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Protein

Pantothenate kinase 2, mitochondrial

Gene

PANK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be the master regulator of the CoA biosynthesis.By similarity

Miscellaneous

The HSS syndrome has been proposed to be renamed because of the unethical activities of Julius Hallervorden and Hugo Spatz during world war II.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Regulated by feedback inhibition by CoA and its thioesters.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 4 (PANK4), Pantothenate kinase 4, Pantothenate kinase 4, Pantothenate kinase 2, mitochondrial (PANK2), Pantothenate kinase 1 (PANK1), Pantothenate kinase 4 (PANK4), Pantothenate kinase 3 (PANK3)
  2. Phosphopantothenate--cysteine ligase (PPCS)
  3. Phosphopantothenoylcysteine decarboxylase (PPCDC)
  4. Bifunctional coenzyme A synthase (COASY)
  5. Bifunctional coenzyme A synthase (COASY)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei392Acetyl-CoABy similarity1
Binding sitei395Acetyl-CoABy similarity1
Binding sitei407Acetyl-CoABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS13177-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.33 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196783 Coenzyme A biosynthesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9BZ23

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00241;UER00352

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pantothenate kinase 2, mitochondrial (EC:2.7.1.33)
Short name:
hPanK2
Alternative name(s):
Pantothenic acid kinase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PANK2
Synonyms:C20orf48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000125779.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15894 PANK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606157 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZ23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodegeneration with brain iron accumulation 1 (NBIA1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in first decade with slow progression or onset in second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.
See also OMIM:234200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060934134E → G in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs765679726Ensembl.1
Natural variantiVAR_015154219G → V in NBIA1; atypical. 1 Publication1
Natural variantiVAR_076594232D → G in NBIA1; atypical; unknown pathological significance. 1 Publication1
Natural variantiVAR_015155234T → A in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs137852965EnsemblClinVar.1
Natural variantiVAR_060935249R → P in NBIA1. 1 Publication1
Natural variantiVAR_015156264R → W in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs137852961EnsemblClinVar.1
Natural variantiVAR_015157278R → C in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs137852966EnsemblClinVar.1
Natural variantiVAR_060936278R → L in NBIA1. 1 Publication1
Natural variantiVAR_015158282L → V in NBIA1. 1 Publication1
Natural variantiVAR_015159286R → C in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs137852962EnsemblClinVar.1
Natural variantiVAR_060937322E → D in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs974575417Ensembl.1
Natural variantiVAR_060938322E → G in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs768230831Ensembl.1
Natural variantiVAR_015160327T → I in NBIA1. 1 Publication1
Natural variantiVAR_015161351S → P in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs137852964EnsemblClinVar.1
Natural variantiVAR_015162355N → S in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs746484727EnsemblClinVar.1
Natural variantiVAR_060939357R → Q in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs754521581Ensembl.1
Natural variantiVAR_076595377F → S in NBIA1; atypical; unknown pathological significance. 1 Publication1
Natural variantiVAR_060940398A → T in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs759223327Ensembl.1
Natural variantiVAR_015163404N → I in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs752078407Ensembl.1
Natural variantiVAR_015164413L → P in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs750176786Ensembl.1
Natural variantiVAR_060941425Missing in NBIA1. 1 Publication1
Natural variantiVAR_060942428C → Y in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs1012947103Ensembl.1
Natural variantiVAR_060943447D → N in NBIA1. 1 Publication1
Natural variantiVAR_015165471S → N in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs137852963EnsemblClinVar.1
Natural variantiVAR_076596489L → P in NBIA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_015166497I → T in NBIA1. 1 Publication1
Natural variantiVAR_015167500N → I in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs759332123Ensembl.1
Natural variantiVAR_060944501I → T in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs775459398Ensembl.1
Natural variantiVAR_060945509A → V in NBIA1. 1 Publication1
Natural variantiVAR_060946511N → D in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs767653843Ensembl.1
Natural variantiVAR_015168521G → R in NBIA1; classic and atypical forms. 3 PublicationsCorresponds to variant dbSNP:rs137852959EnsemblClinVar.1
Natural variantiVAR_015169528T → M in NBIA1; classic and atypical forms; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs137852967EnsemblClinVar.1
Natural variantiVAR_060947532R → W in NBIA1. 1 Publication1
Natural variantiVAR_076597555G → S in NBIA1; atypical; unknown pathological significance. 1 Publication1
Natural variantiVAR_060948563L → P in NBIA1. 1 Publication1
Natural variantiVAR_060949570P → L in NBIA1; atypical. 2 PublicationsCorresponds to variant dbSNP:rs41279408EnsemblClinVar.1
Hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare syndrome with many clinical similarities to PKAN.
See also OMIM:607236

