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Protein

Protocadherin-11 X-linked

Gene

PCDH11X

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • negative regulation of phosphatase activity Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-11 X-linked
Short name:
Protocadherin-11
Alternative name(s):
Protocadherin on the X chromosome
Short name:
PCDH-X
Protocadherin-S
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH11X
Synonyms:KIAA1326, PCDH11, PCDHX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102290.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8656 PCDH11X

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300246 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZA7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 812ExtracellularSequence analysisAdd BLAST789
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei813 – 833HelicalSequence analysisAdd BLAST21
Topological domaini834 – 1347CytoplasmicSequence analysisAdd BLAST514

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27328

Open Targets

More...
OpenTargetsi
ENSG00000102290

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32996

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCDH11X

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023275824 – 1347Protocadherin-11 X-linkedAdd BLAST1324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi773N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZA7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZA7

PeptideAtlas

More...
PeptideAtlasi
Q9BZA7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZA7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79788
79789 [Q9BZA7-2]
79790 [Q9BZA7-3]
79791 [Q9BZA7-4]
79792 [Q9BZA7-5]
79793 [Q9BZA7-6]
79794 [Q9BZA7-7]
79795 [Q9BZA7-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZA7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102290 Expressed in 49 organ(s), highest expression level in corpus callosum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZA7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000432

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118142, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZA7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362186

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BZA7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZA7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 139Cadherin 1PROSITE-ProRule annotationAdd BLAST114
Domaini140 – 249Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini250 – 355Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini362 – 466Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini467 – 570Cadherin 5PROSITE-ProRule annotationAdd BLAST104
Domaini571 – 673Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini677 – 795Cadherin 7PROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi868 – 875Poly-Lys8

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158335

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053523

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZA7

KEGG Orthology (KO)

More...
KOi
K16498

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEGEKMP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G011P

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZA7

TreeFam database of animal gene trees

More...
TreeFami
TF320624

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9BZA7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS
60 70 80 90 100
LIPNKSLTTA MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI
110 120 130 140 150
PRDEHCFYEV EVAILPDEIF RLVKIRFLIE DINDNAPLFP ATVINISIPE
160 170 180 190 200
NSAINSKYTL PAAVDPDVGI NGVQNYELIK SQNIFGLDVI ETPEGDKMPQ
210 220 230 240 250
LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT DTNDNHPVFK
260 270 280 290 300
ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF
310 320 330 340 350
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND
360 370 380 390 400
NVPSIDIRYI VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT
410 420 430 440 450
DHEIPFRLRP VFSNQFLLET AAYLDYESTK EYAIKLLAAD AGKPPLNQSA
460 470 480 490 500
MLFIKVKDEN DNAPVFTQSF VTVSIPENNS PGIQLTKVSA MDADSGPNAK
510 520 530 540 550
INYLLGPDAP PEFSLDCRTG MLTVVKKLDR EKEDKYLFTI LAKDNGVPPL
560 570 580 590 600
TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG
610 620 630 640 650
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR
660 670 680 690 700
VSRSSSAKVT INVVDVNDNK PVFIVPPSNC SYELVLPSTN PGTVVFQVIA
710 720 730 740 750
VDNDTGMNAE VRYSIVGGNT RDLFAIDQET GNITLMEKCD VTDLGLHRVL
760 770 780 790 800
VKANDLGQPD SLFSVVIVNL FVNESVTNAT LINELVRKST EAPVTPNTEI
810 820 830 840 850
ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP HLKAAQKNKQ
860 870 880 890 900
NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG
910 920 930 940 950
NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI
960 970 980 990 1000
QPETPLNSKH HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT
1010 1020 1030 1040 1050
FEVPVSVHTR PPMKEVVRSC TPMKESTTME IWIHPQPQRK SEGKVAGKSQ
1060 1070 1080 1090 1100
RRVTFHLPEG SQESSSDGGL GDHDAGSLTS TSHGLPLGYP QEEYFDRATP
1110 1120 1130 1140 1150
SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT QECLIYGHSD
1160 1170 1180 1190 1200
ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPRVT QTIALCHSPP
1210 1220 1230 1240 1250
VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA
1260 1270 1280 1290 1300
QAAAISHSSP LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA
1310 1320 1330 1340
TSQFYTMSER LHPSDDSIKV IPLTTFTPRQ QARPSRGDSP IMEEHPL
Length:1,347
Mass (Da):147,558
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0227FA6C521FDA84
GO
Isoform 2 (identifier: Q9BZA7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1025: PMKEVVRSCTPMKE → TDSRTSTIEICSEI
     1026-1347: Missing.

Show »
Length:1,025
Mass (Da):113,215
Checksum:i51EE095ED7035A10
GO
Isoform 3 (identifier: Q9BZA7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1048: Missing.

Show »
Length:1,337
Mass (Da):146,517
Checksum:iA96D3B41173C8508
GO
Isoform 4 (identifier: Q9BZA7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1048: Missing.
     1116-1123: Missing.

