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Protein

Transcription regulator protein BACH2

Gene

BACH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9BYV9
SIGNORiQ9BYV9

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH2
Alternative name(s):
BTB and CNC homolog 2
Gene namesi
Name:BACH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112182.14
HGNCiHGNC:14078 BACH2
MIMi605394 gene
neXtProtiNX_Q9BYV9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi521S → A: Leads to nuclear accumulation. 1 Publication1

Organism-specific databases

DisGeNETi60468
OpenTargetsiENSG00000112182
PharmGKBiPA25235

Polymorphism and mutation databases

BioMutaiBACH2
DMDMi17433037

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764561 – 841Transcription regulator protein BACH2Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20Interchain; redox-active1 Publication
Modified residuei315PhosphoserineBy similarity1
Cross-linki382Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei521Phosphoserine; by RPS6KB11 Publication1

Post-translational modificationi

Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.1 Publication
The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.1 Publication

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9BYV9
PaxDbiQ9BYV9
PeptideAtlasiQ9BYV9
PRIDEiQ9BYV9
ProteomicsDBi79726

PTM databases

iPTMnetiQ9BYV9
PhosphoSitePlusiQ9BYV9

Expressioni

Tissue specificityi

B-cell specific.

Gene expression databases

BgeeiENSG00000112182
CleanExiHS_BACH2
ExpressionAtlasiQ9BYV9 baseline and differential
GenevisibleiQ9BYV9 HS

Organism-specific databases

HPAiHPA051384
HPA058384

Interactioni

Subunit structurei

Homodimer; disulfide-linked (PubMed:22194330). Heterodimer of BACH2 and Maf-related transcription factors (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi121913, 15 interactors
IntActiQ9BYV9, 43 interactors
STRINGi9606.ENSP00000257749

Structurei

Secondary structure

1841
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 15Combined sources4
Helixi19 – 33Combined sources15
Beta strandi39 – 43Combined sources5
Beta strandi46 – 50Combined sources5
Helixi52 – 58Combined sources7
Helixi60 – 66Combined sources7
Beta strandi75 – 77Combined sources3
Helixi84 – 94Combined sources11
Beta strandi97 – 101Combined sources5
Turni103 – 105Combined sources3
Helixi106 – 116Combined sources11
Beta strandi118 – 120Combined sources3

3D structure databases

ProteinModelPortaliQ9BYV9
SMRiQ9BYV9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYV9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 103BTBPROSITE-ProRule annotationAdd BLAST67
Domaini646 – 709bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 667Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni671 – 678Leucine-zipperPROSITE-ProRule annotation8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi821 – 841Nuclear export signalBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 169Poly-Glu8

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISV4 Eukaryota
ENOG410ZDVB LUCA
GeneTreeiENSGT00920000148991
HOGENOMiHOG000231712
HOVERGENiHBG050655
InParanoidiQ9BYV9
KOiK09042
OMAiIKVCPRS
OrthoDBiEOG091G02EB
PhylomeDBiQ9BYV9
TreeFamiTF326681

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR011333 SKP1/BTB/POZ_sf
IPR008917 TF_DNA-bd_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BYV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA
60 70 80 90 100
HRAVLAACSE YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL
110 120 130 140 150
LSRENIREVI RCAEFLRMHN LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ
160 170 180 190 200
RPHEDCENSA GEEEDEEEET MDSETAKMAC PRDQMLPEPI SFEAAAIPVA
210 220 230 240 250
EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK NVYNASSHST
260 270 280 290 300
SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA
310 320 330 340 350
KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS
360 370 380 390 400
VELSGLPSTS QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK
410 420 430 440 450
EVSNFTMGSP LRGPGLEALC KQEGELDRRS VIFSSSACDQ VSTSVHSYSG
460 470 480 490 500
VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY SHGGLMADHL PGRMRPNTSC
510 520 530 540 550
PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL PLCEFSSSPC
560 570 580 590 600
SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD
610 620 630 640 650
SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV
660 670 680 690 700
RRRSKNRIAA QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG
710 720 730 740 750
ELLDNFSCLS QEVCRDIQSP EQIQALHRYC PVLRPMDLPT ASSINPAPLG
760 770 780 790 800
AEQNIAASQC AVGENVPCCL EPGAAPPGPP WAPSNTSENC TSGRRLEGTD
810 820 830 840
PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY T
Length:841
Mass (Da):92,537
Last modified:June 1, 2001 - v1
Checksum:i4E926AC325952A93
GO

Sequence cautioni

The sequence BAD92126 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75V → A in BAD92126 (Ref. 3) Curated1
Sequence conflicti291L → F in AAK48898 (PubMed:10949928).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033535418A → T. Corresponds to variant dbSNP:rs34335140Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357835 mRNA Translation: AAK48898.1
AJ271878 mRNA Translation: CAC28130.1
AB208889 mRNA Translation: BAD92126.1 Different initiation.
AL353692 Genomic DNA No translation available.
AL121787 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48530.1
CH471051 Genomic DNA Translation: EAW48531.1
CH471051 Genomic DNA Translation: EAW48532.1
CH471051 Genomic DNA Translation: EAW48533.1
CH471051 Genomic DNA Translation: EAW48534.1
CCDSiCCDS5026.1
RefSeqiNP_001164265.1, NM_001170794.1
NP_068585.1, NM_021813.3
XP_005248816.1, XM_005248759.4
XP_011534341.1, XM_011536039.2
XP_011534342.1, XM_011536040.2
XP_016866654.1, XM_017011165.1
XP_016866655.1, XM_017011166.1
UniGeneiHs.269764

Genome annotation databases

EnsembliENST00000257749; ENSP00000257749; ENSG00000112182
ENST00000343122; ENSP00000345642; ENSG00000112182
ENST00000537989; ENSP00000437473; ENSG00000112182
GeneIDi60468
KEGGihsa:60468
UCSCiuc003pnw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBACH2_HUMAN
AccessioniPrimary (citable) accession number: Q9BYV9
Secondary accession number(s): E1P518
, Q59H70, Q5T793, Q9NTS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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