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

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DisGeNETi
80025

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
PANK2

MalaCards human disease database

More...
MalaCardsi
PANK2
MIMi234200 phenotype
607236 phenotype

Open Targets

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OpenTargetsi
ENSG00000125779

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
216873 Atypical pantothenate kinase-associated neurodegeneration
216866 Classic pantothenate kinase-associated neurodegeneration

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38048

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3407327

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PANK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572682

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002320147 – 570Pantothenate kinase 2, mitochondrialAdd BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei168PhosphoserineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BZ23

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BZ23

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BZ23

PeptideAtlas

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PeptideAtlasi
Q9BZ23

PRoteomics IDEntifications database

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PRIDEi
Q9BZ23

ProteomicsDB human proteome resource

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ProteomicsDBi
79754
79755 [Q9BZ23-2]
79756 [Q9BZ23-3]
79757 [Q9BZ23-4]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q9BZ23-1 [Q9BZ23-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BZ23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BZ23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000125779 Expressed in 223 organ(s), highest expression level in endothelial cell

CleanEx database of gene expression profiles

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CleanExi
HS_PANK2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BZ23 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BZ23 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA008440

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123079, 23 interactors

Protein interaction database and analysis system

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IntActi
Q9BZ23, 3 interactors

Molecular INTeraction database

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MINTi
Q9BZ23

STRING: functional protein association networks

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STRINGi
9606.ENSP00000313377

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9BZ23

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BZ23

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BZ23

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi236 – 243Poly-Glu8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2201 Eukaryota
COG5146 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157626

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053495

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BZ23

KEGG Orthology (KO)

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KOi
K09680

Identification of Orthologs from Complete Genome Data

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OMAi
ELCVMAT

Database of Orthologous Groups

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OrthoDBi
EOG091G0851

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BZ23

TreeFam database of animal gene trees

More...
TreeFami
TF314866

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004567 Type_II_PanK

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03630 Fumble, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00555 panK_eukar, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZ23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRLGPFHPR VHWAAPPSLS SGLHRLLFLR GTRIPSSTTL SPPRHDSLSL
60 70 80 90 100
DGGTVNPPRV REPTGREAFG PSPASSDWLP ARWRNGRGGR PRARLCSGWT
110 120 130 140 150
AAEEARRNPT LGGLLGRQRL LLRMGGGRLG APMERHGRAS ATSVSSAGEQ
160 170 180 190 200
AAGDPEGRRQ EPLRRRASSA SVPAVGASAE GTRRDRLGSY SGPTSVSRQR
210 220 230 240 250
VESLRKKRPL FPWFGLDIGG TLVKLVYFEP KDITAEEEEE EVESLKSIRK
260 270 280 290 300
YLTSNVAYGS TGIRDVHLEL KDLTLCGRKG NLHFIRFPTH DMPAFIQMGR
310 320 330 340 350
DKNFSSLHTV FCATGGGAYK FEQDFLTIGD LQLCKLDELD CLIKGILYID
360 370 380 390 400
SVGFNGRSQC YYFENPADSE KCQKLPFDLK NPYPLLLVNI GSGVSILAVY
410 420 430 440 450
SKDNYKRVTG TSLGGGTFFG LCCLLTGCTT FEEALEMASR GDSTKVDKLV
460 470 480 490 500
RDIYGGDYER FGLPGWAVAS SFGNMMSKEK REAVSKEDLA RATLITITNN
510 520 530 540 550
IGSIARMCAL NENINQVVFV GNFLRINTIA MRLLAYALDY WSKGQLKALF
560 570
SEHEGYFGAV GALLELLKIP
Length:570
Mass (Da):62,681
Last modified:November 28, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9061A60D6CA93BBB
GO
Isoform 3 (identifier: Q9BZ23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.

