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UniProtKB - Q9BYV1 (AGT2_HUMAN)

Entry version 158 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Alanine--glyoxylate aminotransferase 2, mitochondrial

Gene

AGXT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS03685-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BYV1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-73621, Pyrimidine catabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alanine--glyoxylate aminotransferase 2, mitochondrial (EC:2.6.1.44)
Short name:
AGT 2
Alternative name(s):
(R)-3-amino-2-methylpropionate--pyruvate transaminase (EC:2.6.1.40)
Beta-ALAAT II
Beta-alanine-pyruvate aminotransferase
D-AIBAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGXT2
Synonyms:AGT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000113492.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:14412, AGXT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612471, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BYV1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64902

MalaCards human disease database

More...MalaCardsi		AGXT2
MIMi210100, phenotype

Open Targets

More...OpenTargetsi		ENSG00000113492

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24634

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BYV1, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00160, Alanine
DB00145, Glycine
DB00114, Pyridoxal phosphate
DB00119, Pyruvic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AGXT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		17432913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 41Mitochondrion1 PublicationAdd BLAST41
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000126942 – 514Alanine--glyoxylate aminotransferase 2, mitochondrialAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei71N6-acetyllysine; alternateBy similarity1
Modified residuei71N6-succinyllysine; alternateBy similarity1
Modified residuei84N6-acetyllysineBy similarity1
Modified residuei262N6-acetyllysine; alternateBy similarity1
Modified residuei262N6-succinyllysine; alternateBy similarity1
Modified residuei304N6-succinyllysineBy similarity1
Modified residuei350N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei417N6-acetyllysine; alternateBy similarity1
Modified residuei417N6-succinyllysine; alternateBy similarity1
Modified residuei420N6-acetyllysine; alternateBy similarity1
Modified residuei420N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BYV1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BYV1

PeptideAtlas

More...PeptideAtlasi		Q9BYV1

PRoteomics IDEntifications database

More...PRIDEi		Q9BYV1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19698
79711 [Q9BYV1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BYV1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BYV1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113492, Expressed in kidney epithelium and 44 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BYV1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000113492, Group enriched (kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122342, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q9BYV1, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000231420

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BYV1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BYV1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1404, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156125

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016922_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BYV1

KEGG Orthology (KO)

More...KOi		K00827

Identification of Orthologs from Complete Genome Data

More...OMAi		GWGLING

Database of Orthologous Groups

More...OrthoDBi		145181at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BYV1

TreeFam database of animal gene trees

More...TreeFami		TF105945

Family and domain databases

Conserved Domains Database

More...CDDi		cd00610, OAT_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005814, Aminotrans_3
IPR015424, PyrdxlP-dep_Trfase
IPR015422, PyrdxlP-dep_Trfase_dom1
IPR015421, PyrdxlP-dep_Trfase_major

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00202, Aminotran_3, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53383, SSF53383, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00600, AA_TRANSFER_CLASS_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BYV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLIWRHLLR PLCLVTSAPR ILEMHPFLSL GTSRTSVTKL SLHTKPRMPP 
        60         70         80         90        100
CDFMPERYQS LGYNRVLEIH KEHLSPVVTA YFQKPLLLHQ GHMEWLFDAE 
       110        120        130        140        150
GSRYLDFFSG IVTVSVGHCH PKVNAVAQKQ LGRLWHTSTV FFHPPMHEYA 
       160        170        180        190        200
EKLAALLPEP LKVIFLVNSG SEANELAMLM ARAHSNNIDI ISFRGAYHGC 
       210        220        230        240        250
SPYTLGLTNV GTYKMELPGG TGCQPTMCPD VFRGPWGGSH CRDSPVQTIR 
       260        270        280        290        300
KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK 
       310        320        330        340        350
GFLKEAFELV RARGGVCIAD EVQTGFGRLG SHFWGFQTHD VLPDIVTMAK 
       360        370        380        390        400
GIGNGFPMAA VITTPEIAKS LAKCLQHFNT FGGNPMACAI GSAVLEVIKE 
       410        420        430        440        450
ENLQENSQEV GTYMLLKFAK LRDEFEIVGD VRGKGLMIGI EMVQDKISCR 
       460        470        480        490        500
PLPREEVNQI HEDCKHMGLL VGRGSIFSQT FRIAPSMCIT KPEVDFAVEV 
       510 
FRSALTQHME RRAK
Length:514
Mass (Da):57,156
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA562F84FF39B5AC
GO
Isoform 2 (identifier: Q9BYV1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-395: Missing.

