UniProtKB - Q9BYX4 (IFIH1_HUMAN)
Interferon-induced helicase C domain-containing protein 1
IFIH1
Functioni
Miscellaneous
Catalytic activityi
- EC:3.6.4.13
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 907 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 910 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 962 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 964 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: InterPro
- double-stranded RNA binding Source: UniProtKB
- identical protein binding Source: IntAct
- ribonucleoprotein complex binding Source: UniProtKB
- RNA helicase activity Source: UniProtKB-EC
- single-stranded RNA binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cellular response to exogenous dsRNA Source: UniProtKB
- cytoplasmic pattern recognition receptor signaling pathway in response to virus Source: UniProtKB
- defense response to virus Source: UniProtKB
- detection of virus Source: BHF-UCL
- innate immune response Source: GO_Central
- MDA-5 signaling pathway Source: UniProtKB
- negative regulation of type I interferon production Source: Reactome
- positive regulation of interferon-alpha production Source: UniProtKB
- positive regulation of interferon-beta production Source: UniProtKB
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of response to cytokine stimulus Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: UniProtKB
- protein deubiquitination Source: Reactome
- protein sumoylation Source: UniProtKB
- regulation of type III interferon production Source: UniProtKB
- response to virus Source: GO_Central
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BYX4 |
Reactomei | R-HSA-168928, DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-5689880, Ub-specific processing proteases R-HSA-5689896, Ovarian tumor domain proteases R-HSA-918233, TRAF3-dependent IRF activation pathway R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-933543, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling |
SIGNORi | Q9BYX4 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon-induced helicase C domain-containing protein 1Curated (EC:3.6.4.13)Alternative name(s): Clinically amyopathic dermatomyositis autoantigen 140 kDa Short name: CADM-140 autoantigen Helicase with 2 CARD domains Short name: Helicard Interferon-induced with helicase C domain protein 1 Melanoma differentiation-associated protein 5 Short name: MDA-5 Murabutide down-regulated protein RIG-I-like receptor 2 Short name: RLR-2 RNA helicase-DEAD box protein 116 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18873, IFIH1 |
MIMi | 606951, gene |
neXtProti | NX_Q9BYX4 |
VEuPathDBi | HostDB:ENSG00000115267.5 |
Pathology & Biotechi
Involvement in diseasei
Diabetes mellitus, insulin-dependent, 19 (IDDM19)1 Publication
Aicardi-Goutieres syndrome 7 (AGS7)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071375 | 337 | R → G in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777447EnsemblClinVar. | 1 | |
Natural variantiVAR_071376 | 372 | L → F in AGS7; enhances IFNB1 promoter activation; loss of ligand-induced responsiveness. 1 PublicationCorresponds to variant dbSNP:rs587777576EnsemblClinVar. | 1 | |
Natural variantiVAR_071377 | 393 | D → V in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777449EnsemblClinVar. | 1 | |
Natural variantiVAR_071378 | 452 | A → T in AGS7; enhances IFNB1 promoter activation; loss of ligand-induced responsiveness. 1 PublicationCorresponds to variant dbSNP:rs587777575EnsemblClinVar. | 1 | |
Natural variantiVAR_071379 | 495 | G → R in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs672601336EnsemblClinVar. | 1 | |
Natural variantiVAR_071380 | 720 | R → Q in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777445EnsemblClinVar. | 1 | |
Natural variantiVAR_071381 | 779 | R → C in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777448EnsemblClinVar. | 1 | |
Natural variantiVAR_071382 | 779 | R → H in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; enhances IFNB1 promoter activation; no loss of ATP hydrolysis. 2 PublicationsCorresponds to variant dbSNP:rs587777446EnsemblClinVar. | 1 |
