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Protein

Regenerating islet-derived protein 4

Gene

REG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.2 Publications

GO - Molecular functioni

  • heparin binding Source: UniProtKB
  • mannan binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandLectin

Protein family/group databases

MEROPSiI63.002

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 4
Short name:
REG-4
Alternative name(s):
Gastrointestinal secretory protein
REG-like protein
Regenerating islet-derived protein IV
Short name:
Reg IV
Gene namesi
Name:REG4
Synonyms:GISP, RELP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134193.14
HGNCiHGNC:22977 REG4
MIMi609846 gene
neXtProtiNX_Q9BYZ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi83998
OpenTargetsiENSG00000134193
PharmGKBiPA134888932

Polymorphism and mutation databases

BioMutaiREG4
DMDMi68565834

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001743723 – 158Regenerating islet-derived protein 4Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 41PROSITE-ProRule annotation1 Publication
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi58 ↔ 154PROSITE-ProRule annotation1 Publication
Disulfide bondi129 ↔ 146PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BYZ8
PeptideAtlasiQ9BYZ8
PRIDEiQ9BYZ8
ProteomicsDBi79745
79746 [Q9BYZ8-2]

PTM databases

iPTMnetiQ9BYZ8
PhosphoSitePlusiQ9BYZ8

Expressioni

Tissue specificityi

Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.3 Publications

Inductioni

Up-regulated by mucosal injury from active Crohn's disease or ulcerative colitis. Up-regulated in colorectal tumors. Up-regulated in epithelial cells at regenerating margins of peptic ulcers in the stomach and duodenum.3 Publications

Gene expression databases

BgeeiENSG00000134193 Expressed in 63 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_REG4
ExpressionAtlasiQ9BYZ8 baseline and differential
GenevisibleiQ9BYZ8 HS

Organism-specific databases

HPAiCAB025867
HPA046555

Interactioni

Protein-protein interaction databases

BioGridi123843, 7 interactors
STRINGi9606.ENSP00000256585

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BYZ8
SMRiQ9BYZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 155C-type lectinPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 103Carbohydrate-binding6
Regioni135 – 137Carbohydrate-binding3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ9BYZ8
KOiK22244
OMAiCNKRQHF
OrthoDBiEOG091G0PSR
PhylomeDBiQ9BYZ8

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRSMRLLL LLSCLAKTGV LGDIIMRPSC APGWFYHKSN CYGYFRKLRN
60 70 80 90 100
WSDAELECQS YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ
110 120 130 140 150
KRQQWQWIDG AMYLYRSWSG KSMGGNKHCA EMSSNNNFLT WSSNECNKRQ

HFLCKYRP
Length:158
Mass (Da):18,230
Last modified:June 1, 2001 - v1
Checksum:i7308849CBBD6E93E
GO
Isoform 2 (identifier: Q9BYZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-134: LECQSYGNGA...GNKHCAEMSS → VRNLLPAWPG...LDGLQAHTDT
     135-158: Missing.

Show »
Length:134
Mass (Da):14,993
Checksum:iE0E5AD9B96A53EB5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNV6E9PNV6_HUMAN
Regenerating islet-derived protein ...
REG4
103Annotation score:

Sequence cautioni

The sequence AAM95599 differs from that shown. Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050122135N → H. Corresponds to variant dbSNP:rs34996202Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01430556 – 134LECQS…AEMSS → VRNLLPAWPGLSRAKDQPEP QISFDSGSSVLPGHYEEKPL WLVKWREEGCVFNSFNSVSI AEAGAVCQTLDGLQAHTDT in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_014308135 – 158Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007243 mRNA Translation: AAG02562.1
AY126670 mRNA Translation: AAM95598.1
AY126671 mRNA Translation: AAM95599.1 Sequence problems.
AY126672 mRNA Translation: AAM95600.1
AF345934 mRNA Translation: AAK59869.1
AF254415 mRNA Translation: AAK48435.1
AL359752 Genomic DNA No translation available.
BC017089 mRNA Translation: AAH17089.1
CCDSiCCDS53354.1 [Q9BYZ8-2]
CCDS906.1 [Q9BYZ8-1]
RefSeqiNP_001152824.1, NM_001159352.1 [Q9BYZ8-1]
NP_001152825.1, NM_001159353.1 [Q9BYZ8-2]
NP_114433.1, NM_032044.3 [Q9BYZ8-1]
UniGeneiHs.660883

