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Protein

Contactin-associated protein-like 3

Gene

CNTNAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell recognition Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Contactin-associated protein-like 3
Alternative name(s):
Cell recognition molecule Caspr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTNAP3
Synonyms:CASPR3, KIAA1714
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106714.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13834 CNTNAP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610517 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZ76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1245ExtracellularSequence analysisAdd BLAST1220
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1246 – 1266HelicalSequence analysisAdd BLAST21
Topological domaini1267 – 1288CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000106714

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134963289

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNTNAP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572752

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001950926 – 1288Contactin-associated protein-like 3Add BLAST1263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 177By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 364By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi513 ↔ 545By similarity
Disulfide bondi551 ↔ 562By similarity
Disulfide bondi556 ↔ 571By similarity
Disulfide bondi573 ↔ 583By similarity
Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Glycosylationi1023N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1167 ↔ 1203By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZ76

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BZ76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZ76

PeptideAtlas

More...
PeptideAtlasi
Q9BZ76

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZ76

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79776
79777 [Q9BZ76-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZ76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZ76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106714 Expressed in 90 organ(s), highest expression level in lower esophagus

CleanEx database of gene expression profiles

More...
CleanExi
HS_CNTNAP3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZ76 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZ76 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047731

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123011, 54 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297668

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BZ76

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZ76

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 177F5/8 type CPROSITE-ProRule annotationAdd BLAST147
Domaini183 – 364Laminin G-like 1PROSITE-ProRule annotationAdd BLAST182
Domaini370 – 545Laminin G-like 2PROSITE-ProRule annotationAdd BLAST176
Domaini551 – 583EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini584 – 792Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST209
Domaini793 – 958Laminin G-like 3PROSITE-ProRule annotationAdd BLAST166
Domaini962 – 996EGF-like 2PROSITE-ProRule annotationAdd BLAST35
Domaini1015 – 1203Laminin G-like 4PROSITE-ProRule annotationAdd BLAST189

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 48Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3516 Eukaryota
ENOG410XPHG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230964

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057718

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BZ76

Identification of Orthologs from Complete Genome Data

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OMAi
DHCQQEL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00LF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZ76

TreeFam database of animal gene trees

More...
TreeFami
TF321823

Family and domain databases

Conserved Domains Database

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CDDi
cd00057 FA58C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028873 CASPR3
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR43925:SF6 PTHR43925:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZ76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDAPLASALP RSSFSSSSEL
60 70 80 90 100
SSSHGPGFSR LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY
110 120 130 140 150
GSSDWVTSYL LMFSDGGRNW KQYRREESIW GFPGNTNADS VVHYRLQPPF
160 170 180 190 200
EARFLRFLPL AWNPRGRIGM RIEVYGCAYK SEVVYFDGQS ALLYRLDKKP
210 220 230 240 250
LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK LVFFLNSGNA
260 270 280 290 300
KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
310 320 330 340 350
SSYLDLNFEI SFGGIPTPGR SRAFRRKSFH GCLENLYYNG VDVTELAKKH
360 370 380 390 400
KPQILMMGNV SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT
410 420 430 440 450
WNRAGHLLFG ELRRGSGSFV LFLKDGKLKL SLFQPGQSPR NVTAGAGLND
460 470 480 490 500
GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA VLIDSGDTYY FGGCLDNSSG
510 520 530 540 550
SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL QIDSCGITDR
560 570 580 590 600
CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
610 620 630 640 650
PSGLYYIDAD GSGPLGPFLV YCNMTADAAW TVVQHGGPDA VTLRGAPSGH
660 670 680 690 700
PRSAVSFAYA AGAGQLRSAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW
710 720 730 740 750
WVGRTNETHT SWGGSLPDAQ KCTCGLEGNC IDSQYYCNCD AGRNEWTSDT
760 770 780 790 800
IVLSQKEHLP VTQIVMTDAG RPHSEAAYTL GPLLCRGDQS FWNSASFNTE
810 820 830 840 850
TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI RIELRAPTEV
860 870 880 890 900
TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ
910 920 930 940 950
PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV
960 970 980 990 1000
TPGVEPGCAG HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI
1010 1020 1030 1040 1050
SAYFATGSSM TYHFQEHYTL SENSSSLVSS LHRDVTLTRE MITLSFRTTR
1060 1070 1080 1090 1100
TPSLLLYVSS FYEEYLSVIL ANNGSLQIRY KLDRHQNPDA FTFDFKNMAD
1110 1120 1130 1140 1150
GQLHQVKINR EEAVVMVEVN QSTKKQVILS SGTEFNAVKS LILGKVLEAA
1160 1170 1180 1190 1200
GADPDTRRAA TSGFTGCLSA VRFGRAAPLK AALRPSGPSR VTVRGHVAPM
1210 1220 1230 1240 1250
ARCAAGAASG SPARELAPRL AGGAGRSGPA DEGEPLVNAD RRDSAVIGGV
1260 1270 1280
IAVVIFILLC ITAIAIRIYQ QRKLRKENES KVSKKEEC
Length:1,288
Mass (Da):140,690
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF41F1CE8A83D417E
GO
Isoform 2 (identifier: Q9BZ76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1120-1127: NQSTKKQV → IPQMQKSN
     1128-1288: Missing.

