UniProtKB - Q9BZ95 (NSD3_HUMAN)
Protein
Histone-lysine N-methyltransferase NSD3
Gene
NSD3
Organism
Homo sapiens (Human)
Status
Functioni
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.1 Publication
Catalytic activityi
- L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine1 PublicationEC:2.1.1.3701 Publication
- L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine1 PublicationEC:2.1.1.3711 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 701 – 748 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 749 – 805 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 862 – 955 | PHD-type 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Zinc fingeri | 1321 – 1368 | PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- histone-lysine N-methyltransferase activity Source: UniProtKB
- histone methyltransferase activity (H3-K36 specific) Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- transcription regulator activator activity Source: UniProtKB
GO - Biological processi
- histone methylation Source: UniProtKB
- positive regulation of histone H3-K36 trimethylation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator, Methyltransferase, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:HS07446-MONOMER |
PathwayCommonsi | Q9BZ95 |
Reactomei | R-HSA-3214841, PKMTs methylate histone lysines |
SIGNORi | Q9BZ95 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase NSD3 (EC:2.1.1.3701 Publication, EC:2.1.1.3711 Publication)Alternative name(s): Nuclear SET domain-containing protein 3 Protein whistle WHSC1-like 1 isoform 9 with methyltransferase activity to lysine Wolf-Hirschhorn syndrome candidate 1-like protein 1 Short name: WHSC1-like protein 1 |
Gene namesi | ORF Names:DC28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12767, NSD3 |
MIMi | 607083, gene |
neXtProti | NX_Q9BZ95 |
VEuPathDBi | HostDB:ENSG00000147548.16 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- chromatin Source: GO_Central
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Defects in NSD3 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.1 Publication
A chromosomal aberration involving NSD3 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.1 Publication
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 54904 |
OpenTargetsi | ENSG00000147548 |
PharmGKBi | PA37370 |
Miscellaneous databases
Pharosi | Q9BZ95, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3108646 |
Genetic variation databases
BioMutai | WHSC1L1 |
DMDMi | 74761342 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259521 | 1 – 1437 | Histone-lysine N-methyltransferase NSD3Add BLAST | 1437 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 150 | PhosphoserineCombined sources | 1 | |
Cross-linki | 218 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 245 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 457 | PhosphoserineCombined sources | 1 | |
Cross-linki | 502 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 532 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 585 | PhosphoserineCombined sources | 1 | |
Modified residuei | 587 | PhosphoserineCombined sources | 1 | |
Modified residuei | 590 | PhosphoserineCombined sources | 1 | |
Cross-linki | 628 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 655 | PhosphoserineCombined sources | 1 | |
Modified residuei | 790 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 1151 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BZ95 |
jPOSTi | Q9BZ95 |
MassIVEi | Q9BZ95 |
MaxQBi | Q9BZ95 |
PaxDbi | Q9BZ95 |
PeptideAtlasi | Q9BZ95 |
PRIDEi | Q9BZ95 |
ProteomicsDBi | 7208 79779 [Q9BZ95-1] 79780 [Q9BZ95-2] 79781 [Q9BZ95-3] 79782 [Q9BZ95-4] |
PTM databases
iPTMneti | Q9BZ95 |
PhosphoSitePlusi | Q9BZ95 |
Expressioni
Tissue specificityi
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.1 Publication
Gene expression databases
Bgeei | ENSG00000147548, Expressed in kidney and 223 other tissues |
ExpressionAtlasi | Q9BZ95, baseline and differential |
Genevisiblei | Q9BZ95, HS |
Organism-specific databases
HPAi | ENSG00000147548, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BRD4.
