We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9BZ29 (DOCK9_HUMAN)
Protein
Dedicator of cytokinesis protein 9
Gene
DOCK9
Organism
Homo sapiens (Human)
Status
Functioni
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
2 PublicationsMiscellaneous
'Zizim' means 'spike' in Hebrew.Curated
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- guanyl-nucleotide exchange factor activity Source: UniProtKB
GO - Biological processi
- positive regulation of GTPase activity Source: UniProtKB
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | Q9BZ29 |
Reactomei | R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | Q9BZ29 |
Names & Taxonomyi
Protein namesi | Recommended name: Dedicator of cytokinesis protein 9CuratedAlternative name(s): Cdc42 guanine nucleotide exchange factor zizimin-1Curated Short name: Zizimin-1Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14132, DOCK9 |
MIMi | 607325, gene |
neXtProti | NX_Q9BZ29 |
VEuPathDBi | HostDB:ENSG00000088387 |
Subcellular locationi
Other locations
- Endomembrane system Curated
Note: Associated with membranes.Curated
Cytosol
- cytosol Source: Reactome
Other locations
- endomembrane system Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23348 |
OpenTargetsi | ENSG00000088387 |
PharmGKBi | PA134877754 |
Miscellaneous databases
Pharosi | Q9BZ29, Tbio |
Genetic variation databases
BioMutai | DOCK9 |
DMDMi | 24212635 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000189999 | 1 – 2069 | Dedicator of cytokinesis protein 9Add BLAST | 2069 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 170 | PhosphoserineCombined sources | 1 | |
Modified residuei | 433 | PhosphoserineBy similarity | 1 | |
Modified residuei | 443 | PhosphoserineBy similarity | 1 | |
Modified residuei | 927 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1235 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1241 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1255 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1261 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1264 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BZ29 |
jPOSTi | Q9BZ29 |
MassIVEi | Q9BZ29 |
MaxQBi | Q9BZ29 |
PaxDbi | Q9BZ29 |
PeptideAtlasi | Q9BZ29 |
PRIDEi | Q9BZ29 |
ProteomicsDBi | 20137 79758 [Q9BZ29-1] 79759 [Q9BZ29-3] 79760 [Q9BZ29-4] 79761 [Q9BZ29-5] |
PTM databases
GlyGeni | Q9BZ29, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BZ29 |
PhosphoSitePlusi | Q9BZ29 |
Expressioni
Tissue specificityi
Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000088387, Expressed in corpus callosum and 251 other tissues |
ExpressionAtlasi | Q9BZ29, baseline and differential |
Genevisiblei | Q9BZ29, HS |
Organism-specific databases
HPAi | ENSG00000088387, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Homodimer (Probable).
Interacts preferentially with nucleotide-depleted CDC42.
Curated2 PublicationsBinary interactionsi
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 116930, 44 interactors |
IntActi | Q9BZ29, 28 interactors |
MINTi | Q9BZ29 |
STRINGi | 9606.ENSP00000365643 |
Miscellaneous databases
RNActi | Q9BZ29, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BZ29 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BZ29 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 174 – 281 | PHPROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 640 – 818 | C2 DOCK-typePROSITE-ProRule annotationAdd BLAST | 179 | |
Domaini | 1605 – 2069 | DOCKERPROSITE-ProRule annotationAdd BLAST | 465 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 290 – 313 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1241 – 1282 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1693 – 2069 | Interaction with CDC421 PublicationAdd BLAST | 377 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1948 – 1982 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 2034 – 2067 | Sequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 290 – 306 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Domaini
The DOCKER domain is necessary and sufficient for the GEF activity.
