Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 154 (18 Sep 2019)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

CUGBP Elav-like family member 4

Gene

CELF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUGBP Elav-like family member 4
Short name:
CELF-4
Alternative name(s):
Bruno-like protein 4
CUG-BP- and ETR-3-like factor 4
RNA-binding protein BRUNOL-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELF4
Synonyms:BRUNOL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14015 CELF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612679 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56853

Open Targets

More...
OpenTargetsi
ENSG00000101489

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25428

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CELF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761348

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002952211 – 486CUGBP Elav-like family member 4Add BLAST486

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZC1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZC1

PeptideAtlas

More...
PeptideAtlasi
Q9BZC1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZC1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79804 [Q9BZC1-1]
79805 [Q9BZC1-2]
79806 [Q9BZC1-3]
79807 [Q9BZC1-4]
79808 [Q9BZC1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZC1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101489 Expressed in 124 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZC1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZC1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037986

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121213, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZC1, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000410584

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZC1

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BZC1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 135RRM 1PROSITE-ProRule annotationAdd BLAST82
Domaini152 – 232RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini404 – 479RRM 3PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 298Sufficient for RNA-binding and MSE-dependent splicing activityAdd BLAST298
Regioni239 – 258Necessary for TNNT2 exon 5 inclusionAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi260 – 310Ala-richAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0146 Eukaryota
ENOG410XNTW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158673

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZC1

KEGG Orthology (KO)

More...
KOi
K13207

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFTEHEE

Database of Orthologous Groups

More...
OrthoDBi
1209165at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZC1

TreeFam database of animal gene trees

More...
TreeFami
TF314924

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12632 RRM1_CELF3_4_5_6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034648 CELF3/4/5/6_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYIKMATLAN GQADNASLST NGLGSSPGSA GHMNGLSHSP GNPSTIPMKD
60 70 80 90 100
HDAIKLFIGQ IPRNLDEKDL KPLFEEFGKI YELTVLKDRF TGMHKGCAFL
110 120 130 140 150
TYCERESALK AQSALHEQKT LPGMNRPIQV KPADSESRGG SSCLRQPPSQ
160 170 180 190 200
DRKLFVGMLN KQQSEDDVRR LFEAFGNIEE CTILRGPDGN SKGCAFVKYS
210 220 230 240 250
SHAEAQAAIN ALHGSQTMPG ASSSLVVKFA DTDKERTMRR MQQMAGQMGM
260 270 280 290 300
FNPMAIPFGA YGAYAQALMQ QQAALMASVA QGGYLNPMAA FAAAQMQQMA
310 320 330 340 350
ALNMNGLAAA PMTPTSGGST PPGITAPAVP SIPSPIGVNG FTGLPPQANG
360 370 380 390 400
QPAAEAVFAN GIHPYPAQSP TAADPLQQAY AGVQQYAGPA AYPAAYGQIS
410 420 430 440 450
QAFPQPPPMI PQQQREGPEG CNLFIYHLPQ EFGDAELMQM FLPFGFVSFD
460 470 480
NPASAQTAIQ AMNGFQIGMK RLKVQLKRPK DANRPY
Length:486
Mass (Da):51,966
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17EA8A6A6752C565
GO
Isoform 2 (identifier: Q9BZC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-151: QD → H
     388-389: GP → A

Show »
Length:484
Mass (Da):51,777
Checksum:iEAB4512456ED8FAA
GO
Isoform 3 (identifier: Q9BZC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-151: QD → H
     268-268: Missing.

Show »
Length:484
Mass (Da):51,747
Checksum:i090258D14ECB73FC
GO
Isoform 4 (identifier: Q9BZC1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-268: Missing.

Show »
Length:485
Mass (Da):51,853
Checksum:i430142CAE54F71BB
GO
Isoform 5 (identifier: Q9BZC1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-150: GSSCLRQPPSQ → E
     417-444: Missing.