2 PublicationsBinary interactionsi
Hide detailsQ9BZ95
Isoform 3 [Q9BZ95-3]
Protein-protein interaction databases
BioGRIDi | 120250, 74 interactors |
DIPi | DIP-62074N |
IntActi | Q9BZ95, 48 interactors |
MINTi | Q9BZ95 |
STRINGi | 9606.ENSP00000313983 |
Chemistry databases
BindingDBi | Q9BZ95 |
Miscellaneous databases
RNActi | Q9BZ95, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9BZ95 |
SMRi | Q9BZ95 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BZ95 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 270 – 333 | PWWP 1PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 960 – 1022 | PWWP 2PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 1093 – 1143 | AWSPROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 1145 – 1262 | SETPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 1269 – 1285 | Post-SETPROSITE-ProRule annotationAdd BLAST | 17 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1033 – 1069 | Sequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 701 – 748 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 749 – 805 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 862 – 955 | PHD-type 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Zinc fingeri | 1321 – 1368 | PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1081, Eukaryota |
GeneTreei | ENSGT00940000155355 |
HOGENOMi | CLU_004494_2_1_1 |
InParanoidi | Q9BZ95 |
OMAi | SACCMEK |
OrthoDBi | 507784at2759 |
PhylomeDBi | Q9BZ95 |
TreeFami | TF329088 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
IDEALi | IID00496 |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR041306, C5HCH IPR003616, Post-SET_dom IPR000313, PWWP_dom IPR001214, SET_dom IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF17982, C5HCH, 1 hit PF00855, PWWP, 2 hits PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00249, PHD, 5 hits SM00508, PostSET, 1 hit SM00293, PWWP, 2 hits SM00317, SET, 1 hit |
SUPFAMi | SSF57903, SSF57903, 3 hits |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS50812, PWWP, 2 hits PS50280, SET, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BZ95-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNNSDI AEDGGQTPYE
60 70 80 90 100
ATLQQGFQYP ATTEDLPPLT NGYPSSISVY ETQTKYQSYN QYPNGSANGF
110 120 130 140 150
GAVRNFSPTD YYHSEIPNTR PHEILEKPSP PQPPPPPSVP QTVIPKKTGS
160 170 180 190 200
PEIKLKITKT IQNGRELFES SLCGDLLNEV QASEHTKSKH ESRKEKRKKS
210 220 230 240 250
NKHDSSRSEE RKSHKIPKLE PEEQNRPNER VDTVSEKPRE EPVLKEEAPV
260 270 280 290 300
QPILSSVPTT EVSTGVKFQV GDLVWSKVGT YPWWPCMVSS DPQLEVHTKI
310 320 330 340 350
NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHKQYEELL AEATKQASNH
360 370 380 390 400
SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERIEQY TFIYIDKQPE
410 420 430 440 450
EALSQAKKSV ASKTEVKKTR RPRSVLNTQP EQTNAGEVAS SLSSTEIRRH
460 470 480 490 500
SQRRHTSAEE EEPPPVKIAW KTAAARKSLP ASITMHKGSL DLQKCNMSPV
510 520 530 540 550
VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ DRLIISTPNQ
560 570 580 590 600
RNEKPTQSVS SPEATSGSTG SVEKKQQRRS IRTRSESEKS TEVVPKKKIK
610 620 630 640 650
KEQVETVPQA TVKTGLQKGA SEISDSCKPL KKRSRASTDV EMTSSAYRDT
660 670 680 690 700
SDSDSRGLSD LQVGFGKQVD SPSATADADV SDVQSMDSSL SRRGTGMSKK
710 720 730 740 750
DTVCQICESS GDSLIPCEGE CCKHFHLECL GLASLPDSKF ICMECKTGQH
