BCO2

Functionⁱ

Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects.1 Publication

Catalytic activityⁱ

All-trans-beta-carotene + O₂ = all-trans-10'-apo-beta-carotenal + beta-ionone.

Cofactorⁱ

Fe²⁺By similarityNote: Binds 1 Fe²⁺ ion per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	226	Iron; catalyticBy similarity	1
Metal bindingⁱ	286	Iron; catalyticBy similarity	1
Metal bindingⁱ	357	Iron; catalyticBy similarity	1
Metal bindingⁱ	573	Iron; catalyticBy similarity	1

GO - Molecular functionⁱ

beta,beta-carotene-9',10'-cleaving oxygenase activity Source: UniProtKB-EC
beta-carotene 15,15'-monooxygenase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
carotenoid dioxygenase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Source: UniProtKB
Inferred from direct assayⁱ
- 11278918
retinal isomerase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carotene catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 21302131
carotene metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11278918
carotenoid metabolic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21106934
oxidation-reduction process
Source: BHF-UCL
Inferred from direct assayⁱ
- 21302131
regulation of mitochondrial membrane potential
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21106934
regulation of reactive oxygen species metabolic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21106934
retinal metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retinoic acid metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 11278918
retinoid metabolic process Source: Reactome
xanthophyll metabolic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Dioxygenase, Oxidoreductase
Ligand	Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:G66-33846-MONOMER
BRENDAⁱ	1.13.11.71 2681
Reactomeⁱ	R-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta,beta-carotene 9',10'-oxygenase (EC:1.13.11.71) Alternative name(s): B-diox-II Beta-carotene dioxygenase 2
Gene namesⁱ	Name:BCO2 Synonyms:BCDO2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197580.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18503 BCO2
MIMⁱ	611740 gene
neXtProtⁱ	NX_Q9BYV7

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	83875
Open Targets More...OpenTargetsⁱ	ENSG00000197580
PharmGKBⁱ	PA162377424

Polymorphism and mutation databases

BioMutaⁱ	BCO2
DMDMⁱ	308153680

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000143937	1 – 579	Beta,beta-carotene 9',10'-oxygenaseAdd BLAST		579

Proteomic databases

PaxDbⁱ	Q9BYV7
PeptideAtlas More...PeptideAtlasⁱ	Q9BYV7
PRIDEⁱ	Q9BYV7
ProteomicsDBⁱ	79718 79719 [Q9BYV7-2] 79720 [Q9BYV7-4]

PTM databases

iPTMnetⁱ	Q9BYV7
PhosphoSitePlusⁱ	Q9BYV7

Expressionⁱ

Tissue specificityⁱ

Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000197580 Expressed in 158 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_BCO2
ExpressionAtlasⁱ	Q9BYV7 baseline and differential
Genevisibleⁱ	Q9BYV7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039825 HPA040695

HPAⁱ

HPA039825
HPA040695

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000350314

STRINGⁱ

9606.ENSP00000350314

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BYV7
SMRⁱ	Q9BYV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the carotenoid oxygenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1285 Eukaryota COG3670 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044783
HOGENOMⁱ	HOG000232156
HOVERGENⁱ	HBG050679
KEGG Orthology (KO) More...KOⁱ	K10252
OMAⁱ	WEPQYNT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04WW
PhylomeDBⁱ	Q9BYV7
TreeFamⁱ	TF314019

Family and domain databases

InterProⁱ	View protein in InterPro IPR004294 Carotenoid_Oase
PANTHERⁱ	PTHR10543 PTHR10543, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03055 RPE65, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BYV7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFRVFLHFI RSHSATAVDF LPVMVHRLPV FKRYMGNTPQ KKAVFGQCRG 
        60         70         80         90        100
LPCVAPLLTT VEEAPRGISA RVWGHFPKWL NGSLLRIGPG KFEFGKDKYN 
       110        120        130        140        150
HWFDGMALLH QFRMAKGTVT YRSKFLQSDT YKANSAKNRI VISEFGTLAL 
       160        170        180        190        200
PDPCKNVFER FMSRFELPGK AAAMTDNTNV NYVRYKGDYY LCTETNFMNK 
       210        220        230        240        250
VDIETLEKTE KVDWSKFIAV NGATAHPHYD LDGTAYNMGN SFGPYGFSYK 
       260        270        280        290        300
VIRVPPEKVD LGETIHGVQV ICSIASTEKG KPSYYHSFGM TRNYIIFIEQ 
       310        320        330        340        350
PLKMNLWKIA TSKIRGKAFS DGISWEPQCN TRFHVVEKRT GQLLPGRYYS 
       360        370        380        390        400
KPFVTFHQIN AFEDQGCVII DLCCQDNGRT LEVYQLQNLR KAGEGLDQVH 
       410        420        430        440        450
NSAAKSFPRR FVLPLNVSLN APEGDNLSPL SYTSASAVKQ ADGTIWCSHE 
       460        470        480        490        500
NLHQEDLEKE GGIEFPQIYY DRFSGKKYHF FYGCGFRHLV GDSLIKVDVV 
       510        520        530        540        550
NKTLKVWRED GFYPSEPVFV PAPGTNEEDG GVILSVVITP NQNESNFILV 
       560        570 
LDAKNFEELG RAEVPVQMPY GFHGTFIPI

Length:579

Mass (Da):65,674

Last modified:October 5, 2010 - v5

Checksum:ⁱB14F54FCEC1092CE

GO

Isoform 2 (identifier: Q9BYV7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.

« Hide

        10         20         30         40         50
MGNTPQKKAV FGQCRGLPCV APLLTTVEEA PRGISARVWG HFPKWLNGSL 
        60         70         80         90        100
LRIGPGKFEF GKDKYNHWFD GMALLHQFRM AKGTVTYRSK FLQSDTYKAN 
       110        120        130        140        150
SAKNRIVISE FGTLALPDPC KNVFERFMSR FELPGKAAAM TDNTNVNYVR 
       160        170        180        190        200
YKGDYYLCTE TNFMNKVDIE TLEKTEKVDW SKFIAVNGAT AHPHYDLDGT 
       210        220        230        240        250
AYNMGNSFGP YGFSYKVIRV PPEKVDLGET IHGVQVICSI ASTEKGKPSY 
       260        270        280        290        300
YHSFGMTRNY IIFIEQPLKM NLWKIATSKI RGKAFSDGIS WEPQCNTRFH 
       310        320        330        340        350
VVEKRTGQLL PGRYYSKPFV TFHQINAFED QGCVIIDLCC QDNGRTLEVY 
       360        370        380        390        400
QLQNLRKAGE GLDQVHNSAA KSFPRRFVLP LNVSLNAPEG DNLSPLSYTS 
       410        420        430        440        450
ASAVKQADGT IWCSHENLHQ EDLEKEGGIE FPQIYYDRFS GKKYHFFYGC 
       460        470        480        490        500
GFRHLVGDSL IKVDVVNKTL KVWREDGFYP SEPVFVPAPG TNEEDGGVIL 
       510        520        530        540 
SVVITPNQNE SNFILVLDAK NFEELGRAEV PVQMPYGFHG TFIPI

Note: No experimental confirmation available.

Show »

Length:545

Mass (Da):61,526

Checksum:ⁱE09F77FEBB534B65

GO

Isoform 4 (identifier: Q9BYV7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.
501-506: Missing.

« Hide

        10         20         30         40         50
MGNTPQKKAV FGQCRGLPCV APLLTTVEEA PRGISARVWG HFPKWLNGSL 
        60         70         80         90        100
LRIGPGKFEF GKDKYNHWFD GMALLHQFRM AKGTVTYRSK FLQSDTYKAN 
       110        120        130        140        150
SAKNRIVISE FGTLALPDPC KNVFERFMSR FELPGKAAAM TDNTNVNYVR 
       160        170        180        190        200
YKGDYYLCTE TNFMNKVDIE TLEKTEKVDW SKFIAVNGAT AHPHYDLDGT 
       210        220        230        240        250
AYNMGNSFGP YGFSYKVIRV PPEKVDLGET IHGVQVICSI ASTEKGKPSY 
       260        270        280        290        300
YHSFGMTRNY IIFIEQPLKM NLWKIATSKI RGKAFSDGIS WEPQCNTRFH 
       310        320        330        340        350
VVEKRTGQLL PGRYYSKPFV TFHQINAFED QGCVIIDLCC QDNGRTLEVY 
       360        370        380        390        400
QLQNLRKAGE GLDQVHNSAA KSFPRRFVLP LNVSLNAPEG DNLSPLSYTS 
       410        420        430        440        450
ASAVKQADGT IWCSHENLHQ EDLEKEGGIE FPQIYYDRFS GKKYHFFYGC 
       460        470        480        490        500
GFRHLVGDSL IKVDVVWRED GFYPSEPVFV PAPGTNEEDG GVILSVVITP 
       510        520        530 
NQNESNFILV LDAKNFEELG RAEVPVQMPY GFHGTFIPI

Note: No experimental confirmation available.

