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Entry version 125 (07 Oct 2020)
Sequence version 4 (21 Mar 2012)
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Protein

Keratin-associated protein 4-5

Gene

KRTAP4-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BYR2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 4-5
Alternative name(s):
Keratin-associated protein 4.5
Ultrahigh sulfur keratin-associated protein 4.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP4-5
Synonyms:KAP4.5, KRTAP4.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198271.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18899, KRTAP4-5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYR2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198271

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38748

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYR2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP4-5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
380865482

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851731 – 181Keratin-associated protein 4-5Add BLAST181

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYR2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYR2

PeptideAtlas

More...
PeptideAtlasi
Q9BYR2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYR2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79691

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198271, Expressed in upper arm skin and 37 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYR2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198271, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BYR2
With#Exp.IntAct
AXIN2 [Q9Y2T1]3EBI-11993254,EBI-4400025
BAG4 [O95429]3EBI-11993254,EBI-2949658
CRCT1 [Q9UGL9]4EBI-11993254,EBI-713677
CREB5 - isoform 3 [Q02930-3]3EBI-11993254,EBI-10192698
CYSRT1 [A8MQ03]3EBI-11993254,EBI-3867333
FAM76B - isoform 3 [Q5HYJ3-3]3EBI-11993254,EBI-11956087
FBXO34 [Q9NWN3]5EBI-11993254,EBI-719816
GATA1 - isoform 2 [P15976-2]3EBI-11993254,EBI-9090198
GLRX3 [O76003]5EBI-11993254,EBI-374781
HOXA1 [P49639]7EBI-11993254,EBI-740785
KPRP [Q5T749]5EBI-11993254,EBI-10981970
KRTAP1-1 [Q07627]3EBI-11993254,EBI-11959885
KRTAP10-6 [P60371]3EBI-11993254,EBI-12012928
KRTAP10-7 [P60409]3EBI-11993254,EBI-10172290
KRTAP10-8 [P60410]3EBI-11993254,EBI-10171774
KRTAP12-1 [P59990]3EBI-11993254,EBI-10210845
KRTAP13-2 [Q52LG2]3EBI-11993254,EBI-11953846
KRTAP4-2 [Q9BYR5]3EBI-11993254,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-11993254,EBI-11958132
KRTAP5-2 [Q701N4]3EBI-11993254,EBI-11958178
KRTAP5-9 [P26371]3EBI-11993254,EBI-3958099
KRTAP6-1 [Q3LI64]3EBI-11993254,EBI-12111050
KRTAP9-3 [Q9BYQ3]3EBI-11993254,EBI-1043191
LCE1A [Q5T7P2]3EBI-11993254,EBI-11962058
LCE1B [Q5T7P3]3EBI-11993254,EBI-10245913
LCE1C [Q5T751]5EBI-11993254,EBI-12224199
LCE1D [Q5T752]3EBI-11993254,EBI-11741311
LCE1E [Q5T753]3EBI-11993254,EBI-11955335
LCE1F [Q5T754]3EBI-11993254,EBI-11958008
LCE2A [Q5TA79]3EBI-11993254,EBI-10246607
LCE2B [O14633]3EBI-11993254,EBI-11478468
LCE2C [Q5TA81]4EBI-11993254,EBI-11973993
LCE3A [Q5TA76]5EBI-11993254,EBI-9394625
LCE3B [Q5TA77]3EBI-11993254,EBI-11974495
LCE3C [Q5T5A8]8EBI-11993254,EBI-10245291
LCE3D [Q9BYE3]5EBI-11993254,EBI-6658837
LCE3E [Q5T5B0]5EBI-11993254,EBI-10245456
LCE4A [Q5TA78]5EBI-11993254,EBI-10246358
LCE5A [Q5TCM9]3EBI-11993254,EBI-11955689
LELP1 [Q5T871]3EBI-11993254,EBI-18115868
MEOX2 [Q6FHY5]3EBI-11993254,EBI-16439278
NOTCH2NLC [P0DPK4]3EBI-11993254,EBI-22310682
NUFIP2 [Q7Z417]3EBI-11993254,EBI-1210753
OTX1 [P32242]3EBI-11993254,EBI-740446
PEAR1 [Q5VY43]3EBI-11993254,EBI-1249608
POTEB3 [A0JP26]3EBI-11993254,EBI-18165900
POU4F2 [Q12837]3EBI-11993254,EBI-17236143
PRKAB2 [O43741]3EBI-11993254,EBI-1053424
RORB - isoform 1 [Q92753-1]3EBI-11993254,EBI-18560266
SH3GLB2 [Q9NR46]3EBI-11993254,EBI-749607
SHFL - isoform 4 [Q9NUL5-4]3EBI-11993254,EBI-11955083
SLC4A7 [Q9Y6M7]3EBI-11993254,EBI-1044546
SMCP [P49901]5EBI-11993254,EBI-750494
TRIM42 [Q8IWZ5]3EBI-11993254,EBI-5235829
TSPAN4 [O14817]3EBI-11993254,EBI-8652667
YY1 [P25490]3EBI-11993254,EBI-765538
ZNF552 [Q9H707]6EBI-11993254,EBI-2555731
ZNF774 [Q6NX45]3EBI-11993254,EBI-10251462
ZNF835 [Q9Y2P0]3EBI-11993254,EBI-5667516
ZNF837 [Q96EG3]3EBI-11993254,EBI-11962574

