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Entry version 120 (18 Sep 2019)
Sequence version 1 (01 Jun 2001)
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Protein

FERM domain-containing protein 8

Gene

FRMD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FERM domain-containing protein 8
Alternative name(s):
Band4.1 inhibitor LRP interactor1 Publication
Short name:
Bili1 Publication
iRhom tail-associated protein1 Publication
Short name:
iTAP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRMD8
ORF Names:FKSG44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25462 FRMD8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618337 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZ67

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000126391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162388963

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FRMD8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002957781 – 464FERM domain-containing protein 8Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei24PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei439PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZ67

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BZ67

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZ67

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BZ67

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZ67

PeptideAtlas

More...
PeptideAtlasi
Q9BZ67

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZ67

ProteomicsDB human proteome resource

More...
ProteomicsDBi
5840
79768 [Q9BZ67-1]
79769 [Q9BZ67-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZ67

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZ67

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with high expression in heart and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126391 Expressed in 187 organ(s), highest expression level in vagina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZ67 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZ67 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002861
HPA005506

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with iRhom1/RHBDF1 and iRhom2/RHBDF2 (via cytoplasmic N-termini); this interaction leads to mutual protein stabilization (PubMed:29897333).

Interacts with ADAM17; this interaction is indirect and mediated by iRhom proteins (PubMed:29897333, PubMed:29897336).

Interacts with LRP6; this interaction affects LRP6-binding to AXIN1 (PubMed:19572019).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123761, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZ67, 12 interactors

Molecular INTeraction database

More...
MINTi
Q9BZ67

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319726

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 376FERMPROSITE-ProRule annotationAdd BLAST347

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4335 Eukaryota
ENOG410ZV6V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063721

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285969

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZ67

Identification of Orthologs from Complete Genome Data

More...
OMAi
RHQPYKL

Database of Orthologous Groups

More...
OrthoDBi
1068540at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZ67

TreeFam database of animal gene trees

More...
TreeFami
TF317921

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR011993 PH-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373 FERM_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZ67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGTEGSAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLP
60 70 80 90 100
SLSAHELHRA VREVLQLPDI ALDVFALWLV SPLLEVQLKP KHQPYKLGRQ
110 120 130 140 150
WPELLLRFTS APDDDVAMDE PFLQFRRNVF FPKRRELQIH DEEVLRLLYE
160 170 180 190 200
EAKGNVLAAR YPCDVEDCEA LGALVCRVQL GPYQPGRPAA CDLREKLDSF
210 220 230 240 250
LPAHLCKRGQ SLFAALRGRG ARAGPGEQGL LNAYRQVQEV SSDGGCEAAL
260 270 280 290 300
GTHYRAYLLK CHELPFYGCA FFHGEVDKPA QGFLHRGGRK PVSVAISLEG
310 320 330 340 350
VHVIDSREKH VLLGLRFQEL SWDHTSPEEE EPILWLEFDG DSEGTPVNKL
360 370 380 390 400
LKIYSKQAEL MSSLIEYCIE LSQAAEPAGP QDSATGSPSD PSSSLAPVQR
410 420 430 440 450
PKLRRQGSVV SSRIQHLSTI DYVEDGKGIR RVKPKRTTSF FSRQLSLGQG
460
SYTVVQPGDS LEQG
Length:464
Mass (Da):51,218
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F880DFCA5C12D7A
GO
Isoform 2 (identifier: Q9BZ67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-84: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):45,134
Checksum:iB48B3053C3625769
GO
Isoform 3 (identifier: Q9BZ67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-118: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):47,228
Checksum:i076AD7F0718DC1BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS62E9PS62_HUMAN
FERM domain-containing protein 8
FRMD8
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRP1E9PRP1_HUMAN
FERM domain-containing protein 8
FRMD8
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRA3E9PRA3_HUMAN
FERM domain-containing protein 8
FRMD8
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N4M4Q8N4M4_HUMAN
FERM domain-containing protein 8
FRMD8
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198D → N in AAH51695 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02708529 – 84Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_05605985 – 118Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF334946 mRNA Translation: AAG50295.1
AK074850 mRNA Translation: BAC11244.1
AK304363 mRNA Translation: BAG65203.1
AP000944 Genomic DNA No translation available.
BC044658 mRNA Translation: AAH44658.1
BC051695 mRNA Translation: AAH51695.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73320.1 [Q9BZ67-3]
CCDS76432.1 [Q9BZ67-2]
CCDS8102.1 [Q9BZ67-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001287761.1, NM_001300832.2 [Q9BZ67-2]
NP_001287762.1, NM_001300833.2 [Q9BZ67-3]
NP_114110.1, NM_031904.4 [Q9BZ67-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317568; ENSP00000319726; ENSG00000126391 [Q9BZ67-1]
ENST00000355991; ENSP00000348270; ENSG00000126391 [Q9BZ67-2]
ENST00000416776; ENSP00000392111; ENSG00000126391 [Q9BZ67-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83786