Show »

Length:539

Mass (Da):60,842

Checksum:ⁱDD12ACD19DD37669

GO

Isoform 5 (identifier: Q9BYV7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
173-245: Missing.

« Hide

        10         20         30         40         50
MFFRVFLHFI RSHSATAVDF LPVMVHRLPV FKRYMGNTPQ KKAVFGQCRG 
        60         70         80         90        100
LPCVAPLLTT VEEAPRGISA RVWGHFPKWL NGSLLRIGPG KFEFGKDKYN 
       110        120        130        140        150
HWFDGMALLH QFRMAKGTVT YRSKFLQSDT YKANSAKNRI VISEFGTLAL 
       160        170        180        190        200
PDPCKNVFER FMSRFELPGK AAGFSYKVIR VPPEKVDLGE TIHGVQVICS 
       210        220        230        240        250
IASTEKGKPS YYHSFGMTRN YIIFIEQPLK MNLWKIATSK IRGKAFSDGI 
       260        270        280        290        300
SWEPQCNTRF HVVEKRTGQL LPGRYYSKPF VTFHQINAFE DQGCVIIDLC 
       310        320        330        340        350
CQDNGRTLEV YQLQNLRKAG EGLDQVHNSA AKSFPRRFVL PLNVSLNAPE 
       360        370        380        390        400
GDNLSPLSYT SASAVKQADG TIWCSHENLH QEDLEKEGGI EFPQIYYDRF 
       410        420        430        440        450
SGKKYHFFYG CGFRHLVGDS LIKVDVVNKT LKVWREDGFY PSEPVFVPAP 
       460        470        480        490        500
GTNEEDGGVI LSVVITPNQN ESNFILVLDA KNFEELGRAE VPVQMPYGFH 

GTFIPI

Note: No experimental confirmation available.

Show »

Length:506

Mass (Da):57,337

Checksum:ⁱ4E62A2574461C1D4

GO

Isoform 6 (identifier: Q9BYV7-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-105: Missing.

« Hide

        10         20         30         40         50
MALLHQFRMA KGTVTYRSKF LQSDTYKANS AKNRIVISEF GTLALPDPCK 
        60         70         80         90        100
NVFERFMSRF ELPGKAAAMT DNTNVNYVRY KGDYYLCTET NFMNKVDIET 
       110        120        130        140        150
LEKTEKVDWS KFIAVNGATA HPHYDLDGTA YNMGNSFGPY GFSYKVIRVP 
       160        170        180        190        200
PEKVDLGETI HGVQVICSIA STEKGKPSYY HSFGMTRNYI IFIEQPLKMN 
       210        220        230        240        250
LWKIATSKIR GKAFSDGISW EPQCNTRFHV VEKRTGQLLP GRYYSKPFVT 
       260        270        280        290        300
FHQINAFEDQ GCVIIDLCCQ DNGRTLEVYQ LQNLRKAGEG LDQVHNSAAK 
       310        320        330        340        350
SFPRRFVLPL NVSLNAPEGD NLSPLSYTSA SAVKQADGTI WCSHENLHQE 
       360        370        380        390        400
DLEKEGGIEF PQIYYDRFSG KKYHFFYGCG FRHLVGDSLI KVDVVNKTLK 
       410        420        430        440        450
VWREDGFYPS EPVFVPAPGT NEEDGGVILS VVITPNQNES NFILVLDAKN 
       460        470 
FEELGRAEVP VQMPYGFHGT FIPI

Note: No experimental confirmation available.

Show »

Length:474

Mass (Da):53,630

Checksum:ⁱ3C3EA5F8FFB9CFA0

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PS89	E9PS89_HUMAN	Beta,beta-carotene 9',10'-oxygenase Beta,beta-carotene 9',10'-oxygenase	BCO2	98	Annotation score:
V9GYA9	V9GYA9_HUMAN	Beta,beta-carotene 9',10'-oxygenase Beta,beta-carotene 9',10'-oxygenase	BCO2	212	Annotation score:
H0YCN8	H0YCN8_HUMAN	Beta,beta-carotene 9',10'-oxygenase Beta,beta-carotene 9',10'-oxygenase	BCO2	273	Annotation score:
E9PPP9	E9PPP9_HUMAN	Beta,beta-carotene 9',10'-oxygenase Beta,beta-carotene 9',10'-oxygenase	BCO2	50	Annotation score:
H0YCL7	H0YCL7_HUMAN	Beta,beta-carotene 9',10'-oxygenase Beta,beta-carotene 9',10'-oxygenase	BCO2	71	Annotation score:

