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Entry version 173 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Transcription regulator protein BACH2

Gene

BACH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that acts as repressor or activator (By similarity).

Binds to Maf recognition elements (MARE) (By similarity).

Plays an important role in coordinating transcription activation and repression by MAFK (By similarity).

Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862).

Positively regulates the nuclear import of actin (By similarity).

Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9BYV9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BYV9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BYV9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription regulator protein BACH2
Alternative name(s):
BTB and CNC homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BACH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:14078, BACH2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605394, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYV9

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000112182.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 60 (IMD60)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant primary immunologic disorder characterized by intestinal inflammation, recurrent sino-pulmonary infections, impaired lymphocyte maturation, and variably decreased immunoglobulin production.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08221624L → P in IMD60; impairs protein stability; the mutant is unsoluble and forms multiple aggregates. 1 Publication1
Natural variantiVAR_082217788E → K in IMD60; unknown pathological significance; severely decreased localization in the nucleus; the mutant aggregates in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs757652995EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi521S → A: Leads to nuclear accumulation. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
60468

MalaCards human disease database

More...
MalaCardsi
BACH2
MIMi618394, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112182

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25235

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYV9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BACH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17433037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000764561 – 841Transcription regulator protein BACH2Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi20Interchain; redox-active1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei315PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki382Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei521Phosphoserine; by RPS6KB11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.1 Publication
The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.1 Publication

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BYV9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BYV9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BYV9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYV9

PeptideAtlas

More...
PeptideAtlasi
Q9BYV9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYV9

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
79726

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9BYV9, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

B-cell specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112182, Expressed in neocortex and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BYV9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYV9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112182, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (PubMed:22194330). Heterodimer of BACH2 and Maf-related transcription factors (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9BYV9
With#Exp.IntAct
ANKRD55 [Q3KP44]3EBI-1642333,EBI-14493093
AP1M1 [Q9BXS5]3EBI-1642333,EBI-541426
BAHD1 [Q8TBE0]3EBI-1642333,EBI-742750
BATF3 [Q9NR55]5EBI-1642333,EBI-10312707
CBX8 [Q9HC52]3EBI-1642333,EBI-712912
CCDC185 [Q8N715]3EBI-1642333,EBI-740814
CENPP [Q6IPU0]3EBI-1642333,EBI-10250303
CFAP58 [Q5T655]3EBI-1642333,EBI-10245749
CTSZ [Q9UBR2]3EBI-1642333,EBI-8636823
CWF19L2 [Q2TBE0]3EBI-1642333,EBI-5453285
ELOA [Q14241]3EBI-1642333,EBI-742350
ENPP7 [Q6UWV6]3EBI-1642333,EBI-12047821
FAM161A [Q3B820]3EBI-1642333,EBI-719941
FARS2 [O95363]3EBI-1642333,EBI-2513774
FOSL2 [P15408]4EBI-1642333,EBI-3893419
HMG20A [Q9NP66]3EBI-1642333,EBI-740641
INSYN2A [Q6ZSG2]3EBI-1642333,EBI-12146621
KAT5 [Q92993]3EBI-1642333,EBI-399080
LUZP4 [Q9P127]3EBI-1642333,EBI-10198848
MAFF [Q9ULX9]3EBI-1642333,EBI-721128
MAFG [O15525]5EBI-1642333,EBI-713514
MAFK [O60675]3EBI-1642333,EBI-2559512
MCRS1 [Q96EZ8]3EBI-1642333,EBI-348259
MLX - isoform Beta [Q9UH92-3]3EBI-1642333,EBI-8852072
NXF1 [Q9UBU9]3EBI-1642333,EBI-398874
PSMC5 [P62195]3EBI-1642333,EBI-357745
RPL9P9 [P32969]3EBI-1642333,EBI-358122
RPP25 [Q9BUL9]3EBI-1642333,EBI-366570
SCNM1 [Q9BWG6]3EBI-1642333,EBI-748391
SLC43A1 [O75387]3EBI-1642333,EBI-9661945
SMYD1 [Q8NB12]3EBI-1642333,EBI-8463848
TCEA2 [Q15560]3EBI-1642333,EBI-710310
TRAF4 [Q9BUZ4]3EBI-1642333,EBI-3650647
TRIM42 [Q8IWZ5]3EBI-1642333,EBI-5235829
TSHZ2 [Q9NRE2]3EBI-1642333,EBI-10687282
TULP3 [O75386]4EBI-1642333,EBI-5357290
ZBTB24 [O43167]3EBI-1642333,EBI-744471
ZBTB34 [Q8NCN2]3EBI-1642333,EBI-11317716
ZNF124 [Q15973]3EBI-1642333,EBI-2555767
ZNF438 [Q7Z4V0]3EBI-1642333,EBI-11962468
ZNF774 [Q6NX45]3EBI-1642333,EBI-10251462
ZNF792 [Q3KQV3]3EBI-1642333,EBI-10240849