Show »
Length:279
Mass (Da):30,753
Checksum:iF5702EFD761FEB2B
GO
Isoform 2 (identifier: Q9BZ23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: Produced by alternative initiation at Met-124 of isoform 1.
Show »
Length:447
Mass (Da):49,117
Checksum:i07B4333A838BD6A8
GO
Isoform 4 (identifier: Q9BZ23-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     111-111: L → M

Note: May be produced by alternative initiation at Leu-111 of isoform 1. No experimental confirmation available.
Show »
Length:460
Mass (Da):50,582
Checksum:i5453A42C35481D52
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YF29A0A2R8YF29_HUMAN
Pantothenate kinase 2, mitochondria...
PANK2
403Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYH1V9GYH1_HUMAN
Pantothenate kinase 2, mitochondria...
PANK2
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYZ0V9GYZ0_HUMAN
HCG39342, isoform CRA_b
PANK2 hCG_39342
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFI4A0A2R8YFI4_HUMAN
Pantothenate kinase 2, mitochondria...
PANK2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05173 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti460R → G in BAB13897 (PubMed:14702039).Curated1
Sequence conflicti475M → K in BAB13897 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05448494R → P1 PublicationCorresponds to variant dbSNP:rs71647827EnsemblClinVar.1
Natural variantiVAR_015152111L → Q2 PublicationsCorresponds to variant dbSNP:rs71647828EnsemblClinVar.1
Natural variantiVAR_015153126G → A3 PublicationsCorresponds to variant dbSNP:rs3737084EnsemblClinVar.1
Natural variantiVAR_060934134E → G in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs765679726Ensembl.1
Natural variantiVAR_015154219G → V in NBIA1; atypical. 1 Publication1
Natural variantiVAR_076594232D → G in NBIA1; atypical; unknown pathological significance. 1 Publication1
Natural variantiVAR_015155234T → A in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs137852965EnsemblClinVar.1
Natural variantiVAR_060935249R → P in NBIA1. 1 Publication1
Natural variantiVAR_015156264R → W in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs137852961EnsemblClinVar.1
Natural variantiVAR_015157278R → C in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs137852966EnsemblClinVar.1
Natural variantiVAR_060936278R → L in NBIA1. 1 Publication1
Natural variantiVAR_015158282L → V in NBIA1. 1 Publication1
Natural variantiVAR_015159286R → C in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs137852962EnsemblClinVar.1
Natural variantiVAR_060937322E → D in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs974575417Ensembl.1
Natural variantiVAR_060938322E → G in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs768230831Ensembl.1
Natural variantiVAR_015160327T → I in NBIA1. 1 Publication1
Natural variantiVAR_015161351S → P in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs137852964EnsemblClinVar.1
Natural variantiVAR_015162355N → S in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs746484727EnsemblClinVar.1
Natural variantiVAR_060939357R → Q in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs754521581Ensembl.1
Natural variantiVAR_076595377F → S in NBIA1; atypical; unknown pathological significance. 1 Publication1
Natural variantiVAR_060940398A → T in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs759223327Ensembl.1
Natural variantiVAR_015163404N → I in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs752078407Ensembl.1
Natural variantiVAR_015164413L → P in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs750176786Ensembl.1
Natural variantiVAR_060941425Missing in NBIA1. 1 Publication1
Natural variantiVAR_060942428C → Y in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs1012947103Ensembl.1
