Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9BYR6 (KRA33_HUMAN)

Entry version 121 (10 Feb 2021)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Keratin-associated protein 3-3

Gene

KRTAP3-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BYR6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 3-3
Alternative name(s):
High sulfur keratin-associated protein 3.3
Keratin-associated protein 3.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP3-3
Synonyms:KAP3.3, KRTAP3.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18890, KRTAP3-3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BYR6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000212899.2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		85293

Open Targets

More...OpenTargetsi		ENSG00000212899

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38742

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BYR6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRTAP3-3

Domain mapping of disease mutations (DMDM)

More...DMDMi		48474631

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851671 – 98Keratin-associated protein 3-3Add BLAST98

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BYR6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BYR6

PeptideAtlas

More...PeptideAtlasi		Q9BYR6

PRoteomics IDEntifications database

More...PRIDEi		Q9BYR6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79695

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BYR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BYR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Localized to the upper cortex of the hair shaft.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000212899, Expressed in upper arm skin and 75 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BYR6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000212899, Group enriched (skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BYR6
With#Exp.IntAct
ALDH3B1 [P43353]3EBI-3957694,EBI-2558314
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-3957694,EBI-12224467
ARID5A [Q03989]3EBI-3957694,EBI-948603
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-3957694,EBI-12006308
BEX2 [Q9BXY8]3EBI-3957694,EBI-745073
CELF5 [Q8N6W0]3EBI-3957694,EBI-12139335
CERCAM [Q5T4B2]3EBI-3957694,EBI-12261896
CTSZ [Q9UBR2]3EBI-3957694,EBI-8636823
CYSRT1 [A8MQ03]3EBI-3957694,EBI-3867333
DCANP1 [Q8TF63]3EBI-3957694,EBI-10275670
DCDC2B [A2VCK2]3EBI-3957694,EBI-10173222
DMRT3 [Q9NQL9]3EBI-3957694,EBI-9679045
DOCK2 [Q92608]3EBI-3957694,EBI-448771
ERMAP [Q96PL5]3EBI-3957694,EBI-13361852
FADS6 [Q8N9I5]3EBI-3957694,EBI-3943864
FAM168A - isoform 2 [Q92567-2]3EBI-3957694,EBI-11978259
FARS2 [O95363]3EBI-3957694,EBI-2513774
FOXC2 [Q99958]3EBI-3957694,EBI-3956892
FOXH1 [O75593]3EBI-3957694,EBI-1759806
FOXP3 [Q9BZS1]3EBI-3957694,EBI-983719
GNE - isoform 2 [Q9Y223-2]3EBI-3957694,EBI-11975289
GPS2 [Q13227]3EBI-3957694,EBI-713355
GSTP1 [P09211]3EBI-3957694,EBI-353467
GUCD1 - isoform 2 [Q96NT3-2]3EBI-3957694,EBI-11978177
hCG_2003792 [A0A024R5S0]3EBI-3957694,EBI-10188461
HOXA1 [P49639]3EBI-3957694,EBI-740785
HR [O43593]3EBI-3957694,EBI-2880706
KLHL38 [Q2WGJ6]3EBI-3957694,EBI-6426443
KRT83 [P78385]5EBI-3957694,EBI-10221390
KRTAP12-3 [P60328]3EBI-3957694,EBI-11953334
KRTAP12-4 [P60329]3EBI-3957694,EBI-10176396
KRTAP13-2 [Q52LG2]3EBI-3957694,EBI-11953846
KRTAP15-1 [Q3LI76]3EBI-3957694,EBI-11992140
KRTAP19-2 [Q3LHN2]3EBI-3957694,EBI-12196745
KRTAP19-7 [Q3SYF9]3EBI-3957694,EBI-10241353
KRTAP4-11 [Q9BYQ6]3EBI-3957694,EBI-10302392
KRTAP4-2 [Q9BYR5]3EBI-3957694,EBI-10172511
KRTAP5-6 [Q6L8G9]3EBI-3957694,EBI-10250562
KRTAP6-2 [Q3LI66]3EBI-3957694,EBI-11962084
KRTAP9-3 [Q9BYQ3]3EBI-3957694,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-3957694,EBI-11958364
LASP1 - isoform 2 [Q14847-2]3EBI-3957694,EBI-9088686
LCE1F [Q5T754]3EBI-3957694,EBI-11958008
LCE2B [O14633]3EBI-3957694,EBI-11478468
LCE3A [Q5TA76]3EBI-3957694,EBI-9394625
LCE3C [Q5T5A8]3EBI-3957694,EBI-10245291
LCE3D [Q9BYE3]3EBI-3957694,EBI-6658837
LCE3E [Q5T5B0]3EBI-3957694,EBI-10245456
LCE4A [Q5TA78]3EBI-3957694,EBI-10246358
LONRF1 [Q17RB8]3EBI-3957694,EBI-2341787
LRRN4 [Q8WUT4]3EBI-3957694,EBI-745046
MRPL23 [Q16540]3EBI-3957694,EBI-1046141
MXD3 [Q9BW11]3EBI-3957694,EBI-741574
NR1D2 [Q6NSM0]3EBI-3957694,EBI-10250949
NTAQ1 [Q96HA8]3EBI-3957694,EBI-741158
NUFIP2 [Q7Z417]3EBI-3957694,EBI-1210753
ODF3B [A8MYP8]3EBI-3957694,EBI-12010090
OLIG3 [Q7RTU3]3EBI-3957694,EBI-10225049
OTX1 [P32242]6EBI-3957694,EBI-740446
P2RY6 [Q15077]3EBI-3957694,EBI-10235794
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-3957694,EBI-11022007
PHLDA1 [A2BDE7]3EBI-3957694,EBI-14084211
PITX1 [P78337]3EBI-3957694,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-3957694,EBI-12138495
PLSCR3 [Q9NRY6]3EBI-3957694,EBI-750734
PLSCR4 [Q9NRQ2]3EBI-3957694,EBI-769257
PRKAB2 [O43741]3EBI-3957694,EBI-1053424
PVR [P15151]3EBI-3957694,EBI-3919694
SHISA6 [Q6ZSJ9]3EBI-3957694,EBI-12037847
SMARCC1 [Q92922]3EBI-3957694,EBI-355653
TNFRSF12A [Q9NP84]3EBI-3957694,EBI-2851995
VENTX [O95231]3EBI-3957694,EBI-10191303
VGLL3 - isoform 2 [A8MV65-2]3EBI-3957694,EBI-11957216
ZNF503 [Q96F45]3EBI-3957694,EBI-8832437

