DOCK9

Functionⁱ

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.2 Publications

Miscellaneous

'Zizim' means 'spike' in Hebrew.Curated

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
guanyl-nucleotide exchange factor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: Reactome
positive regulation of GTPase activity Source: UniProtKB
small GTPase mediated signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factor

Molecular function

Guanine-nucleotide releasing factor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dedicator of cytokinesis protein 9Curated Alternative name(s): Cdc42 guanine nucleotide exchange factor zizimin-1Curated Short name: Zizimin-1Curated
Gene namesⁱ	Name:DOCK9Imported Synonyms:KIAA1058, ZIZ1Curated
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000088387.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14132 DOCK9
MIMⁱ	607325 gene
neXtProtⁱ	NX_Q9BZ29

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23348
Open Targets More...OpenTargetsⁱ	ENSG00000088387
PharmGKBⁱ	PA134877754

Polymorphism and mutation databases

BioMutaⁱ	DOCK9
DMDMⁱ	24212635

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000189999	1 – 2069	Dedicator of cytokinesis protein 9Add BLAST		2069

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	21	PhosphoserineCombined sources	1
Modified residueⁱ	32	PhosphoserineCombined sources	1
Modified residueⁱ	167	PhosphoserineCombined sources	1
Modified residueⁱ	170	PhosphoserineCombined sources	1
Modified residueⁱ	433	PhosphoserineBy similarity	1
Modified residueⁱ	443	PhosphoserineBy similarity	1
Modified residueⁱ	927	PhosphoserineCombined sources	1
Modified residueⁱ	1235	PhosphoserineCombined sources	1
Modified residueⁱ	1241	PhosphothreonineCombined sources	1
Modified residueⁱ	1255	PhosphoserineCombined sources	1
Modified residueⁱ	1261	PhosphoserineBy similarity	1
Modified residueⁱ	1264	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BZ29
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BZ29
PaxDbⁱ	Q9BZ29
PeptideAtlas More...PeptideAtlasⁱ	Q9BZ29
PRIDEⁱ	Q9BZ29
ProteomicsDBⁱ	79758 79759 [Q9BZ29-3] 79760 [Q9BZ29-4] 79761 [Q9BZ29-5]

PTM databases

iPTMnetⁱ	Q9BZ29
PhosphoSitePlusⁱ	Q9BZ29

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000088387
ExpressionAtlasⁱ	Q9BZ29 baseline and differential
Genevisibleⁱ	Q9BZ29 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034061 CAB034065 HPA043940

HPAⁱ

CAB034061
CAB034065
HPA043940

Interactionⁱ

Subunit structureⁱ

Homodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42.Curated2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
NEB	P20929	2	EBI-2695893,EBI-1049657
SMAD2	Q15796	3	EBI-2695893,EBI-1040141
SMAD3	P84022	3	EBI-2695893,EBI-347161

Show more details

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
guanyl-nucleotide exchange factor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116930, 8 interactors
IntActⁱ	Q9BZ29, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q9BZ29
STRINGⁱ	9606.ENSP00000365643

