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Protein

Solute carrier family 2, facilitated glucose transporter member 11

Gene

SLC2A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitative glucose transporter.1 Publication

Caution

Has been described as GLUT10 in literature, but this gene name has already been used for SLC2A10.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189200 Cellular hexose transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.1.44 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 11
Alternative name(s):
Glucose transporter type 10
Short name:
GLUT-10
Glucose transporter type 11
Short name:
GLUT-11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC2A11
Synonyms:GLUT10, GLUT11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000133460.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14239 SLC2A11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610367 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 61ExtracellularSequence analysisAdd BLAST29
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 97CytoplasmicSequence analysisAdd BLAST15
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 128ExtracellularSequence analysis10
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 157CytoplasmicSequence analysis8
Transmembranei158 – 178Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini179 – 187ExtracellularSequence analysis9
Transmembranei188 – 208Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini209 – 273CytoplasmicSequence analysisAdd BLAST65
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 311ExtracellularSequence analysisAdd BLAST17
Transmembranei312 – 332Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini333 – 338CytoplasmicSequence analysis6
Transmembranei339 – 359Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini360 – 364ExtracellularSequence analysis5
Transmembranei365 – 385Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini386 – 408CytoplasmicSequence analysisAdd BLAST23
Transmembranei409 – 429Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini430 – 435ExtracellularSequence analysis6
Transmembranei436 – 456Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini457 – 496CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
66035

Open Targets

More...
OpenTargetsi
ENSG00000133460

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37861

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC2A11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17366685

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503801 – 496Solute carrier family 2, facilitated glucose transporter member 11Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYW1

PeptideAtlas

More...
PeptideAtlasi
Q9BYW1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYW1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79727
79728 [Q9BYW1-2]
79729 [Q9BYW1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133460 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC2A11

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BYW1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYW1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042960
HPA071184

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122454, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381399

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BYW1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0569 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202871

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG014816

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYW1

KEGG Orthology (KO)

More...
KOi
K08148

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYW1

TreeFam database of animal gene trees

More...
TreeFami
TF313762

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00171 SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00879 SP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYW1-1) [UniParc]FASTAAdd to basket
Also known as: GLUT11

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW
60 70 80 90 100
QARTGEPLPD HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV
110 120 130 140 150
NNIFVVSAAI LFGFSRKAGS FEMIMLGRLL VGVNAGVSMN IQPMYLGESA
160 170 180 190 200
PKELRGAVAM SSAIFTALGI VMGQVVGLRE LLGGPQAWPL LLASCLVPGA
210 220 230 240 250
LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA GELEELEEER
260 270 280 290 300
AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF
310 320 330 340 350
RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC
360 370 380 390 400
WGSIFTVALC LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD
410 420 430 440 450
QMARPAACMV CGALMWIMLI LVGLGFPFIM EALSHFLYVP FLGVCVCGAI
460 470 480 490
YTGLFLPETK GKTFQEISKE LHRLNFPRRA QGPTWRSLEV IQSTEL
Length:496
Mass (Da):53,703
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55FFEA82C7007D6D
GO
Isoform 2 (identifier: Q9BYW1-2) [UniParc]FASTAAdd to basket
Also known as: GLUT11-s

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM
     179-245: RELLGGPQAW...SGDLAGELEE → STTAATGLRG...SGQCHGALRE
     246-496: Missing.

Show »
Length:242
Mass (Da):25,022
Checksum:i195731E90310ED9E
GO
Isoform 3 (identifier: Q9BYW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM

Show »
Length:499
Mass (Da):54,015
Checksum:i7AFD0B6773A935AF
GO
Isoform 4 (identifier: Q9BYW1-4) [UniParc]FASTAAdd to basket
Also known as: GLUT11-L

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MEDELEPSLRPRTQ

Show »
Length:503
Mass (Da):54,488
Checksum:i61EC2EAB693FB88B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X018A0A087X018_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
535Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCM7B5MCM7_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB79F8WB79_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCM1B5MCM1_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFA8F8WFA8_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCV3F8WCV3_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBG9F8WBG9_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBK0F8WBK0_HUMAN
Solute carrier family 2, facilitate...
SLC2A11
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229A → E in AAL39061 (PubMed:12175779).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04670460D → N. Corresponds to variant dbSNP:rs7292659Ensembl.1
Natural variantiVAR_046705232R → Q2 PublicationsCorresponds to variant dbSNP:rs9608213Ensembl.1
Natural variantiVAR_061881301R → Q. Corresponds to variant dbSNP:rs36015336Ensembl.1
Natural variantiVAR_046706420I → F. Corresponds to variant dbSNP:rs34096096Ensembl.1
Natural variantiVAR_061882469K → E. Corresponds to variant dbSNP:rs60882514Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0062931 – 7MRALRRL → MLHALLRSRM in isoform 2 and isoform 3. 1 Publication7
Alternative sequenceiVSP_0456501 – 7MRALRRL → MEDELEPSLRPRTQ in isoform 4. 2 Publications7
Alternative sequenceiVSP_006294179 – 245RELLG…GELEE → STTAATGLRGLGRGAGGAGG GARCLPGLPCPAPMGAVPAS GPEETGDKPRGSGQCHGALR E in isoform 2. CuratedAdd BLAST67
Alternative sequenceiVSP_006295246 – 496Missing in isoform 2. CuratedAdd BLAST251

