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Entry version 162 (22 Apr 2020)
Sequence version 3 (14 Oct 2008)
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Protein

Tripartite motif-containing protein 54

Gene

TRIM54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May bind and stabilize microtubules during myotubes formation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri121 – 163B box-typePROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 54
Alternative name(s):
Muscle-specific RING finger protein
Short name:
MuRF
Muscle-specific RING finger protein 3
Short name:
MuRF-3
Short name:
MuRF3
RING finger protein 30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM54
Synonyms:MURF, MURF3, RNF30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16008 TRIM54

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606474 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYV2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57159

Open Targets

More...
OpenTargetsi
ENSG00000138100

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34434

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYV2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM54

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572715

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562821 – 358Tripartite motif-containing protein 54Add BLAST358

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BYV2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BYV2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYV2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BYV2

PeptideAtlas

More...
PeptideAtlasi
Q9BYV2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYV2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79712 [Q9BYV2-1]
79713 [Q9BYV2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138100 Expressed in apex of heart and 100 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYV2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138100 Tissue enriched (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer and heterooligomer.

Interacts with tubulin (By similarity).

Interacts with TRIM63 and probably with TRIM55.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BYV2
With#Exp.IntAct
A8K2R33EBI-2130429,EBI-9977437
Q9BRL53EBI-2130429,EBI-10296986
ADCY4 [Q8NFM4]3EBI-2130429,EBI-2838710
AIFM2 [Q9BRQ8]3EBI-2130429,EBI-3956936
ANKRD11 [X5D778]3EBI-2130429,EBI-17183751
ARFIP2 [P53365]3EBI-2130429,EBI-638194
ARHGEF5 [Q12774]6EBI-2130429,EBI-602199
ARHGEF6 [Q15052]3EBI-2130429,EBI-1642523
