Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase 33

Gene

STK33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei145ATPPROSITE-ProRule annotation1
Active sitei238Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 130ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9BYT3

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 33 (EC:2.7.11.1)
Gene namesi
Name:STK33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000130413.15
HGNCiHGNC:14568 STK33
MIMi607670 gene
neXtProtiNX_Q9BYT3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi65975
OpenTargetsiENSG00000130413
PharmGKBiPA37900

Chemistry databases

ChEMBLiCHEMBL6005
GuidetoPHARMACOLOGYi2221

Polymorphism and mutation databases

BioMutaiSTK33
DMDMi74761329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326441 – 514Serine/threonine-protein kinase 33Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BYT3
MaxQBiQ9BYT3
PaxDbiQ9BYT3
PeptideAtlasiQ9BYT3
PRIDEiQ9BYT3
ProteomicsDBi79704
79705 [Q9BYT3-2]

PTM databases

iPTMnetiQ9BYT3
PhosphoSitePlusiQ9BYT3

Expressioni

Tissue specificityi

Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.2 Publications

Gene expression databases

BgeeiENSG00000130413
CleanExiHS_STK33
ExpressionAtlasiQ9BYT3 baseline and differential
GenevisibleiQ9BYT3 HS

Organism-specific databases

HPAiHPA015742
HPA056855

Interactioni

Subunit structurei

Interacts with VIME.By similarity

Protein-protein interaction databases

BioGridi122426, 9 interactors
IntActiQ9BYT3, 4 interactors
STRINGi9606.ENSP00000320754

Chemistry databases

BindingDBiQ9BYT3

Structurei

3D structure databases

ProteinModelPortaliQ9BYT3
SMRiQ9BYT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 381Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi443 – 446Poly-Glu4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00840000129744
HOGENOMiHOG000293198
HOVERGENiHBG094004
InParanoidiQ9BYT3
KOiK08813
OMAiFETPKKM
OrthoDBiEOG091G0BST
PhylomeDBiQ9BYT3
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADSGLDKKS TKCPDCSSAS QKDVLCVCSS KTRVPPVLVV EMSQTSSIGS
60 70 80 90 100
AESLISLERK KEKNINRDIT SRKDLPSRTS NVERKASQQQ WGRGNFTEGK
110 120 130 140 150
VPHIRIENGA AIEEIYTFGR ILGKGSFGIV IEATDKETET KWAIKKVNKE
160 170 180 190 200
KAGSSAVKLL EREVNILKSV KHEHIIHLEQ VFETPKKMYL VMELCEDGEL
210 220 230 240 250
KEILDRKGHF SENETRWIIQ SLASAIAYLH NNDIVHRDLK LENIMVKSSL
260 270 280 290 300
IDDNNEINLN IKVTDFGLAV KKQSRSEAML QATCGTPIYM APEVISAHDY
310 320 330 340 350
SQQCDIWSIG VVMYMLLRGE PPFLASSEEK LFELIRKGEL HFENAVWNSI
360 370 380 390 400
SDCAKSVLKQ LMKVDPAHRI TAKELLDNQW LTGNKLSSVR PTNVLEMMKE
410 420 430 440 450
WKNNPESVEE NTTEEKNKPS TEEKLKSYQP WGNVPDANYT SDEEEEKQST
460 470 480 490 500
AYEKQFPATS KDNFDMCSSS FTSSKLLPAE IKGEMEKTPV TPSQGTATKY
510
PAKSGALSRT KKKL
Length:514
Mass (Da):57,831
Last modified:June 1, 2001 - v1
Checksum:iC251691ECB2DAC1A
GO
Isoform 2 (identifier: Q9BYT3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-448: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):50,176
Checksum:iFA0DE1B89F81956A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436 – 437DA → ET in AAH31231 (PubMed:15489334).Curated2
Sequence conflicti451A → T in AAH31231 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06174660K → E. Corresponds to variant dbSNP:rs60786172Ensembl.1
Natural variantiVAR_04117298E → D1 PublicationCorresponds to variant dbSNP:rs34525052Ensembl.1
Natural variantiVAR_041173160L → V in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041174436D → E1 PublicationCorresponds to variant dbSNP:rs3751096Ensembl.1
Natural variantiVAR_041175437A → T1 PublicationCorresponds to variant dbSNP:rs3751095Ensembl.1
Natural variantiVAR_041176458A → E1 PublicationCorresponds to variant dbSNP:rs35296353Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017939383 – 448Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303380 mRNA Translation: CAC29064.1
AK093251 mRNA Translation: BAC04109.1
BC031231 mRNA Translation: AAH31231.1
AL833011 mRNA Translation: CAH56302.1
CCDSiCCDS7789.1 [Q9BYT3-1]
RefSeqiNP_001275987.1, NM_001289058.1
NP_001275988.1, NM_001289059.1
NP_001275990.1, NM_001289061.1 [Q9BYT3-1]
NP_112168.1, NM_030906.3 [Q9BYT3-1]
XP_011518590.1, XM_011520288.2 [Q9BYT3-1]
XP_011518592.1, XM_011520290.2 [Q9BYT3-1]
XP_011518594.1, XM_011520292.2
XP_011518595.1, XM_011520293.2
XP_011518596.1, XM_011520294.1
XP_011518597.1, XM_011520295.2 [Q9BYT3-1]
XP_016873632.1, XM_017018143.1
XP_016873633.1, XM_017018144.1 [Q9BYT3-1]
XP_016873634.1, XM_017018145.1 [Q9BYT3-1]
XP_016873635.1, XM_017018146.1 [Q9BYT3-1]
XP_016873636.1, XM_017018147.1 [Q9BYT3-1]
XP_016873637.1, XM_017018148.1 [Q9BYT3-1]
XP_016873638.1, XM_017018149.1
XP_016873639.1, XM_017018150.1
XP_016873640.1, XM_017018151.1
XP_016873641.1, XM_017018152.1 [Q9BYT3-1]
XP_016873642.1, XM_017018153.1 [Q9BYT3-1]
XP_016873643.1, XM_017018154.1 [Q9BYT3-1]
XP_016873644.1, XM_017018155.1 [Q9BYT3-1]
XP_016873645.1, XM_017018156.1 [Q9BYT3-1]
XP_016873648.1, XM_017018159.1 [Q9BYT3-2]
XP_016873649.1, XM_017018160.1
UniGeneiHs.501833

Genome annotation databases

EnsembliENST00000315204; ENSP00000320754; ENSG00000130413 [Q9BYT3-1]
ENST00000396672; ENSP00000379905; ENSG00000130413 [Q9BYT3-1]
ENST00000447869; ENSP00000416750; ENSG00000130413 [Q9BYT3-1]
GeneIDi65975
KEGGihsa:65975
UCSCiuc001mgi.3 human [Q9BYT3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTK33_HUMAN
AccessioniPrimary (citable) accession number: Q9BYT3
Secondary accession number(s): Q658S6, Q8NEF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health