Natural variantiVAR_060943447D → N in NBIA1. 1 Publication1
Natural variantiVAR_015165471S → N in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs137852963EnsemblClinVar.1
Natural variantiVAR_076596489L → P in NBIA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_015166497I → T in NBIA1. 1 Publication1
Natural variantiVAR_015167500N → I in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs759332123Ensembl.1
Natural variantiVAR_060944501I → T in NBIA1; atypical. 1 PublicationCorresponds to variant dbSNP:rs775459398Ensembl.1
Natural variantiVAR_060945509A → V in NBIA1. 1 Publication1
Natural variantiVAR_060946511N → D in NBIA1. 1 PublicationCorresponds to variant dbSNP:rs767653843Ensembl.1
Natural variantiVAR_015168521G → R in NBIA1; classic and atypical forms. 3 PublicationsCorresponds to variant dbSNP:rs137852959EnsemblClinVar.1
Natural variantiVAR_015169528T → M in NBIA1; classic and atypical forms; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs137852967EnsemblClinVar.1
Natural variantiVAR_060947532R → W in NBIA1. 1 Publication1
Natural variantiVAR_076597555G → S in NBIA1; atypical; unknown pathological significance. 1 Publication1
Natural variantiVAR_060948563L → P in NBIA1. 1 Publication1
Natural variantiVAR_060949570P → L in NBIA1; atypical. 2 PublicationsCorresponds to variant dbSNP:rs41279408EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0074241 – 291Missing in isoform 3. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_0188251 – 123Missing in isoform 2. CuratedAdd BLAST123
Alternative sequenceiVSP_0384941 – 110Missing in isoform 4. CuratedAdd BLAST110
Alternative sequenceiVSP_038495111L → M in isoform 4. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF494409 mRNA Translation: AAN32907.1
AK021791 mRNA Translation: BAB13897.1
AK097796 mRNA Translation: BAC05173.1 Different initiation.
EU595875 Genomic DNA Translation: ACD11492.1
AL031670 Genomic DNA No translation available.
AL353194 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10478.1
CH471133 Genomic DNA Translation: EAX10476.1
AL713654 mRNA Translation: CAD28463.1
BK000010 mRNA Translation: DAA00004.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13071.2 [Q9BZ23-1]
CCDS13072.1 [Q9BZ23-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001311120.1, NM_001324191.1 [Q9BZ23-2]
NP_079236.3, NM_024960.5 [Q9BZ23-2]
NP_705902.2, NM_153638.3 [Q9BZ23-1]
NP_705904.1, NM_153640.3 [Q9BZ23-2]
XP_005260893.3, XM_005260836.4 [Q9BZ23-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.114180
Hs.516859

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316562; ENSP00000313377; ENSG00000125779 [Q9BZ23-1]
ENST00000497424; ENSP00000417609; ENSG00000125779 [Q9BZ23-2]
ENST00000610179; ENSP00000477429; ENSG00000125779 [Q9BZ23-3]
ENST00000621507; ENSP00000481523; ENSG00000125779 [Q9BZ23-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80025

UCSC genome browser

More...
UCSCi
uc002wkb.4 human [Q9BZ23-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494409 mRNA Translation: AAN32907.1
AK021791 mRNA Translation: BAB13897.1
AK097796 mRNA Translation: BAC05173.1 Different initiation.
EU595875 Genomic DNA Translation: ACD11492.1
AL031670 Genomic DNA No translation available.
AL353194 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10478.1
CH471133 Genomic DNA Translation: EAX10476.1
AL713654 mRNA Translation: CAD28463.1
BK000010 mRNA Translation: DAA00004.1
CCDSiCCDS13071.2 [Q9BZ23-1]
CCDS13072.1 [Q9BZ23-2]
RefSeqiNP_001311120.1, NM_001324191.1 [Q9BZ23-2]
NP_079236.3, NM_024960.5 [Q9BZ23-2]
NP_705902.2, NM_153638.3 [Q9BZ23-1]
NP_705904.1, NM_153640.3 [Q9BZ23-2]
XP_005260893.3, XM_005260836.4 [Q9BZ23-2]
UniGeneiHs.114180
Hs.516859

