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Entry version 182 (25 May 2022)
Sequence version 3 (18 May 2010)
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Protein

Histone-lysine N-methyltransferase SETD2

Gene

SETD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439).

It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550).

Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity).

Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844).

Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243).

Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002).

Acts as a tumor suppressor (PubMed:24509477).

H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772).

H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193).

Required during angiogenesis (By similarity).

Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity).

In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426).

Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565).

Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426).

By similarity13 Publications

(Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Specifically inhibited by sinefungin derivatives. N-propyl sinefungin (Pr-SNF) interacts preferentially with SETD2.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.14 min(-1).1 Publication
  1. KM=1.21 µM for S-adenosyl-L-methionine1 Publication
  2. KM=0.42 µM for histone H31 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1499Zinc 1Combined sources3 Publications1
Metal bindingi1501Zinc 1Combined sources3 Publications1
Metal bindingi1516Zinc 1Combined sources3 Publications1
Metal bindingi1516Zinc 2Combined sources3 Publications1
Metal bindingi1520Zinc 1Combined sources3 Publications1
Metal bindingi1529Zinc 2Combined sources3 Publications1
Metal bindingi1533Zinc 2Combined sources3 Publications1
Metal bindingi1539Zinc 2Combined sources3 Publications1
Metal bindingi1631Zinc 3Combined sources3 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1676S-adenosyl-L-methionineCombined sources3 Publications1
Metal bindingi1678Zinc 3Combined sources3 Publications1
Binding sitei1679S-adenosyl-L-methionine; via amide nitrogenCombined sources3 Publications1
Metal bindingi1680Zinc 3Combined sources3 Publications1
Metal bindingi1685Zinc 3Combined sources3 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, Methyltransferase, Transferase
Biological processAntiviral defense, Differentiation, DNA damage, DNA repair, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.1.1.359, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9BYW2

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214841, PKMTs methylate histone lysines

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9BYW2

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9BYW2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD2Curated (EC:2.1.1.3593 Publications)
Alternative name(s):
HIF-1
Huntingtin yeast partner B1 Publication
Huntingtin-interacting protein 1
Short name:
HIP-1
Huntingtin-interacting protein B1 Publication
Lysine N-methyltransferase 3A1 Publication
Protein-lysine N-methyltransferase SETD2Curated (EC:2.1.1.-2 Publications)
SET domain-containing protein 21 Publication
Short name:
hSET21 Publication
p231HBP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SETD2
Synonyms:HIF1, HYPB1 Publication, KIAA17321 Publication, KMT3A1 Publication, SET22 Publications
ORF Names:HSPC069
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18420, SETD2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612778, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9BYW2

