UniProtKB - Q9BZA7 (PC11X_HUMAN)
Protein
Protocadherin-11 X-linked
Gene
PCDH11X
Organism
Homo sapiens (Human)
Status
Functioni
Potential calcium-dependent cell-adhesion protein.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- negative regulation of phosphatase activity Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q9BZA7 |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin-11 X-linkedShort name: Protocadherin-11 Alternative name(s): Protocadherin on the X chromosome Short name: PCDH-X Protocadherin-S |
Gene namesi | Name:PCDH11X Synonyms:KIAA1326, PCDH11, PCDHX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102290.21 |
HGNCi | HGNC:8656, PCDH11X |
MIMi | 300246, gene |
neXtProti | NX_Q9BZA7 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 812 | ExtracellularSequence analysisAdd BLAST | 789 | |
Transmembranei | 813 – 833 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 834 – 1347 | CytoplasmicSequence analysisAdd BLAST | 514 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 27328 |
OpenTargetsi | ENSG00000102290 |
PharmGKBi | PA32996 |
Miscellaneous databases
Pharosi | Q9BZA7, Tbio |
Polymorphism and mutation databases
BioMutai | PCDH11X |
DMDMi | 74761344 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000232758 | 24 – 1347 | Protocadherin-11 X-linkedAdd BLAST | 1324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 27 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 344 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 553 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 773 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9BZA7 |
MassIVEi | Q9BZA7 |
PaxDbi | Q9BZA7 |
PeptideAtlasi | Q9BZA7 |
PRIDEi | Q9BZA7 |
ProteomicsDBi | 79788 [Q9BZA7-1] 79789 [Q9BZA7-2] 79790 [Q9BZA7-3] 79791 [Q9BZA7-4] 79792 [Q9BZA7-5] 79793 [Q9BZA7-6] 79794 [Q9BZA7-7] 79795 [Q9BZA7-8] |
PTM databases
GlyConnecti | 2065, 1 N-Linked glycan (1 site) |
GlyGeni | Q9BZA7, 6 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9BZA7 |
PhosphoSitePlusi | Q9BZA7 |
Expressioni
Tissue specificityi
Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.2 Publications
Gene expression databases
Bgeei | ENSG00000102290, Expressed in cortical plate and 72 other tissues |
Genevisiblei | Q9BZA7, HS |
Organism-specific databases
HPAi | ENSG00000102290, Group enriched (brain, ovary, parathyroid gland) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 118142, 5 interactors |
IntActi | Q9BZA7, 2 interactors |
STRINGi | 9606.ENSP00000362186 |
Miscellaneous databases
RNActi | Q9BZA7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 139 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 114 | |
Domaini | 140 – 249 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 250 – 355 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 362 – 466 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 467 – 570 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 571 – 673 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 677 – 795 | Cadherin 7PROSITE-ProRule annotationAdd BLAST | 119 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 868 – 875 | Poly-Lys | 8 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QPMK, Eukaryota |
GeneTreei | ENSGT00940000158335 |
HOGENOMi | CLU_006480_5_2_1 |
InParanoidi | Q9BZA7 |
OMAi | KPPHYGT |
PhylomeDBi | Q9BZA7 |
TreeFami | TF320624 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR013585, Protocadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 6 hits PF08266, Cadherin_2, 1 hit PF08374, Protocadherin, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 7 hits |