Note: No experimental confirmation available.
Show »
Length:1,127
Mass (Da):124,116
Checksum:iCB24B889FE46BEB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NC89A6NC89_HUMAN
Contactin-associated protein-like 3
CNTNAP3
1,207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AM99B1AM99_HUMAN
Contactin-associated protein-like 3
CNTNAP3
745Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2X6F2Z2X6_HUMAN
Contactin-associated protein-like 3
CNTNAP3
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMA2B1AMA2_HUMAN
Contactin-associated protein-like 3
CNTNAP3
1,039Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21805 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21S → R in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti33A → S in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti89M → I in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti711S → Y in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti711S → Y in BAB21805 (PubMed:11214970).Curated1
Sequence conflicti714G → V in BAB21805 (PubMed:11214970).Curated1
Sequence conflicti769 – 771AGR → TGQ in AAG52889 (PubMed:12093160).Curated3
Sequence conflicti777A → D in AAG52889 (PubMed:12093160).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046710628A → S. Corresponds to variant dbSNP:rs1758272Ensembl.1
Natural variantiVAR_046711845R → H1 PublicationCorresponds to variant dbSNP:rs7852039Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0035351120 – 1127NQSTKKQV → IPQMQKSN in isoform 2. 1 Publication8
Alternative sequenceiVSP_0035361128 – 1288Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF333769 mRNA Translation: AAG52889.2
AB051501 mRNA Translation: BAB21805.2 Different initiation.
AL162501 Genomic DNA No translation available.
AL353729 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6616.1 [Q9BZ76-1]

NCBI Reference Sequences

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RefSeqi
NP_387504.2, NM_033655.3 [Q9BZ76-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.128474
Hs.521495
Hs.604441

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000297668; ENSP00000297668; ENSG00000106714 [Q9BZ76-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79937

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79937

UCSC genome browser

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UCSCi
uc004abi.4 human [Q9BZ76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333769 mRNA Translation: AAG52889.2
AB051501 mRNA Translation: BAB21805.2 Different initiation.
AL162501 Genomic DNA No translation available.
AL353729 Genomic DNA No translation available.
CCDSiCCDS6616.1 [Q9BZ76-1]
RefSeqiNP_387504.2, NM_033655.3 [Q9BZ76-1]
UniGeneiHs.128474
Hs.521495
Hs.604441

3D structure databases

ProteinModelPortaliQ9BZ76
SMRiQ9BZ76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123011, 54 interactors
STRINGi9606.ENSP00000297668

PTM databases

iPTMnetiQ9BZ76
PhosphoSitePlusiQ9BZ76

Polymorphism and mutation databases

BioMutaiCNTNAP3
DMDMi209572752

Proteomic databases

EPDiQ9BZ76
MaxQBiQ9BZ76
PaxDbiQ9BZ76
PeptideAtlasiQ9BZ76
PRIDEiQ9BZ76
ProteomicsDBi79776
79777 [Q9BZ76-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297668; ENSP00000297668; ENSG00000106714 [Q9BZ76-1]
GeneIDi79937
KEGGihsa:79937
UCSCiuc004abi.4 human [Q9BZ76-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79937
EuPathDBiHostDB:ENSG00000106714.17

GeneCards: human genes, protein and diseases

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GeneCardsi
CNTNAP3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0008061
HGNCiHGNC:13834 CNTNAP3
HPAiHPA047731
MIMi610517 gene
neXtProtiNX_Q9BZ76
OpenTargetsiENSG00000106714
PharmGKBiPA134963289

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3516 Eukaryota
ENOG410XPHG LUCA
GeneTreeiENSGT00940000160228
HOGENOMiHOG000230964
HOVERGENiHBG057718
InParanoidiQ9BZ76
OMAiDHCQQEL
OrthoDBiEOG091G00LF
PhylomeDBiQ9BZ76
TreeFamiTF321823

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79937

Protein Ontology

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PROi
PR:Q9BZ76

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106714 Expressed in 90 organ(s), highest expression level in lower esophagus
CleanExiHS_CNTNAP3
ExpressionAtlasiQ9BZ76 baseline and differential
GenevisibleiQ9BZ76 HS

Family and domain databases

CDDicd00057 FA58C, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028873 CASPR3
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G
PANTHERiPTHR43925:SF6 PTHR43925:SF6, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZ76
Secondary accession number(s): B1AMA0, Q9C0E9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: December 5, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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