ARMC7 [Q9H6L4]3EBI-2130429,EBI-742909
BYSL [Q13895]7EBI-2130429,EBI-358049
C12orf49 [Q9H741]3EBI-2130429,EBI-2836158
C1orf109 [Q9NX04]6EBI-2130429,EBI-8643161
C1orf216 [Q8TAB5]3EBI-2130429,EBI-747505
C1QTNF2 [Q9BXJ5]3EBI-2130429,EBI-2817707
C2CD6 [Q53TS8]3EBI-2130429,EBI-739879
CARD9 [Q9H257]3EBI-2130429,EBI-751319
CBX8 [Q9HC52]3EBI-2130429,EBI-712912
CCDC102B [Q68D86]6EBI-2130429,EBI-10171570
CCDC146 [Q8IYE0]3EBI-2130429,EBI-10749669
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-2130429,EBI-10247802
CCDC28A [Q7Z6N9]3EBI-2130429,EBI-10258115
CCDC28A [Q8IWP9]3EBI-2130429,EBI-355471
CCDC87 [Q9NVE4]3EBI-2130429,EBI-749261
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-2130429,EBI-10175300
CDC37 [Q16543]3EBI-2130429,EBI-295634
CDK18 [Q07002]3EBI-2130429,EBI-746238
CDKN1A [P38936]6EBI-2130429,EBI-375077
CENPX [A8MT69]3EBI-2130429,EBI-5529694
CENPX - isoform 2 [A8MT69-2]3EBI-2130429,EBI-13128870
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-2130429,EBI-10181988
CFAP206 [Q8IYR0]3EBI-2130429,EBI-749051
CFAP53 [Q96M91]3EBI-2130429,EBI-742422
CHCHD2 [Q9Y6H1]3EBI-2130429,EBI-2321769
CHD2 - isoform 3 [O14647-3]3EBI-2130429,EBI-11985957
CMIP - isoform 3 [Q8IY22-3]3EBI-2130429,EBI-12149877
CRADD [P78560]3EBI-2130429,EBI-520375
CSNK2B [P67870]3EBI-2130429,EBI-348169
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-2130429,EBI-11962928
CWF19L2 [Q2TBE0]6EBI-2130429,EBI-5453285
CYTH4 [Q8WWE8]3EBI-2130429,EBI-10277443
DCAF8 [Q5TAQ9]2EBI-2130429,EBI-740686
DCUN1D1 [Q96GG9]3EBI-2130429,EBI-740086
DDX6 [P26196]3EBI-2130429,EBI-351257
DEUP1 [Q05D60]6EBI-2130429,EBI-748597
DNAL4 [O96015]3EBI-2130429,EBI-742362
DTNB - isoform 5 [O60941-5]3EBI-2130429,EBI-11984733
DTX2 [Q86UW9]9EBI-2130429,EBI-740376
EHHADH [Q08426]3EBI-2130429,EBI-2339219
EIF4E2 [O60573]3EBI-2130429,EBI-398610
ELMO1 [Q92556]3EBI-2130429,EBI-346417
ELOA [Q14241]3EBI-2130429,EBI-742350
ENKD1 [Q9H0I2]6EBI-2130429,EBI-744099
EPM2AIP1 [Q7L775]6EBI-2130429,EBI-6255981
EXOC7 - isoform 1 [Q9UPT5-1]3EBI-2130429,EBI-6251402
EXOC8 [Q8IYI6]3EBI-2130429,EBI-742102
EXOSC5 [Q9NQT4]6EBI-2130429,EBI-371876
FAM110A [Q9BQ89]6EBI-2130429,EBI-1752811
FAM124A [Q86V42]3EBI-2130429,EBI-744506
FAM124B [Q9H5Z6]3EBI-2130429,EBI-741626
FAM161A [Q3B820]6EBI-2130429,EBI-719941
FAM50B [Q9Y247]3EBI-2130429,EBI-742802
FAM90A1 [Q86YD7]3EBI-2130429,EBI-6658203
FARS2 [O95363]3EBI-2130429,EBI-2513774
FBF1 - isoform 6 [Q8TES7-6]3EBI-2130429,EBI-10244131
FBXO16 [Q8IX29]3EBI-2130429,EBI-12063229
FBXW2 [Q9UKT8]2EBI-2130429,EBI-914727
FLJ13057 [Q53SE7]3EBI-2130429,EBI-10172181
GAS8 [O95995]3EBI-2130429,EBI-1052570
