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Entry version 137 (07 Oct 2020)
Sequence version 2 (14 Oct 2008)
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Protein

Keratin-associated protein 9-2

Gene

KRTAP9-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BYQ4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 9-2
Alternative name(s):
Keratin-associated protein 9.2
Ultrahigh sulfur keratin-associated protein 9.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP9-2
Synonyms:KAP9.2, KRTAP9.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000239886.5

Human Gene Nomenclature Database

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HGNCi
HGNC:16926, KRTAP9-2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYQ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38424

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYQ4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP9-2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572642

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851881 – 174Keratin-associated protein 9-2Add BLAST174

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYQ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYQ4

PeptideAtlas

More...
PeptideAtlasi
Q9BYQ4

PRoteomics IDEntifications database

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PRIDEi
Q9BYQ4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
79684

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYQ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000239886, Expressed in skin of abdomen and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYQ4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000239886, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BYQ4
With#Exp.IntAct
ADAM12 - isoform 4 [O43184-4]5EBI-1044640,EBI-12006944
ADAMTSL4 - isoform 3 [Q6UY14-3]6EBI-1044640,EBI-10173507
AGXT [P21549]3EBI-1044640,EBI-727098
AQP1 [P29972]3EBI-1044640,EBI-745213
ARFGAP1 [Q8N6T3]3EBI-1044640,EBI-716933
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-1044640,EBI-12006308
AXIN2 [Q9Y2T1]3EBI-1044640,EBI-4400025
C22orf39 [Q6P5X5]3EBI-1044640,EBI-7317823
CARD10 [Q9BWT7]3EBI-1044640,EBI-3866279
CATSPER1 [Q8NEC5]8EBI-1044640,EBI-744545
CCDC28A [Q8IWP9]3EBI-1044640,EBI-355471
CERK [Q8TCT0]3EBI-1044640,EBI-10274247
CHRD [Q9H2X0]3EBI-1044640,EBI-947551
CNNM3 [Q8NE01]3EBI-1044640,EBI-741032
COL8A1 [P27658]3EBI-1044640,EBI-747133
CRCT1 [Q9UGL9]3EBI-1044640,EBI-713677
CREB5 - isoform 3 [Q02930-3]13EBI-1044640,EBI-10192698
CTRC [Q99895]3EBI-1044640,EBI-10295404
CYP21A2 [Q08AG9]3EBI-1044640,EBI-14156412
CYSRT1 [A8MQ03]3EBI-1044640,EBI-3867333
DMRT3 [Q9NQL9]3EBI-1044640,EBI-9679045
DOCK2 [Q92608]3EBI-1044640,EBI-448771
FAM76B [Q5HYJ3]3EBI-1044640,EBI-751192
FAM76B - isoform 3 [Q5HYJ3-3]3EBI-1044640,EBI-11956087
FBXO34 [Q9NWN3]3EBI-1044640,EBI-719816
GATA1 [P15976]3EBI-1044640,EBI-3909284
GEMIN4 [P57678]3EBI-1044640,EBI-356700
GLRX3 [O76003]8EBI-1044640,EBI-374781
GNE [Q9Y223]3EBI-1044640,EBI-4291090
GNE - isoform 2 [Q9Y223-2]3EBI-1044640,EBI-11975289
GNG13 [Q9P2W3]3EBI-1044640,EBI-11427343
GUCD1 - isoform 2 [Q96NT3-2]3EBI-1044640,EBI-11978177
HAPLN2 [Q9GZV7]3EBI-1044640,EBI-11956675
HOXA1 [P49639]13EBI-1044640,EBI-740785
ITGB4 - isoform Beta-4A [P16144-2]3EBI-1044640,EBI-11051601
JOSD1 [Q15040]6EBI-1044640,EBI-2510602
KLHL38 [Q2WGJ6]5EBI-1044640,EBI-6426443
KRT31 [Q15323]3EBI-1044640,EBI-948001
KRTAP1-1 [Q07627]3EBI-1044640,EBI-11959885
KRTAP1-5 [Q9BYS1]3EBI-1044640,EBI-11741292
KRTAP10-11 [P60412]6EBI-1044640,EBI-10217483
KRTAP10-5 [P60370]5EBI-1044640,EBI-10172150