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	178 – 183	Combined sources	6
Helixⁱ	190 – 194	Combined sources	5
Beta strandⁱ	198 – 206	Combined sources	9
Beta strandⁱ	208 – 210	Combined sources	3
Beta strandⁱ	212 – 220	Combined sources	9
Beta strandⁱ	227 – 230	Combined sources	4
Turnⁱ	232 – 234	Combined sources	3
Beta strandⁱ	248 – 252	Combined sources	5
Beta strandⁱ	254 – 256	Combined sources	3
Beta strandⁱ	258 – 262	Combined sources	5
Helixⁱ	266 – 291	Combined sources	26
Helixⁱ	1610 – 1628	Combined sources	19
Helixⁱ	1631 – 1651	Combined sources	21
Beta strandⁱ	1677 – 1679	Combined sources	3
Helixⁱ	1682 – 1685	Combined sources	4
Turnⁱ	1686 – 1688	Combined sources	3
Helixⁱ	1690 – 1695	Combined sources	6
Beta strandⁱ	1708 – 1710	Combined sources	3
Helixⁱ	1711 – 1727	Combined sources	17
Helixⁱ	1731 – 1733	Combined sources	3
Helixⁱ	1734 – 1738	Combined sources	5
Turnⁱ	1739 – 1741	Combined sources	3
Helixⁱ	1742 – 1747	Combined sources	6
Helixⁱ	1751 – 1774	Combined sources	24
Beta strandⁱ	1781 – 1788	Combined sources	8
Helixⁱ	1808 – 1810	Combined sources	3
Beta strandⁱ	1814 – 1820	Combined sources	7
Helixⁱ	1825 – 1840	Combined sources	16
Helixⁱ	1842 – 1844	Combined sources	3
Beta strandⁱ	1845 – 1848	Combined sources	4
Helixⁱ	1856 – 1858	Combined sources	3
Beta strandⁱ	1863 – 1873	Combined sources	11
Helixⁱ	1877 – 1882	Combined sources	6
Helixⁱ	1887 – 1889	Combined sources	3
Beta strandⁱ	1890 – 1902	Combined sources	13
Beta strandⁱ	1904 – 1909	Combined sources	6
Turnⁱ	1912 – 1914	Combined sources	3
Beta strandⁱ	1916 – 1929	Combined sources	14
Beta strandⁱ	1931 – 1945	Combined sources	15
Helixⁱ	1947 – 1967	Combined sources	21
Helixⁱ	1973 – 1984	Combined sources	12
Beta strandⁱ	1987 – 1989	Combined sources	3
Helixⁱ	1993 – 1999	Combined sources	7
Helixⁱ	2013 – 2037	Combined sources	25
Turnⁱ	2041 – 2043	Combined sources	3
Helixⁱ	2044 – 2064	Combined sources	21

3D structure databases

ProteinModelPortalⁱ	Q9BZ29
SMRⁱ	Q9BZ29
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BZ29

EvolutionaryTraceⁱ

Q9BZ29

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	174 – 281	PHPROSITE-ProRule annotationAdd BLAST	108
Domainⁱ	640 – 818	DHR-1PROSITE-ProRule annotationAdd BLAST	179
Domainⁱ	1605 – 2069	DHR-2PROSITE-ProRule annotationAdd BLAST	465

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	75 – 135	Interaction with activated CDC42By similarityAdd BLAST		61

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1948 – 1982	Sequence analysisAdd BLAST		35
Coiled coilⁱ	2034 – 2067	Sequence analysisAdd BLAST		34

Domainⁱ

The DHR-2 domain is necessary and sufficient for the GEF activity.

Sequence similaritiesⁱ

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1997 Eukaryota ENOG410XNVY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119234
HOGENOMⁱ	HOG000231373
HOVERGENⁱ	HBG107819
InParanoidⁱ	Q9BZ29
KEGG Orthology (KO) More...KOⁱ	K21853
PhylomeDBⁱ	Q9BZ29
TreeFamⁱ	TF313629

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08697 C2_Dock-D, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR037809 C2_Dock-D IPR035892 C2_domain_sf IPR027007 DHR-1_domain IPR027357 DHR-2 IPR026791 DOCK IPR026796 DOCK9 IPR010703 DOCK_C IPR021816 DOCK_C/D_N IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR23317 PTHR23317, 1 hit PTHR23317:SF77 PTHR23317:SF77, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06920 DHR-2, 1 hit PF14429 DOCK-C2, 1 hit PF11878 DUF3398, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 5 hits
PROSITEⁱ	View protein in PROSITE PS51650 DHR_1, 1 hit PS51651 DHR_2, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9BZ29-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE 
        60         70         80         90        100
PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK 
       110        120        130        140        150
AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV 
       160        170        180        190        200
HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR 
       210        220        230        240        250
FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE 
       260        270        280        290        300
LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 
       310        320        330        340        350
EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF 
       360        370        380        390        400
SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT 
       410        420        430        440        450
LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI 
       460        470        480        490        500
LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS 
       510        520        530        540        550
SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY 
       560        570        580        590        600
RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 
       610        620        630        640        650
NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL 
       660        670        680        690        700
KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA 
       710        720        730        740        750
VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV 
       760        770        780        790        800
VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE 
       810        820        830        840        850
IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV 
       860        870        880        890        900
KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 
       910        920        930        940        950
QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF 
       960        970        980        990       1000
LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV 
      1010       1020       1030       1040       1050
VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI 
      1060       1070       1080       1090       1100
SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL 
      1110       1120       1130       1140       1150
DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD 
      1160       1170       1180       1190       1200
DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 
      1210       1220       1230       1240       1250
LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA 
      1260       1270       1280       1290       1300
DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI 
      1310       1320       1330       1340       1350
KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK 
      1360       1370       1380       1390       1400
RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV 
      1410       1420       1430       1440       1450
CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK 
      1460       1470       1480       1490       1500
NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL 
      1510       1520       1530       1540       1550
LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII 
      1560       1570       1580       1590       1600
NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ 
      1610       1620       1630       1640       1650
YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT 
      1660       1670       1680       1690       1700
RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME 
      1710       1720       1730       1740       1750
DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD 
      1760       1770       1780       1790       1800
FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE 
      1810       1820       1830       1840       1850
TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD 
      1860       1870       1880       1890       1900
SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM 
      1910       1920       1930       1940       1950
PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV 
      1960       1970       1980       1990       2000
AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL 
      2010       2020       2030       2040       2050
DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK 
      2060 
ANYREMAKEL SEIMHEQLG

