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Entry version 138 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Protocadherin-11 Y-linked

Gene

PCDH11Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-11 Y-linked
Short name:
Protocadherin-11
Alternative name(s):
Protocadherin on the Y chromosome
Short name:
PCDH-Y
Protocadherin prostate cancer
Short name:
Protocadherin-PC
Protocadherin-22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH11Y
Synonyms:PCDH11, PCDH22, PCDHY
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15813 PCDH11Y

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
400022 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 844ExtracellularSequence analysisAdd BLAST816
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei845 – 865HelicalSequence analysisAdd BLAST21
Topological domaini866 – 1340CytoplasmicSequence analysisAdd BLAST475

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.

Organism-specific databases

DisGeNET

More...
DisGeNETi
83259

Open Targets

More...
OpenTargetsi
ENSG00000099715

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32997

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZA8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCDH11Y

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762719

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023276429 – 1340Protocadherin-11 Y-linkedAdd BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi805N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZA8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZA8

PeptideAtlas

More...
PeptideAtlasi
Q9BZA8

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZA8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79796 [Q9BZA8-1]
79797 [Q9BZA8-2]
79798 [Q9BZA8-3]
79799 [Q9BZA8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099715 Expressed in 70 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZA8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000432

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123635, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 171Cadherin 1PROSITE-ProRule annotationAdd BLAST114
Domaini172 – 281Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini282 – 387Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini394 – 498Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini499 – 602Cadherin 5PROSITE-ProRule annotationAdd BLAST104
Domaini603 – 705Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini709 – 827Cadherin 7PROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi900 – 907Poly-Lys8

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158335

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZA8

KEGG Orthology (KO)

More...
KOi
K16498

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFEFIPL

Database of Orthologous Groups

More...
OrthoDBi
82835at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZA8

TreeFam database of animal gene trees

More...
TreeFami
TF320624

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRVGFLIIS SSSSLSPLLL VSVVRVNTTN CHKCLLSGTY IFAVLLVCVV
60 70 80 90 100
FHSGAQEKNY TIREEIPENV LIGNLLKDLN LSLIPNKSLT TTMQFKLVYK
110 120 130 140 150
TGDVPLIRIE EDTGEIFTTG ARIDREKLCA GIPRDEHCFY EVEVAILPDE
160 170 180 190 200
IFRLVKIRFL IEDINDNAPL FPATVINISI PENSAINSKY TLPAAVDPDV
210 220 230 240 250
GINGVQNYEL IKSQNIFGLD VIETPEGDKM PQLIVQKELD REEKDTYVMK
260 270 280 290 300
VKVEDGGFPQ RSSTAILQVS VTDTNDNHPV FKETEIEVSI PENAPVGTSV
310 320 330 340 350
TQLHATDADI GENAKIHFSF SNLVSNIARR LFHLNATTGL ITIKEPLDRE
360 370 380 390 400
ETPNHKLLVL ASDGGLMPAR AMVLVNVTDV NDNVPSIDIR YIVNPVNDTV
410 420 430 440 450
VLSENIPLNT KIALITVTDK DADHNGRVTC FTDHEIPFRL RPVFSNQFLL
460 470 480 490 500
ENAAYLDYES TKEYAIKLLA ADAGKPPLNQ SAMLFIKVKD ENDNAPVFTQ
510 520 530 540 550
SFVTVSIPEN NSPGIQLMKV SATDADSGPN AEINYLLGPD APPEFSLDRR
560 570 580 590 600
TGMLTVVKKL DREKEDKYLF TILAKDNGVP PLTSNVTVFV SIIDQNDNSP
610 620 630 640 650
VFTHNEYKFY VPENLPRHGT VGLITVTDPD YGDNSAVTLS ILDENDDFTI
660 670 680 690 700
DSQTGVIRPN ISFDREKQES YTFYVKAEDG GRVSRSSSAK VTINVVDVND
710 720 730 740 750
NKPVFIVPPY NYSYELVLPS TNPGTVVFQV IAVDNDTGMN AEVRYSIVGG
760 770 780 790 800
NTRDLFAIDQ ETGNITLMEK CDVTDLGLHR VLVKANDLGQ PDSLFSVVIV
810 820 830 840 850
NLFVNESVTN ATLINELVRK SIEAPVTPNT EIADVSSPTS DYVKILVAAV
860 870 880 890 900
AGTITVVVVI FITAVVRCRQ APHLKAAQKN MQNSEWATPN PENRQMIMMK
910 920 930 940 950
KKKKKKKHSP KNLLLNVVTI EETKADDVDS DGNRVTLDLP IDLEEQTMGK
960 970 980 990 1000
YNWVTTPTTF KPDSPDLARH YKSASPQPAF QIQPETPLNL KHHIIQELPL
1010 1020 1030 1040 1050
DNTFVACDSI SNCSSSSSDP YSVSDCGYPV TTFEVPVSVH TRPSQRRVTF
1060 1070 1080 1090 1100
HLPEGSQESS SDGGLGDHDA GSLTSTSHGL PLGYPQEEYF DRATPSNRTE
1110 1120 1130 1140 1150
GDGNSDPEST FIPGLKKEIT VQPTVEEASD NCTQECLIYG HSDACWMPAS
1160 1170 1180 1190 1200
LDHSSSSQAQ ASALCHSPPL SQASTQHHSP PVTQTIVLCH SPPVTQTIAL
1210 1220 1230 1240 1250
CHSPPPIQVS ALHHSPPLVQ GTALHHSPPS AQASALCYSP PLAQAAAISH
1260 1270 1280 1290 1300
SSSLPQVIAL HRSQAQSSVS LQQGWVQGAN GLCSVDQGVQ GSATSQFYTM
1310 1320 1330 1340
SERLHPSDDS IKVIPLTTFA PRQQARPSRG DSPIMETHPL
Length:1,340
Mass (Da):146,775
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10C1A56510FF4014
GO
Isoform 2 (identifier: Q9BZA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1048: SQRRV → TDSRT
     1049-1340: Missing.

