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UniProtKB - Q9BZA7 (PC11X_HUMAN)

Entry version 157 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Protocadherin-11 X-linked

Gene

PCDH11X

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BZA7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-11 X-linked
Short name:
Protocadherin-11
Alternative name(s):
Protocadherin on the X chromosome
Short name:
PCDH-X
Protocadherin-S
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH11X
Synonyms:KIAA1326, PCDH11, PCDHX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000102290.21

Human Gene Nomenclature Database

More...HGNCi		HGNC:8656, PCDH11X

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300246, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BZA7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 812ExtracellularSequence analysisAdd BLAST789
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei813 – 833HelicalSequence analysisAdd BLAST21
Topological domaini834 – 1347CytoplasmicSequence analysisAdd BLAST514

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27328

Open Targets

More...OpenTargetsi		ENSG00000102290

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32996

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BZA7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PCDH11X

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023275824 – 1347Protocadherin-11 X-linkedAdd BLAST1324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi773N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BZA7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BZA7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BZA7

PeptideAtlas

More...PeptideAtlasi		Q9BZA7

PRoteomics IDEntifications database

More...PRIDEi		Q9BZA7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79788 [Q9BZA7-1]
79789 [Q9BZA7-2]
79790 [Q9BZA7-3]
79791 [Q9BZA7-4]
79792 [Q9BZA7-5]
79793 [Q9BZA7-6]
79794 [Q9BZA7-7]
79795 [Q9BZA7-8]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2065, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BZA7, 6 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BZA7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BZA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102290, Expressed in cortical plate and 72 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BZA7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102290, Group enriched (brain, ovary, parathyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118142, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q9BZA7, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362186

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BZA7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BZA7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 139Cadherin 1PROSITE-ProRule annotationAdd BLAST114
Domaini140 – 249Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini250 – 355Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini362 – 466Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini467 – 570Cadherin 5PROSITE-ProRule annotationAdd BLAST104
Domaini571 – 673Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini677 – 795Cadherin 7PROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi868 – 875Poly-Lys8

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPMK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006480_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BZA7

KEGG Orthology (KO)

More...KOi		K16498

Identification of Orthologs from Complete Genome Data

More...OMAi		KPPHYGT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BZA7

TreeFam database of animal gene trees

More...TreeFami		TF320624

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR013585, Protocadherin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 6 hits
PF08266, Cadherin_2, 1 hit
PF08374, Protocadherin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232, CADHERIN_1, 5 hits
PS50268, CADHERIN_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9BZA7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS 
        60         70         80         90        100
LIPNKSLTTA MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI 
       110        120        130        140        150
PRDEHCFYEV EVAILPDEIF RLVKIRFLIE DINDNAPLFP ATVINISIPE 
       160        170        180        190        200
NSAINSKYTL PAAVDPDVGI NGVQNYELIK SQNIFGLDVI ETPEGDKMPQ 
       210        220        230        240        250
LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT DTNDNHPVFK 
       260        270        280        290        300
ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF 
       310        320        330        340        350
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND 
       360        370        380        390        400
NVPSIDIRYI VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT 
       410        420        430        440        450
DHEIPFRLRP VFSNQFLLET AAYLDYESTK EYAIKLLAAD AGKPPLNQSA 
       460        470        480        490        500
MLFIKVKDEN DNAPVFTQSF VTVSIPENNS PGIQLTKVSA MDADSGPNAK 
       510        520        530        540        550
INYLLGPDAP PEFSLDCRTG MLTVVKKLDR EKEDKYLFTI LAKDNGVPPL 
       560        570        580        590        600
TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG 
       610        620        630        640        650
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR 
       660        670        680        690        700
VSRSSSAKVT INVVDVNDNK PVFIVPPSNC SYELVLPSTN PGTVVFQVIA 
       710        720        730        740        750
VDNDTGMNAE VRYSIVGGNT RDLFAIDQET GNITLMEKCD VTDLGLHRVL 
       760        770        780        790        800
VKANDLGQPD SLFSVVIVNL FVNESVTNAT LINELVRKST EAPVTPNTEI 
       810        820        830        840        850
ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP HLKAAQKNKQ 
       860        870        880        890        900
NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG 
       910        920        930        940        950
NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI 
       960        970        980        990       1000
QPETPLNSKH HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT 
      1010       1020       1030       1040       1050
FEVPVSVHTR PPMKEVVRSC TPMKESTTME IWIHPQPQRK SEGKVAGKSQ 
      1060       1070       1080       1090       1100
RRVTFHLPEG SQESSSDGGL GDHDAGSLTS TSHGLPLGYP QEEYFDRATP 
      1110       1120       1130       1140       1150
SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT QECLIYGHSD 
      1160       1170       1180       1190       1200
ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPRVT QTIALCHSPP 
      1210       1220       1230       1240       1250
VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA 
      1260       1270       1280       1290       1300
QAAAISHSSP LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA 
      1310       1320       1330       1340 
TSQFYTMSER LHPSDDSIKV IPLTTFTPRQ QARPSRGDSP IMEEHPL
Length:1,347
Mass (Da):147,558
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0227FA6C521FDA84
GO
Isoform 2 (identifier: Q9BZA7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1025: PMKEVVRSCTPMKE → TDSRTSTIEICSEI
     1026-1347: Missing.