Length:2,069

Mass (Da):236,446

Last modified:October 19, 2002 - v2

Checksum:ⁱ95073CD751745AAE

GO

Isoform 2 (identifier: Q9BZ29-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP

« Hide

        10         20         30         40         50
MQADKCRTSS RSVKKELVIE SPLQYKDAAQ GEVEAESPGP VPAKPKLIEP 
        60         70         80         90        100
LDYENVIVQK KTQILNDCLR EMLLFPYDDF QTAILRRQGR YICSTVPAKA 
       110        120        130        140        150
EEEAQSLFVT ECIKTYNSDW HLVNYKYEDY SGEFRQLPNK VVKLDKLPVH 
       160        170        180        190        200
VYEVDEEVDK DEDAASLGSQ KGGITKHGWL YKGNMNSAIS VTMRSFKRRF 
       210        220        230        240        250
FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN NKVRRFAFEL 
       260        270        280        290        300
KMQDKSSYLL AADSEVEMEE WITILNKILQ LNFEAAMQEK RNGDSHEDDE 
       310        320        330        340        350
QSKLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFS 
       360        370        380        390        400
SAEPEVKSFE EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL 
       410        420        430        440        450
SLFDIKYNRK ISADFHVDLN HFSVRQMLAT TSPALMNGSG QSPSVLKGIL 
       460        470        480        490        500
HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK VLQGSITHCA EPYMKSSDSS 
       510        520        530        540        550
KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD KNARFSAIYR 
       560        570        580        590        600
QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDN VSSDFPNYVN 
       610        620        630        640        650
SSYIPTKQFE TCSKTPITFE VEEFVPCIPK HTQPYTIYTN HLYVYPKYLK 
       660        670        680        690        700
YDSQKSFAKA RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSAFAAV 
       710        720        730        740        750
LHHHQNPEFY DEIKIELPTQ LHEKHHLLLT FFHVSCDNSS KGSTKKRDVV 
       760        770        780        790        800
ETQVGYSWLP LLKDGRVVTS EQHIPVSANL PSGYLGYQEL GMGRHYGPEI 
       810        820        830        840        850
KWVDGGKPLL KISTHLVSTV YTQDQHLHNF FQYCQKTESG AQALGNELVK 
       860        870        880        890        900
YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV TRVIIHVVAQ 
       910        920        930        940        950
CHEEGLESHL RSYVKYAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL 
       960        970        980        990       1000
TSNKLLKYSW FFFDVLIKSM AQHLIENSKV KLLRNQRFPA SYHHAVETVV 
      1010       1020       1030       1040       1050
NMLMPHITQK FRDNPEASKN ANHSLAVFIK RCFTFMDRGF VFKQINNYIS 
      1060       1070       1080       1090       1100
CFAPGDPKTL FEYKFEFLRV VCNHEHYIPL NLPMPFGKGR IQRYQDLQLD 
      1110       1120       1130       1140       1150
YSLTDEFCRN HFLVGLLLRE VGTALQEFRE VRLIAISVLK NLLIKHSFDD 
      1160       1170       1180       1190       1200
RYASRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN AGMTVKDESL 
      1210       1220       1230       1240       1250
ALPAVNPLVT PQKGSTLDNS LHKDLLGAIS GIASPYTTST PNINSVRNAD 
      1260       1270       1280       1290       1300
SRGSLISTDS GNSLPERNSE KSNSLDKHQQ SSTLGNSVVR CDKLDQSEIK 
      1310       1320       1330       1340       1350
SLLMCFLYIL KSMSDDALFT YWNKASTSEL MDFFTISEVC LHQFQYMGKR 
      1360       1370       1380       1390       1400
YIARTGMMHA RLQQLGSLDN SLTFNHSYGH SDADVLHQSL LEANIATEVC 
      1410       1420       1430       1440       1450
LTALDTLSLF TLAFKNQLLA DHGHNPLMKK VFDVYLCFLQ KHQSETALKN 
      1460       1470       1480       1490       1500
VFTALRSLIY KFPSTFYEGR ADMCAALCYE ILKCCNSKLS SIRTEASQLL 
      1510       1520       1530       1540       1550
YFLMRNNFDY TGKKSFVRTH LQVIISVSQL IADVVGIGGT RFQQSLSIIN 
      1560       1570       1580       1590       1600
NCANSDRLIK HTSFSSDVKD LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY 
      1610       1620       1630       1640       1650
SLAKSYASTP ELRKTWLDSM ARIHVKNGDL SEAAMCYVHV TALVAEYLTR 
      1660       1670       1680       1690       1700
KEAVQWEPPL LPHSHSACLR RSRGGVFRQG CTAFRVITPN IDEEASMMED 
      1710       1720       1730       1740       1750
VGMQDVHFNE DVLMELLEQC ADGLWKAERY ELIADIYKLI IPIYEKRRDF 
      1760       1770       1780       1790       1800
ERLAHLYDTL HRAYSKVTEV MHSGRRLLGT YFRVAFFGQA AQYQFTDSET 
      1810       1820       1830       1840       1850
DVEGFFEDED GKEYIYKEPK LTPLSEISQR LLKLYSDKFG SENVKMIQDS 
      1860       1870       1880       1890       1900
GKVNPKDLDS KYAYIQVTHV IPFFDEKELQ ERKTEFERSH NIRRFMFEMP 
      1910       1920       1930       1940       1950
FTQTGKRQGG VEEQCKRRTI LTAIHCFPYV KKRIPVMYQH HTDLNPIEVA 
      1960       1970       1980       1990       2000
IDEMSKKVAE LRQLCSSAEV DMIKLQLKLQ GSVSVQVNAG PLAYARAFLD 
      2010       2020       2030       2040       2050
DTNTKRYPDN KVKLLKEVFR QFVEACGQAL AVNERLIKED QLEYQEEMKA 
      2060 
NYREMAKELS EIMHEQLG

