UniProtKB - Q9BYR6 (KRA33_HUMAN)
Protein
Keratin-associated protein 3-3
Gene
KRTAP3-3
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- keratinization Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q9BYR6 |
Reactomei | R-HSA-6805567, Keratinization |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 3-3Alternative name(s): High sulfur keratin-associated protein 3.3 Keratin-associated protein 3.3 |
Gene namesi | Name:KRTAP3-3 Synonyms:KAP3.3, KRTAP3.3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18890, KRTAP3-3 |
neXtProti | NX_Q9BYR6 |
VEuPathDBi | HostDB:ENSG00000212899.2 |
Subcellular locationi
Cytoskeleton
- keratin filament Source: InterPro
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
DisGeNETi | 85293 |
OpenTargetsi | ENSG00000212899 |
PharmGKBi | PA38742 |
Miscellaneous databases
Pharosi | Q9BYR6, Tdark |
Genetic variation databases
BioMutai | KRTAP3-3 |
DMDMi | 48474631 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185167 | 1 – 98 | Keratin-associated protein 3-3Add BLAST | 98 |
Proteomic databases
MassIVEi | Q9BYR6 |
PaxDbi | Q9BYR6 |
PeptideAtlasi | Q9BYR6 |
PRIDEi | Q9BYR6 |
ProteomicsDBi | 79695 |
PTM databases
iPTMneti | Q9BYR6 |
PhosphoSitePlusi | Q9BYR6 |
Expressioni
Tissue specificityi
Localized to the upper cortex of the hair shaft.1 Publication
Gene expression databases
Bgeei | ENSG00000212899, Expressed in upper arm skin and 75 other tissues |
Genevisiblei | Q9BYR6, HS |
Organism-specific databases
HPAi | ENSG00000212899, Group enriched (skin, tongue) |
Interactioni
Subunit structurei
Interacts with hair keratins.
Binary interactionsi
Q9BYR6
Protein-protein interaction databases
BioGRIDi | 124457, 80 interactors |
IntActi | Q9BYR6, 75 interactors |
STRINGi | 9606.ENSP00000375428 |
Miscellaneous databases
RNActi | Q9BYR6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 3 – 7 | 1 | 5 | |
Repeati | 47 – 51 | 2 | 5 | |
Repeati | 89 – 93 | 3 | 5 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 3 – 59 | 3 X 5 AA repeats of C-C-X(3)Add BLAST | 57 |
Sequence similaritiesi
Belongs to the KRTAP type 3 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00390000001157 |
HOGENOMi | CLU_2359185_0_0_1 |
InParanoidi | Q9BYR6 |
OMAi | CHVPQPC |
OrthoDBi | 1591683at2759 |
PhylomeDBi | Q9BYR6 |
TreeFami | TF338042 |
Family and domain databases
InterProi | View protein in InterPro IPR007659, Keratin_matx |
PANTHERi | PTHR23260, PTHR23260, 1 hit |
Pfami | View protein in Pfam PF04579, Keratin_matx, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BYR6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDCCASRGCS VPTGPATTIC SSDKSCRCGV CLPSTCPHTV WLLEPTCCDN
60 70 80 90
CPPPCHIPQP CVPTCFLLNS CQPTPGLETL NLTTFTQPCC EPCLPRGC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | C → Y in AAH69099 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ406933 mRNA Translation: CAC27572.1 BC069099 mRNA Translation: AAH69099.1 BC069448 mRNA Translation: AAH69448.1 BC093845 mRNA Translation: AAH93845.1 BC093847 mRNA Translation: AAH93847.1 |
CCDSi | CCDS32643.1 |
RefSeqi | NP_149441.1, NM_033185.2 |
Genome annotation databases
Ensembli | ENST00000391586; ENSP00000375428; ENSG00000212899 ENST00000572132; ENSP00000458618; ENSG00000263101 |
GeneIDi | 85293 |
KEGGi | hsa:85293 |
UCSCi | uc002hvr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ406933 mRNA Translation: CAC27572.1 BC069099 mRNA Translation: AAH69099.1 BC069448 mRNA Translation: AAH69448.1 BC093845 mRNA Translation: AAH93845.1 BC093847 mRNA Translation: AAH93847.1 |
CCDSi | CCDS32643.1 |
RefSeqi | NP_149441.1, NM_033185.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124457, 80 interactors |
IntActi | Q9BYR6, 75 interactors |
STRINGi | 9606.ENSP00000375428 |
PTM databases
iPTMneti | Q9BYR6 |
PhosphoSitePlusi | Q9BYR6 |
Genetic variation databases
BioMutai | KRTAP3-3 |
DMDMi | 48474631 |
Proteomic databases
MassIVEi | Q9BYR6 |
PaxDbi | Q9BYR6 |
PeptideAtlasi | Q9BYR6 |
PRIDEi | Q9BYR6 |
ProteomicsDBi | 79695 |
Protocols and materials databases
Antibodypediai | 63700, 43 antibodies |
DNASUi | 85293 |
Genome annotation databases
Ensembli | ENST00000391586; ENSP00000375428; ENSG00000212899 ENST00000572132; ENSP00000458618; ENSG00000263101 |
GeneIDi | 85293 |
KEGGi | hsa:85293 |
UCSCi | uc002hvr.1, human |
Organism-specific databases
CTDi | 85293 |
DisGeNETi | 85293 |
GeneCardsi | KRTAP3-3 |
HGNCi | HGNC:18890, KRTAP3-3 |
HPAi | ENSG00000212899, Group enriched (skin, tongue) |
neXtProti | NX_Q9BYR6 |
OpenTargetsi | ENSG00000212899 |
PharmGKBi | PA38742 |
VEuPathDBi | HostDB:ENSG00000212899.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00390000001157 |
HOGENOMi | CLU_2359185_0_0_1 |
InParanoidi | Q9BYR6 |
OMAi | CHVPQPC |
OrthoDBi | 1591683at2759 |
PhylomeDBi | Q9BYR6 |
TreeFami | TF338042 |
Enzyme and pathway databases
PathwayCommonsi | Q9BYR6 |
Reactomei | R-HSA-6805567, Keratinization |
Miscellaneous databases
BioGRID-ORCSi | 85293, 2 hits in 839 CRISPR screens |
GenomeRNAii | 85293 |
Pharosi | Q9BYR6, Tdark |
PROi | PR:Q9BYR6 |
RNActi | Q9BYR6, protein |
Gene expression databases
Bgeei | ENSG00000212899, Expressed in upper arm skin and 75 other tissues |
Genevisiblei | Q9BYR6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007659, Keratin_matx |
PANTHERi | PTHR23260, PTHR23260, 1 hit |
Pfami | View protein in Pfam PF04579, Keratin_matx, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KRA33_HUMAN | |
Accessioni | Q9BYR6Primary (citable) accession number: Q9BYR6 Secondary accession number(s): Q52LP0, Q6NTD4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families