760 770 780 790 800
PCFSCKVSGK DVKRCSVGAC GKFYHEACVR KFPTAIFESK GFRCPQHCCS
810 820 830 840 850
ACSMEKDIHK ASKGRMMRCL RCPVAYHSGD ACIAAGSMLV SSYILICSNH
860 870 880 890 900
SKRSSNSSAV NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH YLLNESNRAE
910 920 930 940 950
LMKLPMIPSS SASKKKCEKG GRLLCCESCP ASFHPECLSI EMPEGCWNCN
960 970 980 990 1000
DCKAGKKLHY KQIVWVKLGN YRWWPAEICN PRSVPLNIQG LKHDLGDFPV
1010 1020 1030 1040 1050
FFFGSHDYYW VHQGRVFPYV EGDKSFAEGQ TSINKTFKKA LEEAAKRFQE
1060 1070 1080 1090 1100
LKAQRESKEA LEIEKNSRKP PPYKHIKANK VIGKVQIQVA DLSEIPRCNC
1110 1120 1130 1140 1150
KPADENPCGL ESECLNRMLQ YECHPQVCPA GDRCQNQCFT KRLYPDAEII
1160 1170 1180 1190 1200
KTERRGWGLR TKRSIKKGEF VNEYVGELID EEECRLRIKR AHENSVTNFY
1210 1220 1230 1240 1250
MLTVTKDRII DAGPKGNYSR FMNHSCNPNC ETQKWTVNGD VRVGLFALCD
1260 1270 1280 1290 1300
IPAGMELTFN YNLDCLGNGR TECHCGADNC SGFLGVRPKS ACASTNEEKA
1310 1320 1330 1340 1350
KNAKLKQKRR KIKTEPKQMH EDYCFQCGDG GELVMCDKKD CPKAYHLLCL
1360 1370 1380 1390 1400
NLTQPPYGKW ECPWHQCDEC SSAAVSFCEF CPHSFCKDHE KGALVPSALE
1410 1420 1430
GRLCCSEHDP MAPVSPEYWS KIKCKWESQD HGEEVKE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PKA2 | E9PKA2_HUMAN | Histone-lysine N-methyltransferase ... | NSD3 | 282 | Annotation score: | ||
H0YE68 | H0YE68_HUMAN | Histone-lysine N-methyltransferase ... | NSD3 | 77 | Annotation score: | ||
E9PKL3 | E9PKL3_HUMAN | Histone-lysine N-methyltransferase ... | NSD3 | 15 | Annotation score: | ||
E9PQ95 | E9PQ95_HUMAN | Histone-lysine N-methyltransferase ... | NSD3 | 25 | Annotation score: |
Sequence cautioni
The sequence AAG44637 differs from that shown. Reason: Frameshift.Curated
The sequence AAI07735 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91110 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 436 | G → R in AAI15007 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 578 | R → G in AAI15007 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 829 | G → E in CAC28350 (PubMed:11374904).Curated | 1 | |
Sequence conflicti | 829 | G → E in CAC28351 (PubMed:11374904).Curated | 1 | |
Sequence conflicti | 926 | C → R in AAI15007 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1308 | K → R in AAI15007 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1430 | D → G in AAI15007 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061215 | 186 | T → M. Corresponds to variant dbSNP:rs13034EnsemblClinVar. | 1 | |
Natural variantiVAR_028950 | 383 | R → P. Corresponds to variant dbSNP:rs2234552EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021427 | 67 – 129 | Missing in isoform 4. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_021428 | 620 – 645 | ASEIS…EMTSS → SADRGVQGSVRFSDSSVSAA IEETVD in isoform 3. 5 PublicationsAdd BLAST | 26 | |
Alternative sequenceiVSP_021429 | 646 – 1437 | Missing in isoform 3. 5 PublicationsAdd BLAST | 792 | |