s (8)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9BZA7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS
60 70 80 90 100
LIPNKSLTTA MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI
110 120 130 140 150
PRDEHCFYEV EVAILPDEIF RLVKIRFLIE DINDNAPLFP ATVINISIPE
160 170 180 190 200
NSAINSKYTL PAAVDPDVGI NGVQNYELIK SQNIFGLDVI ETPEGDKMPQ
210 220 230 240 250
LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT DTNDNHPVFK
260 270 280 290 300
ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF
310 320 330 340 350
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND
360 370 380 390 400
NVPSIDIRYI VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT
410 420 430 440 450
DHEIPFRLRP VFSNQFLLET AAYLDYESTK EYAIKLLAAD AGKPPLNQSA
460 470 480 490 500
MLFIKVKDEN DNAPVFTQSF VTVSIPENNS PGIQLTKVSA MDADSGPNAK
510 520 530 540 550
INYLLGPDAP PEFSLDCRTG MLTVVKKLDR EKEDKYLFTI LAKDNGVPPL
560 570 580 590 600
TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG
610 620 630 640 650
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR
660 670 680 690 700
VSRSSSAKVT INVVDVNDNK PVFIVPPSNC SYELVLPSTN PGTVVFQVIA
710 720 730 740 750
VDNDTGMNAE VRYSIVGGNT RDLFAIDQET GNITLMEKCD VTDLGLHRVL
760 770 780 790 800
VKANDLGQPD SLFSVVIVNL FVNESVTNAT LINELVRKST EAPVTPNTEI
810 820 830 840 850
ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP HLKAAQKNKQ
860 870 880 890 900
NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG
910 920 930 940 950
NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI
960 970 980 990 1000
QPETPLNSKH HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT
1010 1020 1030 1040 1050
FEVPVSVHTR PPMKEVVRSC TPMKESTTME IWIHPQPQRK SEGKVAGKSQ
1060 1070 1080 1090 1100
RRVTFHLPEG SQESSSDGGL GDHDAGSLTS TSHGLPLGYP QEEYFDRATP
1110 1120 1130 1140 1150
SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT QECLIYGHSD
1160 1170 1180 1190 1200
ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPRVT QTIALCHSPP
1210 1220 1230 1240 1250
VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA
1260 1270 1280 1290 1300
QAAAISHSSP LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA
1310 1320 1330 1340
TSQFYTMSER LHPSDDSIKV IPLTTFTPRQ QARPSRGDSP IMEEHPL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 242 – 244 | TND → PNA in AAK82655 (Ref. 4) Curated | 3 | |
Sequence conflicti | 242 – 244 | TND → PNA in AAK82656 (Ref. 4) Curated | 3 | |
Sequence conflicti | 252 | T → P in AAK82655 (Ref. 4) Curated | 1 | |
Sequence conflicti | 252 | T → P in AAK82656 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036109 | 42 | D → G in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1451414636Ensembl. | 1 | |
Natural variantiVAR_048575 | 1018 | R → Q. Corresponds to variant dbSNP:rs4252205EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017979 | 1012 – 1048 | Missing in isoform 5. 2 PublicationsAdd BLAST | 37 | |
Alternative sequenceiVSP_017980 | 1012 – 1025 | PMKEV…TPMKE → TDSRTSTIEICSEI in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_017981 | 1012 – 1021 | PMKEVVRSCT → VGIQVSNTTF in isoform 7. 2 Publications | 10 | |
Alternative sequenceiVSP_017982 | 1022 – 1347 | Missing in isoform 7. 2 PublicationsAdd BLAST | 326 | |
Alternative sequenceiVSP_017983 | 1026 – 1347 | Missing in isoform 2. 1 PublicationAdd BLAST | 322 | |
Alternative sequenceiVSP_017984 | 1039 – 1048 | Missing in isoform 3 and isoform 4. 2 Publications | 10 | |