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121913, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BYV9, 48 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000257749

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYV9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1841
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BYV9

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BYV9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 103BTBPROSITE-ProRule annotationAdd BLAST67
Domaini646 – 709bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 173DisorderedSequence analysisAdd BLAST21
Regioni204 – 226DisorderedSequence analysisAdd BLAST23
Regioni246 – 329DisorderedSequence analysisAdd BLAST84
Regioni583 – 610DisorderedSequence analysisAdd BLAST28
Regioni651 – 667Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni671 – 678Leucine-zipperPROSITE-ProRule annotation8
Regioni777 – 816DisorderedSequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi821 – 841Nuclear export signalBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi246 – 270Polar residuesSequence analysisAdd BLAST25
Compositional biasi296 – 310Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi583 – 604Polar residuesSequence analysisAdd BLAST22
Compositional biasi784 – 798Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3863, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015243_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYV9

Identification of Orthologs from Complete Genome Data

More...
OMAi
QIKCEPS

Database of Orthologous Groups

More...
OrthoDBi
521871at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYV9

TreeFam database of animal gene trees

More...
TreeFami
TF326681

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14719, bZIP_BACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210, BTB/POZ_dom
IPR004827, bZIP
IPR043321, bZIP_BACH
IPR004826, bZIP_Maf
IPR011333, SKP1/BTB/POZ_sf
IPR008917, TF_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651, BTB, 1 hit
PF03131, bZIP_Maf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338, BRLZ, 1 hit
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47454, SSF47454, 1 hit
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097, BTB, 1 hit
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BYV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA
60 70 80 90 100
HRAVLAACSE YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL
110 120 130 140 150
LSRENIREVI RCAEFLRMHN LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ
160 170 180 190 200
RPHEDCENSA GEEEDEEEET MDSETAKMAC PRDQMLPEPI SFEAAAIPVA
210 220 230 240 250
EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK NVYNASSHST
260 270 280 290 300
SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA
310 320 330 340 350
KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS
360 370 380 390 400
VELSGLPSTS QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK
410 420 430 440 450
EVSNFTMGSP LRGPGLEALC KQEGELDRRS VIFSSSACDQ VSTSVHSYSG
460 470 480 490 500
VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY SHGGLMADHL PGRMRPNTSC
510 520 530 540 550
PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL PLCEFSSSPC
560 570 580 590 600
SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD
610 620 630 640 650
SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV
660 670 680 690 700
RRRSKNRIAA QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG
710 720 730 740 750
ELLDNFSCLS QEVCRDIQSP EQIQALHRYC PVLRPMDLPT ASSINPAPLG
760 770 780 790 800
AEQNIAASQC AVGENVPCCL EPGAAPPGPP WAPSNTSENC TSGRRLEGTD
810 820 830 840
PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY T
Length:841
Mass (Da):92,537
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E926AC325952A93
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z6Q0Q7Z6Q0_HUMAN
Transcription regulator protein BAC...
BACH2
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92126 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75V → A in BAD92126 (Ref. 3) Curated1
Sequence conflicti291L → F in AAK48898 (PubMed:10949928).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08221624L → P in IMD60; impairs protein stability; the mutant is unsoluble and forms multiple aggregates. 1 Publication1
Natural variantiVAR_033535418A → T. Corresponds to variant dbSNP:rs34335140EnsemblClinVar.1
Natural variantiVAR_082217788E → K in IMD60; unknown pathological significance; severely decreased localization in the nucleus; the mutant aggregates in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs757652995EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF357835 mRNA Translation: AAK48898.1
AJ271878 mRNA Translation: CAC28130.1
AB208889 mRNA Translation: BAD92126.1 Different initiation.
AL353692 Genomic DNA No translation available.
AL121787 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48530.1
CH471051 Genomic DNA Translation: EAW48531.1
CH471051 Genomic DNA Translation: EAW48532.1
CH471051 Genomic DNA Translation: EAW48533.1
CH471051 Genomic DNA Translation: EAW48534.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5026.1