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ271290 mRNA Translation: CAC29020.1
AB049214 Genomic DNA Translation: BAB68410.1
AB067443 Genomic DNA Translation: BAB83505.1
AF443201 mRNA Translation: AAL39061.1
CR456373 mRNA Translation: CAG30259.1
AK075467 mRNA Translation: BAC11637.1
AK314502 mRNA Translation: BAG37102.1
AP000350 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59618.1
BC100808 mRNA Translation: AAI00809.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13818.1 [Q9BYW1-4]
CCDS33616.1 [Q9BYW1-3]
CCDS46673.1 [Q9BYW1-1]

NCBI Reference Sequences

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RefSeqi
NP_001020109.1, NM_001024938.3 [Q9BYW1-1]
NP_001020110.1, NM_001024939.3 [Q9BYW1-3]
NP_110434.3, NM_030807.4 [Q9BYW1-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.661910
Hs.743282

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000316185; ENSP00000326748; ENSG00000133460 [Q9BYW1-3]
ENST00000345044; ENSP00000342542; ENSG00000133460 [Q9BYW1-1]
ENST00000398356; ENSP00000381399; ENSG00000133460 [Q9BYW1-4]
ENST00000618502; ENSP00000482495; ENSG00000275744 [Q9BYW1-1]
ENST00000619254; ENSP00000480839; ENSG00000275744 [Q9BYW1-4]
ENST00000620942; ENSP00000483163; ENSG00000275744 [Q9BYW1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
66035

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:66035

UCSC genome browser

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UCSCi
uc002zym.6 human [Q9BYW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271290 mRNA Translation: CAC29020.1
AB049214 Genomic DNA Translation: BAB68410.1
AB067443 Genomic DNA Translation: BAB83505.1
AF443201 mRNA Translation: AAL39061.1
CR456373 mRNA Translation: CAG30259.1
AK075467 mRNA Translation: BAC11637.1
AK314502 mRNA Translation: BAG37102.1
AP000350 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59618.1
BC100808 mRNA Translation: AAI00809.1
CCDSiCCDS13818.1 [Q9BYW1-4]
CCDS33616.1 [Q9BYW1-3]
CCDS46673.1 [Q9BYW1-1]
RefSeqiNP_001020109.1, NM_001024938.3 [Q9BYW1-1]
NP_001020110.1, NM_001024939.3 [Q9BYW1-3]
NP_110434.3, NM_030807.4 [Q9BYW1-4]
UniGeneiHs.661910
Hs.743282

3D structure databases

ProteinModelPortaliQ9BYW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122454, 1 interactor
STRINGi9606.ENSP00000381399

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBi2.A.1.1.44 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9BYW1
PhosphoSitePlusiQ9BYW1

Polymorphism and mutation databases

BioMutaiSLC2A11
DMDMi17366685

Proteomic databases

PaxDbiQ9BYW1
PeptideAtlasiQ9BYW1
PRIDEiQ9BYW1
ProteomicsDBi79727
79728 [Q9BYW1-2]
79729 [Q9BYW1-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
66035
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316185; ENSP00000326748; ENSG00000133460 [Q9BYW1-3]
ENST00000345044; ENSP00000342542; ENSG00000133460 [Q9BYW1-1]
ENST00000398356; ENSP00000381399; ENSG00000133460 [Q9BYW1-4]
ENST00000618502; ENSP00000482495; ENSG00000275744 [Q9BYW1-1]
ENST00000619254; ENSP00000480839; ENSG00000275744 [Q9BYW1-4]
ENST00000620942; ENSP00000483163; ENSG00000275744 [Q9BYW1-3]
GeneIDi66035
KEGGihsa:66035
UCSCiuc002zym.6 human [Q9BYW1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
66035
DisGeNETi66035
EuPathDBiHostDB:ENSG00000133460.19

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC2A11
HGNCiHGNC:14239 SLC2A11
HPAiHPA042960
HPA071184
MIMi610367 gene
neXtProtiNX_Q9BYW1
OpenTargetsiENSG00000133460
PharmGKBiPA37861

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000161061
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiQ9BYW1
KOiK08148
PhylomeDBiQ9BYW1
TreeFamiTF313762

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC2A11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC2A11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
66035

Protein Ontology

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PROi
PR:Q9BYW1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133460 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SLC2A11
ExpressionAtlasiQ9BYW1 baseline and differential
GenevisibleiQ9BYW1 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYW1
Secondary accession number(s): E9PH55
, Q542Y4, Q6ICJ5, Q8WXF9, Q8WYM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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