Singleton-Merten syndrome 1 (SGMRT1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073666 | 822 | R → Q in SGMRT1; gain-of-function mutation resulting in enhanced INFB1 induction. 1 PublicationCorresponds to variant dbSNP:rs376048533EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 251 | D → A: No cleavage and no acceleration of DNA degradation. 1 Publication | 1 | |
Mutagenesisi | 444 | E → A: No acceleration of DNA degradation, no binding to ATP, and no helicase activity. 1 Publication | 1 | |
Mutagenesisi | 828 | S → A: Promotes multimerization after polyI:C stimulation; greatly enhances signaling. 1 Publication | 1 | |
Mutagenesisi | 828 | S → D: Inhibits multimerization after polyI:C stimulation. 1 Publication | 1 | |
Mutagenesisi | 829 | T → A: Moderately increases signaling. 1 Publication | 1 |
Keywords - Diseasei
Aicardi-Goutieres syndrome, Diabetes mellitus, Disease variantOrganism-specific databases
DisGeNETi | 64135 |
GeneReviewsi | IFIH1 |
MalaCardsi | IFIH1 |
MIMi | 182250, phenotype 610155, phenotype 615846, phenotype |
OpenTargetsi | ENSG00000115267 |
Orphaneti | 51, Aicardi-Goutieres syndrome 85191, Singleton-Merten dysplasia |
PharmGKBi | PA134889215 |
Miscellaneous databases
Pharosi | Q9BYX4, Tbio |
Genetic variation databases
BioMutai | IFIH1 |
DMDMi | 134047802 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000102012 | 1 – 1025 | Interferon-induced helicase C domain-containing protein 1Add BLAST | 1025 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 289 | PhosphoserineBy similarity | 1 | |
Modified residuei | 291 | PhosphoserineBy similarity | 1 | |
Modified residuei | 301 | PhosphoserineBy similarity | 1 | |
Modified residuei | 645 | PhosphoserineBy similarity | 1 | |
Modified residuei | 828 | Phosphoserine; by RIOK31 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 208 – 209 | CleavageBy similarity | 2 | |
Sitei | 216 – 217 | CleavageBy similarity | 2 | |
Sitei | 251 – 252 | CleavageBy similarity | 2 |
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BYX4 |
jPOSTi | Q9BYX4 |
MassIVEi | Q9BYX4 |
MaxQBi | Q9BYX4 |
PaxDbi | Q9BYX4 |
PeptideAtlasi | Q9BYX4 |
PRIDEi | Q9BYX4 |
ProteomicsDBi | 79740 [Q9BYX4-1] 79741 [Q9BYX4-2] |
PTM databases
iPTMneti | Q9BYX4 |
PhosphoSitePlusi | Q9BYX4 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000115267, Expressed in parotid gland and 224 other tissues |
ExpressionAtlasi | Q9BYX4, baseline and differential |
Genevisiblei | Q9BYX4, HS |
Organism-specific databases
HPAi | ENSG00000115267, Low tissue specificity |
Interactioni
Subunit structurei
Monomer in the absence of ligands and homodimerizes in the presence of dsRNA ligands. Can assemble into helical or linear polymeric filaments on long dsRNA.
Interacts with MAVS/IPS1.
Interacts (via the CARD domains) with TKFC, the interaction is inhibited by viral infection (PubMed:17600090).
Interacts with PCBP2.
Interacts with NLRC5.
Interacts with PIAS2-beta.
Interacts with DDX60.
Interacts with ANKRD17.
Interacts with IKBKE (PubMed:17600090).
Interacts with ATG5 and ATG12, either as ATG5 and ATG12 monomers or as ATG12-ATG5 conjugates (PubMed:17709747).
Interacts with ZCCHC3; leading to activate IFIH1/MDA5 (PubMed:30193849).
Interacts with RNF123 (PubMed:27312109).
Interacts with DDX3X (PubMed:20127681).
16 Publications(Microbial infection) Interacts with V protein of paramyxoviruses; these interactions prevent IFN-beta induction, and subsquent establishment of an antiviral state.
1 Publication(Microbial infection) Interacts with herpes simplex virus 1 protein US11; this interaction prevents the interaction of MAVS/IPS1 to IFIH1.
1 Publication(Microbial infection) Interacts with Encephalomyocarditis virus protein 2C; this interaction inhibits the induction of the IFN-beta signal pathway.
1 Publication(Microbial infection) Interacts with protease 3C of coxsackievirus A16; this interaction inhibits IFIH1 thereby attenuating type-I IFN production.
1 PublicationBinary interactionsi
Hide detailsQ9BYX4
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 122082, 35 interactors |
DIPi | DIP-42607N |
IntActi | Q9BYX4, 47 interactors |
STRINGi | 9606.ENSP00000263642 |
Miscellaneous databases
RNActi | Q9BYX4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9BYX4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BYX4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 97 | CARD 1Add BLAST | 91 | |
Domaini | 110 – 190 | CARD 2Add BLAST | 81 | |
Domaini | 316 – 509 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 194 | |
Domaini | 700 – 882 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 183 | |
Domaini | 893 – 1020 | RLR CTRPROSITE-ProRule annotationAdd BLAST | 128 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0354, Eukaryota |
GeneTreei | ENSGT00940000153173 |
HOGENOMi | CLU_006888_0_0_1 |
InParanoidi | Q9BYX4 |
OMAi | CCLFSDE |
OrthoDBi | 1337630at2759 |
PhylomeDBi | Q9BYX4 |
TreeFami | TF330258 |
Family and domain databases
Gene3Di | 2.170.150.30, 1 hit |
InterProi | View protein in InterPro IPR031964, CARD_dom IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR041204, RIG-I_C IPR038557, RLR_C_sf IPR021673, RLR_CTR |
Pfami | View protein in Pfam PF16739, CARD_2, 2 hits PF00271, Helicase_C, 1 hit PF04851, ResIII, 1 hit PF18119, RIG-I_C, 1 hit PF11648, RIG-I_C-RD, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51789, RLR_CTR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNGYSTDEN FRYLISCFRA RVKMYIQVEP VLDYLTFLPA EVKEQIQRTV
60 70 80 90 100
ATSGNMQAVE LLLSTLEKGV WHLGWTREFV EALRRTGSPL AARYMNPELT
110 120 130 140 150
DLPSPSFENA HDEYLQLLNL LQPTLVDKLL VRDVLDKCME EELLTIEDRN
160 170 180 190 200
RIAAAENNGN ESGVRELLKR IVQKENWFSA FLNVLRQTGN NELVQELTGS
210 220 230 240 250
DCSESNAEIE NLSQVDGPQV EEQLLSTTVQ PNLEKEVWGM ENNSSESSFA
260 270 280 290 300
DSSVVSESDT SLAEGSVSCL DESLGHNSNM GSDSGTMGSD SDEENVAARA
310 320 330 340 350
SPEPELQLRP YQMEVAQPAL EGKNIIICLP TGSGKTRVAV YIAKDHLDKK
360 370 380 390 400
KKASEPGKVI VLVNKVLLVE QLFRKEFQPF LKKWYRVIGL SGDTQLKISF
410 420 430 440 450
PEVVKSCDII ISTAQILENS LLNLENGEDA GVQLSDFSLI IIDECHHTNK
460 470 480 490 500
EAVYNNIMRH YLMQKLKNNR LKKENKPVIP LPQILGLTAS PGVGGATKQA
510 520 530 540 550
KAEEHILKLC ANLDAFTIKT VKENLDQLKN QIQEPCKKFA IADATREDPF
560 570 580 590 600
KEKLLEIMTR IQTYCQMSPM SDFGTQPYEQ WAIQMEKKAA KEGNRKERVC
610 620 630 640 650
AEHLRKYNEA LQINDTIRMI DAYTHLETFY NEEKDKKFAV IEDDSDEGGD
660 670 680 690 700
DEYCDGDEDE DDLKKPLKLD ETDRFLMTLF FENNKMLKRL AENPEYENEK
710 720 730 740 750
LTKLRNTIME QYTRTEESAR GIIFTKTRQS AYALSQWITE NEKFAEVGVK
760 770 780 790 800
AHHLIGAGHS SEFKPMTQNE QKEVISKFRT GKINLLIATT VAEEGLDIKE
810 820 830 840 850
CNIVIRYGLV TNEIAMVQAR GRARADESTY VLVAHSGSGV IEHETVNDFR
860 870 880 890 900
EKMMYKAIHC VQNMKPEEYA HKILELQMQS IMEKKMKTKR NIAKHYKNNP
910 920 930 940 950
SLITFLCKNC SVLACSGEDI HVIEKMHHVN MTPEFKELYI VRENKALQKK
960 970 980 990 1000
CADYQINGEI ICKCGQAWGT MMVHKGLDLP CLKIRNFVVV FKNNSTKKQY
1010 1020
KKWVELPITF PNLDYSECCL FSDED
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IRK8 | A0A3B3IRK8_HUMAN | RNA helicase | IFIH1 | 986 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 439 | L → F in AAG54076 (PubMed:14645903).Curated | 1 | |
Sequence conflicti | 475 | N → H in BAB71141 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 592 | E → K in AAG34368 (PubMed:11805321).Curated | 1 | |
Sequence conflicti | 598 | R → S in AAG54076 (PubMed:14645903).Curated | 1 | |