Alternative sequenceiVSP_017985 | 1049 – 1065 | SQRRV…SQESS → TVLTSSSPSAMTLSYLD in isoform 6. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_017986 | 1066 – 1347 | Missing in isoform 6. 1 PublicationAdd BLAST | 282 | |
Alternative sequenceiVSP_017987 | 1116 – 1123 | Missing in isoform 8 and isoform 4. 1 Publication | 8 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000361655; ENSP00000355105; ENSG00000102290 [Q9BZA7-4] ENST00000373088; ENSP00000362180; ENSG00000102290 [Q9BZA7-5] ENST00000373094; ENSP00000362186; ENSG00000102290 [Q9BZA7-1] ENST00000373097; ENSP00000362189; ENSG00000102290 [Q9BZA7-3] ENST00000406881; ENSP00000384758; ENSG00000102290 [Q9BZA7-8] ENST00000504220; ENSP00000423762; ENSG00000102290 [Q9BZA7-6] |
GeneIDi | 27328 |
KEGGi | hsa:27328 |
UCSCi | uc004efk.3, human [Q9BZA7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q9BZA7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118142, 5 interactors |
IntActi | Q9BZA7, 2 interactors |
STRINGi | 9606.ENSP00000362186 |
PTM databases
GlyConnecti | 2065, 1 N-Linked glycan (1 site) |
GlyGeni | Q9BZA7, 6 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9BZA7 |
PhosphoSitePlusi | Q9BZA7 |
Polymorphism and mutation databases
BioMutai | PCDH11X |
DMDMi | 74761344 |
Proteomic databases
jPOSTi | Q9BZA7 |
MassIVEi | Q9BZA7 |
PaxDbi | Q9BZA7 |
PeptideAtlasi | Q9BZA7 |
PRIDEi | Q9BZA7 |
ProteomicsDBi | 79788 [Q9BZA7-1] 79789 [Q9BZA7-2] 79790 [Q9BZA7-3] 79791 [Q9BZA7-4] 79792 [Q9BZA7-5] 79793 [Q9BZA7-6] 79794 [Q9BZA7-7] 79795 [Q9BZA7-8] |
Protocols and materials databases
Antibodypediai | 28445, 89 antibodies |
DNASUi | 27328 |
Genome annotation databases
Ensembli | ENST00000361655; ENSP00000355105; ENSG00000102290 [Q9BZA7-4] ENST00000373088; ENSP00000362180; ENSG00000102290 [Q9BZA7-5] ENST00000373094; ENSP00000362186; ENSG00000102290 [Q9BZA7-1] ENST00000373097; ENSP00000362189; ENSG00000102290 [Q9BZA7-3] ENST00000406881; ENSP00000384758; ENSG00000102290 [Q9BZA7-8] ENST00000504220; ENSP00000423762; ENSG00000102290 [Q9BZA7-6] |
GeneIDi | 27328 |
KEGGi | hsa:27328 |
UCSCi | uc004efk.3, human [Q9BZA7-1] |
Organism-specific databases
CTDi | 27328 |
DisGeNETi | 27328 |
EuPathDBi | HostDB:ENSG00000102290.21 |
GeneCardsi | PCDH11X |
HGNCi | HGNC:8656, PCDH11X |
HPAi | ENSG00000102290, Group enriched (brain, ovary, parathyroid gland) |
MIMi | 300246, gene |
neXtProti | NX_Q9BZA7 |
OpenTargetsi | ENSG00000102290 |
PharmGKBi | PA32996 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPMK, Eukaryota |
GeneTreei | ENSGT00940000158335 |
HOGENOMi | CLU_006480_5_2_1 |
InParanoidi | Q9BZA7 |
OMAi | KPPHYGT |
PhylomeDBi | Q9BZA7 |
TreeFami | TF320624 |
Enzyme and pathway databases
PathwayCommonsi | Q9BZA7 |
Miscellaneous databases
BioGRID-ORCSi | 27328, 16 hits in 466 CRISPR screens |
ChiTaRSi | PCDH11X, human |
GeneWikii | PCDH11X |
GenomeRNAii | 27328 |
Pharosi | Q9BZA7, Tbio |
PROi | PR:Q9BZA7 |
RNActi | Q9BZA7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102290, Expressed in cortical plate and 72 other tissues |
Genevisiblei | Q9BZA7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR013585, Protocadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 6 hits PF08266, Cadherin_2, 1 hit PF08374, Protocadherin, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PC11X_HUMAN | |
Accessioni | Q9BZA7Primary (citable) accession number: Q9BZA7 Secondary accession number(s): A6NIQ4 Q9P2X5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations