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Protein

Keratin-associated protein 1-5

Gene

KRTAP1-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 1-5
Alternative name(s):
High sulfur keratin-associated protein 1.5
Keratin-associated protein 1.5
Gene namesi
Name:KRTAP1-5
Synonyms:KAP1.5, KRTAP1.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000221852.4
HGNCiHGNC:16777 KRTAP1-5
MIMi608822 gene
neXtProtiNX_Q9BYS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221852
PharmGKBiPA38417

Polymorphism and mutation databases

BioMutaiKRTAP1-5
DMDMi56749988

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851611 – 174Keratin-associated protein 1-5Add BLAST174

Proteomic databases

PaxDbiQ9BYS1
PeptideAtlasiQ9BYS1
PRIDEiQ9BYS1
ProteomicsDBi79699

Expressioni

Tissue specificityi

Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication

Gene expression databases

BgeeiENSG00000221852
CleanExiHS_KRTAP1-5
GenevisibleiQ9BYS1 HS

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ9BYS1, 37 interactors
STRINGi9606.ENSP00000355302

Structurei

3D structure databases

ProteinModelPortaliQ9BYS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 17215 X 5 AA repeats of C-C-[QEPVRC]-[TPIVLE]-[SRHVP]Add BLAST170

Sequence similaritiesi

Belongs to the KRTAP type 1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00730000111060
HOGENOMiHOG000234033
HOVERGENiHBG008671
InParanoidiQ9BYS1
OMAiVCCCEPT
PhylomeDBiQ9BYS1
TreeFamiTF351356

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF01500 Keratin_B2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9BYS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCCQTSFCG YPSFSISGTC GSSCCQPSCC ETSCCQPRSC QTSFCGFPSF
60 70 80 90 100
STSGTCSSSC CQPSCCETSC CQPSCCETSC CQPSCCQISS CGTGCGIGGG
110 120 130 140 150
ISYGQEGSSG AVSTRIRWCR PDSRVEGTYL PPCCVVSCTP PSCCQLHHAQ
160 170
ASCCRPSYCG QSCCRPVCCC EPTC
Length:174
Mass (Da):18,010
Last modified:June 1, 2001 - v1
Checksum:iFD8F32C958A9B291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406928 mRNA Translation: CAC27567.1
AC007455 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60697.1
BC069533 mRNA Translation: AAH69533.1
BC093841 mRNA Translation: AAH93841.1
BC101555 mRNA Translation: AAI01556.1
CCDSiCCDS42321.1
RefSeqiNP_114163.1, NM_031957.1
UniGeneiHs.534499

Genome annotation databases

EnsembliENST00000361883; ENSP00000355302; ENSG00000221852
ENST00000572212; ENSP00000461651; ENSG00000261862
GeneIDi83895
KEGGihsa:83895
UCSCiuc002hvu.4 human

Similar proteinsi

Entry informationi

Entry nameiKRA15_HUMAN
AccessioniPrimary (citable) accession number: Q9BYS1
Secondary accession number(s): A6NJW6
, A6NLZ6, B6ZDR1, Q52LP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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