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E26X-ray2.14A/B/C/D205-568[»]
ProteinModelPortaliQ9BZ23
SMRiQ9BZ23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123079, 23 interactors
IntActiQ9BZ23, 3 interactors
MINTiQ9BZ23
STRINGi9606.ENSP00000313377

Chemistry databases

BindingDBiQ9BZ23
ChEMBLiCHEMBL3407327

PTM databases

iPTMnetiQ9BZ23
PhosphoSitePlusiQ9BZ23

Polymorphism and mutation databases

BioMutaiPANK2
DMDMi118572682

Proteomic databases

EPDiQ9BZ23
MaxQBiQ9BZ23
PaxDbiQ9BZ23
PeptideAtlasiQ9BZ23
PRIDEiQ9BZ23
ProteomicsDBi79754
79755 [Q9BZ23-2]
79756 [Q9BZ23-3]
79757 [Q9BZ23-4]
TopDownProteomicsiQ9BZ23-1 [Q9BZ23-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316562; ENSP00000313377; ENSG00000125779 [Q9BZ23-1]
ENST00000497424; ENSP00000417609; ENSG00000125779 [Q9BZ23-2]
ENST00000610179; ENSP00000477429; ENSG00000125779 [Q9BZ23-3]
ENST00000621507; ENSP00000481523; ENSG00000125779 [Q9BZ23-2]
GeneIDi80025
KEGGihsa:80025
UCSCiuc002wkb.4 human [Q9BZ23-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80025
DisGeNETi80025
EuPathDBiHostDB:ENSG00000125779.21

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PANK2
GeneReviewsiPANK2
HGNCiHGNC:15894 PANK2
HPAiHPA008440
MalaCardsiPANK2
MIMi234200 phenotype
606157 gene
607236 phenotype
neXtProtiNX_Q9BZ23
OpenTargetsiENSG00000125779
Orphaneti216873 Atypical pantothenate kinase-associated neurodegeneration
216866 Classic pantothenate kinase-associated neurodegeneration
PharmGKBiPA38048

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2201 Eukaryota
COG5146 LUCA
GeneTreeiENSGT00940000157626
HOVERGENiHBG053495
InParanoidiQ9BZ23
KOiK09680
OMAiELCVMAT
OrthoDBiEOG091G0851
PhylomeDBiQ9BZ23
TreeFamiTF314866

Enzyme and pathway databases

UniPathwayi
UPA00241;UER00352

BioCyciMetaCyc:HS13177-MONOMER
BRENDAi2.7.1.33 2681
ReactomeiR-HSA-196783 Coenzyme A biosynthesis
SABIO-RKiQ9BZ23

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PANK2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PANK2_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80025

Protein Ontology

More...
PROi
PR:Q9BZ23

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125779 Expressed in 223 organ(s), highest expression level in endothelial cell
CleanExiHS_PANK2
ExpressionAtlasiQ9BZ23 baseline and differential
GenevisibleiQ9BZ23 HS

Family and domain databases

InterProiView protein in InterPro
IPR004567 Type_II_PanK
PfamiView protein in Pfam
PF03630 Fumble, 1 hit
TIGRFAMsiTIGR00555 panK_eukar, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPANK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZ23
Secondary accession number(s): B1AK33
, B2Z3X0, D3DVZ0, Q5T7I2, Q5T7I4, Q7RTX5, Q8N7Q4, Q8TCR5, Q9BYW5, Q9HAF2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: November 28, 2006
Last modified: December 5, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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