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UniProtKB - Q9BZ29 (DOCK9_HUMAN)

Entry version 176 (23 Feb 2022)
Sequence version 2 (19 Oct 2002)
Previous versions | rss
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Protein

Dedicator of cytokinesis protein 9

Gene

DOCK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.

2 Publications

Miscellaneous

'Zizim' means 'spike' in Hebrew.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BZ29

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BZ29

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 9Curated
Alternative name(s):
Cdc42 guanine nucleotide exchange factor zizimin-1Curated
Short name:
Zizimin-1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK9Imported
Synonyms:KIAA1058, ZIZ1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14132, DOCK9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607325, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BZ29

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000088387

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23348

Open Targets

More...OpenTargetsi		ENSG00000088387

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134877754

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BZ29, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DOCK9

Domain mapping of disease mutations (DMDM)

More...DMDMi		24212635

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899991 – 2069Dedicator of cytokinesis protein 9Add BLAST2069

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Modified residuei443PhosphoserineBy similarity1
Modified residuei927PhosphoserineCombined sources1
Modified residuei1235PhosphoserineCombined sources1
Modified residuei1241PhosphothreonineCombined sources1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1261PhosphoserineBy similarity1
Modified residuei1264PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BZ29

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BZ29

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BZ29

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BZ29

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BZ29

PeptideAtlas

More...PeptideAtlasi		Q9BZ29

PRoteomics IDEntifications database

More...PRIDEi		Q9BZ29

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20137
79758 [Q9BZ29-1]
79759 [Q9BZ29-3]
79760 [Q9BZ29-4]
79761 [Q9BZ29-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BZ29, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BZ29

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BZ29

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088387, Expressed in corpus callosum and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BZ29, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BZ29, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088387, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable).

Interacts preferentially with nucleotide-depleted CDC42.

Curated2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116930, 44 interactors

Protein interaction database and analysis system

More...IntActi		Q9BZ29, 28 interactors

Molecular INTeraction database

More...MINTi		Q9BZ29

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365643

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BZ29, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12069
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BZ29

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9BZ29

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 281PHPROSITE-ProRule annotationAdd BLAST108
Domaini640 – 818C2 DOCK-typePROSITE-ProRule annotationAdd BLAST179
Domaini1605 – 2069DOCKERPROSITE-ProRule annotationAdd BLAST465

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni290 – 313DisorderedSequence analysisAdd BLAST24
Regioni1241 – 1282DisorderedSequence analysisAdd BLAST42
Regioni1693 – 2069Interaction with CDC421 PublicationAdd BLAST377

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1948 – 1982Sequence analysisAdd BLAST35
Coiled coili2034 – 2067Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 306Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain is necessary and sufficient for the GEF activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1997, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155972

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BZ29

Database of Orthologous Groups

More...OrthoDBi		20156at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BZ29

TreeFam database of animal gene trees

More...TreeFami		TF313629

Family and domain databases

Conserved Domains Database

More...CDDi		cd08697, C2_Dock-D, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR037809, C2_Dock-D
IPR027007, C2_DOCK-type_domain
IPR035892, C2_domain_sf
IPR026791, DOCK
IPR026796, DOCK9
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR027357, DOCKER_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR23317, PTHR23317, 1 hit
PTHR23317:SF77, PTHR23317:SF77, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZ29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE 
        60         70         80         90        100
PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK 
       110        120        130        140        150
AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV 
       160        170        180        190        200
HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR 
       210        220        230        240        250
FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE 
       260        270        280        290        300
LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 
       310        320        330        340        350
EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF 
       360        370        380        390        400
SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT 
       410        420        430        440        450
LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI 
       460        470        480        490        500
LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS 
       510        520        530        540        550
SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY 
       560        570        580        590        600
RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 
       610        620        630        640        650
NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL 
       660        670        680        690        700
KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA 
       710        720        730        740        750
VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV 
       760        770        780        790        800
VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE 
       810        820        830        840        850
IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV 
       860        870        880        890        900
KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 
       910        920        930        940        950
QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF 
       960        970        980        990       1000
LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV 
      1010       1020       1030       1040       1050
VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI 
      1060       1070       1080       1090       1100
SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL 
      1110       1120       1130       1140       1150
DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD 
      1160       1170       1180       1190       1200
DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 
      1210       1220       1230       1240       1250
LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA 
      1260       1270       1280       1290       1300
DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI 
      1310       1320       1330       1340       1350
KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK 
      1360       1370       1380       1390       1400
RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV 
      1410       1420       1430       1440       1450
CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK 
      1460       1470       1480       1490       1500
NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL 
      1510       1520       1530       1540       1550
LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII 
      1560       1570       1580       1590       1600
NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ 
      1610       1620       1630       1640       1650
YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT 
      1660       1670       1680       1690       1700
RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME 
      1710       1720       1730       1740       1750
DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD 
      1760       1770       1780       1790       1800
FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE 
      1810       1820       1830       1840       1850
TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD 
      1860       1870       1880       1890       1900
SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM 
      1910       1920       1930       1940       1950
PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV 
      1960       1970       1980       1990       2000
AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL 
      2010       2020       2030       2040       2050
DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK 
      2060 
ANYREMAKEL SEIMHEQLG
Length:2,069
Mass (Da):236,446
Last modified:October 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95073CD751745AAE
GO
Isoform 2 (identifier: Q9BZ29-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP

Show »
Length:2,068
Mass (Da):236,425
Checksum:iC2654DB8162F26F1
GO
Isoform 3 (identifier: Q9BZ29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1355-1378: RTGMMHARLQQLGSLDNSLTFNHS → SVRKISSVLGISVDNG

Show »
Length:2,061
Mass (Da):235,361
Checksum:iDEB17F98C3573D68
GO
Isoform 4 (identifier: Q9BZ29-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1791-1804: Missing.
     2068-2069: LG → ICPLEEKTSVLPNSLHIFNAISGTPTSTMVHGMTSSSSVV

Note: Produced by exon skipping that results in a frameshift.Curated
Show »
Length:2,093
Mass (Da):238,846
Checksum:iA540EC1EDDCFFDB5
GO
Isoform 5 (identifier: Q9BZ29-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP
     1234-1254: ASPYTTSTPNINSVRNADSRG → GNAPCSCGLLSTITLKVSWSQ
     1255-2069: Missing.

Show »
Length:1,253
Mass (Da):142,650
Checksum:i7BA871F8ACA17693
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A088AWN3A0A088AWN3_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
2,081Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSY4A0A0A0MSY4_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
2,101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MT38A0A0A0MT38_HUMAN
Dedicator of cytokinesis 9, isoform...
DOCK9 hCG_29512
1,254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6ZSL5Q6ZSL5_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
1,393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFH5A0A0D9SFH5_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
705Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HIE8A0A804HIE8_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
2,092Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3S1H0Y3S1_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
669Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ79H7BZ79_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVL8A0A1B0GVL8_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JUD8Q5JUD8_HUMAN
Dedicator of cytokinesis protein 9
DOCK9
424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83010 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti170S → P in BAG54337 (PubMed:14702039).Curated1
Sequence conflicti296S → P in BAG54337 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062000455A → T. Corresponds to variant dbSNP:rs56010605Ensembl.1
Natural variantiVAR_0530671416K → E. Corresponds to variant dbSNP:rs16955934Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0171281 – 43MSQPP…GSVLL → MQADKCRTSSRSVKKELVIE SPLQYKDAAQGEVEAESPGP VP in isoform 2 and isoform 5. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_0456831234 – 1254ASPYT…ADSRG → GNAPCSCGLLSTITLKVSWS Q in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0456841255 – 2069Missing in isoform 5. 1 PublicationAdd BLAST815
Alternative sequenceiVSP_0040241355 – 1378RTGMM…TFNHS → SVRKISSVLGISVDNG in isoform 3. CuratedAdd BLAST24
Alternative sequenceiVSP_0077091791 – 1804Missing in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0077102068 – 2069LG → ICPLEEKTSVLPNSLHIFNA ISGTPTSTMVHGMTSSSSVV in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF527605 mRNA Translation: AAM90306.1
AB028981 mRNA Translation: BAA83010.2 Different initiation.
AK126492 mRNA Translation: BAG54337.1
AL139084 Genomic DNA No translation available.
AL161420 Genomic DNA No translation available.
AL391122 Genomic DNA No translation available.
BC043506 mRNA Translation: AAH43506.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45062.1 [Q9BZ29-5]
CCDS45063.1 [Q9BZ29-6]

