitochondrial
Short name:
L2mt
Short name:
MRP-L2
Mitochondrial large ribosomal subunit protein mL371 Publication
Gene namesi
Name:MRPL37
Synonyms:MRPL2, RPML2
ORF Names:HSPC235
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116221.15
HGNCiHGNC:14034 MRPL37
MIMi611843 gene
neXtProtiNX_Q9BZE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116221
PharmGKBiPA30968

Polymorphism and mutation databases

BioMutaiMRPL37
DMDMi152083350

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000004590530 – 42339S ribosomal protein L37, mitochondrialAdd BLAST394

Proteomic databases

EPDiQ9BZE1
MaxQBiQ9BZE1
PaxDbiQ9BZE1
PeptideAtlasiQ9BZE1
PRIDEiQ9BZE1
ProteomicsDBi79819

PTM databases

iPTMnetiQ9BZE1
PhosphoSitePlusiQ9BZE1
SwissPalmiQ9BZE1

Expressioni

Gene expression databases

BgeeiENSG00000116221 Expressed in 197 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL2
HS_MRPL37
ExpressionAtlasiQ9BZE1 baseline and differential
GenevisibleiQ9BZE1 HS

Organism-specific databases

HPAiHPA025767
HPA025826
HPA025951

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL37 forms a heterodimer with mL65.3 Publications

Protein-protein interaction databases

BioGridi119410, 84 interactors
CORUMiQ9BZE1
DIPiDIP-59718N
IntActiQ9BZE1, 27 interactors
MINTiQ9BZE1
STRINGi9606.ENSP00000354086

Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BZE1
SMRiQ9BZE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IKEJ Eukaryota
ENOG410ZT8U LUCA
GeneTreeiENSGT00390000000867
HOGENOMiHOG000253919
HOVERGENiHBG080542
InParanoidiQ9BZE1
KOiK17418
PhylomeDBiQ9BZE1
TreeFamiTF323297

Family and domain databases

InterProiView protein in InterPro
IPR010793 Ribosomal_L37/S30
PfamiView protein in Pfam
PF07147 PDCD9, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BZE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY
60 70 80 90 100
EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK
110 120 130 140 150
DQACYIFHHR CRLLEGVKQA LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ
160 170 180 190 200
DECVLNVISH ARLWQTTEEI PKRETYCPVI VDNLIQLCKS QILKHPSLAR
210 220 230 240 250
RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA SREEIEATKN
260 270 280 290 300
HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR
310 320 330 340 350
PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR
360 370 380 390 400
VFHFLVFQLN TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP
410 420
VGPVGFKPET FRKFLALYLH GAA
Length:423
Mass (Da):48,117
Last modified:May 29, 2007 - v2
Checksum:i9556DAF4349F6EEB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R369S4R369_HUMAN
39S ribosomal protein L37, mitochon...
MRPL37
483Annotation score:
A6NHR2A6NHR2_HUMAN
39S ribosomal protein L37, mitochon...
MRPL37
292Annotation score:
H0Y4J2H0Y4J2_HUMAN
39S ribosomal protein L37, mitochon...
MRPL37
264Annotation score:

Sequence cautioni

The sequence AAF36155 differs from that shown. Reason: Frameshift at positions 9, 13, 25, 30 and 326.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025269322L → V1 PublicationCorresponds to variant dbSNP:rs2275408Ensembl.1
Natural variantiVAR_025270366C → S3 PublicationsCorresponds to variant dbSNP:rs13571Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325707 mRNA Translation: AAG52881.1
AF151069 mRNA Translation: AAF36155.1 Frameshift.
DQ205685 Genomic DNA Translation: ABA27099.1
AL357673 Genomic DNA No translation available.
AL161644 Genomic DNA No translation available.
BC000041 mRNA Translation: AAH00041.1
AB051344 Genomic DNA Translation: BAB54934.1
CCDSiCCDS589.1
RefSeqiNP_057575.2, NM_016491.3
UniGeneiHs.584908

Genome annotation databases

EnsembliENST00000360840; ENSP00000354086; ENSG00000116221
GeneIDi51253
KEGGihsa:51253
UCSCiuc001cxa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325707 mRNA Translation: AAG52881.1
AF151069 mRNA Translation: AAF36155.1 Frameshift.
DQ205685 Genomic DNA Translation: ABA27099.1
AL357673 Genomic DNA No translation available.
AL161644 Genomic DNA No translation available.
BC000041 mRNA Translation: AAH00041.1
AB051344 Genomic DNA Translation: BAB54934.1
CCDSiCCDS589.1
RefSeqiNP_057575.2, NM_016491.3
UniGeneiHs.584908

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4051-423[»]
3J9Melectron microscopy3.5051-423[»]
5OOLelectron microscopy3.0651-423[»]
5OOMelectron microscopy3.0351-423[»]
ProteinModelPortaliQ9BZE1
SMRiQ9BZE1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119410, 84 interactors
CORUMiQ9BZE1
DIPiDIP-59718N
IntActiQ9BZE1, 27 interactors
MINTiQ9BZE1
STRINGi9606.ENSP00000354086

PTM databases

iPTMnetiQ9BZE1
PhosphoSitePlusiQ9BZE1
SwissPalmiQ9BZE1

Polymorphism and mutation databases

BioMutaiMRPL37
DMDMi152083350

Proteomic databases

EPDiQ9BZE1
MaxQBiQ9BZE1
PaxDbiQ9BZE1
PeptideAtlasiQ9BZE1
PRIDEiQ9BZE1
ProteomicsDBi79819

Protocols and materials databases

DNASUi51253
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360840; ENSP00000354086; ENSG00000116221
GeneIDi51253
KEGGihsa:51253
UCSCiuc001cxa.4 human

Organism-specific databases

CTDi51253
EuPathDBiHostDB:ENSG00000116221.15
GeneCardsiMRPL37
HGNCiHGNC:14034 MRPL37
HPAiHPA025767
HPA025826
HPA025951
MIMi611843 gene
neXtProtiNX_Q9BZE1
OpenTargetsiENSG00000116221
PharmGKBiPA30968
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKEJ Eukaryota
ENOG410ZT8U LUCA
GeneTreeiENSGT00390000000867
HOGENOMiHOG000253919
HOVERGENiHBG080542
InParanoidiQ9BZE1
KOiK17418
PhylomeDBiQ9BZE1
TreeFamiTF323297

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL37 human
GeneWikiiMRPL37
GenomeRNAii51253
PROiPR:Q9BZE1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116221 Expressed in 197 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL2
HS_MRPL37
ExpressionAtlasiQ9BZE1 baseline and differential
GenevisibleiQ9BZE1 HS

Family and domain databases

InterProiView protein in InterPro
IPR010793 Ribosomal_L37/S30
PfamiView protein in Pfam
PF07147 PDCD9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM37_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE1
Secondary accession number(s): Q96Q67, Q9BWR1, Q9P0P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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