Show »
Length:1,025
Mass (Da):113,215
Checksum:i51EE095ED7035A10
GO
Isoform 3 (identifier: Q9BZA7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1048: Missing.

Show »
Length:1,337
Mass (Da):146,517
Checksum:iA96D3B41173C8508
GO
Isoform 4 (identifier: Q9BZA7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1048: Missing.
     1116-1123: Missing.

Show »
Length:1,329
Mass (Da):145,662
Checksum:iDA7DC585324AD261
GO
Isoform 5 (identifier: Q9BZA7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1048: Missing.

Show »
Length:1,310
Mass (Da):143,350
Checksum:i948FE29C9EA7D312
GO
Isoform 6 (identifier: Q9BZA7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1049-1065: SQRRVTFHLPEGSQESS → TVLTSSSPSAMTLSYLD
     1066-1347: Missing.

Show »
Length:1,065
Mass (Da):117,642
Checksum:i71AB11952A3EEA81
GO
Isoform 7 (identifier: Q9BZA7-7) [UniParc]FASTAAdd to basket
Also known as: Protocadherin-Xa

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1021: PMKEVVRSCT → VGIQVSNTTF
     1022-1347: Missing.

Show »
Length:1,021
Mass (Da):112,726
Checksum:i9F4471F5C597F902
GO
Isoform 8 (identifier: Q9BZA7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1116-1123: Missing.

Show »
Length:1,339
Mass (Da):146,703
Checksum:iCD1D563B7D8FE105
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242 – 244TND → PNA in AAK82655 (Ref. 4) Curated3
Sequence conflicti242 – 244TND → PNA in AAK82656 (Ref. 4) Curated3
Sequence conflicti252T → P in AAK82655 (Ref. 4) Curated1
Sequence conflicti252T → P in AAK82656 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03610942D → G in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1451414636Ensembl.1
Natural variantiVAR_0485751018R → Q. Corresponds to variant dbSNP:rs4252205Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0179791012 – 1048Missing in isoform 5. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_0179801012 – 1025PMKEV…TPMKE → TDSRTSTIEICSEI in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0179811012 – 1021PMKEVVRSCT → VGIQVSNTTF in isoform 7. 2 Publications10
Alternative sequenceiVSP_0179821022 – 1347Missing in isoform 7. 2 PublicationsAdd BLAST326
Alternative sequenceiVSP_0179831026 – 1347Missing in isoform 2. 1 PublicationAdd BLAST322
Alternative sequenceiVSP_0179841039 – 1048Missing in isoform 3 and isoform 4. 2 Publications10
Alternative sequenceiVSP_0179851049 – 1065SQRRV…SQESS → TVLTSSSPSAMTLSYLD in isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0179861066 – 1347Missing in isoform 6. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_0179871116 – 1123Missing in isoform 8 and isoform 4. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB026187 mRNA Translation: BAA90765.1
AJ276804 mRNA Translation: CAC13123.1
AF332218 mRNA Translation: AAK13470.1
AF332219 mRNA Translation: AAK13471.1
AF206516 mRNA Translation: AAK82655.1
AF217288 mRNA Translation: AAK82656.1
AY861432 mRNA Translation: AAX56122.1
AY861433 mRNA Translation: AAX56123.1
AY861434 mRNA Translation: AAX56124.1
AY861435 mRNA Translation: AAX56125.1
AC004388 Genomic DNA No translation available.
AL121869 Genomic DNA No translation available.
AL133274 Genomic DNA No translation available.
AL133321 Genomic DNA No translation available.
AJ564931 mRNA Translation: CAD92410.1
AJ564932 mRNA Translation: CAD92411.1
AJ564933 mRNA Translation: CAD92412.1
AJ564934 mRNA Translation: CAD92413.1
AJ564935 mRNA Translation: CAD92414.1
AJ564936 mRNA Translation: CAD92415.1
AJ564942 mRNA Translation: CAD92421.1
AJ564945 mRNA Translation: CAD92424.1
AJ564946 mRNA Translation: CAD92425.1
AJ564947 mRNA Translation: CAD92426.1
AB037747 mRNA Translation: BAA92564.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14461.1 [Q9BZA7-1]
CCDS14462.1 [Q9BZA7-3]
CCDS55458.1 [Q9BZA7-6]
CCDS55459.1 [Q9BZA7-8]
CCDS55460.1 [Q9BZA7-4]
CCDS55461.1 [Q9BZA7-5]