Sequence cautionⁱ

The sequence CAC27994 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26	H → Y in CAC27994 (PubMed:11278918).Curated	1
Sequence conflictⁱ	177	N → D in CAC27994 (PubMed:11278918).Curated	1
Sequence conflictⁱ	258	K → E in CAC27994 (PubMed:11278918).Curated	1
Sequence conflictⁱ	429	P → Q in BAG60185 (PubMed:14702039).Curated	1
Sequence conflictⁱ	446	W → C in CAC27994 (PubMed:11278918).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047047	231	L → P3 PublicationsCorresponds to variant dbSNP:rs10891338Ensembl.	1
Natural variantⁱVAR_047048	289	G → E. Corresponds to variant dbSNP:rs17113607Ensembl.	1
Natural variantⁱVAR_047049	548	I → L5 PublicationsCorresponds to variant dbSNP:rs2217401Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046915	1 – 105	Missing in isoform 6. 1 PublicationAdd BLAST	105
Alternative sequenceⁱVSP_008599	1 – 34	Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST	34
Alternative sequenceⁱVSP_046916	173 – 245	Missing in isoform 5. 1 PublicationAdd BLAST	73
Alternative sequenceⁱVSP_008600	501 – 506	Missing in isoform 4. 1 Publication	6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF276432 mRNA Translation: AAK69433.1 AK027801 mRNA Translation: BAB55379.1 AK297853 mRNA Translation: BAG60185.1 EF444956 Genomic DNA Translation: ACA05952.1 AP002884 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67192.1 BC041656 mRNA Translation: AAH41656.2 AJ290393 mRNA Translation: CAC27994.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41716.1 [Q9BYV7-2] CCDS58181.1 [Q9BYV7-5] CCDS58182.1 [Q9BYV7-4] CCDS58183.1 [Q9BYV7-6] CCDS8358.2 [Q9BYV7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001032367.2, NM_001037290.2 NP_001243326.1, NM_001256397.1 NP_001243327.1, NM_001256398.1 NP_001243329.1, NM_001256400.1
UniGeneⁱ	Hs.728325

Genome annotation databases

Ensemblⁱ	ENST00000357685; ENSP00000350314; ENSG00000197580 [Q9BYV7-1] ENST00000361053; ENSP00000354338; ENSG00000197580 [Q9BYV7-5] ENST00000438022; ENSP00000414843; ENSG00000197580 [Q9BYV7-2] ENST00000526088; ENSP00000436615; ENSG00000197580 [Q9BYV7-4] ENST00000531169; ENSP00000437053; ENSG00000197580 [Q9BYV7-2] ENST00000532593; ENSP00000431802; ENSG00000197580 [Q9BYV7-6]
GeneIDⁱ	83875
KEGGⁱ	hsa:83875
UCSC genome browser More...UCSCⁱ	uc001pnf.4 human [Q9BYV7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BYV7	Beta,beta-carotene 9',10'-dioxygenase variant 2		HUMAN		556	UniRef100_Q9BYV7
Isoform 2 of Beta,beta-carotene 9',10'-oxygenase		HUMAN		545
Isoform 6 of Beta,beta-carotene 9',10'-oxygenase		HUMAN		474
Beta,beta-carotene 9',10'-oxygenase		HUMAN		98
Q9BYV7-5	Beta,beta-carotene 9',10'-dioxygenase variant 3		HUMAN		483	UniRef100_B0YIX7