Show »

Length:2,068

Mass (Da):236,425

Checksum:ⁱC2654DB8162F26F1

GO

Isoform 3 (identifier: Q9BZ29-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1355-1378: RTGMMHARLQQLGSLDNSLTFNHS → SVRKISSVLGISVDNG

« Hide

        10         20         30         40         50
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE 
        60         70         80         90        100
PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK 
       110        120        130        140        150
AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV 
       160        170        180        190        200
HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR 
       210        220        230        240        250
FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE 
       260        270        280        290        300
LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 
       310        320        330        340        350
EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF 
       360        370        380        390        400
SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT 
       410        420        430        440        450
LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI 
       460        470        480        490        500
LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS 
       510        520        530        540        550
SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY 
       560        570        580        590        600
RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 
       610        620        630        640        650
NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL 
       660        670        680        690        700
KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA 
       710        720        730        740        750
VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV 
       760        770        780        790        800
VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE 
       810        820        830        840        850
IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV 
       860        870        880        890        900
KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 
       910        920        930        940        950
QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF 
       960        970        980        990       1000
LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV 
      1010       1020       1030       1040       1050
VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI 
      1060       1070       1080       1090       1100
SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL 
      1110       1120       1130       1140       1150
DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD 
      1160       1170       1180       1190       1200
DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 
      1210       1220       1230       1240       1250
LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA 
      1260       1270       1280       1290       1300
DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI 
      1310       1320       1330       1340       1350
KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK 
      1360       1370       1380       1390       1400
RYIASVRKIS SVLGISVDNG YGHSDADVLH QSLLEANIAT EVCLTALDTL 
      1410       1420       1430       1440       1450
SLFTLAFKNQ LLADHGHNPL MKKVFDVYLC FLQKHQSETA LKNVFTALRS 
      1460       1470       1480       1490       1500
LIYKFPSTFY EGRADMCAAL CYEILKCCNS KLSSIRTEAS QLLYFLMRNN 
      1510       1520       1530       1540       1550
FDYTGKKSFV RTHLQVIISV SQLIADVVGI GGTRFQQSLS IINNCANSDR 
      1560       1570       1580       1590       1600
LIKHTSFSSD VKDLTKRIRT VLMATAQMKE HENDPEMLVD LQYSLAKSYA 
      1610       1620       1630       1640       1650
STPELRKTWL DSMARIHVKN GDLSEAAMCY VHVTALVAEY LTRKEAVQWE 
      1660       1670       1680       1690       1700
PPLLPHSHSA CLRRSRGGVF RQGCTAFRVI TPNIDEEASM MEDVGMQDVH 
      1710       1720       1730       1740       1750
FNEDVLMELL EQCADGLWKA ERYELIADIY KLIIPIYEKR RDFERLAHLY 
      1760       1770       1780       1790       1800
DTLHRAYSKV TEVMHSGRRL LGTYFRVAFF GQAAQYQFTD SETDVEGFFE 
      1810       1820       1830       1840       1850
DEDGKEYIYK EPKLTPLSEI SQRLLKLYSD KFGSENVKMI QDSGKVNPKD 
      1860       1870       1880       1890       1900
LDSKYAYIQV THVIPFFDEK ELQERKTEFE RSHNIRRFMF EMPFTQTGKR 
      1910       1920       1930       1940       1950
QGGVEEQCKR RTILTAIHCF PYVKKRIPVM YQHHTDLNPI EVAIDEMSKK 
      1960       1970       1980       1990       2000
VAELRQLCSS AEVDMIKLQL KLQGSVSVQV NAGPLAYARA FLDDTNTKRY 
      2010       2020       2030       2040       2050
PDNKVKLLKE VFRQFVEACG QALAVNERLI KEDQLEYQEE MKANYREMAK 
      2060 
ELSEIMHEQL G

Note: No experimental confirmation available.

Show »

Length:2,061

