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Entry version 152 (13 Nov 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Cytoplasmic polyadenylation element-binding protein 1

Gene

CPEB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei411Important for the positionning of RRM1 relative to RRM21 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi515Zinc 1Combined sources1 Publication1
Metal bindingi518Zinc 1Combined sources1 Publication1
Metal bindingi527Zinc 2Combined sources1 Publication1
Metal bindingi532Zinc 2Combined sources1 Publication1
Metal bindingi537Zinc 1Combined sources1 Publication1
Metal bindingi540Zinc 1Combined sources1 Publication1
Metal bindingi545Zinc 2; via tele nitrogenCombined sources1 Publication1
Metal bindingi553Zinc 2; via pros nitrogenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor, Ribonucleoprotein, RNA-binding
Biological processmRNA processing, Translation regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 1
Short name:
CPE-BP1
Short name:
CPE-binding protein 1
Short name:
h-CPEB
Short name:
hCPEB-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPEB1
Synonyms:CPEB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21744 CPEB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607342 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Membrane, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi172T → A: Does not affect its localization. 1 Publication1
Mutagenesisi172T → D: Does not affect its localization. 1 Publication1
Mutagenesisi314F → A: Abolishes stress granule assembly and correct localization in dcp1 bodies. 1 Publication1
Mutagenesisi545H → A: Abolishes stress granule assembly and correct localization in dcp1 bodies. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
64506

Open Targets

More...
OpenTargetsi
ENSG00000214575

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134929879

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZB8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CPEB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002692511 – 566Cytoplasmic polyadenylation element-binding protein 1Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43PhosphoserineCombined sources1
Modified residuei172Phosphothreonine; by AURKA and CAMK2ABy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine/threonine residues by AURKA within positions 166 and 197. Phosphorylation and dephosphorylation on Thr-172 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-172 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-172 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZB8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BZB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZB8

PeptideAtlas

More...
PeptideAtlasi
Q9BZB8

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZB8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79800 [Q9BZB8-1]
79801 [Q9BZB8-2]
79802 [Q9BZB8-3]
79803 [Q9BZB8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214575 Expressed in 175 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZB8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZB8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040396

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with kinesin, dynein, APLP1, APLP2, TENT2/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1 (By similarity).

Interacts with TENT4B; the interaction is required for TENT4B-mediated translational control (PubMed:28383716).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122202, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZB8, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000477715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1566
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZB8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini311 – 408RRM 1PROSITE-ProRule annotationAdd BLAST98
Domaini430 – 511RRM 2PROSITE-ProRule annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni330 – 566Necessary for stress granule assembly and correct localization in dcp1 bodiesAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi178 – 217Ser-richAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (PubMed:24990967). The interdomain linker (411-429) acts as a hinge to fix the relative orientation of the 2 RRMs (PubMed:24990967). The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs (PubMed:23500490, PubMed:24990967). A continuous hydrophobic interface is formed between the 2 RRMs (PubMed:24990967).2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM CPEB family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITXD Eukaryota
ENOG410YBXF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290661

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZB8

KEGG Orthology (KO)

More...
KOi
K02602

Database of Orthologous Groups

More...
OrthoDBi
1075356at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZB8

TreeFam database of animal gene trees

More...
TreeFami
TF317658

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12723 RRM1_CPEB1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.130, 1 hit
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032292 CEBP1_N
IPR032296 CEBP_ZZ
IPR038446 CEBP_ZZ_sf
IPR034819 CPEB
IPR034977 CPEB1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12566 PTHR12566, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16368 CEBP1_N, 1 hit
PF16366 CEBP_ZZ, 1 hit
PF16367 RRM_7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZB8-1) [UniParc]FASTAAdd to basket
Also known as: hCPEB long, hCPEBg

