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Protein

Melanoma-associated antigen B5

Gene

MAGEB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B5
Alternative name(s):
Cancer/testis antigen 3.3
Short name:
CT3.3
MAGE-B5 antigen
Gene namesi
Name:MAGEB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000188408.5
HGNCiHGNC:23795 MAGEB5
MIMi300466 gene
neXtProtiNX_Q9BZ81

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188408

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567161 – 275Melanoma-associated antigen B5Add BLAST275

Proteomic databases

PaxDbiQ9BZ81
PeptideAtlasiQ9BZ81
PRIDEiQ9BZ81
ProteomicsDBi79778

PTM databases

iPTMnetiQ9BZ81
PhosphoSitePlusiQ9BZ81

Expressioni

Tissue specificityi

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.

Gene expression databases

BgeeiENSG00000188408 Expressed in 3 organ(s), highest expression level in testis
CleanExiHS_MAGEB5

Organism-specific databases

HPAiHPA052627

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368315

Structurei

3D structure databases

ProteinModelPortaliQ9BZ81
SMRiQ9BZ81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 239MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiQ9BZ81
OMAiNCANKED
OrthoDBiEOG091G0TJ0
PhylomeDBiQ9BZ81
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR030085 MAGEB5
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF35 PTHR11736:SF35, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BZ81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSAGVFNAG SDERANSRDE EYPCSSEVSP STESSCSNFI NIKVGLLEQF
60 70 80 90 100
LLYKFKMKQR ILKEDMLKIV NPRYQNQFAE IHRRASEHIE VVFAVDLKEV
110 120 130 140 150
NPTCHLYDLV SKLKLPNNGR IHVGKVLPKT GLLMTFLVVI FLKGNCANKE
160 170 180 190 200
DTWKFLDMMQ IYDGKKYYIY GEPRKLITQD FVRLTYLEYH QVPCSYPAHY
210 220 230 240 250
QFLWGPRAYT ETSKMKVLEY LAKVNDIAPG AFSSQYEEAL QDEEESPSQR
260 270
CSRNWHYCSG QDCLRAKFSS FSQPY
Length:275
Mass (Da):31,906
Last modified:September 11, 2007 - v2
Checksum:i57EDE75D76D07004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333705 Genomic DNA Translation: AAK00357.1
CCDSiCCDS65233.1
RefSeqiNP_001258681.1, NM_001271752.1
UniGeneiHs.224079

Genome annotation databases

EnsembliENST00000602297; ENSP00000473493; ENSG00000188408
GeneIDi347541
KEGGihsa:347541
UCSCiuc031thc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333705 Genomic DNA Translation: AAK00357.1
CCDSiCCDS65233.1
RefSeqiNP_001258681.1, NM_001271752.1
UniGeneiHs.224079

3D structure databases

ProteinModelPortaliQ9BZ81
SMRiQ9BZ81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368315

PTM databases

iPTMnetiQ9BZ81
PhosphoSitePlusiQ9BZ81

Proteomic databases

PaxDbiQ9BZ81
PeptideAtlasiQ9BZ81
PRIDEiQ9BZ81
ProteomicsDBi79778

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602297; ENSP00000473493; ENSG00000188408
GeneIDi347541
KEGGihsa:347541
UCSCiuc031thc.1 human

Organism-specific databases

CTDi347541
EuPathDBiHostDB:ENSG00000188408.5
GeneCardsiMAGEB5
HGNCiHGNC:23795 MAGEB5
HPAiHPA052627
MIMi300466 gene
neXtProtiNX_Q9BZ81
OpenTargetsiENSG00000188408
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiQ9BZ81
OMAiNCANKED
OrthoDBiEOG091G0TJ0
PhylomeDBiQ9BZ81
TreeFamiTF328505

Miscellaneous databases

GenomeRNAii347541
PROiPR:Q9BZ81
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188408 Expressed in 3 organ(s), highest expression level in testis
CleanExiHS_MAGEB5

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR030085 MAGEB5
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF35 PTHR11736:SF35, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAGB5_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 11, 2007
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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