Mass (Da):235,361

Checksum:ⁱDEB17F98C3573D68

GO

Isoform 4 (identifier: Q9BZ29-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1791-1804: Missing.
2068-2069: LG → ICPLEEKTSVLPNSLHIFNAISGTPTSTMVHGMTSSSSVV

« Hide

        10         20         30         40         50
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE 
        60         70         80         90        100
PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK 
       110        120        130        140        150
AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV 
       160        170        180        190        200
HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR 
       210        220        230        240        250
FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE 
       260        270        280        290        300
LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 
       310        320        330        340        350
EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF 
       360        370        380        390        400
SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT 
       410        420        430        440        450
LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI 
       460        470        480        490        500
LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS 
       510        520        530        540        550
SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY 
       560        570        580        590        600
RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 
       610        620        630        640        650
NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL 
       660        670        680        690        700
KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA 
       710        720        730        740        750
VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV 
       760        770        780        790        800
VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE 
       810        820        830        840        850
IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV 
       860        870        880        890        900
KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 
       910        920        930        940        950
QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF 
       960        970        980        990       1000
LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV 
      1010       1020       1030       1040       1050
VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI 
      1060       1070       1080       1090       1100
SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL 
      1110       1120       1130       1140       1150
DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD 
      1160       1170       1180       1190       1200
DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 
      1210       1220       1230       1240       1250
LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA 
      1260       1270       1280       1290       1300
DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI 
      1310       1320       1330       1340       1350
KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK 
      1360       1370       1380       1390       1400
RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV 
      1410       1420       1430       1440       1450
CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK 
      1460       1470       1480       1490       1500
NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL 
      1510       1520       1530       1540       1550
LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII 
      1560       1570       1580       1590       1600
NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ 
      1610       1620       1630       1640       1650
YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT 
      1660       1670       1680       1690       1700
RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME 
      1710       1720       1730       1740       1750
DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD 
      1760       1770       1780       1790       1800
FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ GFFEDEDGKE 
      1810       1820       1830       1840       1850
YIYKEPKLTP LSEISQRLLK LYSDKFGSEN VKMIQDSGKV NPKDLDSKYA 
      1860       1870       1880       1890       1900
YIQVTHVIPF FDEKELQERK TEFERSHNIR RFMFEMPFTQ TGKRQGGVEE 
      1910       1920       1930       1940       1950
QCKRRTILTA IHCFPYVKKR IPVMYQHHTD LNPIEVAIDE MSKKVAELRQ 
      1960       1970       1980       1990       2000
LCSSAEVDMI KLQLKLQGSV SVQVNAGPLA YARAFLDDTN TKRYPDNKVK 
      2010       2020       2030       2040       2050
LLKEVFRQFV EACGQALAVN ERLIKEDQLE YQEEMKANYR EMAKELSEIM 
      2060       2070       2080       2090 
HEQICPLEEK TSVLPNSLHI FNAISGTPTS TMVHGMTSSS SVV