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000181555

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal cell carcinoma (RCC)4 Publications
The disease may be caused by variants affecting the gene represented in this entry. Defects of SETD2 are associated with loss of DNA methylation at non-promoter regions (PubMed:23792563). SETD2 defects lead to aberrant and reduced nucleosome compaction and chromatin association of key replication proteins, such as MCM7 and DNA polymerase delta, leading to hinder replication fork progression and prevent loading of RAD51 homologous recombination repair factor at DNA breaks (PubMed:25728682).2 Publications
Disease descriptionRenal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0698121733N → D in RCC; defects in recruitment of the MutS alpha complex. 1 Publication1
Natural variantiVAR_0698131769S → P in RCC; defects in recruitment of the MutS alpha complex. 1 Publication1
Luscan-Lumish syndrome (LLS)4 Publications
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome with a variable phenotype. Clinical features include macrocephaly, distinctive facial appearance, postnatal overgrowth, various degrees of learning difficulties, autism spectrum disorder, and intellectual disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0765361815L → W in LLS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869025570EnsemblClinVar.1
Leukemia, acute lymphoblastic (ALL)2 Publications
The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionA subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0790542K → R in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_07905519E → G in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_079057226P → S in ALL; unknown pathological significance; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780963440Ensembl.1
Natural variantiVAR_079058267V → I in ALL; unknown pathological significance; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs186148199EnsemblClinVar.1
Natural variantiVAR_079059470S → P in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_079060499T → A in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_079061761M → I in ALL; unknown pathological significance; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs188887061EnsemblClinVar.1
Natural variantiVAR_079062794 – 2564Missing in ALL; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST1771
Natural variantiVAR_0790641076S → P in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790651093S → G in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790661171T → A in ALL; unknown pathological significance; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs540476365Ensembl.1
Natural variantiVAR_0790671351D → G in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790681365G → E in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790701416 – 2564Missing in ALL; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST1149
Natural variantiVAR_0790711453D → N in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790721493D → N in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790731496 – 2564Missing in ALL; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST1069
Natural variantiVAR_0790741609L → P in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790751654K → Q in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790761663T → M in ALL; unknown pathological significance; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1478147351Ensembl.1
Natural variantiVAR_0790781821L → P in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790791915V → A in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790801920E → V in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790812077 – 2564Missing in ALL; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST488
Natural variantiVAR_0790832214T → A in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790852361P → S in ALL; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790872524 – 2564Missing in ALL; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST41
Natural variantiVAR_0790882546 – 2564Missing in ALL; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST19
Leukemia, acute myelogenous (AML)2 Publications
The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionA subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07905670 – 2564Missing in AML; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST2495
Natural variantiVAR_079063800S → N in AML; unknown pathological significance; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1169288572Ensembl.1
Natural variantiVAR_0790691397D → G in AML; unknown pathological significance; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754921650Ensembl.1
Natural variantiVAR_0790771804L → S in AML; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790822122R → W in AML; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_0790842325 – 2564Missing in AML; unknown pathological significance; somatic mutation. 1 PublicationAdd BLAST240
Natural variantiVAR_0790862505F → L in AML; Impairs interaction with hyperphosphorylated POLR2A; unknown pathological significance; somatic mutation. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1589F → A: Strongly reduced methyltransferase activity. 1 Publication1
Mutagenesisi1604Y → A: Increased methyltransferase activity. 1 Publication1
Mutagenesisi1625R → H or G: Loss of methyltransferase activity. Abolishes ability to monomethylate STAT1. 2 Publications1
Mutagenesisi1631C → A: Does not affect methyltransferase activity. 1 Publication1
Mutagenesisi1636E → A: Increased methyltransferase activity. 1 Publication1
Mutagenesisi1637T → A: Increased methyltransferase activity. 1 Publication1
Mutagenesisi1668F → A: Strongly reduced methyltransferase activity. 2 Publications1
Mutagenesisi1669Q → A: Loss of methyltransferase activity. 1 Publication1
Mutagenesisi1670R → A, V, L, I or F: Impaired methyltransferase activity. 1 Publication1
Mutagenesisi1670R → P, W, K or Q: Loss of methyltransferase activity. 1 Publication1
Mutagenesisi1671Y → A: Strongly reduced methyltransferase activity. 2 Publications1
Mutagenesisi2475R → A: Does not affect interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2476K → A: Does not affect interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2480Q → A: Does not affect interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2481F → A: Does not affect interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2483V → A: Impairs interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2506K → A: Impairs interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2510R → A: Impairs interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2514H → A: Impairs interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2515G → A or T: Does not affect interaction with hyperphosphorylated POLR2A. 1 Publication1
Mutagenesisi2528E → A: Increases interaction with hyperphosphorylated POLR2A; when associated with A-2531. 1 Publication1
Mutagenesisi2531E → A: Increases interaction with hyperphosphorylated POLR2A; when associated with A-2528. 1 Publication1

Keywords - Diseasei

Autism spectrum disorder, Disease variant, Mental retardation, Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
29072

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SETD2

MalaCards human disease database

More...
MalaCardsi
SETD2
MIMi144700, phenotype
601626, phenotype
613065, phenotype
616831, phenotype

Open Targets

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OpenTargetsi
ENSG00000181555

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
821, Sotos syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA143485612

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9BYW2, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3108647

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SETD2

Domain mapping of disease mutations (DMDM)

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DMDMi
296452963

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002523671 – 2564Histone-lysine N-methyltransferase SETD2Add BLAST2564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei131PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei422PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei626PhosphothreonineCombined sources1
Cross-linki637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei698PhosphoserineBy similarity1
Modified residuei708PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Cross-linki776Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1228PhosphoserineCombined sources1
Modified residuei1413PhosphoserineBy similarity1
Modified residuei1415PhosphoserineBy similarity1
Modified residuei1417PhosphoserineBy similarity1
Modified residuei1696PhosphoserineCombined sources1
Modified residuei1844PhosphoserineBy similarity1
Modified residuei1845PhosphoserineBy similarity1
Modified residuei1853PhosphothreonineCombined sources1
Modified residuei1872PhosphothreonineCombined sources1
Modified residuei1888PhosphoserineCombined sources1
Modified residuei1952PhosphoserineCombined sources1
Modified residuei1980PhosphoserineBy similarity1
Modified residuei1988PhosphoserineBy similarity1
Modified residuei1995PhosphoserineBy similarity1
Modified residuei2080PhosphoserineCombined sources1
Modified residuei2082PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be automethylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BYW2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BYW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BYW2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BYW2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BYW2