Alternative sequenceiVSP_021430 | 871 – 919 | Missing in isoform 2. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_054489 | 1196 – 1206 | Missing in isoform 5. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF332468 mRNA Translation: AAK00354.1 AF332469 mRNA Translation: AAK00355.1 AJ295990 mRNA Translation: CAC28350.1 AJ295991 mRNA Translation: CAC28351.1 AJ295992 mRNA Translation: CAC28352.1 AF255649 mRNA Translation: AAG44637.1 Frameshift. AK000360 mRNA Translation: BAA91110.1 Different initiation. AK022560 mRNA Translation: BAB14099.1 AK127594 mRNA No translation available. CH471080 Genomic DNA Translation: EAW63320.1 CH471080 Genomic DNA Translation: EAW63321.1 BC012059 mRNA Translation: AAH12059.1 BC062631 mRNA Translation: AAH62631.1 BC101717 mRNA Translation: AAI01718.1 BC107734 mRNA Translation: AAI07735.1 Sequence problems. BC113469 mRNA Translation: AAI13470.1 BC115006 mRNA Translation: AAI15007.1 BC143510 mRNA Translation: AAI43511.1 AC087362 Genomic DNA No translation available. AC087623 Genomic DNA No translation available. |
CCDSi | CCDS43729.1 [Q9BZ95-1] CCDS6105.1 [Q9BZ95-3] |
RefSeqi | NP_060248.2, NM_017778.2 [Q9BZ95-3] NP_075447.1, NM_023034.1 [Q9BZ95-1] |
Genome annotation databases
Ensembli | ENST00000316985; ENSP00000313410; ENSG00000147548 [Q9BZ95-3] ENST00000317025; ENSP00000313983; ENSG00000147548 [Q9BZ95-1] ENST00000433384; ENSP00000393284; ENSG00000147548 [Q9BZ95-2] ENST00000527502; ENSP00000434730; ENSG00000147548 [Q9BZ95-5] |
GeneIDi | 54904 |
KEGGi | hsa:54904 |
UCSCi | uc003xli.4, human [Q9BZ95-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF332468 mRNA Translation: AAK00354.1 AF332469 mRNA Translation: AAK00355.1 AJ295990 mRNA Translation: CAC28350.1 AJ295991 mRNA Translation: CAC28351.1 AJ295992 mRNA Translation: CAC28352.1 AF255649 mRNA Translation: AAG44637.1 Frameshift. AK000360 mRNA Translation: BAA91110.1 Different initiation. AK022560 mRNA Translation: BAB14099.1 AK127594 mRNA No translation available. CH471080 Genomic DNA Translation: EAW63320.1 CH471080 Genomic DNA Translation: EAW63321.1 BC012059 mRNA Translation: AAH12059.1 BC062631 mRNA Translation: AAH62631.1 BC101717 mRNA Translation: AAI01718.1 BC107734 mRNA Translation: AAI07735.1 Sequence problems. BC113469 mRNA Translation: AAI13470.1 BC115006 mRNA Translation: AAI15007.1 BC143510 mRNA Translation: AAI43511.1 AC087362 Genomic DNA No translation available. AC087623 Genomic DNA No translation available. |
CCDSi | CCDS43729.1 [Q9BZ95-1] CCDS6105.1 [Q9BZ95-3] |
RefSeqi | NP_060248.2, NM_017778.2 [Q9BZ95-3] NP_075447.1, NM_023034.1 [Q9BZ95-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DAQ | NMR | - | A | 957-1053 | [»] | |
2NCZ | NMR | - | B | 152-163 | [»] | |
2ND1 | NMR | - | B | 593-605 | [»] | |
4GND | X-ray | 2.27 | A/C | 1310-1413 | [»] | |
4GNE | X-ray | 1.47 | A | 1310-1413 | [»] | |
4GNF | X-ray | 1.55 | A | 1310-1413 | [»] | |
4GNG | X-ray | 1.73 | A/D | 1310-1413 | [»] | |
4RXJ | X-ray | 2.10 | A | 953-1064 | [»] | |
5UPD | X-ray | 1.80 | A | 1054-1285 | [»] | |
6CEN | X-ray | 1.61 | A | 1058-1285 | [»] | |
6G24 | X-ray | 2.10 | A | 263-398 | [»] | |
6G25 | X-ray | 1.43 | A | 263-398 | [»] | |
6G27 | X-ray | 1.65 | A | 263-398 | [»] | |
6G29 | X-ray | 1.70 | A | 263-398 | [»] | |
6G2B | X-ray | 1.61 | A | 263-398 | [»] | |
6G2C | X-ray | 1.76 | A | 263-398 | [»] | |
6G2E | X-ray | 1.85 | A | 263-398 | [»] | |
6G2F | X-ray | 1.74 | A | 263-398 | [»] | |
6G2O | X-ray | 1.81 | A | 263-398 | [»] | |
6G3P | X-ray | 2.80 | A/B/C/D | 247-398 | [»] | |
6G3T | X-ray | 2.53 | A/B/C/D | 247-398 | [»] | |
7CRP | electron microscopy | 3.20 | I | 680-1437 | [»] | |