Show »
Length:439
Mass (Da):49,297
Checksum:i00C1D064946D2A8F
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variants in AGXT2 are association with beta-aminoisobutyric aciduria (BAIBA)[MIMi:210100]. Excretion of beta-aminoisobutyric acid in urine is a common, benign, metabolic trait.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061006102S → I. Corresponds to variant dbSNP:rs37370Ensembl.1
Natural variantiVAR_023483102S → N3 PublicationsCorresponds to variant dbSNP:rs37370Ensembl.1
Natural variantiVAR_061007102S → T. Corresponds to variant dbSNP:rs37370Ensembl.1
Natural variantiVAR_048231132G → R. Corresponds to variant dbSNP:rs16870794Ensembl.1
Natural variantiVAR_022140140V → I Polymorphism; associated with an increased risk for coronary heart disease (CHD) in smoker and diabetic mellitus (DM) patients in a Chinese population; higher plasma symmetric (SDMA) dimethylarginine as well as plasma and urinary beta-aminoisobutyrate (BAIB) concentrations; localized to the mitochondrion as the wild-type; reduces alanine-glyoxylate aminotransferase activity. 4 PublicationsCorresponds to variant dbSNP:rs37369EnsemblClinVar.1
Natural variantiVAR_022141212T → I3 PublicationsCorresponds to variant dbSNP:rs180749Ensembl.1
Natural variantiVAR_048232492P → R. Corresponds to variant dbSNP:rs17245714Ensembl.1
Natural variantiVAR_029513498V → L Polymorphism; higher plasma and urinary beta-aminoisobutyrate (BAIB) concentrations. 2 PublicationsCorresponds to variant dbSNP:rs16899974Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055802321 – 395Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ292204 mRNA Translation: CAC24841.1
AB193309 mRNA Translation: BAD66662.1
AK223128 mRNA Translation: BAD96848.1
AK223144 mRNA No translation available.
AK223375 mRNA Translation: BAD97095.1
AC010368 Genomic DNA No translation available.
BC144268 mRNA Translation: AAI44269.1
BC150603 mRNA Translation: AAI50604.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3908.1 [Q9BYV1-1]
CCDS78000.1 [Q9BYV1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001293102.1, NM_001306173.1 [Q9BYV1-2]
NP_114106.1, NM_031900.3 [Q9BYV1-1]
XP_016865237.1, XM_017009748.1 [Q9BYV1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000231420; ENSP00000231420; ENSG00000113492 [Q9BYV1-1]
ENST00000510428; ENSP00000422799; ENSG00000113492 [Q9BYV1-2]
ENST00000618015; ENSP00000479154; ENSG00000113492 [Q9BYV1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64902

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64902

UCSC genome browser

More...UCSCi		uc003jjf.4, human [Q9BYV1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292204 mRNA Translation: CAC24841.1
AB193309 mRNA Translation: BAD66662.1
AK223128 mRNA Translation: BAD96848.1
AK223144 mRNA No translation available.
AK223375 mRNA Translation: BAD97095.1
AC010368 Genomic DNA No translation available.
BC144268 mRNA Translation: AAI44269.1
BC150603 mRNA Translation: AAI50604.1
CCDSiCCDS3908.1 [Q9BYV1-1]
CCDS78000.1 [Q9BYV1-2]
RefSeqiNP_001293102.1, NM_001306173.1 [Q9BYV1-2]
NP_114106.1, NM_031900.3 [Q9BYV1-1]
XP_016865237.1, XM_017009748.1 [Q9BYV1-2]

3D structure databases

SMRiQ9BYV1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122342, 3 interactors
IntActiQ9BYV1, 2 interactors
STRINGi9606.ENSP00000231420

Chemistry databases

DrugBankiDB00160, Alanine
DB00145, Glycine
DB00114, Pyridoxal phosphate
DB00119, Pyruvic acid

PTM databases

iPTMnetiQ9BYV1
PhosphoSitePlusiQ9BYV1

Polymorphism and mutation databases

BioMutaiAGXT2
DMDMi17432913

Proteomic databases

MassIVEiQ9BYV1
PaxDbiQ9BYV1
PeptideAtlasiQ9BYV1
PRIDEiQ9BYV1
ProteomicsDBi19698
79711 [Q9BYV1-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43482, 136 antibodies

Genome annotation databases

EnsembliENST00000231420; ENSP00000231420; ENSG00000113492 [Q9BYV1-1]
ENST00000510428; ENSP00000422799; ENSG00000113492 [Q9BYV1-2]
ENST00000618015; ENSP00000479154; ENSG00000113492 [Q9BYV1-2]
GeneIDi64902
KEGGihsa:64902
UCSCiuc003jjf.4, human [Q9BYV1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64902
DisGeNETi64902
EuPathDBiHostDB:ENSG00000113492.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		AGXT2
HGNCiHGNC:14412, AGXT2
HPAiENSG00000113492, Group enriched (kidney, liver)
MalaCardsiAGXT2
MIMi210100, phenotype
612471, gene
neXtProtiNX_Q9BYV1
OpenTargetsiENSG00000113492
PharmGKBiPA24634

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1404, Eukaryota
GeneTreeiENSGT00940000156125
HOGENOMiCLU_016922_8_0_1
InParanoidiQ9BYV1
KOiK00827
OMAiGWGLING
OrthoDBi145181at2759
PhylomeDBiQ9BYV1
TreeFamiTF105945

Enzyme and pathway databases

BioCyciMetaCyc:HS03685-MONOMER
PathwayCommonsiQ9BYV1
ReactomeiR-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-73621, Pyrimidine catabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64902, 1 hit in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AGXT2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64902
PharosiQ9BYV1, Tbio

Protein Ontology

More...PROi		PR:Q9BYV1
RNActiQ9BYV1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000113492, Expressed in kidney epithelium and 44 other tissues
GenevisibleiQ9BYV1, HS

Family and domain databases

CDDicd00610, OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005814, Aminotrans_3
IPR015424, PyrdxlP-dep_Trfase
IPR015422, PyrdxlP-dep_Trfase_dom1
IPR015421, PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202, Aminotran_3, 1 hit
PIRSFiPIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383, SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600, AA_TRANSFER_CLASS_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYV1
Secondary accession number(s): B7ZM47
, E9PDL7, Q53FB4, Q53FY7, Q53G03, Q5W7Q1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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