Show »
Length:1,048
Mass (Da):115,920
Checksum:iAC0796ACEBD304E9
GO
Isoform 3 (identifier: Q9BZA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MFRVGFLIISSSSSLSPLLLV → MTVGFNSDIS
     1044-1048: SQRRV → TDSRT
     1049-1340: Missing.

Show »
Length:1,037
Mass (Da):114,723
Checksum:i72CB8AB1EBA9ACCC
GO
Isoform 4 (identifier: Q9BZA8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1053: SQRRVTFHLP → VGIQVSNTTF
     1054-1340: Missing.

Show »
Length:1,053
Mass (Da):116,406
Checksum:i0DD1C6721B4F6553
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUC5A0A087WUC5_HUMAN
Protocadherin-11 Y-linked
PCDH11Y
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026020917V → F2 PublicationsCorresponds to variant dbSNP:rs2524543Ensembl.1
Natural variantiVAR_0260211012N → K2 PublicationsCorresponds to variant dbSNP:rs2563389Ensembl.1
Natural variantiVAR_0485761320A → T. Corresponds to variant dbSNP:rs2556900Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0179961 – 21MFRVG…PLLLV → MTVGFNSDIS in isoform 3. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0179971044 – 1053SQRRVTFHLP → VGIQVSNTTF in isoform 4. 1 Publication10
Alternative sequenceiVSP_0179981044 – 1048SQRRV → TDSRT in isoform 2 and isoform 3. 3 Publications5
Alternative sequenceiVSP_0179991049 – 1340Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST292
Alternative sequenceiVSP_0180001054 – 1340Missing in isoform 4. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ276803 mRNA Translation: CAC13122.1
AF277053 mRNA Translation: AAL55729.1
AF332216 mRNA Translation: AAK13468.1
AF332217 mRNA Translation: AAK13469.1
AJ564958 mRNA Translation: CAD92429.1
AJ564959 mRNA Translation: CAD92430.1
AJ564960 mRNA Translation: CAD92431.1
AJ564961 mRNA Translation: CAD92432.1
AJ564962 mRNA Translation: CAD92433.1
AJ564963 mRNA Translation: CAD92434.1
AJ564966 mRNA Translation: CAD92437.1
AJ564969 mRNA Translation: CAD92440.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14776.1 [Q9BZA8-3]
CCDS14777.1 [Q9BZA8-2]
CCDS76066.1 [Q9BZA8-1]