NCBI Reference Sequences

More...RefSeqi		NP_001161832.1, NM_001168360.1 [Q9BZA7-8]
NP_001161833.1, NM_001168361.1 [Q9BZA7-6]
NP_001161834.1, NM_001168362.1 [Q9BZA7-5]
NP_001161835.1, NM_001168363.1 [Q9BZA7-4]
NP_116750.1, NM_032968.4 [Q9BZA7-1]
NP_116751.1, NM_032969.4 [Q9BZA7-3]
XP_011529216.1, XM_011530914.2 [Q9BZA7-1]
XP_016884911.1, XM_017029422.1 [Q9BZA7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361655; ENSP00000355105; ENSG00000102290 [Q9BZA7-4]
ENST00000373088; ENSP00000362180; ENSG00000102290 [Q9BZA7-5]
ENST00000373094; ENSP00000362186; ENSG00000102290 [Q9BZA7-1]
ENST00000373097; ENSP00000362189; ENSG00000102290 [Q9BZA7-3]
ENST00000406881; ENSP00000384758; ENSG00000102290 [Q9BZA7-8]
ENST00000504220; ENSP00000423762; ENSG00000102290 [Q9BZA7-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27328

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27328

UCSC genome browser

More...UCSCi		uc004efk.3, human [Q9BZA7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026187 mRNA Translation: BAA90765.1
AJ276804 mRNA Translation: CAC13123.1
AF332218 mRNA Translation: AAK13470.1
AF332219 mRNA Translation: AAK13471.1
AF206516 mRNA Translation: AAK82655.1
AF217288 mRNA Translation: AAK82656.1
AY861432 mRNA Translation: AAX56122.1
AY861433 mRNA Translation: AAX56123.1
AY861434 mRNA Translation: AAX56124.1
AY861435 mRNA Translation: AAX56125.1
AC004388 Genomic DNA No translation available.
AL121869 Genomic DNA No translation available.
AL133274 Genomic DNA No translation available.
AL133321 Genomic DNA No translation available.
AJ564931 mRNA Translation: CAD92410.1
AJ564932 mRNA Translation: CAD92411.1
AJ564933 mRNA Translation: CAD92412.1
AJ564934 mRNA Translation: CAD92413.1
AJ564935 mRNA Translation: CAD92414.1
AJ564936 mRNA Translation: CAD92415.1
AJ564942 mRNA Translation: CAD92421.1
AJ564945 mRNA Translation: CAD92424.1
AJ564946 mRNA Translation: CAD92425.1
AJ564947 mRNA Translation: CAD92426.1
AB037747 mRNA Translation: BAA92564.1
CCDSiCCDS14461.1 [Q9BZA7-1]
CCDS14462.1 [Q9BZA7-3]
CCDS55458.1 [Q9BZA7-6]
CCDS55459.1 [Q9BZA7-8]
CCDS55460.1 [Q9BZA7-4]
CCDS55461.1 [Q9BZA7-5]
RefSeqiNP_001161832.1, NM_001168360.1 [Q9BZA7-8]
NP_001161833.1, NM_001168361.1 [Q9BZA7-6]
NP_001161834.1, NM_001168362.1 [Q9BZA7-5]
NP_001161835.1, NM_001168363.1 [Q9BZA7-4]
NP_116750.1, NM_032968.4 [Q9BZA7-1]
NP_116751.1, NM_032969.4 [Q9BZA7-3]
XP_011529216.1, XM_011530914.2 [Q9BZA7-1]
XP_016884911.1, XM_017029422.1 [Q9BZA7-2]