GEM [P55040]3EBI-2130429,EBI-744104
GNG13 [Q9P2W3]3EBI-2130429,EBI-11427343
GNL3L [Q9NVN8]3EBI-2130429,EBI-746682
GTF2I - isoform 2 [P78347-2]3EBI-2130429,EBI-12033200
GTF2IRD2 [Q86UP8]3EBI-2130429,EBI-6425928
GTF2IRD2B [Q6EKJ0]3EBI-2130429,EBI-12338155
HAUS1 [Q96CS2]3EBI-2130429,EBI-2514791
hCG_1987119 [A0A024R8L2]3EBI-2130429,EBI-14103818
HDAC10 [Q969S8]2EBI-2130429,EBI-301762
HGS [O14964]3EBI-2130429,EBI-740220
HOXB5 [P09067]3EBI-2130429,EBI-3893317
ING3 [A0A0C4DG38]3EBI-2130429,EBI-10263367
INPP5J [Q15735]6EBI-2130429,EBI-10236940
IQUB [Q8NA54]4EBI-2130429,EBI-10220600
ITPKB [P27987]3EBI-2130429,EBI-751388
KANK2 [Q63ZY3]3EBI-2130429,EBI-2556193
KAT14 [Q9H8E8]3EBI-2130429,EBI-750907
KIF9 [Q9HAQ2]3EBI-2130429,EBI-8472129
KIFC3 [Q9BVG8]3EBI-2130429,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-2130429,EBI-14069005
KLHL38 [Q2WGJ6]6EBI-2130429,EBI-6426443
KLHL42 [Q9P2K6]3EBI-2130429,EBI-739890
KPNA2 [P52292]3EBI-2130429,EBI-349938
KRT1 [P04264]3EBI-2130429,EBI-298429
KRT3 [P12035]3EBI-2130429,EBI-2430095
KRT4 [P19013]4EBI-2130429,EBI-2371606
KRT6A [P02538]11EBI-2130429,EBI-702198
KRT6B [P04259]6EBI-2130429,EBI-740907
KRT6C [P48668]6EBI-2130429,EBI-2564105
KRT75 [O95678]3EBI-2130429,EBI-2949715
KRT76 [Q01546]3EBI-2130429,EBI-2952745
KRT78 [Q8N1N4]3EBI-2130429,EBI-1056564
KRT79 [Q5XKE5]3EBI-2130429,EBI-2514135
LENG1 [Q96BZ8]6EBI-2130429,EBI-726510
LIN37 [Q96GY3]3EBI-2130429,EBI-748884
LMO1 [P25800]3EBI-2130429,EBI-8639312
LMO2 [P25791]3EBI-2130429,EBI-739696
LMO3 - isoform 4 [Q8TAP4-4]3EBI-2130429,EBI-11742507
LMO4 [P61968]3EBI-2130429,EBI-2798728
LNX1 [Q8TBB1]7EBI-2130429,EBI-739832
LSM2 [Q9Y333]3EBI-2130429,EBI-347416
MAD2L2 [Q9UI95]3EBI-2130429,EBI-77889
MBD3 [O95983]3EBI-2130429,EBI-1783068
MBD3 - isoform 2 [O95983-2]3EBI-2130429,EBI-11978579
MCM7 [P33993]3EBI-2130429,EBI-355924
MEAF6 [Q9HAF1]3EBI-2130429,EBI-399266
MFAP1 [P55081]6EBI-2130429,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]6EBI-2130429,EBI-10172526
MMTAG2 [Q9BU76]3EBI-2130429,EBI-742459
MNS1 [Q8NEH6]3EBI-2130429,EBI-743811
MYLK2 [Q9H1R3]2EBI-2130429,EBI-356910
MYO5B [Q9ULV0]3EBI-2130429,EBI-311356
MYO5B - isoform 2 [Q9ULV0-2]3EBI-2130429,EBI-14093244
NEK6 - isoform 4 [Q9HC98-4]3EBI-2130429,EBI-11750983
NGLY1 [Q96IV0]7EBI-2130429,EBI-6165879
OSGIN1 [Q9UJX0]3EBI-2130429,EBI-9057006
OSTF1 [Q92882]3EBI-2130429,EBI-1051152
OTUB2 [Q96DC9]4EBI-2130429,EBI-746259
PARVG [Q9HBI0]3EBI-2130429,EBI-3921217
PICK1 [Q9NRD5]3EBI-2130429,EBI-79165
PIK3R3 [Q8N381]3EBI-2130429,EBI-749096
PLK4 [O00444]3EBI-2130429,EBI-746202
PPP1R18 [Q6NYC8]6EBI-2130429,EBI-2557469