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124457, 80 interactors

Protein interaction database and analysis system

More...IntActi		Q9BYR6, 75 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000375428

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BYR6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3 – 715
Repeati47 – 5125
Repeati89 – 9335

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3 – 593 X 5 AA repeats of C-C-X(3)Add BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 3 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4726, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001157

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_2359185_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BYR6

Identification of Orthologs from Complete Genome Data

More...OMAi		CHVPQPC

Database of Orthologous Groups

More...OrthoDBi		1591683at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BYR6

TreeFam database of animal gene trees

More...TreeFami		TF338042

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007659, Keratin_matx

The PANTHER Classification System

More...PANTHERi		PTHR23260, PTHR23260, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04579, Keratin_matx, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BYR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDCCASRGCS VPTGPATTIC SSDKSCRCGV CLPSTCPHTV WLLEPTCCDN 
        60         70         80         90 
CPPPCHIPQP CVPTCFLLNS CQPTPGLETL NLTTFTQPCC EPCLPRGC
Length:98
Mass (Da):10,365
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9807DC59B72799AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90C → Y in AAH69099 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ406933 mRNA Translation: CAC27572.1
BC069099 mRNA Translation: AAH69099.1
BC069448 mRNA Translation: AAH69448.1
BC093845 mRNA Translation: AAH93845.1
BC093847 mRNA Translation: AAH93847.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32643.1

NCBI Reference Sequences

More...RefSeqi		NP_149441.1, NM_033185.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000391586; ENSP00000375428; ENSG00000212899
ENST00000572132; ENSP00000458618; ENSG00000263101

Database of genes from NCBI RefSeq genomes

More...GeneIDi		85293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:85293

UCSC genome browser

More...UCSCi		uc002hvr.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406933 mRNA Translation: CAC27572.1
BC069099 mRNA Translation: AAH69099.1
BC069448 mRNA Translation: AAH69448.1
BC093845 mRNA Translation: AAH93845.1
BC093847 mRNA Translation: AAH93847.1
CCDSiCCDS32643.1
RefSeqiNP_149441.1, NM_033185.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124457, 80 interactors
IntActiQ9BYR6, 75 interactors
STRINGi9606.ENSP00000375428

PTM databases

iPTMnetiQ9BYR6
PhosphoSitePlusiQ9BYR6

Genetic variation databases

BioMutaiKRTAP3-3
DMDMi48474631

Proteomic databases

MassIVEiQ9BYR6
PaxDbiQ9BYR6
PeptideAtlasiQ9BYR6
PRIDEiQ9BYR6
ProteomicsDBi79695

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		63700, 43 antibodies

The DNASU plasmid repository

More...DNASUi		85293

Genome annotation databases

EnsembliENST00000391586; ENSP00000375428; ENSG00000212899
ENST00000572132; ENSP00000458618; ENSG00000263101
GeneIDi85293
KEGGihsa:85293
UCSCiuc002hvr.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		85293
DisGeNETi85293

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRTAP3-3
HGNCiHGNC:18890, KRTAP3-3
HPAiENSG00000212899, Group enriched (skin, tongue)
neXtProtiNX_Q9BYR6
OpenTargetsiENSG00000212899
PharmGKBiPA38742
VEuPathDBiHostDB:ENSG00000212899.2

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
GeneTreeiENSGT00390000001157
HOGENOMiCLU_2359185_0_0_1
InParanoidiQ9BYR6
OMAiCHVPQPC
OrthoDBi1591683at2759
PhylomeDBiQ9BYR6
TreeFamiTF338042

Enzyme and pathway databases

PathwayCommonsiQ9BYR6
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		85293, 2 hits in 839 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		85293
PharosiQ9BYR6, Tdark

Protein Ontology

More...PROi		PR:Q9BYR6
RNActiQ9BYR6, protein

Gene expression databases

BgeeiENSG00000212899, Expressed in upper arm skin and 75 other tissues
GenevisibleiQ9BYR6, HS

Family and domain databases

InterProiView protein in InterPro
IPR007659, Keratin_matx
PANTHERiPTHR23260, PTHR23260, 1 hit
PfamiView protein in Pfam
PF04579, Keratin_matx, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA33_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYR6
Secondary accession number(s): Q52LP0, Q6NTD4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: February 10, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again