Note: Produced by exon skipping that results in a frameshift. No experimental confirmation available.

Show »

Length:2,093

Mass (Da):238,846

Checksum:ⁱA540EC1EDDCFFDB5

GO

Isoform 5 (identifier: Q9BZ29-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP
     1234-1254: ASPYTTSTPNINSVRNADSRG → GNAPCSCGLLSTITLKVSWSQ
     1255-2069: Missing.

« Hide

        10         20         30         40         50
MQADKCRTSS RSVKKELVIE SPLQYKDAAQ GEVEAESPGP VPAKPKLIEP 
        60         70         80         90        100
LDYENVIVQK KTQILNDCLR EMLLFPYDDF QTAILRRQGR YICSTVPAKA 
       110        120        130        140        150
EEEAQSLFVT ECIKTYNSDW HLVNYKYEDY SGEFRQLPNK VVKLDKLPVH 
       160        170        180        190        200
VYEVDEEVDK DEDAASLGSQ KGGITKHGWL YKGNMNSAIS VTMRSFKRRF 
       210        220        230        240        250
FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN NKVRRFAFEL 
       260        270        280        290        300
KMQDKSSYLL AADSEVEMEE WITILNKILQ LNFEAAMQEK RNGDSHEDDE 
       310        320        330        340        350
QSKLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFS 
       360        370        380        390        400
SAEPEVKSFE EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL 
       410        420        430        440        450
SLFDIKYNRK ISADFHVDLN HFSVRQMLAT TSPALMNGSG QSPSVLKGIL 
       460        470        480        490        500
HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK VLQGSITHCA EPYMKSSDSS 
       510        520        530        540        550
KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD KNARFSAIYR 
       560        570        580        590        600
QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDN VSSDFPNYVN 
       610        620        630        640        650
SSYIPTKQFE TCSKTPITFE VEEFVPCIPK HTQPYTIYTN HLYVYPKYLK 
       660        670        680        690        700
YDSQKSFAKA RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSAFAAV 
       710        720        730        740        750
LHHHQNPEFY DEIKIELPTQ LHEKHHLLLT FFHVSCDNSS KGSTKKRDVV 
       760        770        780        790        800
ETQVGYSWLP LLKDGRVVTS EQHIPVSANL PSGYLGYQEL GMGRHYGPEI 
       810        820        830        840        850
KWVDGGKPLL KISTHLVSTV YTQDQHLHNF FQYCQKTESG AQALGNELVK 
       860        870        880        890        900
YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV TRVIIHVVAQ 
       910        920        930        940        950
CHEEGLESHL RSYVKYAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL 
       960        970        980        990       1000
TSNKLLKYSW FFFDVLIKSM AQHLIENSKV KLLRNQRFPA SYHHAVETVV 
      1010       1020       1030       1040       1050
NMLMPHITQK FRDNPEASKN ANHSLAVFIK RCFTFMDRGF VFKQINNYIS 
      1060       1070       1080       1090       1100
CFAPGDPKTL FEYKFEFLRV VCNHEHYIPL NLPMPFGKGR IQRYQDLQLD 
      1110       1120       1130       1140       1150
YSLTDEFCRN HFLVGLLLRE VGTALQEFRE VRLIAISVLK NLLIKHSFDD 
      1160       1170       1180       1190       1200
RYASRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN AGMTVKDESL 
      1210       1220       1230       1240       1250
ALPAVNPLVT PQKGSTLDNS LHKDLLGAIS GIGNAPCSCG LLSTITLKVS 

WSQ

Note: No experimental confirmation available.