PRKAB2 [O43741]3EBI-2130429,EBI-1053424
PRPF18 [Q99633]3EBI-2130429,EBI-2798416
PRR35 [P0CG20]3EBI-2130429,EBI-11986293
PSMA1 [P25786]3EBI-2130429,EBI-359352
RABGEF1 [Q9UJ41]3EBI-2130429,EBI-913954
RABGEF1 - isoform 3 [Q9UJ41-4]3EBI-2130429,EBI-14093916
RAD23A [P54725]3EBI-2130429,EBI-746453
RASSF10 [A6NK89]3EBI-2130429,EBI-6912267
RBM41 [Q96IZ5]3EBI-2130429,EBI-740773
RCOR3 [Q9P2K3]3EBI-2130429,EBI-743428
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-2130429,EBI-1504830
RNF4 [P78317]3EBI-2130429,EBI-2340927
RSRC2 - isoform 2 [Q7L4I2-2]3EBI-2130429,EBI-10256202
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-2130429,EBI-11984663
SCNM1 [Q9BWG6]6EBI-2130429,EBI-748391
SDCBP [O00560]6EBI-2130429,EBI-727004
SEC14L4 [Q9UDX3]3EBI-2130429,EBI-10320311
SH2D1B [O14796]6EBI-2130429,EBI-3923013
SHC3 [Q92529]3EBI-2130429,EBI-79084
SMARCD1 [Q96GM5]3EBI-2130429,EBI-358489
SMARCE1 [Q969G3]6EBI-2130429,EBI-455078
SNF8 [Q96H20]6EBI-2130429,EBI-747719
SPG21 [Q9NZD8]6EBI-2130429,EBI-742688
SRCAP - isoform 3 [Q6ZRS2-3]3EBI-2130429,EBI-12029182
SSX2IP [Q9Y2D8]3EBI-2130429,EBI-2212028
TBC1D22B [Q9NU19]5EBI-2130429,EBI-8787464
TCAF1 - isoform 2 [Q9Y4C2-2]3EBI-2130429,EBI-11974855
TCEA2 [Q15560]6EBI-2130429,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-2130429,EBI-11955057
TCHP [Q9BT92]3EBI-2130429,EBI-740781
TEAD4 [Q15561]3EBI-2130429,EBI-747736
TEPSIN [Q96N21]3EBI-2130429,EBI-11139477
THOC1 [Q96FV9]3EBI-2130429,EBI-1765605
TJAP1 [Q5JTD0]3EBI-2130429,EBI-2814077
TRIML2 [Q8N7C3]3EBI-2130429,EBI-11059915
TSG101 [Q99816]3EBI-2130429,EBI-346882
TSHZ3 [Q63HK5]6EBI-2130429,EBI-9053916
TSSK3 [Q96PN8]3EBI-2130429,EBI-3918381
TTC23 [Q5W5X9]3EBI-2130429,EBI-6447954
TTC23 - isoform 3 [Q5W5X9-3]3EBI-2130429,EBI-9090990
TTC9C [Q8N5M4]3EBI-2130429,EBI-2851213
UBE2D1 [P51668]3EBI-2130429,EBI-743540
UBE2D2 [P62837]3EBI-2130429,EBI-347677
UBE2D4 [Q9Y2X8]3EBI-2130429,EBI-745527
UBE2I [Q7KZS0]3EBI-2130429,EBI-10180829
UBL4A [P11441]3EBI-2130429,EBI-356983
USHBP1 [Q8N6Y0]6EBI-2130429,EBI-739895
UTP14C [Q08E77]3EBI-2130429,EBI-10225961
VPS28 [Q548N1]3EBI-2130429,EBI-10243107
VPS9D1 [Q9Y2B5]3EBI-2130429,EBI-9031083
WDR34 [Q96EX3]3EBI-2130429,EBI-2556091
WDYHV1 [Q96HA8]6EBI-2130429,EBI-741158
XAF1 [Q6GPH4]6EBI-2130429,EBI-2815120
ZBTB16 [Q05516]6EBI-2130429,EBI-711925
ZFHX3 - isoform B [Q15911-2]3EBI-2130429,EBI-10237226
ZGPAT [Q8N5A5]3EBI-2130429,EBI-3439227
ZNF250 - isoform 3 [P15622-3]6EBI-2130429,EBI-10177272
ZNF417 [Q8TAU3]6EBI-2130429,EBI-740727
ZNF572 [Q7Z3I7]9EBI-2130429,EBI-10172590
ZNF587 [Q96SQ5]6EBI-2130429,EBI-6427977