NCBI Reference Sequences

More...
RefSeqi
NP_001164265.1, NM_001170794.1
NP_068585.1, NM_021813.3
XP_005248816.1, XM_005248759.4
XP_011534341.1, XM_011536039.2
XP_011534342.1, XM_011536040.2
XP_016866654.1, XM_017011165.1
XP_016866655.1, XM_017011166.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257749; ENSP00000257749; ENSG00000112182
ENST00000343122; ENSP00000345642; ENSG00000112182
ENST00000537989; ENSP00000437473; ENSG00000112182

Database of genes from NCBI RefSeq genomes

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GeneIDi
60468

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60468

UCSC genome browser

More...
UCSCi
uc003pnw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357835 mRNA Translation: AAK48898.1
AJ271878 mRNA Translation: CAC28130.1
AB208889 mRNA Translation: BAD92126.1 Different initiation.
AL353692 Genomic DNA No translation available.
AL121787 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48530.1
CH471051 Genomic DNA Translation: EAW48531.1
CH471051 Genomic DNA Translation: EAW48532.1
CH471051 Genomic DNA Translation: EAW48533.1
CH471051 Genomic DNA Translation: EAW48534.1
CCDSiCCDS5026.1
RefSeqiNP_001164265.1, NM_001170794.1
NP_068585.1, NM_021813.3
XP_005248816.1, XM_005248759.4
XP_011534341.1, XM_011536039.2
XP_011534342.1, XM_011536040.2
XP_016866654.1, XM_017011165.1
XP_016866655.1, XM_017011166.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OHUX-ray2.10A/B/C/D/E/F9-129[»]
3OHVX-ray2.20A/B/C/D/E/F9-129[»]
SMRiQ9BYV9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121913, 54 interactors
IntActiQ9BYV9, 48 interactors
STRINGi9606.ENSP00000257749

PTM databases

GlyGeniQ9BYV9, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ9BYV9
PhosphoSitePlusiQ9BYV9

Genetic variation databases

BioMutaiBACH2
DMDMi17433037

Proteomic databases

jPOSTiQ9BYV9
MassIVEiQ9BYV9
MaxQBiQ9BYV9
PaxDbiQ9BYV9
PeptideAtlasiQ9BYV9
PRIDEiQ9BYV9
ProteomicsDBi79726

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31919, 232 antibodies

The DNASU plasmid repository

More...
DNASUi
60468

Genome annotation databases

EnsembliENST00000257749; ENSP00000257749; ENSG00000112182
ENST00000343122; ENSP00000345642; ENSG00000112182
ENST00000537989; ENSP00000437473; ENSG00000112182
GeneIDi60468
KEGGihsa:60468
UCSCiuc003pnw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60468
DisGeNETi60468

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BACH2
HGNCiHGNC:14078, BACH2
HPAiENSG00000112182, Tissue enhanced (lymphoid)
MalaCardsiBACH2
MIMi605394, gene
618394, phenotype
neXtProtiNX_Q9BYV9
OpenTargetsiENSG00000112182
PharmGKBiPA25235
VEuPathDBiHostDB:ENSG00000112182.14

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3863, Eukaryota
GeneTreeiENSGT00940000158228
HOGENOMiCLU_015243_0_0_1
InParanoidiQ9BYV9
OMAiQIKCEPS
OrthoDBi521871at2759
PhylomeDBiQ9BYV9
TreeFamiTF326681

Enzyme and pathway databases

PathwayCommonsiQ9BYV9
SignaLinkiQ9BYV9
SIGNORiQ9BYV9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
60468, 6 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BACH2, human
EvolutionaryTraceiQ9BYV9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BACH2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
60468
PharosiQ9BYV9, Tbio

Protein Ontology

More...
PROi
PR:Q9BYV9
RNActiQ9BYV9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112182, Expressed in neocortex and 209 other tissues
ExpressionAtlasiQ9BYV9, baseline and differential
GenevisibleiQ9BYV9, HS

Family and domain databases

CDDicd14719, bZIP_BACH, 1 hit
Gene3Di3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR004827, bZIP
IPR043321, bZIP_BACH
IPR004826, bZIP_Maf
IPR011333, SKP1/BTB/POZ_sf
IPR008917, TF_DNA-bd_sf
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF03131, bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
SM00225, BTB, 1 hit
SUPFAMiSSF47454, SSF47454, 1 hit
SSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBACH2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYV9
Secondary accession number(s): E1P518
, Q59H70, Q5T793, Q9NTS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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