NCBI Reference Sequences

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RefSeqi
NP_001265548.1, NM_001278619.1 [Q9BZA8-3]
NP_116753.1, NM_032971.2 [Q9BZA8-3]
NP_116754.1, NM_032972.2 [Q9BZA8-2]
NP_116755.1, NM_032973.2 [Q9BZA8-1]
XP_016885571.1, XM_017030082.1 [Q9BZA8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000215473; ENSP00000215473; ENSG00000099715 [Q9BZA8-4]
ENST00000333703; ENSP00000330552; ENSG00000099715 [Q9BZA8-3]
ENST00000362095; ENSP00000355419; ENSG00000099715 [Q9BZA8-2]
ENST00000400457; ENSP00000383306; ENSG00000099715 [Q9BZA8-1]
ENST00000622698; ENSP00000482115; ENSG00000099715 [Q9BZA8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83259

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83259

UCSC genome browser

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UCSCi
uc004fql.3 human [Q9BZA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276803 mRNA Translation: CAC13122.1
AF277053 mRNA Translation: AAL55729.1
AF332216 mRNA Translation: AAK13468.1
AF332217 mRNA Translation: AAK13469.1
AJ564958 mRNA Translation: CAD92429.1
AJ564959 mRNA Translation: CAD92430.1
AJ564960 mRNA Translation: CAD92431.1
AJ564961 mRNA Translation: CAD92432.1
AJ564962 mRNA Translation: CAD92433.1
AJ564963 mRNA Translation: CAD92434.1
AJ564966 mRNA Translation: CAD92437.1
AJ564969 mRNA Translation: CAD92440.1
CCDSiCCDS14776.1 [Q9BZA8-3]
CCDS14777.1 [Q9BZA8-2]
CCDS76066.1 [Q9BZA8-1]
RefSeqiNP_001265548.1, NM_001278619.1 [Q9BZA8-3]
NP_116753.1, NM_032971.2 [Q9BZA8-3]
NP_116754.1, NM_032972.2 [Q9BZA8-2]
NP_116755.1, NM_032973.2 [Q9BZA8-1]
XP_016885571.1, XM_017030082.1 [Q9BZA8-3]

3D structure databases

SMRiQ9BZA8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123635, 1 interactor

PTM databases

iPTMnetiQ9BZA8
PhosphoSitePlusiQ9BZA8

Polymorphism and mutation databases

BioMutaiPCDH11Y
DMDMi74762719

Proteomic databases

EPDiQ9BZA8
MassIVEiQ9BZA8
PeptideAtlasiQ9BZA8
PRIDEiQ9BZA8
ProteomicsDBi79796 [Q9BZA8-1]
79797 [Q9BZA8-2]
79798 [Q9BZA8-3]
79799 [Q9BZA8-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
83259

Genome annotation databases

EnsembliENST00000215473; ENSP00000215473; ENSG00000099715 [Q9BZA8-4]
ENST00000333703; ENSP00000330552; ENSG00000099715 [Q9BZA8-3]
ENST00000362095; ENSP00000355419; ENSG00000099715 [Q9BZA8-2]
ENST00000400457; ENSP00000383306; ENSG00000099715 [Q9BZA8-1]
ENST00000622698; ENSP00000482115; ENSG00000099715 [Q9BZA8-3]
GeneIDi83259
KEGGihsa:83259
UCSCiuc004fql.3 human [Q9BZA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83259
DisGeNETi83259

GeneCards: human genes, protein and diseases

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GeneCardsi
PCDH11Y
HGNCiHGNC:15813 PCDH11Y
HPAiHPA000432
MIMi400022 gene
neXtProtiNX_Q9BZA8
OpenTargetsiENSG00000099715
PharmGKBiPA32997

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000158335
InParanoidiQ9BZA8
KOiK16498
OMAiTFEFIPL
OrthoDBi82835at2759
PhylomeDBiQ9BZA8
TreeFamiTF320624

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PCDH11Y human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83259
PharosiQ9BZA8

Protein Ontology

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PROi
PR:Q9BZA8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099715 Expressed in 70 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9BZA8 baseline and differential
GenevisibleiQ9BZA8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin
PfamiView protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPC11Y_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZA8
Secondary accession number(s): Q70LR6
, Q70LR8, Q70LS0, Q70LS1, Q70LS2, Q70LS3, Q70LS4, Q70LS5, Q8WY34, Q9BZA9, Q9H4E1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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