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Protein

Keratin-associated protein 4-5

Gene

KRTAP4-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

  • aging Source: UniProtKB
  • hair cycle Source: UniProtKB
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 4-5
Alternative name(s):
Keratin-associated protein 4.5
Ultrahigh sulfur keratin-associated protein 4.5
Gene namesi
Name:KRTAP4-5
Synonyms:KAP4.5, KRTAP4.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198271.4
HGNCiHGNC:18899 KRTAP4-5
neXtProtiNX_Q9BYR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi85289
OpenTargetsiENSG00000198271
PharmGKBiPA38748

Polymorphism and mutation databases

BioMutaiKRTAP4-5
DMDMi380865482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851731 – 181Keratin-associated protein 4-5Add BLAST181

Proteomic databases

PaxDbiQ9BYR2
PeptideAtlasiQ9BYR2
PRIDEiQ9BYR2
ProteomicsDBi79691

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000198271 Expressed in 34 organ(s), highest expression level in upper arm skin
CleanExiHS_KRTAP4-5
GenevisibleiQ9BYR2 HS

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Protein-protein interaction databases

IntActiQ9BYR2, 58 interactors
STRINGi9606.ENSP00000340546

Structurei

3D structure databases

ProteinModelPortaliQ9BYR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 915
Repeati20 – 2425
Repeati25 – 2935
Repeati30 – 3445
Repeati35 – 3955
Repeati40 – 4465
Repeati45 – 4975
Repeati55 – 5985
Repeati60 – 6495
Repeati65 – 69105
Repeati70 – 74115
Repeati75 – 79125
Repeati80 – 84135
Repeati85 – 89145
Repeati90 – 94155
Repeati95 – 99165
Repeati100 – 104175
Repeati105 – 109185
Repeati110 – 114195
Repeati115 – 119205
Repeati120 – 124215
Repeati125 – 129225
Repeati130 – 134235
Repeati135 – 139245
Repeati140 – 144255
Repeati145 – 149265

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 15426 X 5 AA repeats of C-C-[GRQVCHIEK]-[SPTR]-[VSTQYC]Add BLAST150

Sequence similaritiesi

Belongs to the KRTAP type 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00880000137902
HOGENOMiHOG000234030
HOVERGENiHBG108074
InParanoidiQ9BYR2
OMAiCCWPSGL
OrthoDBiEOG093702X4
TreeFamiTF351356

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9BYR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSSCCGSVS SEQSCGLENC CRPSCCQTTC CRTTCCRPSC CKPQCCQSVC
60 70 80 90 100
YQPTCCHPSC CISSCCRPYC CESSCCRPCC CQTTCCRTTC CRTTCCCPSC
110 120 130 140 150
CVSSCCRPQC CQSVCCQPTC CRPSCCISSC CHPSCCESSC CRPCCCVRPV
160 170 180
CGRVSCHTTC YRPTCVISTC PRPLCCASSC C
Length:181
Mass (Da):19,363
Last modified:March 21, 2012 - v4
Checksum:i95D9CC0125D0549A
GO

Polymorphismi

Numerous size polymorphism are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments (PubMed:15955084). Allele shown is KAP4.5-v1 (PubMed:15955084).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0576486C → R. Corresponds to variant dbSNP:rs238829Ensembl.1
Natural variantiVAR_06456022R → C1 PublicationCorresponds to variant dbSNP:rs1497383Ensembl.1
Natural variantiVAR_06456167R → H1 PublicationCorresponds to variant dbSNP:rs238830Ensembl.1
Natural variantiVAR_06382680C → CCCRPS. 1
Natural variantiVAR_064562125C → Y1 PublicationCorresponds to variant dbSNP:rs1846044Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406937 mRNA Translation: CAC27576.1
AC100808 Genomic DNA No translation available.
CCDSiCCDS32650.1
RefSeqiNP_149445.3, NM_033188.3
UniGeneiHs.514863

Genome annotation databases

EnsembliENST00000343246; ENSP00000340546; ENSG00000198271
GeneIDi85289
KEGGihsa:85289
UCSCiuc060fat.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406937 mRNA Translation: CAC27576.1
AC100808 Genomic DNA No translation available.
CCDSiCCDS32650.1
RefSeqiNP_149445.3, NM_033188.3
UniGeneiHs.514863

3D structure databases

ProteinModelPortaliQ9BYR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BYR2, 58 interactors
STRINGi9606.ENSP00000340546

Polymorphism and mutation databases

BioMutaiKRTAP4-5
DMDMi380865482

Proteomic databases

PaxDbiQ9BYR2
PeptideAtlasiQ9BYR2
PRIDEiQ9BYR2
ProteomicsDBi79691

Protocols and materials databases

DNASUi85289
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343246; ENSP00000340546; ENSG00000198271
GeneIDi85289
KEGGihsa:85289
UCSCiuc060fat.1 human

Organism-specific databases

CTDi85289
DisGeNETi85289
EuPathDBiHostDB:ENSG00000198271.4
GeneCardsiKRTAP4-5
H-InvDBiHIX0039105
HGNCiHGNC:18899 KRTAP4-5
neXtProtiNX_Q9BYR2
OpenTargetsiENSG00000198271
PharmGKBiPA38748
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00880000137902
HOGENOMiHOG000234030
HOVERGENiHBG108074
InParanoidiQ9BYR2
OMAiCCWPSGL
OrthoDBiEOG093702X4
TreeFamiTF351356

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

GenomeRNAii85289
PROiPR:Q9BYR2

Gene expression databases

BgeeiENSG00000198271 Expressed in 34 organ(s), highest expression level in upper arm skin
CleanExiHS_KRTAP4-5
GenevisibleiQ9BYR2 HS

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKRA45_HUMAN
AccessioniPrimary (citable) accession number: Q9BYR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 21, 2012
Last modified: September 12, 2018
This is version 111 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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