PeptideAtlas

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PeptideAtlasi
Q9BYW2

PRoteomics IDEntifications database

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PRIDEi
Q9BYW2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
79730 [Q9BYW2-1]
79731 [Q9BYW2-2]
79732 [Q9BYW2-3]

2D gel databases

USC-OGP 2-DE database

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OGPi
Q9BYW2

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q9BYW2, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BYW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BYW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000181555, Expressed in oviduct epithelium and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BYW2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BYW2, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000181555, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Specifically interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A): binds to CTD heptad repeats doubly phosphorylated on 'Ser-2' and 'Ser-5' of each heptad (PubMed:16118227, PubMed:16314571).

Interacts with HTT (PubMed:11461154, PubMed:9700202, PubMed:10958656).

Interacts with IWS1 (PubMed:19141475).

Interacts with p53/TP53; leading to regulate p53/TP53 target genes (PubMed:18585004).

Component of a complex with HNRNPL (PubMed:19332550).

Interacts with TUBA1A; the interaction is independent on alpha-tubulin acetylation on 'Lys-40' (PubMed:27518565).

Interacts with STAT1 (PubMed:28753426).

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
118845, 106 interactors

Protein interaction database and analysis system

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IntActi
Q9BYW2, 37 interactors

Molecular INTeraction database

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MINTi
Q9BYW2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000386759

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9BYW2

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9BYW2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12564
Legend: HelixTurnBeta strandPDB Structure known for this area
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3D structure databases

AlphaFold Protein Structure Database

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AlphaFoldDBi
Q9BYW2

Biological Magnetic Resonance Data Bank

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BMRBi
Q9BYW2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BYW2

Database of comparative protein structure models

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ModBasei
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Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
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Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9BYW2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1494 – 1548AWSPROSITE-ProRule annotationAdd BLAST55
Domaini1550 – 1667SETPROSITE-ProRule annotationAdd BLAST118
Domaini1674 – 1690Post-SETPROSITE-ProRule annotationAdd BLAST17
Domaini2389 – 2422WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni180 – 211DisorderedSequence analysisAdd BLAST32
Regioni272 – 561DisorderedSequence analysisAdd BLAST290
Regioni607 – 626DisorderedSequence analysisAdd BLAST20
Regioni964 – 995DisorderedSequence analysisAdd BLAST32
Regioni1036 – 1101DisorderedSequence analysisAdd BLAST66
Regioni1133 – 1233DisorderedSequence analysisAdd BLAST101
Regioni1264 – 1352DisorderedSequence analysisAdd BLAST89
Regioni1393 – 1443DisorderedSequence analysisAdd BLAST51
Regioni1418 – 1714Interaction with TUBA1A1 PublicationAdd BLAST297
Regioni1560 – 1562S-adenosyl-L-methionine bindingCombined sources3 Publications3
Regioni1603 – 1605S-adenosyl-L-methionine bindingCombined sources3 Publications3
Regioni1628 – 1629S-adenosyl-L-methionine bindingCombined sources3 Publications2
Regioni1831 – 1872DisorderedSequence analysisAdd BLAST42
Regioni1921 – 2142DisorderedSequence analysisAdd BLAST222
Regioni2137 – 2366Low charge region1 PublicationAdd BLAST230
Regioni2439 – 2465DisorderedSequence analysisAdd BLAST27
Regioni2457 – 2564Interaction with POLR2A1 PublicationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2117 – 2146Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi185 – 201Pro residuesSequence analysisAdd BLAST17
Compositional biasi276 – 297Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi298 – 327Polar residuesSequence analysisAdd BLAST30
Compositional biasi340 – 411Basic and acidic residuesSequence analysisAdd BLAST72
Compositional biasi424 – 471Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi486 – 526Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi544 – 560Polar residuesSequence analysisAdd BLAST17
Compositional biasi967 – 993Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1061 – 1094Polar residuesSequence analysisAdd BLAST34
Compositional biasi1140 – 1154Polar residuesSequence analysisAdd BLAST15
Compositional biasi1164 – 1179Polar residuesSequence analysisAdd BLAST16
Compositional biasi1211 – 1233Polar residuesSequence analysisAdd BLAST23
Compositional biasi1393 – 1432Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1831 – 1867Polar residuesSequence analysisAdd BLAST37
Compositional biasi1924 – 1949Polar residuesSequence analysisAdd BLAST