7CRQ | electron microscopy | 3.15 | I/L | 680-1437 | [»] | |
7CRR | electron microscopy | 3.48 | I | 680-1437 | [»] | |
BMRBi | Q9BZ95 | |||||
SMRi | Q9BZ95 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120250, 74 interactors |
DIPi | DIP-62074N |
IntActi | Q9BZ95, 48 interactors |
MINTi | Q9BZ95 |
STRINGi | 9606.ENSP00000313983 |
Chemistry databases
BindingDBi | Q9BZ95 |
ChEMBLi | CHEMBL3108646 |
PTM databases
iPTMneti | Q9BZ95 |
PhosphoSitePlusi | Q9BZ95 |
Genetic variation databases
BioMutai | WHSC1L1 |
DMDMi | 74761342 |
Proteomic databases
EPDi | Q9BZ95 |
jPOSTi | Q9BZ95 |
MassIVEi | Q9BZ95 |
MaxQBi | Q9BZ95 |
PaxDbi | Q9BZ95 |
PeptideAtlasi | Q9BZ95 |
PRIDEi | Q9BZ95 |
ProteomicsDBi | 7208 79779 [Q9BZ95-1] 79780 [Q9BZ95-2] 79781 [Q9BZ95-3] 79782 [Q9BZ95-4] |
Protocols and materials databases
ABCDi | Q9BZ95, 2 sequenced antibodies |
Antibodypediai | 984, 342 antibodies |
DNASUi | 54904 |
Genome annotation databases
Ensembli | ENST00000316985; ENSP00000313410; ENSG00000147548 [Q9BZ95-3] ENST00000317025; ENSP00000313983; ENSG00000147548 [Q9BZ95-1] ENST00000433384; ENSP00000393284; ENSG00000147548 [Q9BZ95-2] ENST00000527502; ENSP00000434730; ENSG00000147548 [Q9BZ95-5] |
GeneIDi | 54904 |
KEGGi | hsa:54904 |
UCSCi | uc003xli.4, human [Q9BZ95-1] |
Organism-specific databases
CTDi | 54904 |
DisGeNETi | 54904 |
GeneCardsi | NSD3 |
HGNCi | HGNC:12767, NSD3 |
HPAi | ENSG00000147548, Low tissue specificity |
MIMi | 607083, gene |
neXtProti | NX_Q9BZ95 |
OpenTargetsi | ENSG00000147548 |
PharmGKBi | PA37370 |
VEuPathDBi | HostDB:ENSG00000147548.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1081, Eukaryota |
GeneTreei | ENSGT00940000155355 |
HOGENOMi | CLU_004494_2_1_1 |
InParanoidi | Q9BZ95 |
OMAi | SACCMEK |
OrthoDBi | 507784at2759 |
PhylomeDBi | Q9BZ95 |
TreeFami | TF329088 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS07446-MONOMER |
PathwayCommonsi | Q9BZ95 |
Reactomei | R-HSA-3214841, PKMTs methylate histone lysines |
SIGNORi | Q9BZ95 |
Miscellaneous databases
BioGRID-ORCSi | 54904, 15 hits in 1007 CRISPR screens |
ChiTaRSi | WHSC1L1, human |
EvolutionaryTracei | Q9BZ95 |
GeneWikii | WHSC1L1 |
GenomeRNAii | 54904 |
Pharosi | Q9BZ95, Tbio |
PROi | PR:Q9BZ95 |
RNActi | Q9BZ95, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147548, Expressed in kidney and 223 other tissues |
ExpressionAtlasi | Q9BZ95, baseline and differential |
Genevisiblei | Q9BZ95, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
IDEALi | IID00496 |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR041306, C5HCH IPR003616, Post-SET_dom IPR000313, PWWP_dom IPR001214, SET_dom IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF17982, C5HCH, 1 hit PF00855, PWWP, 2 hits PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00249, PHD, 5 hits SM00508, PostSET, 1 hit SM00293, PWWP, 2 hits SM00317, SET, 1 hit |
SUPFAMi | SSF57903, SSF57903, 3 hits |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS50812, PWWP, 2 hits PS50280, SET, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NSD3_HUMAN | |
Accessioni | Q9BZ95Primary (citable) accession number: Q9BZ95 Secondary accession number(s): B7ZL11 Q9NXA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families