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSLEEEAG RIKDCWDNQE APALSTCSNA NIFRRINAIL DNSLDFSRVC
60 70 80 90 100
TTPINRGIHD HLPDFQDSEE TVTSRMLFPT SAQESSRGLP DANDLCLGLQ
110 120 130 140 150
SLSLTGWDRP WSTQDSDSSA QSSTHSVLSM LHNPLGNVLG KPPLSFLPLD
160 170 180 190 200
PLGSDLVDKF PAPSVRGSRL DTRPILDSRS SSPSDSDTSG FSSGSDHLSD
210 220 230 240 250
LISSLRISPP LPFLSLSGGG PRDPLKMGVG SRMDQEQAAL AAVTPSPTSA
260 270 280 290 300
SKRWPGASVW PSWDLLEAPK DPFSIEREAR LHRQAAAVNE ATCTWSGQLP
310 320 330 340 350
PRNYKNPIYS CKVFLGGVPW DITEAGLVNT FRVFGSLSVE WPGKDGKHPR
360 370 380 390 400
CPPKGNMPKG YVYLVFELEK SVRSLLQACS HDPLSPDGLS EYYFKMSSRR
410 420 430 440 450
MRCKEVQVIP WVLADSNFVR SPSQRLDPSR TVFVGALHGM LNAEALAAIL
460 470 480 490 500
NDLFGGVVYA GIDTDKHKYP IGSGRVTFNN QRSYLKAVSA AFVEIKTTKF
510 520 530 540 550
TKKVQIDPYL EDSLCHICSS QPGPFFCRDQ VCFKYFCRSC WHWRHSMEGL
560
RHHSPLMRNQ KNRDSS
Length:566
Mass (Da):62,595
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E41E5B0EC69DA87
GO
Isoform 2 (identifier: Q9BZB8-2) [UniParc]FASTAAdd to basket
Also known as: hCPEB short, hCPEBs

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:491
Mass (Da):54,162
Checksum:i561A40FEBD482262
GO
Isoform 3 (identifier: Q9BZB8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MALSL → MAFPL
     354-358: Missing.

Show »
Length:561
Mass (Da):62,111
Checksum:iDCE6E16D700DD14E
GO
Isoform 4 (identifier: Q9BZB8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     354-358: Missing.

Show »
Length:486
Mass (Da):53,635
Checksum:i19FA96CE00D0B9FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R214A0A024R214_HUMAN
Cytoplasmic polyadenylation element...
CPEB1 hCG_26948
626Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXG7A0A087WXG7_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
588Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X171A0A087X171_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
561Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVR7A0A087WVR7_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
564Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNX1H3BNX1_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXP0A0A0J9YXP0_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUQ9A0A087WUQ9_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX15A0A0J9YX15_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPD6H3BPD6_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTE4H3BTE4_HUMAN
Cytoplasmic polyadenylation element...
CPEB1
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti446L → Q in BAB14496 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0763878Missing . 1
Natural variantiVAR_076388233M → I1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0220271 – 75Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST75
Alternative sequenceiVSP_0220281 – 5MALSL → MAFPL in isoform 3. 1 Publication5
Alternative sequenceiVSP_022029354 – 358Missing in isoform 3 and isoform 4. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF329402 mRNA Translation: AAK01239.1
AF329403 mRNA Translation: AAK01240.1
AK023265 mRNA Translation: BAB14496.1
AK300105 mRNA Translation: BAH13212.1
CH471188 Genomic DNA Translation: EAW62449.1
BC035348 mRNA Translation: AAH35348.1
BC050629 mRNA Translation: AAH50629.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42072.2 [Q9BZB8-2]
CCDS45329.2 [Q9BZB8-3]
CCDS45330.2 [Q9BZB8-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001073001.1, NM_001079533.1 [Q9BZB8-2]
NP_001073002.1, NM_001079534.1 [Q9BZB8-4]
NP_001073003.1, NM_001079535.1 [Q9BZB8-4]
NP_001275748.1, NM_001288819.1 [Q9BZB8-4]
NP_085097.3, NM_030594.4 [Q9BZB8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000611163; ENSP00000483857; ENSG00000214575 [Q9BZB8-4]
ENST00000615198; ENSP00000477715; ENSG00000214575 [Q9BZB8-3]
ENST00000616775; ENSP00000482116; ENSG00000277445 [Q9BZB8-2]
ENST00000617462; ENSP00000477557; ENSG00000214575 [Q9BZB8-4]
ENST00000617522; ENSP00000481009; ENSG00000214575 [Q9BZB8-4]
ENST00000618449; ENSP00000483590; ENSG00000214575 [Q9BZB8-2]
ENST00000619696; ENSP00000482965; ENSG00000277445 [Q9BZB8-4]
ENST00000620182; ENSP00000484549; ENSG00000214575 [Q9BZB8-4]
ENST00000620212; ENSP00000478558; ENSG00000277445 [Q9BZB8-4]
ENST00000631674; ENSP00000488352; ENSG00000277445 [Q9BZB8-4]
ENST00000632526; ENSP00000487757; ENSG00000277445 [Q9BZB8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64506

