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Protein

Equilibrative nucleoside transporter 3

Gene

SLC29A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.1 Publication

Kineticsi

  1. KM=1.86 mM for adenosine1 Publication
  2. KM=2.02 mM for uridine1 Publication

    pH dependencei

    Optimum pH is 5.5 for adenosine uptake.1 Publication

    GO - Molecular functioni

    Keywordsi

    Biological processTransport

    Enzyme and pathway databases

    ReactomeiR-HSA-5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)
    R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    Protein family/group databases

    TCDBi2.A.57.1.6 the equilibrative nucleoside transporter (ent) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Equilibrative nucleoside transporter 3
    Short name:
    hENT3
    Alternative name(s):
    Solute carrier family 29 member 3
    Gene namesi
    Name:SLC29A3
    Synonyms:ENT3
    ORF Names:UNQ717/PRO1380
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 10

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000198246.7
    HGNCiHGNC:23096 SLC29A3
    MIMi612373 gene
    neXtProtiNX_Q9BZD2

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 53CytoplasmicSequence analysisAdd BLAST53
    Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
    Topological domaini75 – 105ExtracellularSequence analysisAdd BLAST31
    Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
    Topological domaini127 – 134CytoplasmicSequence analysis8
    Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
    Topological domaini156 – 162ExtracellularSequence analysis7
    Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
    Topological domaini184 – 199CytoplasmicSequence analysisAdd BLAST16
    Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
    Topological domaini221 – 230ExtracellularSequence analysis10
    Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
    Topological domaini252 – 305CytoplasmicSequence analysisAdd BLAST54
    Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
    Topological domaini327 – 337ExtracellularSequence analysisAdd BLAST11
    Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
    Topological domaini359 – 377CytoplasmicSequence analysisAdd BLAST19
    Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
    Topological domaini399 – 415ExtracellularSequence analysisAdd BLAST17
    Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
    Topological domaini437 – 454CytoplasmicSequence analysisAdd BLAST18
    Transmembranei455 – 475HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Histiocytosis-lymphadenopathy plus syndrome (HLAS)9 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA syndrome characterized by the combination of features from 2 or more of four histiocytic disorders, originally thought to be distinct: Faisalabad histiocytosis (FHC), sinus histiocytosis with massive lymphadenopathy (SHML), H syndrome, and pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome (PHID). FHC features include joint deformities, sensorineural hearing loss, and subsequent development of generalized lymphadenopathy and swellings in the eyelids that contain histiocytes. SHML causes lymph node enlargement in children frequently accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. H syndrome is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism; hearing loss is found in about half of patients. PHID is characterized by predominantly antibody-negative insulin-dependent diabetes mellitus associated with pigmented hypertrichosis and variable occurrence of other features of H syndrome.
    See also OMIM:602782
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_067801116M → R in HLAS; partially retained in the endoplasmic reticulum; results in reduced nucleoside transport. 2 PublicationsCorresponds to variant dbSNP:rs267607057EnsemblClinVar.1
    Natural variantiVAR_067802134R → C in HLAS. 1 Publication1
    Natural variantiVAR_067804184S → R in HLAS. 1 PublicationCorresponds to variant dbSNP:rs1023257012Ensembl.1
    Natural variantiVAR_067806363R → Q in HLAS. 2 PublicationsCorresponds to variant dbSNP:rs387907066EnsemblClinVar.1
    Natural variantiVAR_067807363R → W in HLAS. 1 PublicationCorresponds to variant dbSNP:rs387907067EnsemblClinVar.1
    Natural variantiVAR_057884427G → S in HLAS; almost total loss of nucleoside transport. 3 PublicationsCorresponds to variant dbSNP:rs121912583EnsemblClinVar.1
    Natural variantiVAR_057885437G → R in HLAS; results in reduced nucleoside transport. 7 PublicationsCorresponds to variant dbSNP:rs121912584EnsemblClinVar.1
    Natural variantiVAR_067809449T → R in HLAS; results in reduced nucleoside transport. 2 PublicationsCorresponds to variant dbSNP:rs267607058EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi31L → A: Localization at the cell surface; when associated with A-32. 1 Publication1
    Mutagenesisi32L → A: Localization at the cell surface; when associated with A-31. 1 Publication1
    Mutagenesisi427G → A, F, Y or T: Results in impaired nucleoside transport. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi55315
    MalaCardsiSLC29A3
    MIMi602782 phenotype
    OpenTargetsiENSG00000198246
    Orphaneti1782 Dysosteosclerosis
    168569 H syndrome
    PharmGKBiPA134950750