Show »

Length:1,253

Mass (Da):142,650

Checksum:ⁱ7BA871F8ACA17693

GO

Sequence cautionⁱ

The sequence BAA83010 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	170	S → P in BAG54337 (PubMed:14702039).Curated		1
Sequence conflictⁱ	296	S → P in BAG54337 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_062000	455	A → T. Corresponds to variant dbSNP:rs56010605Ensembl.		1
Natural variantⁱVAR_053067	1416	K → E. Corresponds to variant dbSNP:rs16955934Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_017128	1 – 43	MSQPP…GSVLL → MQADKCRTSSRSVKKELVIE SPLQYKDAAQGEVEAESPGP VP in isoform 2 and isoform 5. 2 PublicationsAdd BLAST	43
Alternative sequenceⁱVSP_045683	1234 – 1254	ASPYT…ADSRG → GNAPCSCGLLSTITLKVSWS Q in isoform 5. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_045684	1255 – 2069	Missing in isoform 5. 1 PublicationAdd BLAST	815
Alternative sequenceⁱVSP_004024	1355 – 1378	RTGMM…TFNHS → SVRKISSVLGISVDNG in isoform 3. CuratedAdd BLAST	24
Alternative sequenceⁱVSP_007709	1791 – 1804	Missing in isoform 4. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_007710	2068 – 2069	LG → ICPLEEKTSVLPNSLHIFNA ISGTPTSTMVHGMTSSSSVV in isoform 4. 1 Publication	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF527605 mRNA Translation: AAM90306.1 AB028981 mRNA Translation: BAA83010.2 Different initiation. AK126492 mRNA Translation: BAG54337.1 AL139084 Genomic DNA No translation available. AL161420 Genomic DNA No translation available. AL391122 Genomic DNA No translation available. BC043506 mRNA Translation: AAH43506.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45062.1 [Q9BZ29-5] CCDS45063.1 [Q9BZ29-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001123520.1, NM_001130048.1 [Q9BZ29-5] NP_001123521.1, NM_001130049.1 NP_001123522.1, NM_001130050.1 [Q9BZ29-6] NP_001305778.1, NM_001318849.1 NP_056111.1, NM_015296.2 [Q9BZ29-1]
UniGeneⁱ	Hs.596105

Genome annotation databases

Ensemblⁱ	ENST00000376460; ENSP00000365643; ENSG00000088387 [Q9BZ29-5] ENST00000627024; ENSP00000487551; ENSG00000088387 [Q9BZ29-6]
GeneIDⁱ	23348
KEGGⁱ	hsa:23348
UCSC genome browser More...UCSCⁱ	uc058xyj.1 human [Q9BZ29-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9BZ29	Dedicator of cytokinesis 9		PIG		2290
UPI0008FF52CE		FUKDA		2135
UPI000BB6DFA4		DELLE		2132
UPI00071A43B0		EQUAS		2125
UPI0004F0218D		CALJA		2124
+269
Q9BZ29-6	UPI000BB497FA		Enhydra lutris kenyoni		1488
UPI0006547601		MUSPF		1487
UPI0005F40A3C		CERAT		1415
UPI00076621A4		PANTA		1413
UPI0005767E62		Bison bison bison		1413
+44

Protein	Similar proteins		Species	Score	Length
Q9BZ29	Dedicator of cytokinesis 9		PIG		2290
UPI0008FF52CE		FUKDA		2135
UPI000BB6DFA4		DELLE		2132
UPI00071A43B0		EQUAS		2125
UPI000809CE0A		Cebus capucinus imitator		2124
+378
Q9BZ29-6	UPI000BB497FA		Enhydra lutris kenyoni		1488
UPI0006547601		MUSPF		1487
UPI0005F40A3C		CERAT		1415
UPI00072E9F75		ACIJB		1413
UPI0005767E62		Bison bison bison		1413
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF527605 mRNA Translation: AAM90306.1 AB028981 mRNA Translation: BAA83010.2 Different initiation. AK126492 mRNA Translation: BAG54337.1 AL139084 Genomic DNA No translation available. AL161420 Genomic DNA No translation available. AL391122 Genomic DNA No translation available. BC043506 mRNA Translation: AAH43506.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45062.1 [Q9BZ29-5] CCDS45063.1 [Q9BZ29-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001123520.1, NM_001130048.1 [Q9BZ29-5] NP_001123521.1, NM_001130049.1 NP_001123522.1, NM_001130050.1 [Q9BZ29-6] NP_001305778.1, NM_001318849.1 NP_056111.1, NM_015296.2 [Q9BZ29-1]
UniGeneⁱ	Hs.596105