Protein	Similar proteins		Species	Score	Length	Source
Q9BYV7	Beta,beta-carotene 9',10'-oxygenase		PONAB		557	UniRef90_Q9BYV7
Beta,beta-carotene 9',10'-oxygenase		MACFA		556
Beta,beta-carotene 9',10'-dioxygenase variant 2		HUMAN		556
Uncharacterized protein		MACMU		631
Uncharacterized protein		COLAP		579
+70
Q9BYV7-5	Beta-carotene oxygenase 2		PANTR		506	UniRef90_H2R4A4
Uncharacterized protein		CERAT		506
Uncharacterized protein		MANLE		506
Uncharacterized protein		MACMU		506
Uncharacterized protein		COLAP		506
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9BYV7	Beta,beta-carotene 9',10'-oxygenase		PONAB		557	UniRef50_Q9BYV7
Beta,beta-carotene 9',10'-oxygenase		MACFA		556
Beta,beta-carotene 9',10'-dioxygenase variant 2		HUMAN		556
Uncharacterized protein		MACMU		631
Uncharacterized protein		CERAT		579
+467
Q9BYV7-5	Beta-carotene oxygenase 2		PANTR		506	UniRef50_H2R4A4
Uncharacterized protein		RHIBE		506
Uncharacterized protein		RHIRO		506
Uncharacterized protein		COLAP		506
Uncharacterized protein		MACMU		506
+42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF276432 mRNA Translation: AAK69433.1 AK027801 mRNA Translation: BAB55379.1 AK297853 mRNA Translation: BAG60185.1 EF444956 Genomic DNA Translation: ACA05952.1 AP002884 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67192.1 BC041656 mRNA Translation: AAH41656.2 AJ290393 mRNA Translation: CAC27994.1 Different initiation.
CCDSⁱ	CCDS41716.1 [Q9BYV7-2] CCDS58181.1 [Q9BYV7-5] CCDS58182.1 [Q9BYV7-4] CCDS58183.1 [Q9BYV7-6] CCDS8358.2 [Q9BYV7-1]
RefSeqⁱ	NP_001032367.2, NM_001037290.2 NP_001243326.1, NM_001256397.1 NP_001243327.1, NM_001256398.1 NP_001243329.1, NM_001256400.1
UniGeneⁱ	Hs.728325

3D structure databases

ProteinModelPortalⁱ	Q9BYV7
SMRⁱ	Q9BYV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000350314

STRINGⁱ

9606.ENSP00000350314

PTM databases

iPTMnetⁱ	Q9BYV7
PhosphoSitePlusⁱ	Q9BYV7

Polymorphism and mutation databases

BioMutaⁱ	BCO2
DMDMⁱ	308153680

Proteomic databases

PaxDbⁱ	Q9BYV7
PeptideAtlasⁱ	Q9BYV7
PRIDEⁱ	Q9BYV7
ProteomicsDBⁱ	79718 79719 [Q9BYV7-2] 79720 [Q9BYV7-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000357685; ENSP00000350314; ENSG00000197580 [Q9BYV7-1] ENST00000361053; ENSP00000354338; ENSG00000197580 [Q9BYV7-5] ENST00000438022; ENSP00000414843; ENSG00000197580 [Q9BYV7-2] ENST00000526088; ENSP00000436615; ENSG00000197580 [Q9BYV7-4] ENST00000531169; ENSP00000437053; ENSG00000197580 [Q9BYV7-2] ENST00000532593; ENSP00000431802; ENSG00000197580 [Q9BYV7-6]
GeneIDⁱ	83875
KEGGⁱ	hsa:83875
UCSCⁱ	uc001pnf.4 human [Q9BYV7-1]

Organism-specific databases

CTDⁱ	83875
DisGeNETⁱ	83875
EuPathDBⁱ	HostDB:ENSG00000197580.11
GeneCardsⁱ	BCO2
HGNCⁱ	HGNC:18503 BCO2
HPAⁱ	HPA039825 HPA040695
MIMⁱ	611740 gene
neXtProtⁱ	NX_Q9BYV7
OpenTargetsⁱ	ENSG00000197580
PharmGKBⁱ	PA162377424
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1285 Eukaryota COG3670 LUCA
GeneTreeⁱ	ENSGT00500000044783
HOGENOMⁱ	HOG000232156
HOVERGENⁱ	HBG050679
KOⁱ	K10252
OMAⁱ	WEPQYNT
OrthoDBⁱ	EOG091G04WW
PhylomeDBⁱ	Q9BYV7
TreeFamⁱ	TF314019

Enzyme and pathway databases

BioCycⁱ	MetaCyc:G66-33846-MONOMER
BRENDAⁱ	1.13.11.71 2681
Reactomeⁱ	R-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	BCO2 human
GenomeRNAiⁱ	83875
Protein Ontology More...PROⁱ	PR:Q9BYV7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197580 Expressed in 158 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_BCO2
ExpressionAtlasⁱ	Q9BYV7 baseline and differential
Genevisibleⁱ	Q9BYV7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004294 Carotenoid_Oase
PANTHERⁱ	PTHR10543 PTHR10543, 1 hit
Pfamⁱ	View protein in Pfam PF03055 RPE65, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BCDO2_HUMAN
Accessionⁱ	Q9BYV7Primary (citable) accession number: Q9BYV7 Secondary accession number(s): B0YIX5 Q96JY5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 5, 2010
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q9BYV7 (BCDO2_HUMAN)

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Beta,beta-carotene 9',10'-oxygenase

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