    Polymorphism and mutation databases

    BioMutaiSLC29A3
    DMDMi313104188

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002093431 – 475Equilibrative nucleoside transporter 3Add BLAST475

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei21PhosphoserineBy similarity1
    Modified residuei23PhosphoserineCombined sources1
    Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    EPDiQ9BZD2
    MaxQBiQ9BZD2
    PaxDbiQ9BZD2
    PeptideAtlasiQ9BZD2
    PRIDEiQ9BZD2
    ProteomicsDBi79812
    79813 [Q9BZD2-2]

    PTM databases

    iPTMnetiQ9BZD2
    PhosphoSitePlusiQ9BZD2

    Expressioni

    Tissue specificityi

    Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart.1 Publication

    Gene expression databases

    BgeeiENSG00000198246 Expressed in 190 organ(s), highest expression level in chorionic villus
    CleanExiHS_SLC29A3
    GenevisibleiQ9BZD2 HS

    Organism-specific databases

    HPAiHPA046085
    HPA054976
    HPA057905

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CREB3O43889-23EBI-12701374,EBI-625022

    Protein-protein interaction databases

    IntActiQ9BZD2, 1 interactor
    STRINGi9606.ENSP00000362285

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZD2
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1479 Eukaryota
    ENOG410Y3MT LUCA
    GeneTreeiENSGT00390000002232
    HOVERGENiHBG108444
    InParanoidiQ9BZD2
    KOiK15014
    OMAiCNYQPRV
    OrthoDBiEOG091G09WB
    PhylomeDBiQ9BZD2
    TreeFamiTF313950

    Family and domain databases

    InterProiView protein in InterPro
    IPR030193 ENT3
    IPR002259 Eqnu_transpt
    PANTHERiPTHR10332 PTHR10332, 1 hit
    PTHR10332:SF17 PTHR10332:SF17, 1 hit
    PfamiView protein in Pfam
    PF01733 Nucleoside_tran, 1 hit
    PIRSFiPIRSF016379 ENT, 1 hit
    PRINTSiPR01130 DERENTRNSPRT

    Sequences (2+)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9BZD2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAVVSEDDFQ HSSNSTYRTT SSSLRADQEA LLEKLLDRPP PGLQRPEDRF
    60 70 80 90 100
    CGTYIIFFSL GIGSLLPWNF FITAKEYWMF KLRNSSSPAT GEDPEGSDIL
    110 120 130 140 150
    NYFESYLAVA STVPSMLCLV ANFLLVNRVA VHIRVLASLT VILAIFMVIT
    160 170 180 190 200
    ALVKVDTSSW TRGFFAVTIV CMVILSGAST VFSSSIYGMT GSFPMRNSQA
    210 220 230 240 250
    LISGGAMGGT VSAVASLVDL AASSDVRNSA LAFFLTATVF LVLCMGLYLL
    260 270 280 290 300
    LSRLEYARYY MRPVLAAHVF SGEEELPQDS LSAPSVASRF IDSHTPPLRP
    310 320 330 340 350
    ILKKTASLGF CVTYVFFITS LIYPAICTNI ESLNKGSGSL WTTKFFIPLT
    360 370 380 390 400
    TFLLYNFADL CGRQLTAWIQ VPGPNSKALP GFVLLRTCLI PLFVLCNYQP
    410 420 430 440 450
    RVHLKTVVFQ SDVYPALLSS LLGLSNGYLS TLALLYGPKI VPRELAEATG
    460 470
    VVMSFYVCLG LTLGSACSTL LVHLI
    Length:475
    Mass (Da):51,815
    Last modified:November 30, 2010 - v3
    Checksum:iDBF0918ECA6D5A70
    GO
    Isoform 2 (identifier: Q9BZD2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-146: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:329
    Mass (Da):35,502
    Checksum:iA06B3DCAB26EB536
    GO

    Computationally mapped potential isoform sequencesi

    There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2R8YDR8A0A2R8YDR8_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    397Annotation score:
    A0A2R8Y5R8A0A2R8Y5R8_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    148Annotation score:
    A0A2R8YDA4A0A2R8YDA4_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    144Annotation score:
    A0A2R8Y863A0A2R8Y863_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    99Annotation score:
    A0A2R8Y657A0A2R8Y657_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    222Annotation score:
    A0A2R8Y4B7A0A2R8Y4B7_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    196Annotation score:
    A0A2R8Y4I0A0A2R8Y4I0_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    122Annotation score:
    A0A2R8YGC2A0A2R8YGC2_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    198Annotation score:
    A0A2R8Y5U2A0A2R8Y5U2_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A3
    120Annotation score:

