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Protein

Putative GRINL1B complex locus protein 2

Gene

GCOM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative GRINL1B complex locus protein 2
Alternative name(s):
Glutamate receptor-like protein 1B
Gene namesi
Name:GCOM2
Synonyms:GRINL1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15712 GCOM2
MIMi608311 gene
neXtProtiNX_Q9BZD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi172046229

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262291 – 368Putative GRINL1B complex locus protein 2Add BLAST368

Proteomic databases

EPDiQ9BZD3
MaxQBiQ9BZD3
PeptideAtlasiQ9BZD3
PRIDEiQ9BZD3
ProteomicsDBi79814

PTM databases

iPTMnetiQ9BZD3
PhosphoSitePlusiQ9BZD3

Expressioni

Organism-specific databases

HPAiHPA068141

Structurei

3D structure databases

ProteinModelPortaliQ9BZD3
SMRiQ9BZD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 39Sequence analysisAdd BLAST25
Coiled coili301 – 335Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 280Poly-Arg4

Sequence similaritiesi

Belongs to the GRINL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVF6 Eukaryota
ENOG410ZKMZ LUCA
HOVERGENiHBG098324
InParanoidiQ9BZD3

Family and domain databases

InterProiView protein in InterPro
IPR026213 GRINL1
PfamiView protein in Pfam
PF15328 GCOM2, 1 hit
PRINTSiPR02085 POLR2GRINL1

Sequencei

Sequence statusi: Complete.

Q9BZD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCLLPRGFEP QAPEDLAQRS LVELREMLKL QERLLRNEKF ICKLPDKGKK
60 70 80 90 100
IFDSFAKLKA AIAECEEVRR KNELFHPVSL DCKLRQKAIA EVDVGTDKAR
110 120 130 140 150
NSDPILDTSS LVPGCSSVDN IKSSQTSQNQ GLGRPTLEGD EETSEVEYTV
160 170 180 190 200
NKGPASSNRD RVPPSSEASE HHPQHRVSSQ AEDTSSSFDN LFIDRLQRIT
210 220 230 240 250
IADQGEQQSE ENASTKNLTG LSSGTQKKPH YMEVLEMRAK NPGPQLRKFK
260 270 280 290 300
TNVLPFRQND SSSHCQKSGS PISSKERRRR DKQHLDDITA ARLLPLHHMP
310 320 330 340 350
TQLLSIEESL ALQKQQKQNY EEMQAKLAAQ KLAERPNIKM RSYNPEGESS
360
GRYREVRDED DDWSSDEF
Length:368
Mass (Da):41,713
Last modified:March 18, 2008 - v2
Checksum:iA642B1D9A908BCB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054145176R → H in an acute myeloid leukemia sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096727 Genomic DNA No translation available.
AF326970 Genomic DNA Translation: AAG50023.1

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096727 Genomic DNA No translation available.
AF326970 Genomic DNA Translation: AAG50023.1

3D structure databases

ProteinModelPortaliQ9BZD3
SMRiQ9BZD3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9BZD3
PhosphoSitePlusiQ9BZD3

Polymorphism and mutation databases

DMDMi172046229

Proteomic databases

EPDiQ9BZD3
MaxQBiQ9BZD3
PeptideAtlasiQ9BZD3
PRIDEiQ9BZD3
ProteomicsDBi79814

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGCOM2
HGNCiHGNC:15712 GCOM2
HPAiHPA068141
MIMi608311 gene
neXtProtiNX_Q9BZD3
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVF6 Eukaryota
ENOG410ZKMZ LUCA
HOVERGENiHBG098324
InParanoidiQ9BZD3

Miscellaneous databases

PROiPR:Q9BZD3
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR026213 GRINL1
PfamiView protein in Pfam
PF15328 GCOM2, 1 hit
PRINTSiPR02085 POLR2GRINL1
ProtoNetiSearch...

Entry informationi

Entry nameiGCOM2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 10, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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