AGXT2

Functionⁱ

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.3 Publications

Catalytic activityⁱ

L-alanine + glyoxylate = pyruvate + glycine.

(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.

Keywordsⁱ

Molecular function	Aminotransferase, Transferase
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03685-MONOMER
Reactomeⁱ	R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-73621 Pyrimidine catabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alanine--glyoxylate aminotransferase 2, mitochondrial (EC:2.6.1.44) Short name: AGT 2 Alternative name(s): (R)-3-amino-2-methylpropionate--pyruvate transaminase (EC:2.6.1.40) Beta-ALAAT II Beta-alanine-pyruvate aminotransferase D-AIBAT
Gene namesⁱ	Name:AGXT2 Synonyms:AGT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113492.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14412 AGXT2
MIMⁱ	612471 gene
neXtProtⁱ	NX_Q9BYV1

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64902
MalaCards human disease database More...MalaCardsⁱ	AGXT2
MIMⁱ	210100 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000113492
PharmGKBⁱ	PA24634

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00145 Glycine DB00160 L-Alanine DB00114 Pyridoxal Phosphate DB00119 Pyruvic acid

DrugBankⁱ

DB00145 Glycine
DB00160 L-Alanine
DB00114 Pyridoxal Phosphate
DB00119 Pyruvic acid

Polymorphism and mutation databases

BioMutaⁱ	AGXT2
DMDMⁱ	17432913

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 41	Mitochondrion1 PublicationAdd BLAST		41
ChainⁱPRO_0000001269	42 – 514	Alanine--glyoxylate aminotransferase 2, mitochondrialAdd BLAST		473

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	71	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	71	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	84	N6-acetyllysineBy similarity	1
Modified residueⁱ	262	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	262	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	304	N6-succinyllysineBy similarity	1
Modified residueⁱ	350	N6-(pyridoxal phosphate)lysineBy similarity	1
Modified residueⁱ	417	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	417	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	420	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	420	N6-succinyllysine; alternateBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

PaxDbⁱ	Q9BYV1
PeptideAtlas More...PeptideAtlasⁱ	Q9BYV1
PRIDEⁱ	Q9BYV1
ProteomicsDBⁱ	79711

PTM databases

iPTMnetⁱ	Q9BYV1
PhosphoSitePlusⁱ	Q9BYV1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000113492 Expressed in 31 organ(s), highest expression level in kidney epithelium
CleanExⁱ	HS_AGXT2
Genevisibleⁱ	Q9BYV1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037382

HPAⁱ

HPA037382

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

BioGridⁱ	122342, 2 interactors
IntActⁱ	Q9BYV1, 2 interactors
STRINGⁱ	9606.ENSP00000231420

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BYV1
SMRⁱ	Q9BYV1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1404 Eukaryota COG0160 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062907
HOGENOMⁱ	HOG000020206
HOVERGENⁱ	HBG004196
InParanoidⁱ	Q9BYV1
KEGG Orthology (KO) More...KOⁱ	K00827
OMAⁱ	GIATCTL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06LW
PhylomeDBⁱ	Q9BYV1
TreeFamⁱ	TF105945

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610 OAT_like, 1 hit
Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR005814 Aminotrans_3 IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202 Aminotran_3, 1 hit
PIRSFⁱ	PIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
PROSITEⁱ	View protein in PROSITE PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BYV1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLIWRHLLR PLCLVTSAPR ILEMHPFLSL GTSRTSVTKL SLHTKPRMPP 
        60         70         80         90        100
CDFMPERYQS LGYNRVLEIH KEHLSPVVTA YFQKPLLLHQ GHMEWLFDAE 
       110        120        130        140        150
GSRYLDFFSG IVTVSVGHCH PKVNAVAQKQ LGRLWHTSTV FFHPPMHEYA 
       160        170        180        190        200
EKLAALLPEP LKVIFLVNSG SEANELAMLM ARAHSNNIDI ISFRGAYHGC 
       210        220        230        240        250
SPYTLGLTNV GTYKMELPGG TGCQPTMCPD VFRGPWGGSH CRDSPVQTIR 
       260        270        280        290        300
KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK 
       310        320        330        340        350
GFLKEAFELV RARGGVCIAD EVQTGFGRLG SHFWGFQTHD VLPDIVTMAK 
       360        370        380        390        400
GIGNGFPMAA VITTPEIAKS LAKCLQHFNT FGGNPMACAI GSAVLEVIKE 
       410        420        430        440        450
ENLQENSQEV GTYMLLKFAK LRDEFEIVGD VRGKGLMIGI EMVQDKISCR 
       460        470        480        490        500
PLPREEVNQI HEDCKHMGLL VGRGSIFSQT FRIAPSMCIT KPEVDFAVEV 
       510 
FRSALTQHME RRAK

Length:514

Mass (Da):57,156

Last modified:June 1, 2001 - v1

Checksum:ⁱCA562F84FF39B5AC

GO

Isoform 2 (identifier: Q9BYV1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
321-395: Missing.

