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Protein

Putative beta-actin-like protein 3

Gene

POTEKP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SignaLinkiQ9BYX7

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-actin-like protein 3
Alternative name(s):
Kappa-actin
POTE ankyrin domain family member K
Gene namesi
Name:POTEKP
Synonyms:ACTBL3
ORF Names:FKSG30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30182 POTEKP
MIMi611266 gene
neXtProtiNX_Q9BYX7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74739412

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078651 – 375Putative beta-actin-like protein 3Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44Methionine (R)-sulfoxideBy similarity1
Modified residuei47Methionine (R)-sulfoxideBy similarity1
Modified residuei84N6-methyllysine1 Publication1

Post-translational modificationi

Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).By similarity
Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.

Keywords - PTMi

Methylation, Oxidation

Proteomic databases

EPDiQ9BYX7
MaxQBiQ9BYX7
PeptideAtlasiQ9BYX7
PRIDEiQ9BYX7
ProteomicsDBi79742
TopDownProteomicsiQ9BYX7

PTM databases

iPTMnetiQ9BYX7
PhosphoSitePlusiQ9BYX7
SwissPalmiQ9BYX7

Expressioni

Tissue specificityi

Expressed in some hepatocellular carcinomas.1 Publication

Organism-specific databases

HPAiHPA041264
HPA041271

Interactioni

Subunit structurei

Interacts with PFN1 and PFDN1. Does not interact with PFN2.1 Publication

Protein-protein interaction databases

IntActiQ9BYX7, 8 interactors
MINTiQ9BYX7

Structurei

3D structure databases

ProteinModelPortaliQ9BYX7
SMRiQ9BYX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiENOG410ITJG Eukaryota
KOG0676 Eukaryota
COG0666 LUCA
COG5277 LUCA
InParanoidiQ9BYX7

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BYX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDTAVLVI DNGSGMCKAG FAGDDAPQAV FPSIVGRPRH QGMMEGMHQK
60 70 80 90 100
ESYVGKEAQS KRGMLTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYTSGRTTG
160 170 180 190 200
IVMDSGDGFT HTVPIYEGNA LPHATLRLDL AGRELTDYLM KILTERGYRF
210 220 230 240 250
TTTAEQEIVR DIKEKLCYVA LDSEQEMAMA ASSSSVEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPCFLGME SCGIHKTTFN SIVKSDVDIR KDLYTNTVLS
310 320 330 340 350
GGTTMYPGIA HRMQKEITAL APSIMKIKII APPKRKYSVW VGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Length:375
Mass (Da):42,016
Last modified:June 1, 2001 - v1
Checksum:i98127B88A9983B7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159F → V in AAX82286 (PubMed:16824795).Curated1
Sequence conflicti177R → P in AAX82286 (PubMed:16824795).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014272 mRNA Translation: AAG50355.1
AY970480 Genomic DNA Translation: AAX82286.1
UniGeneiHs.631267
Hs.654289

Similar proteinsi

Entry informationi

Entry nameiACTBM_HUMAN
AccessioniPrimary (citable) accession number: Q9BYX7
Secondary accession number(s): Q562N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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