Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-lactate dehydrogenase A-like 6B

Gene

LDHAL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-50 is the initiator.Curated

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A-like 6A (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase A-like 6B (LDHAL6B), L-lactate dehydrogenase (HEL-S-133P), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase A chain (LDHA), L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase C chain (LDHC)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148NADBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei187NAD or substrateBy similarity1
Binding sitei218SubstrateBy similarity1
Active sitei242Proton acceptorBy similarity1
Binding sitei297SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 106NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-HSA-70268 Pyruvate metabolism
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase A-like 6B (EC:1.1.1.27)
Gene namesi
Name:LDHAL6B
Synonyms:LDHAL6, LDHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000171989.5
HGNCiHGNC:21481 LDHAL6B
neXtProtiNX_Q9BYZ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi92483
OpenTargetsiENSG00000171989
PharmGKBiPA134943157

Chemistry databases

DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiLDHAL6B
DMDMi116242616

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001684581 – 381L-lactate dehydrogenase A-like 6BAdd BLAST381

Proteomic databases

EPDiQ9BYZ2
MaxQBiQ9BYZ2
PaxDbiQ9BYZ2
PeptideAtlasiQ9BYZ2
PRIDEiQ9BYZ2
ProteomicsDBi79743

PTM databases

iPTMnetiQ9BYZ2
PhosphoSitePlusiQ9BYZ2

Expressioni

Tissue specificityi

Testis specific.

Developmental stagei

Higher expression level in adult testis as compared to 6-week-old fetal testis.

Gene expression databases

BgeeiENSG00000171989
CleanExiHS_LDHAL6B
ExpressionAtlasiQ9BYZ2 baseline and differential
GenevisibleiQ9BYZ2 HS

Organism-specific databases

HPAiHPA053962

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPDQ141032EBI-1108377,EBI-299674

Protein-protein interaction databases

BioGridi124950, 35 interactors
IntActiQ9BYZ2, 7 interactors
MINTiQ9BYZ2
STRINGi9606.ENSP00000302393

Structurei

3D structure databases

ProteinModelPortaliQ9BYZ2
SMRiQ9BYZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiQ9BYZ2
KOiK00016
OMAiSESCHGW
OrthoDBiEOG091G0HME
PhylomeDBiQ9BYZ2
TreeFamiTF314963

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BYZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWTVPVVRA SQRVSSVGAN FLCLGMALCP RQATRIPLNG TWLFTPVSKM
60 70 80 90 100
ATVKSELIER FTSEKPVHHS KVSIIGTGSV GMACAISILL KGLSDELALV
110 120 130 140 150
DLDEDKLKGE TMDLQHGSPF TKMPNIVCSK DYFVTANSNL VIITAGARQE
160 170 180 190 200
KGETRLNLVQ RNVAIFKLMI SSIVQYSPHC KLIIVSNPVD ILTYVAWKLS
210 220 230 240 250
AFPKNRIIGS GCNLDTARFR FLIGQKLGIH SESCHGWILG EHGDSSVPVW
260 270 280 290 300
SGVNIAGVPL KDLNSDIGTD KDPEQWKNVH KEVTATAYEI IKMKGYTSWA
310 320 330 340 350
IGLSVADLTE SILKNLRRIH PVSTIIKGLY GIDEEVFLSI PCILGENGIT
360 370 380
NLIKIKLTPE EEAHLKKSAK TLWEIQNKLK L
Length:381
Mass (Da):41,943
Last modified:October 17, 2006 - v3
Checksum:iF2B2D27E3ADE8A1D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02793614V → M2 PublicationsCorresponds to variant dbSNP:rs3809530Ensembl.1
Natural variantiVAR_02793730P → L2 PublicationsCorresponds to variant dbSNP:rs3809529Ensembl.1
Natural variantiVAR_049757259P → S. Corresponds to variant dbSNP:rs35212259Ensembl.1
Natural variantiVAR_027938326I → T2 PublicationsCorresponds to variant dbSNP:rs3825937Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009108 mRNA Translation: AAG49399.1
AY642121 mRNA Translation: AAT65080.1
AK058192 mRNA Translation: BAB71710.1
BC022034 mRNA Translation: AAH22034.1
CCDSiCCDS10171.1
RefSeqiNP_149972.1, NM_033195.2
UniGeneiHs.307052

Genome annotation databases

EnsembliENST00000307144; ENSP00000302393; ENSG00000171989
GeneIDi92483
KEGGihsa:92483
UCSCiuc002agb.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLDH6B_HUMAN
AccessioniPrimary (citable) accession number: Q9BYZ2
Secondary accession number(s): Q6DUY4, Q96LI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health