NCBI Reference Sequences

More...RefSeqi		NP_001123520.1, NM_001130048.1 [Q9BZ29-5]
NP_001123521.1, NM_001130049.1
NP_001123522.1, NM_001130050.1 [Q9BZ29-6]
NP_001305778.1, NM_001318849.1
NP_056111.1, NM_015296.2 [Q9BZ29-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376460; ENSP00000365643; ENSG00000088387 [Q9BZ29-5]
ENST00000627024; ENSP00000487551; ENSG00000088387 [Q9BZ29-6]
ENST00000652315; ENSP00000498761; ENSG00000088387

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23348

UCSC genome browser

More...UCSCi		uc058xyj.1, human [Q9BZ29-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527605 mRNA Translation: AAM90306.1
AB028981 mRNA Translation: BAA83010.2 Different initiation.
AK126492 mRNA Translation: BAG54337.1
AL139084 Genomic DNA No translation available.
AL161420 Genomic DNA No translation available.
AL391122 Genomic DNA No translation available.
BC043506 mRNA Translation: AAH43506.1
CCDSiCCDS45062.1 [Q9BZ29-5]
CCDS45063.1 [Q9BZ29-6]
RefSeqiNP_001123520.1, NM_001130048.1 [Q9BZ29-5]
NP_001123521.1, NM_001130049.1
NP_001123522.1, NM_001130050.1 [Q9BZ29-6]
NP_001305778.1, NM_001318849.1
NP_056111.1, NM_015296.2 [Q9BZ29-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WG7NMR-A165-301[»]
2WM9X-ray2.20A1605-2067[»]
2WMNX-ray2.39A1605-2067[»]
2WMOX-ray2.20A1605-2067[»]
SMRiQ9BZ29
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116930, 44 interactors
IntActiQ9BZ29, 28 interactors
MINTiQ9BZ29
STRINGi9606.ENSP00000365643

PTM databases

GlyGeniQ9BZ29, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BZ29
PhosphoSitePlusiQ9BZ29

Genetic variation databases

BioMutaiDOCK9
DMDMi24212635

Proteomic databases

EPDiQ9BZ29
jPOSTiQ9BZ29
MassIVEiQ9BZ29
MaxQBiQ9BZ29
PaxDbiQ9BZ29
PeptideAtlasiQ9BZ29
PRIDEiQ9BZ29
ProteomicsDBi20137
79758 [Q9BZ29-1]
79759 [Q9BZ29-3]
79760 [Q9BZ29-4]
79761 [Q9BZ29-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25029, 49 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		23348

Genome annotation databases

EnsembliENST00000376460; ENSP00000365643; ENSG00000088387 [Q9BZ29-5]
ENST00000627024; ENSP00000487551; ENSG00000088387 [Q9BZ29-6]
ENST00000652315; ENSP00000498761; ENSG00000088387
GeneIDi23348
KEGGihsa:23348
UCSCiuc058xyj.1, human [Q9BZ29-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23348
DisGeNETi23348

GeneCards: human genes, protein and diseases

More...GeneCardsi		DOCK9
HGNCiHGNC:14132, DOCK9
HPAiENSG00000088387, Tissue enhanced (brain)
MIMi607325, gene
neXtProtiNX_Q9BZ29
OpenTargetsiENSG00000088387
PharmGKBiPA134877754
VEuPathDBiHostDB:ENSG00000088387

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1997, Eukaryota
GeneTreeiENSGT00940000155972
InParanoidiQ9BZ29
OrthoDBi20156at2759
PhylomeDBiQ9BZ29
TreeFamiTF313629

Enzyme and pathway databases

PathwayCommonsiQ9BZ29
ReactomeiR-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SignaLinkiQ9BZ29

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23348, 4 hits in 1045 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DOCK9, human
EvolutionaryTraceiQ9BZ29

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Dock9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23348
PharosiQ9BZ29, Tbio

Protein Ontology

More...PROi		PR:Q9BZ29
RNActiQ9BZ29, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088387, Expressed in corpus callosum and 251 other tissues
ExpressionAtlasiQ9BZ29, baseline and differential
GenevisibleiQ9BZ29, HS

Family and domain databases

CDDicd08697, C2_Dock-D, 1 hit
Gene3Di1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037809, C2_Dock-D
IPR027007, C2_DOCK-type_domain
IPR035892, C2_domain_sf
IPR026791, DOCK
IPR026796, DOCK9
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR027357, DOCKER_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR23317, PTHR23317, 1 hit
PTHR23317:SF77, PTHR23317:SF77, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZ29
Secondary accession number(s): B3KX25
, E9PFM9, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: February 23, 2022
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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