Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurolysin, mitochondrial

Gene

NLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.By similarity

Catalytic activityi

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi497Zinc; catalyticPROSITE-ProRule annotation1
Active sitei498PROSITE-ProRule annotation1
Metal bindingi501Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi504Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors

Protein family/group databases

MEROPSiM03.002

Names & Taxonomyi

Protein namesi
Recommended name:
Neurolysin, mitochondrial (EC:3.4.24.16)
Alternative name(s):
Angiotensin-binding protein
Microsomal endopeptidase
Short name:
MEP
Mitochondrial oligopeptidase M
Neurotensin endopeptidase
Gene namesi
Name:NLN
Synonyms:AGTBP, KIAA1226
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000123213.22
HGNCiHGNC:16058 NLN
MIMi611530 gene
neXtProtiNX_Q9BYT8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi57486
OpenTargetsiENSG00000123213
PharmGKBiPA31651

Polymorphism and mutation databases

BioMutaiNLN
DMDMi20139130

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionBy similarityAdd BLAST37
ChainiPRO_000002857538 – 704Neurolysin, mitochondrialAdd BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei664N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BYT8
MaxQBiQ9BYT8
PaxDbiQ9BYT8
PeptideAtlasiQ9BYT8
PRIDEiQ9BYT8
ProteomicsDBi79707

PTM databases

iPTMnetiQ9BYT8
PhosphoSitePlusiQ9BYT8

Expressioni

Gene expression databases

BgeeiENSG00000123213
CleanExiHS_NLN
ExpressionAtlasiQ9BYT8 baseline and differential
GenevisibleiQ9BYT8 HS

Organism-specific databases

HPAiHPA031862

Interactioni

Protein-protein interaction databases

BioGridi121555, 28 interactors
IntActiQ9BYT8, 18 interactors
STRINGi9606.ENSP00000370372

Structurei

Secondary structure

1704
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi54 – 77Combined sources24
Turni80 – 82Combined sources3
Turni85 – 88Combined sources4
Helixi89 – 107Combined sources19
Helixi109 – 112Combined sources4
Helixi116 – 137Combined sources22
Helixi140 – 152Combined sources13
Helixi155 – 157Combined sources3
Helixi160 – 175Combined sources16
Turni176 – 179Combined sources4
Helixi182 – 208Combined sources27
Beta strandi212 – 215Combined sources4
Turni217 – 222Combined sources6
Beta strandi229 – 231Combined sources3
Beta strandi239 – 244Combined sources6
Helixi245 – 254Combined sources10
Helixi258 – 268Combined sources11
Turni269 – 272Combined sources4
Helixi273 – 293Combined sources21
Helixi299 – 304Combined sources6
Helixi312 – 348Combined sources37
Turni358 – 360Combined sources3
Helixi361 – 373Combined sources13
Helixi377 – 380Combined sources4
Helixi381 – 383Combined sources3
Helixi386 – 401Combined sources16
Beta strandi404 – 408Combined sources5
Beta strandi419 – 424Combined sources6
Beta strandi426 – 428Combined sources3
Beta strandi431 – 438Combined sources8
Beta strandi450 – 455Combined sources6
Beta strandi461 – 465Combined sources5
Beta strandi468 – 473Combined sources6
Helixi489 – 507Combined sources19
Helixi513 – 515Combined sources3
Turni522 – 526Combined sources5
Helixi527 – 532Combined sources6
Helixi533 – 536Combined sources4
Helixi539 – 545Combined sources7
Turni549 – 551Combined sources3
Helixi557 – 565Combined sources9
Helixi566 – 568Combined sources3
Helixi571 – 588Combined sources18
Beta strandi592 – 594Combined sources3
Helixi596 – 606Combined sources11
Helixi619 – 621Combined sources3
Helixi623 – 625Combined sources3
Turni626 – 628Combined sources3
Helixi635 – 649Combined sources15
Turni650 – 653Combined sources4
Helixi659 – 669Combined sources11
Turni670 – 672Combined sources3
Helixi673 – 675Combined sources3
Helixi678 – 686Combined sources9
Helixi693 – 699Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LUZX-ray2.70A/B38-704[»]
5LV0X-ray2.70A/B38-704[»]
ProteinModelPortaliQ9BYT8
SMRiQ9BYT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2089 Eukaryota
COG0339 LUCA
GeneTreeiENSGT00550000074738
HOGENOMiHOG000245985
HOVERGENiHBG000238
InParanoidiQ9BYT8
KOiK01393
OMAiENWVWDI
OrthoDBiEOG091G0325
PhylomeDBiQ9BYT8
TreeFamiTF300459

Family and domain databases

Gene3Di1.10.1370.10, 2 hits
1.20.1050.40, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR024077 Neurolysin/TOP_dom2
IPR024080 Neurolysin/TOP_N
IPR001567 Pept_M3A_M3B
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARCLLAVR SLRRVGGSRI LLRMTLGREV MSPLQAMSSY TVAGRNVLRW
60 70 80 90 100
DLSPEQIKTR TEELIVQTKQ VYDAVGMLGI EEVTYENCLQ ALADVEVKYI
110 120 130 140 150
VERTMLDFPQ HVSSDKEVRA ASTEADKRLS RFDIEMSMRG DIFERIVHLQ
160 170 180 190 200
ETCDLGKIKP EARRYLEKSI KMGKRNGLHL PEQVQNEIKS MKKRMSELCI
210 220 230 240 250
DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKTDDDKYK ITLKYPHYFP
260 270 280 290 300
VMKKCCIPET RRRMEMAFNT RCKEENTIIL QQLLPLRTKV AKLLGYSTHA
310 320 330 340 350
DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILNL KKKECKDRGF
360 370 380 390 400
EYDGKINAWD LYYYMTQTEE LKYSIDQEFL KEYFPIEVVT EGLLNTYQEL
410 420 430 440 450
LGLSFEQMTD AHVWNKSVTL YTVKDKATGE VLGQFYLDLY PREGKYNHAA
460 470 480 490 500
CFGLQPGCLL PDGSRMMAVA ALVVNFSQPV AGRPSLLRHD EVRTYFHEFG
510 520 530 540 550
HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDVD SLRRLSKHYK
560 570 580 590 600
DGSPIADDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NTSLDAASEY
610 620 630 640 650
AKYCSEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC
660 670 680 690 700
FKKEGIMNPE VGMKYRNLIL KPGGSLDGMD MLHNFLKREP NQKAFLMSRG

LHAP
Length:704
Mass (Da):80,652
Last modified:June 1, 2001 - v1
Checksum:i80136688D79BBEDF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06222479G → S. Corresponds to variant dbSNP:rs34339013Ensembl.1
Natural variantiVAR_054002323S → G. Corresponds to variant dbSNP:rs34063558Ensembl.1
Natural variantiVAR_054003372K → R. Corresponds to variant dbSNP:rs6863012Ensembl.1
Natural variantiVAR_054004417S → G. Corresponds to variant dbSNP:rs2289884Ensembl.1
Natural variantiVAR_024594704P → S. Corresponds to variant dbSNP:rs6860508Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300837 mRNA Translation: CAC27329.1
AB033052 mRNA Translation: BAA86540.2
CCDSiCCDS3989.1
RefSeqiNP_065777.1, NM_020726.4
UniGeneiHs.247460

Genome annotation databases

EnsembliENST00000380985; ENSP00000370372; ENSG00000123213
GeneIDi57486
KEGGihsa:57486
UCSCiuc003juf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNEUL_HUMAN
AccessioniPrimary (citable) accession number: Q9BYT8
Secondary accession number(s): Q9ULJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health