    Sequence cautioni

    The sequence BAA92041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti32L → P in BAG37097 (PubMed:14702039).Curated1
    Sequence conflicti112T → A in BAA92041 (PubMed:14702039).Curated1
    Sequence conflicti306A → S in BAG65311 (PubMed:14702039).Curated1
    Sequence conflicti370Q → R in BAA92041 (PubMed:14702039).Curated1
    Sequence conflicti453M → I in BAG65311 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_01866218R → G1 PublicationCorresponds to variant dbSNP:rs2277257EnsemblClinVar.1
    Natural variantiVAR_067801116M → R in HLAS; partially retained in the endoplasmic reticulum; results in reduced nucleoside transport. 2 PublicationsCorresponds to variant dbSNP:rs267607057EnsemblClinVar.1
    Natural variantiVAR_067802134R → C in HLAS. 1 Publication1
    Natural variantiVAR_018663158S → F4 PublicationsCorresponds to variant dbSNP:rs780668EnsemblClinVar.1
    Natural variantiVAR_067803163G → V1 PublicationCorresponds to variant dbSNP:rs143557881EnsemblClinVar.1
    Natural variantiVAR_067804184S → R in HLAS. 1 PublicationCorresponds to variant dbSNP:rs1023257012Ensembl.1
    Natural variantiVAR_018664239V → I5 PublicationsCorresponds to variant dbSNP:rs2252996EnsemblClinVar.1
    Natural variantiVAR_067805281L → P1 PublicationCorresponds to variant dbSNP:rs79737301EnsemblClinVar.1
    Natural variantiVAR_018665326I → V5 PublicationsCorresponds to variant dbSNP:rs2487068EnsemblClinVar.1
    Natural variantiVAR_067806363R → Q in HLAS. 2 PublicationsCorresponds to variant dbSNP:rs387907066EnsemblClinVar.1
    Natural variantiVAR_067807363R → W in HLAS. 1 PublicationCorresponds to variant dbSNP:rs387907067EnsemblClinVar.1
    Natural variantiVAR_067808407V → M1 PublicationCorresponds to variant dbSNP:rs144517514Ensembl.1
    Natural variantiVAR_057884427G → S in HLAS; almost total loss of nucleoside transport. 3 PublicationsCorresponds to variant dbSNP:rs121912583EnsemblClinVar.1
    Natural variantiVAR_057885437G → R in HLAS; results in reduced nucleoside transport. 7 PublicationsCorresponds to variant dbSNP:rs121912584EnsemblClinVar.1
    Natural variantiVAR_067809449T → R in HLAS; results in reduced nucleoside transport. 2 PublicationsCorresponds to variant dbSNP:rs267607058EnsemblClinVar.1
    Natural variantiVAR_018666452V → E. Corresponds to variant dbSNP:rs999940Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0374361 – 146Missing in isoform 2. 1 PublicationAdd BLAST146

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF326987 mRNA Translation: AAK00958.1
    BK000392 Genomic DNA Translation: DAA00364.1
    AY288928 mRNA Translation: AAP41133.1
    AY358686 mRNA Translation: AAQ89049.1
    AK002022 mRNA Translation: BAA92041.1 Different initiation.
    AK314497 mRNA Translation: BAG37097.1
    AK304503 mRNA Translation: BAG65311.1
    AK316152 mRNA Translation: BAH14523.1
    AL359183 Genomic DNA No translation available.
    AL359384 Genomic DNA No translation available.
    BC000223 mRNA Translation: AAH00223.1
    BC041575 mRNA Translation: AAH41575.1
    BC120996 mRNA Translation: AAI20997.1
    BC120997 mRNA Translation: AAI20998.1
    CCDSiCCDS7310.1 [Q9BZD2-1]
    RefSeqiNP_001167569.1, NM_001174098.1
    NP_060814.4, NM_018344.5 [Q9BZD2-1]
    XP_016871866.1, XM_017016377.1 [Q9BZD2-2]
    UniGeneiHs.438419