Sequence similaritiesi
Belongs to the DOCK family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1997, Eukaryota |
GeneTreei | ENSGT00940000155972 |
InParanoidi | Q9BZ29 |
OrthoDBi | 20156at2759 |
PhylomeDBi | Q9BZ29 |
TreeFami | TF313629 |
Family and domain databases
CDDi | cd08697, C2_Dock-D, 1 hit |
Gene3Di | 1.20.58.740, 1 hit 1.25.40.410, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037809, C2_Dock-D IPR027007, C2_DOCK-type_domain IPR035892, C2_domain_sf IPR026791, DOCK IPR026796, DOCK9 IPR021816, DOCK_C/D_N IPR043161, DOCK_C_lobe_A IPR043162, DOCK_C_lobe_C IPR027357, DOCKER_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR23317, PTHR23317, 1 hit PTHR23317:SF77, PTHR23317:SF77, 1 hit |
Pfami | View protein in Pfam PF06920, DHR-2, 1 hit PF14429, DOCK-C2, 1 hit PF11878, DUF3398, 1 hit PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51650, C2_DOCK, 1 hit PS51651, DOCKER, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BZ29-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE
60 70 80 90 100
PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK
110 120 130 140 150
AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV
160 170 180 190 200
HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR
210 220 230 240 250
FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE
260 270 280 290 300
LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD
310 320 330 340 350
EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF
360 370 380 390 400
SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT
410 420 430 440 450
LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI
460 470 480 490 500
LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS
510 520 530 540 550
SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY
560 570 580 590 600
RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV
610 620 630 640 650
NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL
660 670 680 690 700
KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA
710 720 730 740 750
VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV
760 770 780 790 800
VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE
810 820 830 840 850
IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV
860 870 880 890 900
KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA
910 920 930 940 950
QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF
960 970 980 990 1000
LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV
1010 1020 1030 1040 1050
VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI
1060 1070 1080 1090 1100
SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL
1110 1120 1130 1140 1150
DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD
1160 1170 1180 1190 1200
DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES
1210 1220 1230 1240 1250
LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA
1260 1270 1280 1290 1300
DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI
1310 1320 1330 1340 1350
KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK
1360 1370 1380 1390 1400
RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV
1410 1420 1430 1440 1450
CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK
1460 1470 1480 1490 1500
NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL
1510 1520 1530 1540 1550
LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII
1560 1570 1580 1590 1600
NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ
1610 1620 1630 1640 1650
YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT
1660 1670 1680 1690 1700
RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME
1710 1720 1730 1740 1750
DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD
1760 1770 1780 1790 1800
FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE
1810 1820 1830 1840 1850
TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD
1860 1870 1880 1890 1900
SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM
1910 1920 1930 1940 1950
PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV
1960 1970 1980 1990 2000
AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL
2010 2020 2030 2040 2050
DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK
2060
ANYREMAKEL SEIMHEQLG
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A088AWN3 | A0A088AWN3_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 2,081 | Annotation score: | ||
A0A0A0MSY4 | A0A0A0MSY4_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 2,101 | Annotation score: | ||
A0A0A0MT38 | A0A0A0MT38_HUMAN | Dedicator of cytokinesis 9, isoform... | DOCK9 hCG_29512 | 1,254 | Annotation score: | ||
Q6ZSL5 | Q6ZSL5_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 1,393 | Annotation score: | ||
A0A0D9SFH5 | A0A0D9SFH5_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 705 | Annotation score: | ||
A0A804HIE8 | A0A804HIE8_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 2,092 | Annotation score: | ||
H0Y3S1 | H0Y3S1_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 669 | Annotation score: | ||
H7BZ79 | H7BZ79_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 390 | Annotation score: | ||
A0A1B0GVL8 | A0A1B0GVL8_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 152 | Annotation score: | ||
Q5JUD8 | Q5JUD8_HUMAN | Dedicator of cytokinesis protein 9 | DOCK9 | 424 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BAA83010 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | S → P in BAG54337 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 296 | S → P in BAG54337 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062000 | 455 | A → T. Corresponds to variant dbSNP:rs56010605Ensembl. | 1 | |
