Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 2, facilitated glucose transporter member 11

Gene

SLC2A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.1 Publication

Caution

Has been described as GLUT10 in literature, but this gene name has already been used for SLC2A10.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.1.1.44 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 11
Alternative name(s):
Glucose transporter type 10
Short name:
GLUT-10
Glucose transporter type 11
Short name:
GLUT-11
Gene namesi
Name:SLC2A11
Synonyms:GLUT10, GLUT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000133460.19
HGNCiHGNC:14239 SLC2A11
MIMi610367 gene
neXtProtiNX_Q9BYW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 61ExtracellularSequence analysisAdd BLAST29
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 97CytoplasmicSequence analysisAdd BLAST15
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 128ExtracellularSequence analysis10
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 157CytoplasmicSequence analysis8
Transmembranei158 – 178Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini179 – 187ExtracellularSequence analysis9
Transmembranei188 – 208Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini209 – 273CytoplasmicSequence analysisAdd BLAST65
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 311ExtracellularSequence analysisAdd BLAST17
Transmembranei312 – 332Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini333 – 338CytoplasmicSequence analysis6
Transmembranei339 – 359Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini360 – 364ExtracellularSequence analysis5
Transmembranei365 – 385Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini386 – 408CytoplasmicSequence analysisAdd BLAST23
Transmembranei409 – 429Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini430 – 435ExtracellularSequence analysis6
Transmembranei436 – 456Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini457 – 496CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi66035
OpenTargetsiENSG00000133460
PharmGKBiPA37861

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMutaiSLC2A11
DMDMi17366685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503801 – 496Solute carrier family 2, facilitated glucose transporter member 11Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BYW1
PeptideAtlasiQ9BYW1
PRIDEiQ9BYW1
ProteomicsDBi79727
79728 [Q9BYW1-2]
79729 [Q9BYW1-3]

PTM databases

iPTMnetiQ9BYW1
PhosphoSitePlusiQ9BYW1

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000133460 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SLC2A11
ExpressionAtlasiQ9BYW1 baseline and differential
GenevisibleiQ9BYW1 HS

Organism-specific databases

HPAiHPA042960
HPA071184

Interactioni

Protein-protein interaction databases

BioGridi122454, 1 interactor
STRINGi9606.ENSP00000381399

Structurei

3D structure databases

ProteinModelPortaliQ9BYW1
SMRiQ9BYW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiQ9BYW1
KOiK08148
PhylomeDBiQ9BYW1
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BYW1-1) [UniParc]FASTAAdd to basket
Also known as: GLUT11

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW
60 70 80 90 100
QARTGEPLPD HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV
110 120 130 140 150
NNIFVVSAAI LFGFSRKAGS FEMIMLGRLL VGVNAGVSMN IQPMYLGESA
160 170 180 190 200
PKELRGAVAM SSAIFTALGI VMGQVVGLRE LLGGPQAWPL LLASCLVPGA
210 220 230 240 250
LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA GELEELEEER
260 270 280 290 300
AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF
310 320 330 340 350
RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC
360 370 380 390 400
WGSIFTVALC LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD
410 420 430 440 450
QMARPAACMV CGALMWIMLI LVGLGFPFIM EALSHFLYVP FLGVCVCGAI
460 470 480 490
YTGLFLPETK GKTFQEISKE LHRLNFPRRA QGPTWRSLEV IQSTEL
Length:496
Mass (Da):53,703
Last modified:June 1, 2001 - v1
Checksum:i55FFEA82C7007D6D
GO
Isoform 2 (identifier: Q9BYW1-2) [UniParc]FASTAAdd to basket
Also known as: GLUT11-s

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM
     179-245: RELLGGPQAW...SGDLAGELEE → STTAATGLRG...SGQCHGALRE
     246-496: Missing.

Show »
Length:242
Mass (Da):25,022
Checksum:i195731E90310ED9E
GO
Isoform 3 (identifier: Q9BYW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM

Show »
Length:499
Mass (Da):54,015
Checksum:i7AFD0B6773A935AF
GO
Isoform 4 (identifier: Q9BYW1-4) [UniParc]FASTAAdd to basket
Also known as: GLUT11-L