Show »
Length:1,329
Mass (Da):145,662
Checksum:iDA7DC585324AD261
GO
Isoform 5 (identifier: Q9BZA7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1048: Missing.

Show »
Length:1,310
Mass (Da):143,350
Checksum:i948FE29C9EA7D312
GO
Isoform 6 (identifier: Q9BZA7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1049-1065: SQRRVTFHLPEGSQESS → TVLTSSSPSAMTLSYLD
     1066-1347: Missing.

Show »
Length:1,065
Mass (Da):117,642
Checksum:i71AB11952A3EEA81
GO
Isoform 7 (identifier: Q9BZA7-7) [UniParc]FASTAAdd to basket
Also known as: Protocadherin-Xa

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1021: PMKEVVRSCT → VGIQVSNTTF
     1022-1347: Missing.

Note: No experimental confirmation available.
Show »
Length:1,021
Mass (Da):112,726
Checksum:i9F4471F5C597F902
GO
Isoform 8 (identifier: Q9BZA7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1116-1123: Missing.

Show »
Length:1,339
Mass (Da):146,703
Checksum:iCD1D563B7D8FE105
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242 – 244TND → PNA in AAK82655 (Ref. 4) Curated3
Sequence conflicti242 – 244TND → PNA in AAK82656 (Ref. 4) Curated3
Sequence conflicti252T → P in AAK82655 (Ref. 4) Curated1
Sequence conflicti252T → P in AAK82656 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03610942D → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0485751018R → Q. Corresponds to variant dbSNP:rs4252205Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0179791012 – 1048Missing in isoform 5. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_0179801012 – 1025PMKEV…TPMKE → TDSRTSTIEICSEI in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0179811012 – 1021PMKEVVRSCT → VGIQVSNTTF in isoform 7. 2 Publications10
Alternative sequenceiVSP_0179821022 – 1347Missing in isoform 7. 2 PublicationsAdd BLAST326
Alternative sequenceiVSP_0179831026 – 1347Missing in isoform 2. 1 PublicationAdd BLAST322
Alternative sequenceiVSP_0179841039 – 1048Missing in isoform 3 and isoform 4. 2 Publications10
Alternative sequenceiVSP_0179851049 – 1065SQRRV…SQESS → TVLTSSSPSAMTLSYLD in isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0179861066 – 1347Missing in isoform 6. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_0179871116 – 1123Missing in isoform 8 and isoform 4. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB026187 mRNA Translation: BAA90765.1
AJ276804 mRNA Translation: CAC13123.1
AF332218 mRNA Translation: AAK13470.1
AF332219 mRNA Translation: AAK13471.1
AF206516 mRNA Translation: AAK82655.1
AF217288 mRNA Translation: AAK82656.1
AY861432 mRNA Translation: AAX56122.1
AY861433 mRNA Translation: AAX56123.1
AY861434 mRNA Translation: AAX56124.1
AY861435 mRNA Translation: AAX56125.1
AC004388 Genomic DNA No translation available.
AL121869 Genomic DNA No translation available.
AL133274 Genomic DNA No translation available.
AL133321 Genomic DNA No translation available.
AJ564931 mRNA Translation: CAD92410.1
AJ564932 mRNA Translation: CAD92411.1
AJ564933 mRNA Translation: CAD92412.1
AJ564934 mRNA Translation: CAD92413.1
AJ564935 mRNA Translation: CAD92414.1
AJ564936 mRNA Translation: CAD92415.1
AJ564942 mRNA Translation: CAD92421.1
AJ564945 mRNA Translation: CAD92424.1
AJ564946 mRNA Translation: CAD92425.1
AJ564947 mRNA Translation: CAD92426.1
AB037747 mRNA Translation: BAA92564.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14461.1 [Q9BZA7-1]
CCDS14462.1 [Q9BZA7-3]
CCDS55458.1 [Q9BZA7-6]
CCDS55459.1 [Q9BZA7-8]
CCDS55460.1 [Q9BZA7-4]
CCDS55461.1 [Q9BZA7-5]

NCBI Reference Sequences

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RefSeqi
NP_001161832.1, NM_001168360.1 [Q9BZA7-8]
NP_001161833.1, NM_001168361.1 [Q9BZA7-6]
NP_001161834.1, NM_001168362.1 [Q9BZA7-5]
NP_001161835.1, NM_001168363.1 [Q9BZA7-4]
NP_116750.1, NM_032968.4 [Q9BZA7-1]
NP_116751.1, NM_032969.4 [Q9BZA7-3]
XP_011529216.1, XM_011530914.2 [Q9BZA7-1]
XP_016884911.1, XM_017029422.1 [Q9BZA7-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.655673

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000361655; ENSP00000355105; ENSG00000102290 [Q9BZA7-4]
ENST00000373088; ENSP00000362180; ENSG00000102290 [Q9BZA7-5]
ENST00000373094; ENSP00000362186; ENSG00000102290 [Q9BZA7-1]
ENST00000373097; ENSP00000362189; ENSG00000102290 [Q9BZA7-3]
ENST00000406881; ENSP00000384758; ENSG00000102290 [Q9BZA7-8]
ENST00000504220; ENSP00000423762; ENSG00000102290 [Q9BZA7-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27328

