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Entry version 169 (07 Apr 2021)
Sequence version 2 (09 Jan 2007)
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Protein

Pre-B-cell leukemia transcription factor 4

Gene

PBX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi210 – 272Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BYU1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 4
Alternative name(s):
Homeobox protein PBX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13403, PBX4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608127, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYU1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000105717.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80714

Open Targets

More...
OpenTargetsi
ENSG00000105717

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32973

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYU1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PBX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122065777

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000492411 – 374Pre-B-cell leukemia transcription factor 4Add BLAST374

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BYU1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYU1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BYU1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYU1

PeptideAtlas

More...
PeptideAtlasi
Q9BYU1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYU1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79709

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYU1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105717, Expressed in right lobe of thyroid gland and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BYU1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYU1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105717, Tissue enhanced (testis, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BYU1
With#Exp.IntAct
ARHGEF3 [Q9NR81]3EBI-10302990,EBI-10312733
BCL6 [P41182]3EBI-10302990,EBI-765407
BFSP2 [Q13515]3EBI-10302990,EBI-10229433
C14orf119 [Q9NWQ9]3EBI-10302990,EBI-725606
C1orf109 [Q9NX04]5EBI-10302990,EBI-8643161
CCM2L [Q9NUG4]5EBI-10302990,EBI-350645
CDKN2C [P42773]3EBI-10302990,EBI-711290
CHCHD2 [Q9Y6H1]3EBI-10302990,EBI-2321769
CLCNKA - isoform 3 [P51800-3]3EBI-10302990,EBI-11980535
CPNE7 - isoform 2 [Q9UBL6-2]3EBI-10302990,EBI-12012272
DR1 [Q01658]3EBI-10302990,EBI-750300
EIF1AD [Q8N9N8]3EBI-10302990,EBI-750700
EIF3F [O00303]3EBI-10302990,EBI-711990
EXOC8 [Q8IYI6]3EBI-10302990,EBI-742102
FUS [P35637]3EBI-10302990,EBI-400434
GADD45GIP1 [Q8TAE8]3EBI-10302990,EBI-372506
GEM [P55040]3EBI-10302990,EBI-744104
GINS4 [Q9BRT9]3EBI-10302990,EBI-747500
GPANK1 [O95872]3EBI-10302990,EBI-751540
GTF2B [Q00403]3EBI-10302990,EBI-389564
GTF3C3 [Q9Y5Q9]3EBI-10302990,EBI-1054873
HOXB2 [P14652]3EBI-10302990,EBI-5329558
HOXB5 [P09067]3EBI-10302990,EBI-3893317
HOXC5 [Q00444]3EBI-10302990,EBI-11955357
HOXC8 [P31273]3EBI-10302990,EBI-1752118
HOXD4 [P09016]3EBI-10302990,EBI-12822515
HSBP1L1 [C9JCN9]3EBI-10302990,EBI-2685549
HTT [P42858]3EBI-10302990,EBI-466029
IFT20 - isoform 3 [Q8IY31-3]3EBI-10302990,EBI-9091197
IPO13 [O94829]8EBI-10302990,EBI-747310
KDM1A [O60341]3EBI-10302990,EBI-710124
KLHL38 [Q2WGJ6]3EBI-10302990,EBI-6426443
LMO2 - isoform 3 [P25791-3]3EBI-10302990,EBI-11959475
MAGOHB [Q96A72]3EBI-10302990,EBI-746778
MAPK9 [P45984]3EBI-10302990,EBI-713568
MBD3 - isoform 2 [O95983-2]3EBI-10302990,EBI-11978579
MEIS2 - isoform 4 [O14770-4]6EBI-10302990,EBI-8025850
MIPOL1 [Q8TD10]3EBI-10302990,EBI-2548751
NCK2 [O43639]3EBI-10302990,EBI-713635
NEK6 - isoform 4 [Q9HC98-4]3EBI-10302990,EBI-11750983
NUTF2 [P61970]3EBI-10302990,EBI-591778
PACSIN2 [Q9UNF0]3EBI-10302990,EBI-742503
PICK1 [Q9NRD5]3EBI-10302990,EBI-79165
PIH1D2 [Q8WWB5]6EBI-10302990,EBI-10232538
PIK3R3 [Q92569]3EBI-10302990,EBI-79893
PKNOX1 [P55347]5EBI-10302990,EBI-1373569
PKNOX2 [Q96KN3]3EBI-10302990,EBI-2692890
PPL [O60437]3EBI-10302990,EBI-368321
RBX1 [P62877]3EBI-10302990,EBI-398523
RIPPLY1 [Q0D2K3]3EBI-10302990,EBI-10226430
RIPPLY2 [Q5TAB7]5EBI-10302990,EBI-10246897
SCNM1 [Q9BWG6]3EBI-10302990,EBI-748391
SERTAD1 [Q9UHV2]3EBI-10302990,EBI-748601
SMARCD1 [Q96GM5]3EBI-10302990,EBI-358489
SOD1 [P00441]3EBI-10302990,EBI-990792
SPANXN2 [Q5MJ10]3EBI-10302990,EBI-12023934
SPANXN3 [Q5MJ09]3EBI-10302990,EBI-12037215
SPG21 [Q9NZD8]3EBI-10302990,EBI-742688
TARDBP [Q13148]6EBI-10302990,EBI-372899
TFIP11 [Q9UBB9]9EBI-10302990,EBI-1105213
TRIM41 [Q8WV44]3EBI-10302990,EBI-725997
TSEN15 [Q8WW01]3EBI-10302990,EBI-372432
TSSK3 [Q96PN8]3EBI-10302990,EBI-3918381
TXNDC9 [O14530]5EBI-10302990,EBI-707554
UBTFL1 [P0CB47]3EBI-10302990,EBI-17208936
USHBP1 [Q8N6Y0]3EBI-10302990,EBI-739895
USP20 [A0A024R8A9]3EBI-10302990,EBI-14096082
WWOX - isoform 5 [Q9NZC7-5]3EBI-10302990,EBI-12040603
ZNF330 [Q9Y3S2]3EBI-10302990,EBI-373456
A0A384ME253EBI-10302990,EBI-10211777