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MEDELEPSLRPRTQ

Show »
Length:503
Mass (Da):54,488
Checksum:i61EC2EAB693FB88B
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X018A0A087X018_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
535Annotation score:
B5MCM7B5MCM7_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
179Annotation score:
F8WB79F8WB79_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
222Annotation score:
F8WFA8F8WFA8_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
98Annotation score:
B5MCM1B5MCM1_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
104Annotation score:
F8WCV3F8WCV3_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
105Annotation score:
F8WBG9F8WBG9_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
113Annotation score:
F8WBK0F8WBK0_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
48Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229A → E in AAL39061 (PubMed:12175779).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04670460D → N. Corresponds to variant dbSNP:rs7292659Ensembl.1
Natural variantiVAR_046705232R → Q2 PublicationsCorresponds to variant dbSNP:rs9608213Ensembl.1
Natural variantiVAR_061881301R → Q. Corresponds to variant dbSNP:rs36015336Ensembl.1
Natural variantiVAR_046706420I → F. Corresponds to variant dbSNP:rs34096096Ensembl.1
Natural variantiVAR_061882469K → E. Corresponds to variant dbSNP:rs60882514Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0062931 – 7MRALRRL → MLHALLRSRM in isoform 2 and isoform 3. 1 Publication7
Alternative sequenceiVSP_0456501 – 7MRALRRL → MEDELEPSLRPRTQ in isoform 4. 2 Publications7
Alternative sequenceiVSP_006294179 – 245RELLG…GELEE → STTAATGLRGLGRGAGGAGG GARCLPGLPCPAPMGAVPAS GPEETGDKPRGSGQCHGALR E in isoform 2. CuratedAdd BLAST67
Alternative sequenceiVSP_006295246 – 496Missing in isoform 2. CuratedAdd BLAST251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271290 mRNA Translation: CAC29020.1
AB049214 Genomic DNA Translation: BAB68410.1
AB067443 Genomic DNA Translation: BAB83505.1
AF443201 mRNA Translation: AAL39061.1
CR456373 mRNA Translation: CAG30259.1
AK075467 mRNA Translation: BAC11637.1
AK314502 mRNA Translation: BAG37102.1
AP000350 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59618.1
BC100808 mRNA Translation: AAI00809.1
CCDSiCCDS13818.1 [Q9BYW1-4]
CCDS33616.1 [Q9BYW1-3]
CCDS46673.1 [Q9BYW1-1]
RefSeqiNP_001020109.1, NM_001024938.3 [Q9BYW1-1]
NP_001020110.1, NM_001024939.3 [Q9BYW1-3]
NP_110434.3, NM_030807.4 [Q9BYW1-4]
UniGeneiHs.661910
Hs.743282

Genome annotation databases

EnsembliENST00000316185; ENSP00000326748; ENSG00000133460 [Q9BYW1-3]
ENST00000345044; ENSP00000342542; ENSG00000133460 [Q9BYW1-1]
ENST00000398356; ENSP00000381399; ENSG00000133460 [Q9BYW1-4]
ENST00000618502; ENSP00000482495; ENSG00000275744 [Q9BYW1-1]
ENST00000619254; ENSP00000480839; ENSG00000275744 [Q9BYW1-4]
ENST00000620942; ENSP00000483163; ENSG00000275744 [Q9BYW1-3]
GeneIDi66035
KEGGihsa:66035
UCSCiuc002zym.6 human [Q9BYW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271290 mRNA Translation: CAC29020.1
AB049214 Genomic DNA Translation: BAB68410.1
AB067443 Genomic DNA Translation: BAB83505.1
AF443201 mRNA Translation: AAL39061.1
CR456373 mRNA Translation: CAG30259.1
AK075467 mRNA Translation: BAC11637.1
AK314502 mRNA Translation: BAG37102.1
AP000350 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59618.1
BC100808 mRNA Translation: AAI00809.1
CCDSiCCDS13818.1 [Q9BYW1-4]
CCDS33616.1 [Q9BYW1-3]
CCDS46673.1 [Q9BYW1-1]
RefSeqiNP_001020109.1, NM_001024938.3 [Q9BYW1-1]
NP_001020110.1, NM_001024939.3 [Q9BYW1-3]
NP_110434.3, NM_030807.4 [Q9BYW1-4]
UniGeneiHs.661910
Hs.743282

3D structure databases

ProteinModelPortaliQ9BYW1
SMRiQ9BYW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122454, 1 interactor
STRINGi9606.ENSP00000381399

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBi2.A.1.1.44 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9BYW1
PhosphoSitePlusiQ9BYW1

Polymorphism and mutation databases

BioMutaiSLC2A11
DMDMi17366685

Proteomic databases

PaxDbiQ9BYW1
PeptideAtlasiQ9BYW1
PRIDEiQ9BYW1
ProteomicsDBi79727
79728 [Q9BYW1-2]
79729 [Q9BYW1-3]

Protocols and materials databases

DNASUi66035
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316185; ENSP00000326748; ENSG00000133460 [Q9BYW1-3]
ENST00000345044; ENSP00000342542; ENSG00000133460 [Q9BYW1-1]
ENST00000398356; ENSP00000381399; ENSG00000133460 [Q9BYW1-4]
ENST00000618502; ENSP00000482495; ENSG00000275744 [Q9BYW1-1]
ENST00000619254; ENSP00000480839; ENSG00000275744 [Q9BYW1-4]
ENST00000620942; ENSP00000483163; ENSG00000275744 [Q9BYW1-3]
GeneIDi66035
KEGGihsa:66035
UCSCiuc002zym.6 human [Q9BYW1-1]

Organism-specific databases

CTDi66035
DisGeNETi66035
EuPathDBiHostDB:ENSG00000133460.19
GeneCardsiSLC2A11
HGNCiHGNC:14239 SLC2A11
HPAiHPA042960
HPA071184
MIMi610367 gene
neXtProtiNX_Q9BYW1
OpenTargetsiENSG00000133460
PharmGKBiPA37861
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiQ9BYW1
KOiK08148
PhylomeDBiQ9BYW1
TreeFamiTF313762

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Miscellaneous databases

ChiTaRSiSLC2A11 human
GeneWikiiSLC2A11
GenomeRNAii66035
PROiPR:Q9BYW1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133460 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SLC2A11
ExpressionAtlasiQ9BYW1 baseline and differential
GenevisibleiQ9BYW1 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR11_HUMAN
AccessioniPrimary (citable) accession number: Q9BYW1
Secondary accession number(s): E9PH55
, Q542Y4, Q6ICJ5, Q8WXF9, Q8WYM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again