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27328

UCSC genome browser

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UCSCi
uc004efk.3 human [Q9BZA7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026187 mRNA Translation: BAA90765.1
AJ276804 mRNA Translation: CAC13123.1
AF332218 mRNA Translation: AAK13470.1
AF332219 mRNA Translation: AAK13471.1
AF206516 mRNA Translation: AAK82655.1
AF217288 mRNA Translation: AAK82656.1
AY861432 mRNA Translation: AAX56122.1
AY861433 mRNA Translation: AAX56123.1
AY861434 mRNA Translation: AAX56124.1
AY861435 mRNA Translation: AAX56125.1
AC004388 Genomic DNA No translation available.
AL121869 Genomic DNA No translation available.
AL133274 Genomic DNA No translation available.
AL133321 Genomic DNA No translation available.
AJ564931 mRNA Translation: CAD92410.1
AJ564932 mRNA Translation: CAD92411.1
AJ564933 mRNA Translation: CAD92412.1
AJ564934 mRNA Translation: CAD92413.1
AJ564935 mRNA Translation: CAD92414.1
AJ564936 mRNA Translation: CAD92415.1
AJ564942 mRNA Translation: CAD92421.1
AJ564945 mRNA Translation: CAD92424.1
AJ564946 mRNA Translation: CAD92425.1
AJ564947 mRNA Translation: CAD92426.1
AB037747 mRNA Translation: BAA92564.1
CCDSiCCDS14461.1 [Q9BZA7-1]
CCDS14462.1 [Q9BZA7-3]
CCDS55458.1 [Q9BZA7-6]
CCDS55459.1 [Q9BZA7-8]
CCDS55460.1 [Q9BZA7-4]
CCDS55461.1 [Q9BZA7-5]
RefSeqiNP_001161832.1, NM_001168360.1 [Q9BZA7-8]
NP_001161833.1, NM_001168361.1 [Q9BZA7-6]
NP_001161834.1, NM_001168362.1 [Q9BZA7-5]
NP_001161835.1, NM_001168363.1 [Q9BZA7-4]
NP_116750.1, NM_032968.4 [Q9BZA7-1]
NP_116751.1, NM_032969.4 [Q9BZA7-3]
XP_011529216.1, XM_011530914.2 [Q9BZA7-1]
XP_016884911.1, XM_017029422.1 [Q9BZA7-2]
UniGeneiHs.655673

3D structure databases

ProteinModelPortaliQ9BZA7
SMRiQ9BZA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118142, 2 interactors
IntActiQ9BZA7, 1 interactor
STRINGi9606.ENSP00000362186

PTM databases

iPTMnetiQ9BZA7
PhosphoSitePlusiQ9BZA7

Polymorphism and mutation databases

BioMutaiPCDH11X
DMDMi74761344

Proteomic databases

EPDiQ9BZA7
PaxDbiQ9BZA7
PeptideAtlasiQ9BZA7
PRIDEiQ9BZA7
ProteomicsDBi79788
79789 [Q9BZA7-2]
79790 [Q9BZA7-3]
79791 [Q9BZA7-4]
79792 [Q9BZA7-5]
79793 [Q9BZA7-6]
79794 [Q9BZA7-7]
79795 [Q9BZA7-8]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
27328
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361655; ENSP00000355105; ENSG00000102290 [Q9BZA7-4]
ENST00000373088; ENSP00000362180; ENSG00000102290 [Q9BZA7-5]
ENST00000373094; ENSP00000362186; ENSG00000102290 [Q9BZA7-1]
ENST00000373097; ENSP00000362189; ENSG00000102290 [Q9BZA7-3]
ENST00000406881; ENSP00000384758; ENSG00000102290 [Q9BZA7-8]
ENST00000504220; ENSP00000423762; ENSG00000102290 [Q9BZA7-6]
GeneIDi27328
KEGGihsa:27328
UCSCiuc004efk.3 human [Q9BZA7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27328
DisGeNETi27328
EuPathDBiHostDB:ENSG00000102290.21

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCDH11X

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0176577
HGNCiHGNC:8656 PCDH11X
HPAiHPA000432
MIMi300246 gene
neXtProtiNX_Q9BZA7
OpenTargetsiENSG00000102290
PharmGKBiPA32996

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000158335
HOVERGENiHBG053523
InParanoidiQ9BZA7
KOiK16498
OMAiPEGEKMP
OrthoDBiEOG091G011P
PhylomeDBiQ9BZA7
TreeFamiTF320624

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PCDH11X human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PCDH11X

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27328

Protein Ontology

More...
PROi
PR:Q9BZA7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102290 Expressed in 49 organ(s), highest expression level in corpus callosum
GenevisibleiQ9BZA7 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin
PfamiView protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPC11X_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZA7
Secondary accession number(s): A6NIQ4
, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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