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Entry version 122 (07 Oct 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Keratin-associated protein 4-4

Gene

KRTAP4-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BYR3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 4-4
Alternative name(s):
Keratin-associated protein 4-13
Keratin-associated protein 4.13
Keratin-associated protein 4.4
Ultrahigh sulfur keratin-associated protein 4.13
Ultrahigh sulfur keratin-associated protein 4.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP4-4
Synonyms:KAP4.13, KAP4.4, KRTAP4-13, KRTAP4.13, KRTAP4.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171396.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16928, KRTAP4-4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYR3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000171396

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38426

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYR3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP4-4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37999767

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851721 – 166Keratin-associated protein 4-4Add BLAST166

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYR3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYR3

PeptideAtlas

More...
PeptideAtlasi
Q9BYR3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYR3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79692

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171396, Expressed in upper arm skin and 18 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYR3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171396, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BYR3
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-11958132,EBI-10173507
ALX1 [Q15699]3EBI-11958132,EBI-750671
AQP1 [P29972]3EBI-11958132,EBI-745213
BAG4 [O95429]3EBI-11958132,EBI-2949658
CATSPER1 [Q8NEC5]3EBI-11958132,EBI-744545
CBX2 - isoform 2 [Q14781-2]3EBI-11958132,EBI-11974585
CRCT1 [Q9UGL9]5EBI-11958132,EBI-713677
CREB5 - isoform 3 [Q02930-3]3EBI-11958132,EBI-10192698
CYSRT1 [A8MQ03]4EBI-11958132,EBI-3867333
GLRX3 [O76003]3EBI-11958132,EBI-374781
GNE - isoform 2 [Q9Y223-2]3EBI-11958132,EBI-11975289
HEY2 [Q9UBP5]3EBI-11958132,EBI-750630
HOXA1 [P49639]5EBI-11958132,EBI-740785
KRTAP1-5 [Q9BYS1]3EBI-11958132,EBI-11741292
KRTAP10-10 [P60014]3EBI-11958132,EBI-11955579
KRTAP10-5 [P60370]3EBI-11958132,EBI-10172150
KRTAP10-6 [P60371]3EBI-11958132,EBI-12012928
KRTAP10-8 [P60410]4EBI-11958132,EBI-10171774
KRTAP12-1 [P59990]3EBI-11958132,EBI-10210845
KRTAP12-3 [P60328]3EBI-11958132,EBI-11953334
KRTAP13-2 [Q52LG2]3EBI-11958132,EBI-11953846
KRTAP17-1 [Q9BYP8]3EBI-11958132,EBI-11988175
KRTAP2-4 [Q9BYR9]3EBI-11958132,EBI-14065470
KRTAP26-1 [Q6PEX3]3EBI-11958132,EBI-3957672
KRTAP3-2 [Q9BYR7]3EBI-11958132,EBI-751260
KRTAP4-2 [Q9BYR5]3EBI-11958132,EBI-10172511
KRTAP4-5 [Q9BYR2]3EBI-11958132,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-11958132,EBI-11993296
KRTAP5-7 [Q6L8G8]3EBI-11958132,EBI-11987425
KRTAP5-9 [P26371]3EBI-11958132,EBI-3958099
KRTAP9-2 [Q9BYQ4]3EBI-11958132,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-11958132,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-11958132,EBI-11958364
LCE1A [Q5T7P2]6EBI-11958132,EBI-11962058
LCE1B [Q5T7P3]3EBI-11958132,EBI-10245913
LCE1C [Q5T751]3EBI-11958132,EBI-12224199
LCE1D [Q5T752]3EBI-11958132,EBI-11741311
LCE1E [Q5T753]3EBI-11958132,EBI-11955335
LCE1F [Q5T754]6EBI-11958132,EBI-11958008
LCE2A [Q5TA79]3EBI-11958132,EBI-10246607
LCE2B [O14633]6EBI-11958132,EBI-11478468
LCE2C [Q5TA81]3EBI-11958132,EBI-11973993
LCE3A [Q5TA76]5EBI-11958132,EBI-9394625
LCE3B [Q5TA77]3EBI-11958132,EBI-11974495
LCE3C [Q5T5A8]8EBI-11958132,EBI-10245291
LCE3E [Q5T5B0]3EBI-11958132,EBI-10245456
LCE4A [Q5TA78]3EBI-11958132,EBI-10246358
LCE5A [Q5TCM9]6EBI-11958132,EBI-11955689
MEOX2 [Q6FHY5]3EBI-11958132,EBI-16439278
NOTCH2NLC [P0DPK4]4EBI-11958132,EBI-22310682
NPDC1 [Q9NQX5]3EBI-11958132,EBI-748927
NR4A3 [Q92570]3EBI-11958132,EBI-13644623
NUFIP2 [Q7Z417]3EBI-11958132,EBI-1210753
OTX1 [P32242]3EBI-11958132,EBI-740446
POU4F2 [Q12837]3EBI-11958132,EBI-17236143
SHFL - isoform 4 [Q9NUL5-4]3EBI-11958132,EBI-11955083
SMCP [P49901]6EBI-11958132,EBI-750494
TNS2 [Q63HR2]3EBI-11958132,EBI-949753
TRIM42 [Q8IWZ5]3EBI-11958132,EBI-5235829
ZNF440 [Q8IYI8]3EBI-11958132,EBI-726439
ZNF497 [Q6ZNH5]3EBI-11958132,EBI-10486136
ZNF764 [Q96H86]3EBI-11958132,EBI-745775