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WG7	NMR	-	A	165-301	[»]
	2WM9	X-ray	2.20	A	1605-2067	[»]
	2WMN	X-ray	2.39	A	1605-2067	[»]
	2WMO	X-ray	2.20	A	1605-2067	[»]
ProteinModelPortalⁱ	Q9BZ29
SMRⁱ	Q9BZ29
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116930, 8 interactors
IntActⁱ	Q9BZ29, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q9BZ29
STRINGⁱ	9606.ENSP00000365643

PTM databases

iPTMnetⁱ	Q9BZ29
PhosphoSitePlusⁱ	Q9BZ29

Polymorphism and mutation databases

BioMutaⁱ	DOCK9
DMDMⁱ	24212635

Proteomic databases

EPDⁱ	Q9BZ29
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BZ29
PaxDbⁱ	Q9BZ29
PeptideAtlas More...PeptideAtlasⁱ	Q9BZ29
PRIDEⁱ	Q9BZ29
ProteomicsDBⁱ	79758 79759 [Q9BZ29-3] 79760 [Q9BZ29-4] 79761 [Q9BZ29-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000376460; ENSP00000365643; ENSG00000088387 [Q9BZ29-5] ENST00000627024; ENSP00000487551; ENSG00000088387 [Q9BZ29-6]
GeneIDⁱ	23348
KEGGⁱ	hsa:23348
UCSC genome browser More...UCSCⁱ	uc058xyj.1 human [Q9BZ29-1]

Organism-specific databases

CTDⁱ	23348
DisGeNET More...DisGeNETⁱ	23348
EuPathDBⁱ	HostDB:ENSG00000088387.17
GeneCardsⁱ	DOCK9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14132 DOCK9
Human Protein Atlas More...HPAⁱ	CAB034061 CAB034065 HPA043940
MIMⁱ	607325 gene
neXtProtⁱ	NX_Q9BZ29
Open Targets More...OpenTargetsⁱ	ENSG00000088387
PharmGKBⁱ	PA134877754
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1997 Eukaryota ENOG410XNVY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119234
HOGENOMⁱ	HOG000231373
HOVERGENⁱ	HBG107819
InParanoidⁱ	Q9BZ29
KEGG Orthology (KO) More...KOⁱ	K21853
PhylomeDBⁱ	Q9BZ29
TreeFamⁱ	TF313629

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSⁱ	DOCK9 human
EvolutionaryTraceⁱ	Q9BZ29
GeneWikiⁱ	Dock9
GenomeRNAiⁱ	23348
Protein Ontology More...PROⁱ	PR:Q9BZ29
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000088387
ExpressionAtlasⁱ	Q9BZ29 baseline and differential
Genevisibleⁱ	Q9BZ29 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08697 C2_Dock-D, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR037809 C2_Dock-D IPR035892 C2_domain_sf IPR027007 DHR-1_domain IPR027357 DHR-2 IPR026791 DOCK IPR026796 DOCK9 IPR010703 DOCK_C IPR021816 DOCK_C/D_N IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR23317 PTHR23317, 1 hit PTHR23317:SF77 PTHR23317:SF77, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06920 DHR-2, 1 hit PF14429 DOCK-C2, 1 hit PF11878 DUF3398, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 5 hits
PROSITEⁱ	View protein in PROSITE PS51650 DHR_1, 1 hit PS51651 DHR_2, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DOCK9_HUMAN
Accessionⁱ	Q9BZ29Primary (citable) accession number: Q9BZ29 Secondary accession number(s): B3KX25 Q9UPU4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
	Last sequence update:	October 19, 2002
	Last modified:	June 20, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BZ29 (DOCK9_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Dedicator of cytokinesis protein 9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