« Hide

        10         20         30         40         50
MTLIWRHLLR PLCLVTSAPR ILEMHPFLSL GTSRTSVTKL SLHTKPRMPP 
        60         70         80         90        100
CDFMPERYQS LGYNRVLEIH KEHLSPVVTA YFQKPLLLHQ GHMEWLFDAE 
       110        120        130        140        150
GSRYLDFFSG IVTVSVGHCH PKVNAVAQKQ LGRLWHTSTV FFHPPMHEYA 
       160        170        180        190        200
EKLAALLPEP LKVIFLVNSG SEANELAMLM ARAHSNNIDI ISFRGAYHGC 
       210        220        230        240        250
SPYTLGLTNV GTYKMELPGG TGCQPTMCPD VFRGPWGGSH CRDSPVQTIR 
       260        270        280        290        300
KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK 
       310        320        330        340        350
GFLKEAFELV RARGGVCIAD EVIKEENLQE NSQEVGTYML LKFAKLRDEF 
       360        370        380        390        400
EIVGDVRGKG LMIGIEMVQD KISCRPLPRE EVNQIHEDCK HMGLLVGRGS 
       410        420        430 
IFSQTFRIAP SMCITKPEVD FAVEVFRSAL TQHMERRAK

Note: No experimental confirmation available.

Show »

Length:439

Mass (Da):49,297

Checksum:ⁱ00C1D064946D2A8F

GO

Polymorphismⁱ

Genetic variants in AGXT2 are association with beta-aminoisobutyric aciduria (BAIBA)[MIMⁱ:210100]. Excretion of beta-aminoisobutyric acid in urine is a common, benign, metabolic trait.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_061006	102	S → I. Corresponds to variant dbSNP:rs37370Ensembl.	1
Natural variantⁱVAR_023483	102	S → N3 PublicationsCorresponds to variant dbSNP:rs37370Ensembl.	1
Natural variantⁱVAR_061007	102	S → T. Corresponds to variant dbSNP:rs37370Ensembl.	1
Natural variantⁱVAR_048231	132	G → R. Corresponds to variant dbSNP:rs16870794Ensembl.	1
Natural variantⁱVAR_022140	140	V → I Polymorphism; associated with an increased risk for coronary heart disease (CHD) in smoker and diabetic mellitus (DM) patients in a Chinese population; higher plasma symmetric (SDMA) dimethylarginine as well as plasma and urinary beta-aminoisobutyrate (BAIB) concentrations; localized to the mitochondrion as the wild-type; reduces alanine-glyoxylate aminotransferase activity. 4 PublicationsCorresponds to variant dbSNP:rs37369EnsemblClinVar.	1
Natural variantⁱVAR_022141	212	T → I3 PublicationsCorresponds to variant dbSNP:rs180749Ensembl.	1
Natural variantⁱVAR_048232	492	P → R. Corresponds to variant dbSNP:rs17245714Ensembl.	1
Natural variantⁱVAR_029513	498	V → L Polymorphism; higher plasma and urinary beta-aminoisobutyrate (BAIB) concentrations. 2 PublicationsCorresponds to variant dbSNP:rs16899974Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055802	321 – 395	Missing in isoform 2. 1 PublicationAdd BLAST		75

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ292204 mRNA Translation: CAC24841.1 AB193309 mRNA Translation: BAD66662.1 AK223128 mRNA Translation: BAD96848.1 AK223144 mRNA No translation available. AK223375 mRNA Translation: BAD97095.1 AC010368 Genomic DNA No translation available. BC144268 mRNA Translation: AAI44269.1 BC150603 mRNA Translation: AAI50604.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3908.1 [Q9BYV1-1] CCDS78000.1 [Q9BYV1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001293102.1, NM_001306173.1 [Q9BYV1-2] NP_114106.1, NM_031900.3 [Q9BYV1-1] XP_016865237.1, XM_017009748.1 [Q9BYV1-2]
UniGeneⁱ	Hs.34494

Genome annotation databases

Ensemblⁱ	ENST00000231420; ENSP00000231420; ENSG00000113492 [Q9BYV1-1] ENST00000510428; ENSP00000422799; ENSG00000113492 [Q9BYV1-2] ENST00000618015; ENSP00000479154; ENSG00000113492 [Q9BYV1-2]
GeneIDⁱ	64902
KEGGⁱ	hsa:64902
UCSC genome browser More...UCSCⁱ	uc003jjf.4 human [Q9BYV1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BYV1	Alanine--glyoxylate aminotransferase 2, mitochondrial		PONAB		514	UniRef90_Q9BYV1
Alanine--glyoxylate aminotransferase 2		HUMAN		514
AGXT2 isoform 2		PANTR		514
Uncharacterized protein		PANPA		514
Alanine--glyoxylate aminotransferase 2, mitochondrial		MACMU		514
+25
Q9BYV1-2	AGXT2 isoform 1		PANTR		439	UniRef90_Q9BYV1-2
Uncharacterized protein		PANPA		439
AGXT2 isoform 1		PONAB		439
Alanine--glyoxylate aminotransferase 2		SAIBB		439
Alanine--glyoxylate aminotransferase 2		CALJA		439
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9BYV1	Alanine--glyoxylate aminotransferase 2, mitochondrial		PONAB		514	UniRef50_Q9BYV1
Alanine--glyoxylate aminotransferase 2		GORGO		514
Uncharacterized protein		COLAP		514
Alanine--glyoxylate aminotransferase 2, mitochondrial		MACMU		514
Uncharacterized protein		MACFA		514
+78