Show »
Length:448
Mass (Da):47,727
Checksum:iF518F3D37DA1386C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERH1K7ERH1_HUMAN
CUGBP Elav-like family member 4
CELF4
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DHA8B4DHA8_HUMAN
CUGBP Elav-like family member 4
CELF4
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJK3K7EJK3_HUMAN
CUGBP Elav-like family member 4
CELF4
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY66M0QY66_HUMAN
CUGBP Elav-like family member 4
CELF4
484Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJD7K7EJD7_HUMAN
CUGBP Elav-like family member 4
CELF4
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGR1A0A0C4DGR1_HUMAN
CUGBP Elav-like family member 4
CELF4
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTT3A0A0A0MTT3_HUMAN
CUGBP Elav-like family member 4
CELF4
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ26K7EJ26_HUMAN
CUGBP Elav-like family member 4
CELF4
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENR2K7ENR2_HUMAN
CUGBP Elav-like family member 4
CELF4
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R137M0R137_HUMAN
CUGBP Elav-like family member 4
CELF4
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93011 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60Q → R in BAC11082 (PubMed:14702039).Curated1
Sequence conflicti166D → E in BAC11082 (PubMed:14702039).Curated1
Sequence conflicti215S → G in BAC11082 (PubMed:14702039).Curated1
Sequence conflicti237T → M in BAC11082 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052203388G → S. Corresponds to variant dbSNP:rs12458669Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026828140 – 150GSSCLRQPPSQ → E in isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_026829150 – 151QD → H in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_026830268Missing in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_026831388 – 389GP → A in isoform 2. 1 Publication2
Alternative sequenceiVSP_026832417 – 444Missing in isoform 5. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF329265 mRNA Translation: AAK07475.1
AK074596 mRNA Translation: BAC11082.1
AB209774 mRNA Translation: BAD93011.1 Different initiation.
BC001946 mRNA Translation: AAH01946.2
BC004167 mRNA Translation: AAH04167.2
BC045711 mRNA Translation: AAH45711.1
AF248650 mRNA Translation: AAF86232.1
AF248651 mRNA Translation: AAF86233.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32818.1 [Q9BZC1-1]
CCDS45856.1 [Q9BZC1-4]
CCDS45857.1 [Q9BZC1-3]
CCDS45858.1 [Q9BZC1-5]
CCDS82250.1 [Q9BZC1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001020258.1, NM_001025087.1 [Q9BZC1-4]
NP_001020259.1, NM_001025088.1 [Q9BZC1-3]
NP_001020260.1, NM_001025089.1 [Q9BZC1-5]
NP_001317532.1, NM_001330603.1 [Q9BZC1-2]
NP_064565.1, NM_020180.3 [Q9BZC1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334919; ENSP00000335631; ENSG00000101489 [Q9BZC1-5]
ENST00000361795; ENSP00000355089; ENSG00000101489 [Q9BZC1-3]
ENST00000420428; ENSP00000410584; ENSG00000101489 [Q9BZC1-1]
ENST00000591282; ENSP00000464794; ENSG00000101489 [Q9BZC1-1]
ENST00000591287; ENSP00000464917; ENSG00000101489 [Q9BZC1-2]
ENST00000603232; ENSP00000474788; ENSG00000101489 [Q9BZC1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56853

UCSC genome browser

More...
UCSCi
uc002lae.3 human [Q9BZC1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329265 mRNA Translation: AAK07475.1
AK074596 mRNA Translation: BAC11082.1
AB209774 mRNA Translation: BAD93011.1 Different initiation.
BC001946 mRNA Translation: AAH01946.2
BC004167 mRNA Translation: AAH04167.2
BC045711 mRNA Translation: AAH45711.1
AF248650 mRNA Translation: AAF86232.1
AF248651 mRNA Translation: AAF86233.1
CCDSiCCDS32818.1 [Q9BZC1-1]
CCDS45856.1 [Q9BZC1-4]
CCDS45857.1 [Q9BZC1-3]
CCDS45858.1 [Q9BZC1-5]
CCDS82250.1 [Q9BZC1-2]
RefSeqiNP_001020258.1, NM_001025087.1 [Q9BZC1-4]
NP_001020259.1, NM_001025088.1 [Q9BZC1-3]
NP_001020260.1, NM_001025089.1 [Q9BZC1-5]
NP_001317532.1, NM_001330603.1 [Q9BZC1-2]
NP_064565.1, NM_020180.3 [Q9BZC1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGPNMR-A48-141[»]
2DNKNMR-A143-235[»]
SMRiQ9BZC1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121213, 2 interactors
IntActiQ9BZC1, 4 interactors
STRINGi9606.ENSP00000410584

PTM databases

iPTMnetiQ9BZC1
PhosphoSitePlusiQ9BZC1

Polymorphism and mutation databases

BioMutaiCELF4
DMDMi74761348

Proteomic databases

MassIVEiQ9BZC1
PaxDbiQ9BZC1
PeptideAtlasiQ9BZC1
PRIDEiQ9BZC1
ProteomicsDBi79804 [Q9BZC1-1]
79805 [Q9BZC1-2]
79806 [Q9BZC1-3]
79807 [Q9BZC1-4]
79808 [Q9BZC1-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334919; ENSP00000335631; ENSG00000101489 [Q9BZC1-5]
ENST00000361795; ENSP00000355089; ENSG00000101489 [Q9BZC1-3]
ENST00000420428; ENSP00000410584; ENSG00000101489 [Q9BZC1-1]
ENST00000591282; ENSP00000464794; ENSG00000101489 [Q9BZC1-1]
ENST00000591287; ENSP00000464917; ENSG00000101489 [Q9BZC1-2]
ENST00000603232; ENSP00000474788; ENSG00000101489 [Q9BZC1-4]
GeneIDi56853
KEGGihsa:56853
UCSCiuc002lae.3 human [Q9BZC1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56853
DisGeNETi56853

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CELF4
HGNCiHGNC:14015 CELF4
HPAiHPA037986
MIMi612679 gene
neXtProtiNX_Q9BZC1
OpenTargetsiENSG00000101489
PharmGKBiPA25428

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00940000158673
InParanoidiQ9BZC1
KOiK13207
OMAiEFTEHEE
OrthoDBi1209165at2759
PhylomeDBiQ9BZC1
TreeFamiTF314924

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CELF4 human
EvolutionaryTraceiQ9BZC1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BRUNOL4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56853

Pharos

More...
Pharosi
Q9BZC1

Protein Ontology

More...
PROi
PR:Q9BZC1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101489 Expressed in 124 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ9BZC1 baseline and differential
GenevisibleiQ9BZC1 HS

Family and domain databases

CDDicd12632 RRM1_CELF3_4_5_6, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034648 CELF3/4/5/6_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELF4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZC1
Secondary accession number(s): Q59EN7
, Q86XB9, Q8N2M6, Q9BQ96, Q9NR84, Q9NR85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: September 18, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again