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64506

UCSC genome browser

More...
UCSCi
uc002biq.4 human [Q9BZB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329402 mRNA Translation: AAK01239.1
AF329403 mRNA Translation: AAK01240.1
AK023265 mRNA Translation: BAB14496.1
AK300105 mRNA Translation: BAH13212.1
CH471188 Genomic DNA Translation: EAW62449.1
BC035348 mRNA Translation: AAH35348.1
BC050629 mRNA Translation: AAH50629.1
CCDSiCCDS42072.2 [Q9BZB8-2]
CCDS45329.2 [Q9BZB8-3]
CCDS45330.2 [Q9BZB8-4]
RefSeqiNP_001073001.1, NM_001079533.1 [Q9BZB8-2]
NP_001073002.1, NM_001079534.1 [Q9BZB8-4]
NP_001073003.1, NM_001079535.1 [Q9BZB8-4]
NP_001275748.1, NM_001288819.1 [Q9BZB8-4]
NP_085097.3, NM_030594.4 [Q9BZB8-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M13NMR-A504-566[»]
2MKENMR-A506-566[»]
2MKHNMR-A294-514[»]
2MKKNMR-A294-510[»]
2N1ONMR-B206-213[»]
SMRiQ9BZB8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122202, 12 interactors
IntActiQ9BZB8, 11 interactors
STRINGi9606.ENSP00000477715

PTM databases

iPTMnetiQ9BZB8
PhosphoSitePlusiQ9BZB8

Polymorphism and mutation databases

BioMutaiCPEB1
DMDMi74762720

Proteomic databases

MassIVEiQ9BZB8
MaxQBiQ9BZB8
PaxDbiQ9BZB8
PeptideAtlasiQ9BZB8
PRIDEiQ9BZB8
ProteomicsDBi79800 [Q9BZB8-1]
79801 [Q9BZB8-2]
79802 [Q9BZB8-3]
79803 [Q9BZB8-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64506

Genome annotation databases

EnsembliENST00000611163; ENSP00000483857; ENSG00000214575 [Q9BZB8-4]
ENST00000615198; ENSP00000477715; ENSG00000214575 [Q9BZB8-3]
ENST00000616775; ENSP00000482116; ENSG00000277445 [Q9BZB8-2]
ENST00000617462; ENSP00000477557; ENSG00000214575 [Q9BZB8-4]
ENST00000617522; ENSP00000481009; ENSG00000214575 [Q9BZB8-4]
ENST00000618449; ENSP00000483590; ENSG00000214575 [Q9BZB8-2]
ENST00000619696; ENSP00000482965; ENSG00000277445 [Q9BZB8-4]
ENST00000620182; ENSP00000484549; ENSG00000214575 [Q9BZB8-4]
ENST00000620212; ENSP00000478558; ENSG00000277445 [Q9BZB8-4]
ENST00000631674; ENSP00000488352; ENSG00000277445 [Q9BZB8-4]
ENST00000632526; ENSP00000487757; ENSG00000277445 [Q9BZB8-4]
GeneIDi64506
KEGGihsa:64506
UCSCiuc002biq.4 human [Q9BZB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64506
DisGeNETi64506

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CPEB1
HGNCiHGNC:21744 CPEB1
HPAiHPA040396
MIMi607342 gene
neXtProtiNX_Q9BZB8
OpenTargetsiENSG00000214575
PharmGKBiPA134929879

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITXD Eukaryota
ENOG410YBXF LUCA
GeneTreeiENSGT00940000155524
HOGENOMiHOG000290661
InParanoidiQ9BZB8
KOiK02602
OrthoDBi1075356at2759
PhylomeDBiQ9BZB8
TreeFamiTF317658

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CPEB1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CPEB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64506
PharosiQ9BZB8

Protein Ontology

More...
PROi
PR:Q9BZB8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000214575 Expressed in 175 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9BZB8 baseline and differential
GenevisibleiQ9BZB8 HS

Family and domain databases

CDDicd12723 RRM1_CPEB1, 1 hit
Gene3Di3.30.40.130, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR032292 CEBP1_N
IPR032296 CEBP_ZZ
IPR038446 CEBP_ZZ_sf
IPR034819 CPEB
IPR034977 CPEB1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR12566 PTHR12566, 1 hit
PfamiView protein in Pfam
PF16368 CEBP1_N, 1 hit
PF16366 CEBP_ZZ, 1 hit
PF16367 RRM_7, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPEB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZB8
Secondary accession number(s): B7Z6C6
, Q86W46, Q8IV41, Q9BZB7, Q9H8V5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 13, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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