3D structure databases

SMRiQ9BZA7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118142, 5 interactors
IntActiQ9BZA7, 2 interactors
STRINGi9606.ENSP00000362186

PTM databases

GlyConnecti2065, 1 N-Linked glycan (1 site)
GlyGeniQ9BZA7, 6 sites, 1 N-linked glycan (1 site)
iPTMnetiQ9BZA7
PhosphoSitePlusiQ9BZA7

Polymorphism and mutation databases

BioMutaiPCDH11X
DMDMi74761344

Proteomic databases

jPOSTiQ9BZA7
MassIVEiQ9BZA7
PaxDbiQ9BZA7
PeptideAtlasiQ9BZA7
PRIDEiQ9BZA7
ProteomicsDBi79788 [Q9BZA7-1]
79789 [Q9BZA7-2]
79790 [Q9BZA7-3]
79791 [Q9BZA7-4]
79792 [Q9BZA7-5]
79793 [Q9BZA7-6]
79794 [Q9BZA7-7]
79795 [Q9BZA7-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28445, 89 antibodies

The DNASU plasmid repository

More...DNASUi		27328

Genome annotation databases

EnsembliENST00000361655; ENSP00000355105; ENSG00000102290 [Q9BZA7-4]
ENST00000373088; ENSP00000362180; ENSG00000102290 [Q9BZA7-5]
ENST00000373094; ENSP00000362186; ENSG00000102290 [Q9BZA7-1]
ENST00000373097; ENSP00000362189; ENSG00000102290 [Q9BZA7-3]
ENST00000406881; ENSP00000384758; ENSG00000102290 [Q9BZA7-8]
ENST00000504220; ENSP00000423762; ENSG00000102290 [Q9BZA7-6]
GeneIDi27328
KEGGihsa:27328
UCSCiuc004efk.3, human [Q9BZA7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27328
DisGeNETi27328
EuPathDBiHostDB:ENSG00000102290.21

GeneCards: human genes, protein and diseases

More...GeneCardsi		PCDH11X
HGNCiHGNC:8656, PCDH11X
HPAiENSG00000102290, Group enriched (brain, ovary, parathyroid gland)
MIMi300246, gene
neXtProtiNX_Q9BZA7
OpenTargetsiENSG00000102290
PharmGKBiPA32996

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPMK, Eukaryota
GeneTreeiENSGT00940000158335
HOGENOMiCLU_006480_5_2_1
InParanoidiQ9BZA7
KOiK16498
OMAiKPPHYGT
PhylomeDBiQ9BZA7
TreeFamiTF320624

Enzyme and pathway databases

PathwayCommonsiQ9BZA7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27328, 16 hits in 492 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PCDH11X, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PCDH11X

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27328
PharosiQ9BZA7, Tbio

Protein Ontology

More...PROi		PR:Q9BZA7
RNActiQ9BZA7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102290, Expressed in cortical plate and 72 other tissues
GenevisibleiQ9BZA7, HS

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR013585, Protocadherin
PfamiView protein in Pfam
PF00028, Cadherin, 6 hits
PF08266, Cadherin_2, 1 hit
PF08374, Protocadherin, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 6 hits
SUPFAMiSSF49313, SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 5 hits
PS50268, CADHERIN_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPC11X_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZA7
Secondary accession number(s): A6NIQ4
, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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