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ292204 mRNA Translation: CAC24841.1 AB193309 mRNA Translation: BAD66662.1 AK223128 mRNA Translation: BAD96848.1 AK223144 mRNA No translation available. AK223375 mRNA Translation: BAD97095.1 AC010368 Genomic DNA No translation available. BC144268 mRNA Translation: AAI44269.1 BC150603 mRNA Translation: AAI50604.1
CCDSⁱ	CCDS3908.1 [Q9BYV1-1] CCDS78000.1 [Q9BYV1-2]
RefSeqⁱ	NP_001293102.1, NM_001306173.1 [Q9BYV1-2] NP_114106.1, NM_031900.3 [Q9BYV1-1] XP_016865237.1, XM_017009748.1 [Q9BYV1-2]
UniGeneⁱ	Hs.34494

3D structure databases

ProteinModelPortalⁱ	Q9BYV1
SMRⁱ	Q9BYV1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122342, 2 interactors
IntActⁱ	Q9BYV1, 2 interactors
STRINGⁱ	9606.ENSP00000231420

Chemistry databases

DrugBankⁱ	DB00145 Glycine DB00160 L-Alanine DB00114 Pyridoxal Phosphate DB00119 Pyruvic acid

DrugBankⁱ

DB00145 Glycine
DB00160 L-Alanine
DB00114 Pyridoxal Phosphate
DB00119 Pyruvic acid

PTM databases

iPTMnetⁱ	Q9BYV1
PhosphoSitePlusⁱ	Q9BYV1

Polymorphism and mutation databases

BioMutaⁱ	AGXT2
DMDMⁱ	17432913

Proteomic databases

PaxDbⁱ	Q9BYV1
PeptideAtlasⁱ	Q9BYV1
PRIDEⁱ	Q9BYV1
ProteomicsDBⁱ	79711

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000231420; ENSP00000231420; ENSG00000113492 [Q9BYV1-1] ENST00000510428; ENSP00000422799; ENSG00000113492 [Q9BYV1-2] ENST00000618015; ENSP00000479154; ENSG00000113492 [Q9BYV1-2]
GeneIDⁱ	64902
KEGGⁱ	hsa:64902
UCSCⁱ	uc003jjf.4 human [Q9BYV1-1]

Organism-specific databases

CTDⁱ	64902
DisGeNETⁱ	64902
EuPathDBⁱ	HostDB:ENSG00000113492.13
GeneCardsⁱ	AGXT2
HGNCⁱ	HGNC:14412 AGXT2
HPAⁱ	HPA037382
MalaCardsⁱ	AGXT2
MIMⁱ	210100 phenotype 612471 gene
neXtProtⁱ	NX_Q9BYV1
OpenTargetsⁱ	ENSG00000113492
PharmGKBⁱ	PA24634
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1404 Eukaryota COG0160 LUCA
GeneTreeⁱ	ENSGT00530000062907
HOGENOMⁱ	HOG000020206
HOVERGENⁱ	HBG004196
InParanoidⁱ	Q9BYV1
KOⁱ	K00827
OMAⁱ	GIATCTL
OrthoDBⁱ	EOG091G06LW
PhylomeDBⁱ	Q9BYV1
TreeFamⁱ	TF105945

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03685-MONOMER
Reactomeⁱ	R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-73621 Pyrimidine catabolism

Miscellaneous databases

ChiTaRSⁱ	AGXT2 human
GenomeRNAiⁱ	64902
Protein Ontology More...PROⁱ	PR:Q9BYV1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113492 Expressed in 31 organ(s), highest expression level in kidney epithelium
CleanExⁱ	HS_AGXT2
Genevisibleⁱ	Q9BYV1 HS

Family and domain databases

CDDⁱ	cd00610 OAT_like, 1 hit
Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR005814 Aminotrans_3 IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfamⁱ	View protein in Pfam PF00202 Aminotran_3, 1 hit
PIRSFⁱ	PIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
PROSITEⁱ	View protein in PROSITE PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGT2_HUMAN
Accessionⁱ	Q9BYV1Primary (citable) accession number: Q9BYV1 Secondary accession number(s): B7ZM47 , E9PDL7, Q53FB4, Q53FY7, Q53G03, Q5W7Q1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - Q9BYV1 (AGT2_HUMAN)

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Alanine--glyoxylate aminotransferase 2, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