UCSC genome browser

More...
UCSCi
uc001odu.5 human [Q9BZ67-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334946 mRNA Translation: AAG50295.1
AK074850 mRNA Translation: BAC11244.1
AK304363 mRNA Translation: BAG65203.1
AP000944 Genomic DNA No translation available.
BC044658 mRNA Translation: AAH44658.1
BC051695 mRNA Translation: AAH51695.1
CCDSiCCDS73320.1 [Q9BZ67-3]
CCDS76432.1 [Q9BZ67-2]
CCDS8102.1 [Q9BZ67-1]
RefSeqiNP_001287761.1, NM_001300832.2 [Q9BZ67-2]
NP_001287762.1, NM_001300833.2 [Q9BZ67-3]
NP_114110.1, NM_031904.4 [Q9BZ67-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123761, 7 interactors
IntActiQ9BZ67, 12 interactors
MINTiQ9BZ67
STRINGi9606.ENSP00000319726

PTM databases

iPTMnetiQ9BZ67
PhosphoSitePlusiQ9BZ67

Polymorphism and mutation databases

BioMutaiFRMD8
DMDMi74733481

Proteomic databases

EPDiQ9BZ67
jPOSTiQ9BZ67
MassIVEiQ9BZ67
MaxQBiQ9BZ67
PaxDbiQ9BZ67
PeptideAtlasiQ9BZ67
PRIDEiQ9BZ67
ProteomicsDBi5840
79768 [Q9BZ67-1]
79769 [Q9BZ67-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83786
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317568; ENSP00000319726; ENSG00000126391 [Q9BZ67-1]
ENST00000355991; ENSP00000348270; ENSG00000126391 [Q9BZ67-2]
ENST00000416776; ENSP00000392111; ENSG00000126391 [Q9BZ67-3]
GeneIDi83786
KEGGihsa:83786
UCSCiuc001odu.5 human [Q9BZ67-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83786

GeneCards: human genes, protein and diseases

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GeneCardsi
FRMD8
HGNCiHGNC:25462 FRMD8
HPAiHPA002861
HPA005506
MIMi618337 gene
neXtProtiNX_Q9BZ67
OpenTargetsiENSG00000126391
PharmGKBiPA162388963

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4335 Eukaryota
ENOG410ZV6V LUCA
GeneTreeiENSGT00530000063721
HOGENOMiHOG000285969
InParanoidiQ9BZ67
OMAiRHQPYKL
OrthoDBi1068540at2759
PhylomeDBiQ9BZ67
TreeFamiTF317921

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FRMD8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83786

Pharos

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Pharosi
Q9BZ67

Protein Ontology

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PROi
PR:Q9BZ67

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000126391 Expressed in 187 organ(s), highest expression level in vagina
ExpressionAtlasiQ9BZ67 baseline and differential
GenevisibleiQ9BZ67 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRMD8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZ67
Secondary accession number(s): B4E2P1, Q86V56, Q8NCB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2001
Last modified: September 18, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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