Genome annotation databases

EnsembliENST00000256585; ENSP00000256585; ENSG00000134193 [Q9BYZ8-1]
ENST00000354219; ENSP00000346158; ENSG00000134193 [Q9BYZ8-1]
ENST00000369401; ENSP00000358409; ENSG00000134193 [Q9BYZ8-2]
GeneIDi83998
KEGGihsa:83998
UCSCiuc001eif.4 human [Q9BYZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Binding

Regenerating protein IV

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007243 mRNA Translation: AAG02562.1
AY126670 mRNA Translation: AAM95598.1
AY126671 mRNA Translation: AAM95599.1 Sequence problems.
AY126672 mRNA Translation: AAM95600.1
AF345934 mRNA Translation: AAK59869.1
AF254415 mRNA Translation: AAK48435.1
AL359752 Genomic DNA No translation available.
BC017089 mRNA Translation: AAH17089.1
CCDSiCCDS53354.1 [Q9BYZ8-2]
CCDS906.1 [Q9BYZ8-1]
RefSeqiNP_001152824.1, NM_001159352.1 [Q9BYZ8-1]
NP_001152825.1, NM_001159353.1 [Q9BYZ8-2]
NP_114433.1, NM_032044.3 [Q9BYZ8-1]
UniGeneiHs.660883

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KV3NMR-A29-158[»]
ProteinModelPortaliQ9BYZ8
SMRiQ9BYZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123843, 7 interactors
STRINGi9606.ENSP00000256585

Protein family/group databases

MEROPSiI63.002

PTM databases

iPTMnetiQ9BYZ8
PhosphoSitePlusiQ9BYZ8

Polymorphism and mutation databases

BioMutaiREG4
DMDMi68565834

Proteomic databases

PaxDbiQ9BYZ8
PeptideAtlasiQ9BYZ8
PRIDEiQ9BYZ8
ProteomicsDBi79745
79746 [Q9BYZ8-2]

Protocols and materials databases

DNASUi83998
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256585; ENSP00000256585; ENSG00000134193 [Q9BYZ8-1]
ENST00000354219; ENSP00000346158; ENSG00000134193 [Q9BYZ8-1]
ENST00000369401; ENSP00000358409; ENSG00000134193 [Q9BYZ8-2]
GeneIDi83998
KEGGihsa:83998
UCSCiuc001eif.4 human [Q9BYZ8-1]

Organism-specific databases

CTDi83998
DisGeNETi83998
EuPathDBiHostDB:ENSG00000134193.14
GeneCardsiREG4
HGNCiHGNC:22977 REG4
HPAiCAB025867
HPA046555
MIMi609846 gene
neXtProtiNX_Q9BYZ8
OpenTargetsiENSG00000134193
PharmGKBiPA134888932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ9BYZ8
KOiK22244
OMAiCNKRQHF
OrthoDBiEOG091G0PSR
PhylomeDBiQ9BYZ8

Miscellaneous databases

ChiTaRSiREG4 human
GeneWikiiREG4
GenomeRNAii83998
PROiPR:Q9BYZ8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134193 Expressed in 63 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_REG4
ExpressionAtlasiQ9BYZ8 baseline and differential
GenevisibleiQ9BYZ8 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG4_HUMAN
AccessioniPrimary (citable) accession number: Q9BYZ8
Secondary accession number(s): Q8NER6, Q8NER7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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