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121415, 132 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BYV2, 337 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYV2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYV2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BYV2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini271 – 329COSPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni168 – 211Mediates microtubule-binding and homooligomerizationBy similarityAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili220 – 258Sequence analysisAdd BLAST39

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri121 – 163B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154004

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013137_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYV2

KEGG Orthology (KO)

More...
KOi
K10653

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYESMDQ

Database of Orthologous Groups

More...
OrthoDBi
824972at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYV2

TreeFam database of animal gene trees

More...
TreeFami
TF331669

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit
cd16761 RING-HC_MuRF3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017903 COS_domain
IPR042752 TRIM54_RING-HC
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51262 COS, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BYV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHSKA EQHLMCEEHE EEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE EKLQRVRGLI
260 270 280 290 300
RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
310 320 330 340 350
RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP

EEERPDGP
Length:358
Mass (Da):40,301
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC44B08A9871323F6
GO
Isoform 2 (identifier: Q9BYV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-171: K → KKQDLTLLPRLECSGTNTTYCSLDLPSSSDPPILASQNTKIID

Show »
Length:400
Mass (Da):44,833
Checksum:iD4D12B4FA81A841F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY24296 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC32841 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC32842 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti172S → N in CAC32841 (PubMed:11243782).Curated1
Sequence conflicti214N → T in CAC32841 (PubMed:11243782).Curated1
Sequence conflicti214N → T in CAC32842 (PubMed:11243782).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016061171K → KKQDLTLLPRLECSGTNTTY CSLDLPSSSDPPILASQNTK IID in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ291714 mRNA Translation: CAC32841.1 Different initiation.
AJ291714 mRNA Translation: CAC32842.1 Different initiation.
AC013413 Genomic DNA Translation: AAY24296.1 Different initiation.
CH471053 Genomic DNA Translation: EAX00606.1
BC141807 mRNA Translation: AAI41808.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1745.2 [Q9BYV2-2]
CCDS1746.2 [Q9BYV2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_115935.3, NM_032546.3 [Q9BYV2-2]
NP_912730.2, NM_187841.2 [Q9BYV2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296098; ENSP00000296098; ENSG00000138100 [Q9BYV2-2]
ENST00000380075; ENSP00000369415; ENSG00000138100 [Q9BYV2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57159

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57159

UCSC genome browser

More...
UCSCi
uc002rjn.4 human [Q9BYV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291714 mRNA Translation: CAC32841.1 Different initiation.
AJ291714 mRNA Translation: CAC32842.1 Different initiation.
AC013413 Genomic DNA Translation: AAY24296.1 Different initiation.
CH471053 Genomic DNA Translation: EAX00606.1
BC141807 mRNA Translation: AAI41808.1
CCDSiCCDS1745.2 [Q9BYV2-2]
CCDS1746.2 [Q9BYV2-1]
RefSeqiNP_115935.3, NM_032546.3 [Q9BYV2-2]
NP_912730.2, NM_187841.2 [Q9BYV2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q1DX-ray2.15A122-168[»]
SMRiQ9BYV2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121415, 132 interactors
IntActiQ9BYV2, 337 interactors

PTM databases

iPTMnetiQ9BYV2
PhosphoSitePlusiQ9BYV2

Polymorphism and mutation databases

BioMutaiTRIM54
DMDMi209572715

Proteomic databases

EPDiQ9BYV2
jPOSTiQ9BYV2
MassIVEiQ9BYV2
MaxQBiQ9BYV2
PeptideAtlasiQ9BYV2
PRIDEiQ9BYV2
ProteomicsDBi79712 [Q9BYV2-1]
79713 [Q9BYV2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13583 347 antibodies

Genome annotation databases

EnsembliENST00000296098; ENSP00000296098; ENSG00000138100 [Q9BYV2-2]
ENST00000380075; ENSP00000369415; ENSG00000138100 [Q9BYV2-1]
GeneIDi57159
KEGGihsa:57159
UCSCiuc002rjn.4 human [Q9BYV2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57159
DisGeNETi57159

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM54
HGNCiHGNC:16008 TRIM54
HPAiENSG00000138100 Tissue enriched (skeletal)
MIMi606474 gene
neXtProtiNX_Q9BYV2
OpenTargetsiENSG00000138100
PharmGKBiPA34434

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154004
HOGENOMiCLU_013137_5_1_1
InParanoidiQ9BYV2
KOiK10653
OMAiGYESMDQ
OrthoDBi824972at2759
PhylomeDBiQ9BYV2
TreeFamiTF331669

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIM54 human
EvolutionaryTraceiQ9BYV2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57159
PharosiQ9BYV2 Tbio

Protein Ontology

More...
PROi
PR:Q9BYV2
RNActiQ9BYV2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138100 Expressed in apex of heart and 100 other tissues
GenevisibleiQ9BYV2 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd16761 RING-HC_MuRF3, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017903 COS_domain
IPR042752 TRIM54_RING-HC
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS51262 COS, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYV2
Secondary accession number(s): A5D8T7, Q53SY4, Q9BYV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 14, 2008
Last modified: April 22, 2020
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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