Sequence conflicti | 609 | E → K in AAG54076 (PubMed:14645903).Curated | 1 | |
Sequence conflicti | 782 | K → R in BAB71141 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071375 | 337 | R → G in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777447EnsemblClinVar. | 1 | |
Natural variantiVAR_071376 | 372 | L → F in AGS7; enhances IFNB1 promoter activation; loss of ligand-induced responsiveness. 1 PublicationCorresponds to variant dbSNP:rs587777576EnsemblClinVar. | 1 | |
Natural variantiVAR_071377 | 393 | D → V in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777449EnsemblClinVar. | 1 | |
Natural variantiVAR_071378 | 452 | A → T in AGS7; enhances IFNB1 promoter activation; loss of ligand-induced responsiveness. 1 PublicationCorresponds to variant dbSNP:rs587777575EnsemblClinVar. | 1 | |
Natural variantiVAR_031226 | 460 | H → R. Corresponds to variant dbSNP:rs10930046Ensembl. | 1 | |
Natural variantiVAR_071379 | 495 | G → R in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs672601336EnsemblClinVar. | 1 | |
Natural variantiVAR_071380 | 720 | R → Q in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777445EnsemblClinVar. | 1 | |
Natural variantiVAR_071381 | 779 | R → C in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; no loss of ATP hydrolysis. 1 PublicationCorresponds to variant dbSNP:rs587777448EnsemblClinVar. | 1 | |
Natural variantiVAR_071382 | 779 | R → H in AGS7; enhances the interferon signaling pathway activation; enhances the stability of filament formation; enhances dsRNA binding activity; enhances IFNB1 promoter activation; no loss of ATP hydrolysis. 2 PublicationsCorresponds to variant dbSNP:rs587777446EnsemblClinVar. | 1 | |
Natural variantiVAR_073666 | 822 | R → Q in SGMRT1; gain-of-function mutation resulting in enhanced INFB1 induction. 1 PublicationCorresponds to variant dbSNP:rs376048533EnsemblClinVar. | 1 | |
Natural variantiVAR_021594 | 843 | H → R3 PublicationsCorresponds to variant dbSNP:rs3747517EnsemblClinVar. | 1 | |
Natural variantiVAR_021595 | 946 | A → T Associated with susceptibility to IDDM19. 3 PublicationsCorresponds to variant dbSNP:rs1990760EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013337 | 208 – 221 | EIENL…GPQVE → GICNFTEEDSSNSA in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_013338 | 222 – 1025 | Missing in isoform 2. 1 PublicationAdd BLAST | 804 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095844 mRNA Translation: AAG34368.1 AY017378 mRNA Translation: AAG54076.1 BC046208 mRNA Translation: AAH46208.1 BC078180 mRNA Translation: AAH78180.1 Sequence problems. BC111750 mRNA Translation: AAI11751.1 AK056293 mRNA Translation: BAB71141.1 Different initiation. |
CCDSi | CCDS2217.1 [Q9BYX4-1] |
RefSeqi | NP_071451.2, NM_022168.3 [Q9BYX4-1] |
Genome annotation databases
Ensembli | ENST00000421365; ENSP00000408450; ENSG00000115267 [Q9BYX4-2] ENST00000649979; ENSP00000497271; ENSG00000115267 [Q9BYX4-1] |
GeneIDi | 64135 |
KEGGi | hsa:64135 |
UCSCi | uc002uce.5, human [Q9BYX4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095844 mRNA Translation: AAG34368.1 AY017378 mRNA Translation: AAG54076.1 BC046208 mRNA Translation: AAH46208.1 BC078180 mRNA Translation: AAH78180.1 Sequence problems. BC111750 mRNA Translation: AAI11751.1 AK056293 mRNA Translation: BAB71141.1 Different initiation. |
CCDSi | CCDS2217.1 [Q9BYX4-1] |
RefSeqi | NP_071451.2, NM_022168.3 [Q9BYX4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RQB | NMR | - | A | 896-1025 | [»] | |