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124147, 67 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BYR3, 62 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375076

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYR3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati5 – 915
Repeati20 – 2425
Repeati30 – 3435
Repeati35 – 3945
Repeati40 – 4455
Repeati45 – 4965
Repeati50 – 5475
Repeati55 – 5985
Repeati60 – 6495
Repeati65 – 69105
Repeati70 – 74115
Repeati75 – 79125
Repeati80 – 84135
Repeati85 – 89145
Repeati90 – 94155
Repeati95 – 99165
Repeati100 – 104175
Repeati105 – 109185
Repeati110 – 114195
Repeati115 – 119205
Repeati120 – 124215
Repeati130 – 134225
Repeati135 – 139235
Repeati140 – 144245
Repeati145 – 149255
Repeati150 – 154265

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5 – 15426 X 5 AA repeats of C-C-[GRQVCH]-[SPT]-[VSTQR]Add BLAST150

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4726, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_113141_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYR3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTCCKPS

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494, KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262, PTHR23262, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885, Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BYR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNSCCGSVC SDQGCGLENC CRPSYCQTTC CRTTCCRPSC CVSSCCRPQC
60 70 80 90 100
CQTTCCRTTC CHPSCCVSSC CRPQCCQSVC CQPTCCRPQC CQTTCCRTTC
110 120 130 140 150
CRPSCCRPQC CQSVCCQPTC CCPSYCVSSC CRPQCCQTTC CRTTCCRPSC
160
CVSRCYRPHC GQSLCC
Length:166
Mass (Da):18,023
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC373D121611A7115
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140C → R in CAC27563 (PubMed:11279113).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Numerous size polymorphism are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments (PubMed:15955084).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05345925Y → C. Corresponds to variant dbSNP:rs385055Ensembl.1
Natural variantiVAR_05346035C → S. Corresponds to variant dbSNP:rs444509Ensembl.1
Natural variantiVAR_06455940 – 104Missing in allele KAP4.4-v1. Add BLAST65
Natural variantiVAR_03277240 – 99Missing in allele KAP4.13. 1 PublicationAdd BLAST60
Natural variantiVAR_053461154R → S. Corresponds to variant dbSNP:rs366700Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ296168 mRNA Translation: CAC27563.1
AJ406936 mRNA Translation: CAC27575.1
AC100808 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11383.1

NCBI Reference Sequences

More...
RefSeqi
NP_115913.1, NM_032524.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000390661; ENSP00000375076; ENSG00000171396

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84616

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84616

UCSC genome browser

More...
UCSCi
uc002hwc.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296168 mRNA Translation: CAC27563.1
AJ406936 mRNA Translation: CAC27575.1
AC100808 Genomic DNA No translation available.
CCDSiCCDS11383.1
RefSeqiNP_115913.1, NM_032524.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124147, 67 interactors
IntActiQ9BYR3, 62 interactors
STRINGi9606.ENSP00000375076

Polymorphism and mutation databases

BioMutaiKRTAP4-4
DMDMi37999767

Proteomic databases

MassIVEiQ9BYR3
PaxDbiQ9BYR3
PeptideAtlasiQ9BYR3
PRIDEiQ9BYR3
ProteomicsDBi79692

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
76830, 2 antibodies

Genome annotation databases

EnsembliENST00000390661; ENSP00000375076; ENSG00000171396
GeneIDi84616
KEGGihsa:84616
UCSCiuc002hwc.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84616
EuPathDBiHostDB:ENSG00000171396.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP4-4
HGNCiHGNC:16928, KRTAP4-4
HPAiENSG00000171396, Tissue enriched (skin)
neXtProtiNX_Q9BYR3
OpenTargetsiENSG00000171396
PharmGKBiPA38426

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
GeneTreeiENSGT00940000163975
HOGENOMiCLU_113141_2_0_1
InParanoidiQ9BYR3
OMAiTTCCKPS
TreeFamiTF351356

Enzyme and pathway databases

PathwayCommonsiQ9BYR3
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84616, 31 hits in 862 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84616
PharosiQ9BYR3, Tdark

Protein Ontology

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PROi
PR:Q9BYR3
RNActiQ9BYR3, protein

Gene expression databases

BgeeiENSG00000171396, Expressed in upper arm skin and 18 other tissues
GenevisibleiQ9BYR3, HS

Family and domain databases

InterProiView protein in InterPro
IPR002494, KAP
PANTHERiPTHR23262, PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885, Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA44_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYR3
Secondary accession number(s): Q9BYU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: October 7, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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