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UniProtKB - Q9BYV2 (TRI54_HUMAN)
Protein
Tripartite motif-containing protein 54
Gene
TRIM54
Organism
Homo sapiens (Human)
Status
Functioni
May bind and stabilize microtubules during myotubes formation.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 126 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 129 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 149 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 155 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 26 – 82 | RING-typePROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 121 – 163 | B box-typePROSITE-ProRule annotationAdd BLAST | 43 |
GO - Molecular functioni
- microtubule binding Source: Ensembl
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- microtubule-based process Source: UniProtKB
- negative regulation of microtubule depolymerization Source: UniProtKB
- protein ubiquitination Source: GO_Central
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BYV2 |
SignaLinki | Q9BYV2 |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 54Alternative name(s): Muscle-specific RING finger protein Short name: MuRF Muscle-specific RING finger protein 3 Short name: MuRF-3 Short name: MuRF3 RING finger protein 30 |
Gene namesi | Name:TRIM54 Synonyms:MURF, MURF3, RNF30 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16008, TRIM54 |
MIMi | 606474, gene |
neXtProti | NX_Q9BYV2 |
VEuPathDBi | HostDB:ENSG00000138100 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Z line By similarity
Note: Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity).By similarity
Cytoskeleton
- microtubule Source: UniProtKB
- microtubule associated complex Source: Ensembl
Other locations
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 57159 |
OpenTargetsi | ENSG00000138100 |
PharmGKBi | PA34434 |
Miscellaneous databases
Pharosi | Q9BYV2, Tbio |
Genetic variation databases
BioMutai | TRIM54 |
DMDMi | 209572715 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056282 | 1 – 358 | Tripartite motif-containing protein 54Add BLAST | 358 |
Proteomic databases
EPDi | Q9BYV2 |
MassIVEi | Q9BYV2 |
MaxQBi | Q9BYV2 |
PeptideAtlasi | Q9BYV2 |
PRIDEi | Q9BYV2 |
ProteomicsDBi | 79712 [Q9BYV2-1] 79713 [Q9BYV2-2] |
PTM databases
iPTMneti | Q9BYV2 |
PhosphoSitePlusi | Q9BYV2 |
Expressioni
Tissue specificityi
Specifically expressed in heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000138100, Expressed in apex of heart and 113 other tissues |
Genevisiblei | Q9BYV2, HS |
Organism-specific databases
HPAi | ENSG00000138100, Group enriched (heart muscle, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Homooligomer and heterooligomer.
Interacts with tubulin (By similarity).
Interacts with TRIM63 and probably with TRIM55.
By similarity2 PublicationsBinary interactionsi
Q9BYV2
GO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 121415, 319 interactors |
IntActi | Q9BYV2, 338 interactors |
Miscellaneous databases
RNActi | Q9BYV2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BYV2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BYV2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 271 – 329 | COSPROSITE-ProRule annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 168 – 211 | Mediates microtubule-binding and homooligomerizationBy similarityAdd BLAST | 44 | |
Regioni | 326 – 358 | DisorderedSequence analysisAdd BLAST | 33 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 220 – 258 | Sequence analysisAdd BLAST | 39 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 26 – 82 | RING-typePROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 121 – 163 | B box-typePROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
GeneTreei | ENSGT00940000154004 |
HOGENOMi | CLU_013137_5_1_1 |
InParanoidi | Q9BYV2 |
OMAi | GYESMDQ |
OrthoDBi | 824972at2759 |
PhylomeDBi | Q9BYV2 |
TreeFami | TF331669 |
Family and domain databases
CDDi | cd16761, RING-HC_MuRF3, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR017903, COS_domain IPR033492, TRIM54/TRIM55 IPR042752, TRIM54_RING-HC IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR24103:SF596, PTHR24103:SF596, 1 hit |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS51262, COS, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9BYV2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHSKA EQHLMCEEHE EEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE EKLQRVRGLI
260 270 280 290 300
RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
310 320 330 340 350
RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP
EEERPDGP
Sequence cautioni
The sequence AAY24296 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC32841 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC32842 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 172 | S → N in CAC32841 (PubMed:11243782).Curated | 1 | |
Sequence conflicti | 214 | N → T in CAC32841 (PubMed:11243782).Curated | 1 | |
Sequence conflicti | 214 | N → T in CAC32842 (PubMed:11243782).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016061 | 171 | K → KKQDLTLLPRLECSGTNTTY CSLDLPSSSDPPILASQNTK IID in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ291714 mRNA Translation: CAC32841.1 Different initiation. AJ291714 mRNA Translation: CAC32842.1 Different initiation. AC013413 Genomic DNA Translation: AAY24296.1 Different initiation. CH471053 Genomic DNA Translation: EAX00606.1 BC141807 mRNA Translation: AAI41808.1 |
CCDSi | CCDS1745.2 [Q9BYV2-2] CCDS1746.2 [Q9BYV2-1] |
RefSeqi | NP_115935.3, NM_032546.3 [Q9BYV2-2] NP_912730.2, NM_187841.2 [Q9BYV2-1] |
Genome annotation databases
Ensembli | ENST00000296098; ENSP00000296098; ENSG00000138100 [Q9BYV2-2] ENST00000380075; ENSP00000369415; ENSG00000138100 |
GeneIDi | 57159 |
KEGGi | hsa:57159 |
MANE-Selecti | ENST00000380075.7; ENSP00000369415.3; NM_187841.3; NP_912730.2 |
UCSCi | uc002rjn.4, human [Q9BYV2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ291714 mRNA Translation: CAC32841.1 Different initiation. AJ291714 mRNA Translation: CAC32842.1 Different initiation. AC013413 Genomic DNA Translation: AAY24296.1 Different initiation. CH471053 Genomic DNA Translation: EAX00606.1 BC141807 mRNA Translation: AAI41808.1 |
CCDSi | CCDS1745.2 [Q9BYV2-2] CCDS1746.2 [Q9BYV2-1] |
RefSeqi | NP_115935.3, NM_032546.3 [Q9BYV2-2] NP_912730.2, NM_187841.2 [Q9BYV2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3Q1D | X-ray | 2.15 | A | 122-168 | [»] | |
SMRi | Q9BYV2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121415, 319 interactors |
IntActi | Q9BYV2, 338 interactors |
PTM databases
iPTMneti | Q9BYV2 |
PhosphoSitePlusi | Q9BYV2 |
Genetic variation databases
BioMutai | TRIM54 |
DMDMi | 209572715 |
Proteomic databases
EPDi | Q9BYV2 |
MassIVEi | Q9BYV2 |
MaxQBi | Q9BYV2 |
PeptideAtlasi | Q9BYV2 |
PRIDEi | Q9BYV2 |
ProteomicsDBi | 79712 [Q9BYV2-1] 79713 [Q9BYV2-2] |
Protocols and materials databases
Antibodypediai | 13583, 362 antibodies from 32 providers |
DNASUi | 57159 |
Genome annotation databases
Ensembli | ENST00000296098; ENSP00000296098; ENSG00000138100 [Q9BYV2-2] ENST00000380075; ENSP00000369415; ENSG00000138100 |
GeneIDi | 57159 |
KEGGi | hsa:57159 |
MANE-Selecti | ENST00000380075.7; ENSP00000369415.3; NM_187841.3; NP_912730.2 |
UCSCi | uc002rjn.4, human [Q9BYV2-1] |
Organism-specific databases
CTDi | 57159 |
DisGeNETi | 57159 |
GeneCardsi | TRIM54 |
HGNCi | HGNC:16008, TRIM54 |
HPAi | ENSG00000138100, Group enriched (heart muscle, skeletal muscle, tongue) |
MIMi | 606474, gene |
neXtProti | NX_Q9BYV2 |
OpenTargetsi | ENSG00000138100 |
PharmGKBi | PA34434 |
VEuPathDBi | HostDB:ENSG00000138100 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154004 |
HOGENOMi | CLU_013137_5_1_1 |
InParanoidi | Q9BYV2 |
OMAi | GYESMDQ |
OrthoDBi | 824972at2759 |
PhylomeDBi | Q9BYV2 |
TreeFami | TF331669 |
Enzyme and pathway databases
PathwayCommonsi | Q9BYV2 |
SignaLinki | Q9BYV2 |
Miscellaneous databases
BioGRID-ORCSi | 57159, 5 hits in 1073 CRISPR screens |
ChiTaRSi | TRIM54, human |
EvolutionaryTracei | Q9BYV2 |
GenomeRNAii | 57159 |
Pharosi | Q9BYV2, Tbio |
PROi | PR:Q9BYV2 |
RNActi | Q9BYV2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138100, Expressed in apex of heart and 113 other tissues |
Genevisiblei | Q9BYV2, HS |
Family and domain databases
CDDi | cd16761, RING-HC_MuRF3, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR017903, COS_domain IPR033492, TRIM54/TRIM55 IPR042752, TRIM54_RING-HC IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR24103:SF596, PTHR24103:SF596, 1 hit |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS51262, COS, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI54_HUMAN | |
Accessioni | Q9BYV2Primary (citable) accession number: Q9BYV2 Secondary accession number(s): A5D8T7, Q53SY4, Q9BYV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | October 14, 2008 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references