3B6E | X-ray | 1.60 | A | 277-490 | [»] | |
3GA3 | X-ray | 1.45 | A | 893-1017 | [»] | |
4GL2 | X-ray | 3.56 | A/B | 306-1017 | [»] | |
7JL0 | electron microscopy | 4.30 | A | 287-1025 | [»] | |
7JL2 | electron microscopy | 4.30 | A/C/E | 287-1025 | [»] | |
SMRi | Q9BYX4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122082, 35 interactors |
DIPi | DIP-42607N |
IntActi | Q9BYX4, 47 interactors |
STRINGi | 9606.ENSP00000263642 |
PTM databases
iPTMneti | Q9BYX4 |
PhosphoSitePlusi | Q9BYX4 |
Genetic variation databases
BioMutai | IFIH1 |
DMDMi | 134047802 |
Proteomic databases
EPDi | Q9BYX4 |
jPOSTi | Q9BYX4 |
MassIVEi | Q9BYX4 |
MaxQBi | Q9BYX4 |
PaxDbi | Q9BYX4 |
PeptideAtlasi | Q9BYX4 |
PRIDEi | Q9BYX4 |
ProteomicsDBi | 79740 [Q9BYX4-1] 79741 [Q9BYX4-2] |
Protocols and materials databases
Antibodypediai | 805, 489 antibodies |
Genome annotation databases
Ensembli | ENST00000421365; ENSP00000408450; ENSG00000115267 [Q9BYX4-2] ENST00000649979; ENSP00000497271; ENSG00000115267 [Q9BYX4-1] |
GeneIDi | 64135 |
KEGGi | hsa:64135 |
UCSCi | uc002uce.5, human [Q9BYX4-1] |
Organism-specific databases
CTDi | 64135 |
DisGeNETi | 64135 |
GeneCardsi | IFIH1 |
GeneReviewsi | IFIH1 |
HGNCi | HGNC:18873, IFIH1 |
HPAi | ENSG00000115267, Low tissue specificity |
MalaCardsi | IFIH1 |
MIMi | 182250, phenotype 606951, gene 610155, phenotype 615846, phenotype |
neXtProti | NX_Q9BYX4 |
OpenTargetsi | ENSG00000115267 |
Orphaneti | 51, Aicardi-Goutieres syndrome 85191, Singleton-Merten dysplasia |
PharmGKBi | PA134889215 |
VEuPathDBi | HostDB:ENSG00000115267.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0354, Eukaryota |
GeneTreei | ENSGT00940000153173 |
HOGENOMi | CLU_006888_0_0_1 |
InParanoidi | Q9BYX4 |
OMAi | CCLFSDE |
OrthoDBi | 1337630at2759 |
PhylomeDBi | Q9BYX4 |
TreeFami | TF330258 |
Enzyme and pathway databases
PathwayCommonsi | Q9BYX4 |
Reactomei | R-HSA-168928, DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-5689880, Ub-specific processing proteases R-HSA-5689896, Ovarian tumor domain proteases R-HSA-918233, TRAF3-dependent IRF activation pathway R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-933543, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling |
SIGNORi | Q9BYX4 |
Miscellaneous databases
BioGRID-ORCSi | 64135, 5 hits in 997 CRISPR screens |
ChiTaRSi | IFIH1, human |
EvolutionaryTracei | Q9BYX4 |
GeneWikii | MDA5 |
GenomeRNAii | 64135 |
Pharosi | Q9BYX4, Tbio |
PROi | PR:Q9BYX4 |
RNActi | Q9BYX4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115267, Expressed in parotid gland and 224 other tissues |
ExpressionAtlasi | Q9BYX4, baseline and differential |
Genevisiblei | Q9BYX4, HS |
Family and domain databases
Gene3Di | 2.170.150.30, 1 hit |
InterProi | View protein in InterPro IPR031964, CARD_dom IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR041204, RIG-I_C IPR038557, RLR_C_sf IPR021673, RLR_CTR |
Pfami | View protein in Pfam PF16739, CARD_2, 2 hits PF00271, Helicase_C, 1 hit PF04851, ResIII, 1 hit PF18119, RIG-I_C, 1 hit PF11648, RIG-I_C-RD, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51789, RLR_CTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFIH1_HUMAN | |
Accessioni | Q9BYX4Primary (citable) accession number: Q9BYX4 Secondary accession number(s): Q2NKL6 Q9H3G6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | March 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 184 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families