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124453, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BYR2, 60 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340546

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYR2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati5 – 915
Repeati20 – 2425
Repeati25 – 2935
Repeati30 – 3445
Repeati35 – 3955
Repeati40 – 4465
Repeati45 – 4975
Repeati55 – 5985
Repeati60 – 6495
Repeati65 – 69105
Repeati70 – 74115
Repeati75 – 79125
Repeati80 – 84135
Repeati85 – 89145
Repeati90 – 94155
Repeati95 – 99165
Repeati100 – 104175
Repeati105 – 109185
Repeati110 – 114195
Repeati115 – 119205
Repeati120 – 124215
Repeati125 – 129225
Repeati130 – 134235
Repeati135 – 139245
Repeati140 – 144255
Repeati145 – 149265

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5 – 15426 X 5 AA repeats of C-C-[GRQVCHIEK]-[SPTR]-[VSTQYC]Add BLAST150

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4726, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165435

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_113141_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYR2

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYTSMCY

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494, KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262, PTHR23262, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885, Keratin_B2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BYR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSSCCGSVS SEQSCGLENC CRPSCCQTTC CRTTCCRPSC CKPQCCQSVC
60 70 80 90 100
YQPTCCHPSC CISSCCRPYC CESSCCRPCC CQTTCCRTTC CRTTCCCPSC
110 120 130 140 150
CVSSCCRPQC CQSVCCQPTC CRPSCCISSC CHPSCCESSC CRPCCCVRPV
160 170 180
CGRVSCHTTC YRPTCVISTC PRPLCCASSC C
Length:181
Mass (Da):19,363
Last modified:March 21, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95D9CC0125D0549A
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Numerous size polymorphism are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments (PubMed:15955084). Allele shown is KAP4.5-v1 (PubMed:15955084).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0576486C → R. Corresponds to variant dbSNP:rs238829Ensembl.1
Natural variantiVAR_06456022R → C1 PublicationCorresponds to variant dbSNP:rs1497383Ensembl.1
Natural variantiVAR_06456167R → H1 PublicationCorresponds to variant dbSNP:rs238830Ensembl.1
Natural variantiVAR_06382680C → CCCRPS. 1
Natural variantiVAR_064562125C → Y1 PublicationCorresponds to variant dbSNP:rs1846044Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ406937 mRNA Translation: CAC27576.1
AC100808 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32650.1

NCBI Reference Sequences

More...
RefSeqi
NP_149445.3, NM_033188.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343246; ENSP00000340546; ENSG00000198271

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85289

UCSC genome browser

More...
UCSCi
uc060fat.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406937 mRNA Translation: CAC27576.1
AC100808 Genomic DNA No translation available.
CCDSiCCDS32650.1
RefSeqiNP_149445.3, NM_033188.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124453, 62 interactors
IntActiQ9BYR2, 60 interactors
STRINGi9606.ENSP00000340546

Polymorphism and mutation databases

BioMutaiKRTAP4-5
DMDMi380865482

Proteomic databases

MassIVEiQ9BYR2
PaxDbiQ9BYR2
PeptideAtlasiQ9BYR2
PRIDEiQ9BYR2
ProteomicsDBi79691

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
78096, 1 antibodies

The DNASU plasmid repository

More...
DNASUi
85289

Genome annotation databases

EnsembliENST00000343246; ENSP00000340546; ENSG00000198271
GeneIDi85289
KEGGihsa:85289
UCSCiuc060fat.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85289
EuPathDBiHostDB:ENSG00000198271.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP4-5
HGNCiHGNC:18899, KRTAP4-5
HPAiENSG00000198271, Tissue enriched (skin)
neXtProtiNX_Q9BYR2
OpenTargetsiENSG00000198271
PharmGKBiPA38748

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
GeneTreeiENSGT00940000165435
HOGENOMiCLU_113141_2_0_1
InParanoidiQ9BYR2
OMAiCYTSMCY
TreeFamiTF351356

Enzyme and pathway databases

PathwayCommonsiQ9BYR2
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
85289, 12 hits in 841 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85289
PharosiQ9BYR2, Tbio

Protein Ontology

More...
PROi
PR:Q9BYR2
RNActiQ9BYR2, protein

Gene expression databases

BgeeiENSG00000198271, Expressed in upper arm skin and 37 other tissues
GenevisibleiQ9BYR2, HS

Family and domain databases

InterProiView protein in InterPro
IPR002494, KAP
PANTHERiPTHR23262, PTHR23262, 1 hit
PfamiView protein in Pfam
PF13885, Keratin_B2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA45_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYR2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 21, 2012
Last modified: October 7, 2020
This is version 125 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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