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123272, 78 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BYU1, 75 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251203

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYU1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 209PBCSequence analysisAdd BLAST192

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0774, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162643

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041153_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYU1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCRPEKR

Database of Orthologous Groups

More...
OrthoDBi
804740at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYU1

TreeFam database of animal gene trees

More...
TreeFami
TF314340

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR005542, PBX

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit
PF03792, PBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BYU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPPRPAPS PPAPRRLDTS DVLQQIMAIT DQSLDEAQAR KHALNCHRMK
60 70 80 90 100
PALFSVLCEI KEKTVVSIRG IQDEDPPDAQ LLRLDNMLLA EGVCRPEKRG
110 120 130 140 150
RGGAVARAGT ATPGGCPNDN SIEHSDYRAK LSQIRQIYHS ELEKYEQACR
160 170 180 190 200
EFTTHVTNLL QEQSRMRPVS PKEIERMVGA IHGKFSAIQM QLKQSTCEAV
210 220 230 240 250
MTLRSRLLDA RRKRRNFSKQ ATEVLNEYFY SHLNNPYPSE EAKEELARKG
260 270 280 290 300
GLTISQVSNW FGNKRIRYKK NMGKFQEEAT IYTGKTAVDT TEVGVPGNHA
310 320 330 340 350
SCLSTPSSGS SGPFPLPSAG DAFLTLRTLA SLQPPPGGGC LQSQAQGSWQ
360 370
GATPQPATAS PAGDPGSINS STSN
Length:374
Mass (Da):40,854
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9CE8BE93D0B7ABC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YL59H0YL59_HUMAN
Pre-B-cell leukemia transcription f...
PBX4
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC033067 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti368I → T in BAG53471 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059355169V → I. Corresponds to variant dbSNP:rs8108180Ensembl.1
Natural variantiVAR_059356177M → V. Corresponds to variant dbSNP:rs8108981Ensembl.1
Natural variantiVAR_036439283T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376647012Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097427 mRNA Translation: BAG53471.1
BC033067 mRNA No translation available.
CH471106 Genomic DNA Translation: EAW84835.1
BC141859 mRNA Translation: AAI41860.1
AJ300182 mRNA Translation: CAC28212.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12406.1

NCBI Reference Sequences

More...
RefSeqi
NP_079521.1, NM_025245.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251203; ENSP00000251203; ENSG00000105717

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80714

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80714

UCSC genome browser

More...
UCSCi
uc002nmy.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097427 mRNA Translation: BAG53471.1
BC033067 mRNA No translation available.
CH471106 Genomic DNA Translation: EAW84835.1
BC141859 mRNA Translation: AAI41860.1
AJ300182 mRNA Translation: CAC28212.1
CCDSiCCDS12406.1
RefSeqiNP_079521.1, NM_025245.2

3D structure databases

SMRiQ9BYU1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123272, 78 interactors
IntActiQ9BYU1, 75 interactors
STRINGi9606.ENSP00000251203

PTM databases

iPTMnetiQ9BYU1
PhosphoSitePlusiQ9BYU1

Genetic variation databases

BioMutaiPBX4
DMDMi122065777

Proteomic databases

jPOSTiQ9BYU1
MassIVEiQ9BYU1
MaxQBiQ9BYU1
PaxDbiQ9BYU1
PeptideAtlasiQ9BYU1
PRIDEiQ9BYU1
ProteomicsDBi79709

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28510, 87 antibodies

Genome annotation databases

EnsembliENST00000251203; ENSP00000251203; ENSG00000105717
GeneIDi80714
KEGGihsa:80714
UCSCiuc002nmy.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80714
DisGeNETi80714

GeneCards: human genes, protein and diseases

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GeneCardsi
PBX4
HGNCiHGNC:13403, PBX4
HPAiENSG00000105717, Tissue enhanced (testis, thyroid gland)
MIMi608127, gene
neXtProtiNX_Q9BYU1
OpenTargetsiENSG00000105717
PharmGKBiPA32973
VEuPathDBiHostDB:ENSG00000105717.13

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0774, Eukaryota
GeneTreeiENSGT00940000162643
HOGENOMiCLU_041153_1_0_1
InParanoidiQ9BYU1
OMAiVCRPEKR
OrthoDBi804740at2759
PhylomeDBiQ9BYU1
TreeFamiTF314340

Enzyme and pathway databases

PathwayCommonsiQ9BYU1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
80714, 12 hits in 1006 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PBX4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80714
PharosiQ9BYU1, Tbio

Protein Ontology

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PROi
PR:Q9BYU1
RNActiQ9BYU1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105717, Expressed in right lobe of thyroid gland and 133 other tissues
ExpressionAtlasiQ9BYU1, baseline and differential
GenevisibleiQ9BYU1, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR005542, PBX
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF03792, PBC, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPBX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYU1
Secondary accession number(s): A5D8Y0, B3KUK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 9, 2007
Last modified: April 7, 2021
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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