Natural variantiVAR_053067 | 1416 | K → E. Corresponds to variant dbSNP:rs16955934Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017128 | 1 – 43 | MSQPP…GSVLL → MQADKCRTSSRSVKKELVIE SPLQYKDAAQGEVEAESPGP VP in isoform 2 and isoform 5. 2 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_045683 | 1234 – 1254 | ASPYT…ADSRG → GNAPCSCGLLSTITLKVSWS Q in isoform 5. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_045684 | 1255 – 2069 | Missing in isoform 5. 1 PublicationAdd BLAST | 815 | |
Alternative sequenceiVSP_004024 | 1355 – 1378 | RTGMM…TFNHS → SVRKISSVLGISVDNG in isoform 3. CuratedAdd BLAST | 24 | |
Alternative sequenceiVSP_007709 | 1791 – 1804 | Missing in isoform 4. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_007710 | 2068 – 2069 | LG → ICPLEEKTSVLPNSLHIFNA ISGTPTSTMVHGMTSSSSVV in isoform 4. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF527605 mRNA Translation: AAM90306.1 AB028981 mRNA Translation: BAA83010.2 Different initiation. AK126492 mRNA Translation: BAG54337.1 AL139084 Genomic DNA No translation available. AL161420 Genomic DNA No translation available. AL391122 Genomic DNA No translation available. BC043506 mRNA Translation: AAH43506.1 |
CCDSi | CCDS45062.1 [Q9BZ29-5] CCDS45063.1 [Q9BZ29-6] |
RefSeqi | NP_001123520.1, NM_001130048.1 [Q9BZ29-5] NP_001123521.1, NM_001130049.1 NP_001123522.1, NM_001130050.1 [Q9BZ29-6] NP_001305778.1, NM_001318849.1 NP_056111.1, NM_015296.2 [Q9BZ29-1] |
Genome annotation databases
Ensembli | ENST00000376460; ENSP00000365643; ENSG00000088387 [Q9BZ29-5] ENST00000627024; ENSP00000487551; ENSG00000088387 [Q9BZ29-6] ENST00000652315; ENSP00000498761; ENSG00000088387 |
GeneIDi | 23348 |
KEGGi | hsa:23348 |
UCSCi | uc058xyj.1, human [Q9BZ29-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF527605 mRNA Translation: AAM90306.1 AB028981 mRNA Translation: BAA83010.2 Different initiation. AK126492 mRNA Translation: BAG54337.1 AL139084 Genomic DNA No translation available. AL161420 Genomic DNA No translation available. AL391122 Genomic DNA No translation available. BC043506 mRNA Translation: AAH43506.1 |
CCDSi | CCDS45062.1 [Q9BZ29-5] CCDS45063.1 [Q9BZ29-6] |
RefSeqi | NP_001123520.1, NM_001130048.1 [Q9BZ29-5] NP_001123521.1, NM_001130049.1 NP_001123522.1, NM_001130050.1 [Q9BZ29-6] NP_001305778.1, NM_001318849.1 NP_056111.1, NM_015296.2 [Q9BZ29-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WG7 | NMR | - | A | 165-301 | [»] | |
2WM9 | X-ray | 2.20 | A | 1605-2067 | [»] | |
2WMN | X-ray | 2.39 | A | 1605-2067 | [»] | |
2WMO | X-ray | 2.20 | A | 1605-2067 | [»] | |
SMRi | Q9BZ29 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116930, 44 interactors |
IntActi | Q9BZ29, 28 interactors |
MINTi | Q9BZ29 |
STRINGi | 9606.ENSP00000365643 |
PTM databases
GlyGeni | Q9BZ29, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BZ29 |
PhosphoSitePlusi | Q9BZ29 |
Genetic variation databases
BioMutai | DOCK9 |
DMDMi | 24212635 |
Proteomic databases
EPDi | Q9BZ29 |
jPOSTi | Q9BZ29 |
MassIVEi | Q9BZ29 |
MaxQBi | Q9BZ29 |
PaxDbi | Q9BZ29 |
PeptideAtlasi | Q9BZ29 |
PRIDEi | Q9BZ29 |
ProteomicsDBi | 20137 79758 [Q9BZ29-1] 79759 [Q9BZ29-3] 79760 [Q9BZ29-4] 79761 [Q9BZ29-5] |
Protocols and materials databases
Antibodypediai | 25029, 49 antibodies from 17 providers |
DNASUi | 23348 |
Genome annotation databases
Ensembli | ENST00000376460; ENSP00000365643; ENSG00000088387 [Q9BZ29-5] ENST00000627024; ENSP00000487551; ENSG00000088387 [Q9BZ29-6] ENST00000652315; ENSP00000498761; ENSG00000088387 |
GeneIDi | 23348 |
KEGGi | hsa:23348 |
UCSCi | uc058xyj.1, human [Q9BZ29-1] |
Organism-specific databases
CTDi | 23348 |
DisGeNETi | 23348 |
GeneCardsi | DOCK9 |
HGNCi | HGNC:14132, DOCK9 |
HPAi | ENSG00000088387, Tissue enhanced (brain) |
MIMi | 607325, gene |
neXtProti | NX_Q9BZ29 |
OpenTargetsi | ENSG00000088387 |
PharmGKBi | PA134877754 |
VEuPathDBi | HostDB:ENSG00000088387 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1997, Eukaryota |
GeneTreei | ENSGT00940000155972 |
InParanoidi | Q9BZ29 |
OrthoDBi | 20156at2759 |
PhylomeDBi | Q9BZ29 |
TreeFami | TF313629 |
Enzyme and pathway databases
PathwayCommonsi | Q9BZ29 |
Reactomei | R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | Q9BZ29 |
Miscellaneous databases
BioGRID-ORCSi | 23348, 4 hits in 1045 CRISPR screens |
ChiTaRSi | DOCK9, human |
EvolutionaryTracei | Q9BZ29 |
GeneWikii | Dock9 |
GenomeRNAii | 23348 |
Pharosi | Q9BZ29, Tbio |
PROi | PR:Q9BZ29 |
RNActi | Q9BZ29, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000088387, Expressed in corpus callosum and 251 other tissues |
ExpressionAtlasi | Q9BZ29, baseline and differential |
Genevisiblei | Q9BZ29, HS |
Family and domain databases
CDDi | cd08697, C2_Dock-D, 1 hit |
Gene3Di | 1.20.58.740, 1 hit 1.25.40.410, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037809, C2_Dock-D IPR027007, C2_DOCK-type_domain IPR035892, C2_domain_sf IPR026791, DOCK IPR026796, DOCK9 IPR021816, DOCK_C/D_N IPR043161, DOCK_C_lobe_A IPR043162, DOCK_C_lobe_C IPR027357, DOCKER_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR23317, PTHR23317, 1 hit PTHR23317:SF77, PTHR23317:SF77, 1 hit |
Pfami | View protein in Pfam PF06920, DHR-2, 1 hit PF14429, DOCK-C2, 1 hit PF11878, DUF3398, 1 hit PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51650, C2_DOCK, 1 hit PS51651, DOCKER, 1 hit PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DOCK9_HUMAN | |
Accessioni | Q9BZ29Primary (citable) accession number: Q9BZ29 Secondary accession number(s): B3KX25 Q9UPU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | October 19, 2002 | |
Last modified: | February 23, 2022 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families