    Genome annotation databases

    EnsembliENST00000373189; ENSP00000362285; ENSG00000198246 [Q9BZD2-1]
    ENST00000642647; ENSP00000495980; ENSG00000198246 [Q9BZD2-1]
    GeneIDi55315
    KEGGihsa:55315
    UCSCiuc001jrr.5 human [Q9BZD2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF326987 mRNA Translation: AAK00958.1
    BK000392 Genomic DNA Translation: DAA00364.1
    AY288928 mRNA Translation: AAP41133.1
    AY358686 mRNA Translation: AAQ89049.1
    AK002022 mRNA Translation: BAA92041.1 Different initiation.
    AK314497 mRNA Translation: BAG37097.1
    AK304503 mRNA Translation: BAG65311.1
    AK316152 mRNA Translation: BAH14523.1
    AL359183 Genomic DNA No translation available.
    AL359384 Genomic DNA No translation available.
    BC000223 mRNA Translation: AAH00223.1
    BC041575 mRNA Translation: AAH41575.1
    BC120996 mRNA Translation: AAI20997.1
    BC120997 mRNA Translation: AAI20998.1
    CCDSiCCDS7310.1 [Q9BZD2-1]
    RefSeqiNP_001167569.1, NM_001174098.1
    NP_060814.4, NM_018344.5 [Q9BZD2-1]
    XP_016871866.1, XM_017016377.1 [Q9BZD2-2]
    UniGeneiHs.438419

    3D structure databases

    ProteinModelPortaliQ9BZD2
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9BZD2, 1 interactor
    STRINGi9606.ENSP00000362285

    Protein family/group databases

    TCDBi2.A.57.1.6 the equilibrative nucleoside transporter (ent) family

    PTM databases

    iPTMnetiQ9BZD2
    PhosphoSitePlusiQ9BZD2

    Polymorphism and mutation databases

    BioMutaiSLC29A3
    DMDMi313104188

    Proteomic databases

    EPDiQ9BZD2
    MaxQBiQ9BZD2
    PaxDbiQ9BZD2
    PeptideAtlasiQ9BZD2
    PRIDEiQ9BZD2
    ProteomicsDBi79812
    79813 [Q9BZD2-2]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000373189; ENSP00000362285; ENSG00000198246 [Q9BZD2-1]
    ENST00000642647; ENSP00000495980; ENSG00000198246 [Q9BZD2-1]
    GeneIDi55315
    KEGGihsa:55315
    UCSCiuc001jrr.5 human [Q9BZD2-1]

    Organism-specific databases

    CTDi55315
    DisGeNETi55315
    EuPathDBiHostDB:ENSG00000198246.7
    GeneCardsiSLC29A3
    H-InvDBiHIX0008903
    HGNCiHGNC:23096 SLC29A3
    HPAiHPA046085
    HPA054976
    HPA057905
    MalaCardsiSLC29A3
    MIMi602782 phenotype
    612373 gene
    neXtProtiNX_Q9BZD2
    OpenTargetsiENSG00000198246
    Orphaneti1782 Dysosteosclerosis
    168569 H syndrome
    PharmGKBiPA134950750
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1479 Eukaryota
    ENOG410Y3MT LUCA
    GeneTreeiENSGT00390000002232
    HOVERGENiHBG108444
    InParanoidiQ9BZD2
    KOiK15014
    OMAiCNYQPRV
    OrthoDBiEOG091G09WB
    PhylomeDBiQ9BZD2
    TreeFamiTF313950

    Enzyme and pathway databases

    ReactomeiR-HSA-5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)
    R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    Miscellaneous databases

    ChiTaRSiSLC29A3 human
    GenomeRNAii55315
    PROiPR:Q9BZD2
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000198246 Expressed in 190 organ(s), highest expression level in chorionic villus
    CleanExiHS_SLC29A3
    GenevisibleiQ9BZD2 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR030193 ENT3
    IPR002259 Eqnu_transpt
    PANTHERiPTHR10332 PTHR10332, 1 hit
    PTHR10332:SF17 PTHR10332:SF17, 1 hit
    PfamiView protein in Pfam
    PF01733 Nucleoside_tran, 1 hit
    PIRSFiPIRSF016379 ENT, 1 hit
    PRINTSiPR01130 DERENTRNSPRT
    ProtoNetiSearch...

    Entry informationi

    Entry nameiS29A3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZD2
    Secondary accession number(s): B2RB50
    , B4E2Z9, B7ZA37, Q0VAM9, Q5T465, Q7RTT8, Q8IVZ0, Q9BWI2, Q9NUS9
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: November 30, 2010
    Last modified: September 12, 2018
    This is version 142 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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