KRTAP10-7 [P60409]6EBI-1044640,EBI-10172290
KRTAP10-8 [P60410]11EBI-1044640,EBI-10171774
KRTAP10-9 [P60411]9EBI-1044640,EBI-10172052
KRTAP11-1 [Q8IUC1]3EBI-1044640,EBI-1052037
KRTAP12-1 [P59990]3EBI-1044640,EBI-10210845
KRTAP12-3 [P60328]3EBI-1044640,EBI-11953334
KRTAP13-2 [Q52LG2]3EBI-1044640,EBI-11953846
KRTAP13-3 [Q3SY46]3EBI-1044640,EBI-10241252
KRTAP15-1 [Q3LI76]3EBI-1044640,EBI-11992140
KRTAP17-1 [Q9BYP8]3EBI-1044640,EBI-11988175
KRTAP19-7 [Q3SYF9]3EBI-1044640,EBI-10241353
KRTAP2-4 [Q9BYR9]3EBI-1044640,EBI-14065470
KRTAP26-1 [Q6PEX3]6EBI-1044640,EBI-3957672
KRTAP3-2 [Q9BYR7]3EBI-1044640,EBI-751260
KRTAP4-11 [Q9BYQ6]6EBI-1044640,EBI-10302392
KRTAP4-12 [Q9BQ66]8EBI-1044640,EBI-739863
KRTAP4-2 [Q9BYR5]8EBI-1044640,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-1044640,EBI-11958132
KRTAP4-7 [Q9BYR0]3EBI-1044640,EBI-10302547
KRTAP5-11 [Q6L8G4]5EBI-1044640,EBI-11993296
KRTAP5-2 [Q701N4]4EBI-1044640,EBI-11958178
KRTAP5-3 [Q6L8H2]3EBI-1044640,EBI-11974251
KRTAP5-4 [Q6L8H1]3EBI-1044640,EBI-11963072
KRTAP5-6 [Q6L8G9]8EBI-1044640,EBI-10250562
KRTAP5-7 [Q6L8G8]3EBI-1044640,EBI-11987425
KRTAP5-9 [P26371]6EBI-1044640,EBI-3958099
itself6EBI-1044640,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-1044640,EBI-1043191
KRTAP9-4 [Q9BYQ2]3EBI-1044640,EBI-10185730
KRTAP9-8 [Q9BYQ0]3EBI-1044640,EBI-11958364
LBX1 [P52954]3EBI-1044640,EBI-20141748
LCE1A [Q5T7P2]3EBI-1044640,EBI-11962058
LCE1B [Q5T7P3]11EBI-1044640,EBI-10245913
LCE1D [Q5T752]3EBI-1044640,EBI-11741311
LCE1E [Q5T753]5EBI-1044640,EBI-11955335
LCE1F [Q5T754]3EBI-1044640,EBI-11958008
LCE2A [Q5TA79]6EBI-1044640,EBI-10246607
LCE2B [O14633]5EBI-1044640,EBI-11478468
LCE2C [Q5TA81]3EBI-1044640,EBI-11973993
LCE3A [Q5TA76]8EBI-1044640,EBI-9394625
LCE3B [Q5TA77]3EBI-1044640,EBI-11974495
LCE3C [Q5T5A8]3EBI-1044640,EBI-10245291
LCE3D [Q9BYE3]8EBI-1044640,EBI-6658837
LCE3E [Q5T5B0]6EBI-1044640,EBI-10245456
LCE4A [Q5TA78]9EBI-1044640,EBI-10246358
LCE5A [Q5TCM9]8EBI-1044640,EBI-11955689
LELP1 [Q5T871]3EBI-1044640,EBI-18115868
LINGO1 [Q96FE5]3EBI-1044640,EBI-719955
LMNTD2 [Q8IXW0]3EBI-1044640,EBI-12028858
LNX1 [Q8TBB1]3EBI-1044640,EBI-739832
LYVE1 [Q9Y5Y7]3EBI-1044640,EBI-10329546
MAPKBP1 [O60336]3EBI-1044640,EBI-947402
MEOX2 [P50222]3EBI-1044640,EBI-748397
MEOX2 [Q6FHY5]3EBI-1044640,EBI-16439278
NOTCH2NLA [Q7Z3S9]3EBI-1044640,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-1044640,EBI-22310682
NR1D2 [Q6NSM0]5EBI-1044640,EBI-10250949
NR4A3 [Q92570]3EBI-1044640,EBI-13644623
NTAQ1 [Q96HA8]6EBI-1044640,EBI-741158
NUFIP2 [Q7Z417]6EBI-1044640,EBI-1210753
OTX1 [P32242]10EBI-1044640,EBI-740446
P2RY6 [Q15077]5EBI-1044640,EBI-10235794
P3H3 - isoform 2 [Q8IVL6-2]3EBI-1044640,EBI-12149899
PDE9A [O76083]3EBI-1044640,EBI-742764
PHLDA1 [A2BDE7]3EBI-1044640,EBI-14084211
PIGS [Q96S52]3EBI-1044640,EBI-2908273
PLLP [Q9Y342]3EBI-1044640,EBI-3919291
PLSCR1 [O15162]3EBI-1044640,EBI-740019
POTEB3 [A0JP26]3EBI-1044640,EBI-18165900
POU4F2 [Q12837]6EBI-1044640,EBI-17236143
PRKAB2 [O43741]8EBI-1044640,EBI-1053424
PRKAG1 [P54619]3EBI-1044640,EBI-1181439
PTPMT1 [Q8WUK0]6EBI-1044640,EBI-7199479
RCHY1 [Q96PM5]3EBI-1044640,EBI-947779
RNF31 - isoform 3 [Q96EP0-3]3EBI-1044640,EBI-10225152
RNF8 [O76064]3EBI-1044640,EBI-373337
SDC3 [A0A0S2Z4U3]3EBI-1044640,EBI-10204280
SHFL [Q9NUL5]3EBI-1044640,EBI-10313866
SHFL - isoform 4 [Q9NUL5-4]3EBI-1044640,EBI-11955083
SLC13A5 [Q86YT5]3EBI-1044640,EBI-12002412
SLC39A7 [Q92504]3EBI-1044640,EBI-1051105
SMCP [P49901]8EBI-1044640,EBI-750494
SPATA3 [A0A024R4B0]3EBI-1044640,EBI-14123856
SPATA8 [Q6RVD6]3EBI-1044640,EBI-8635958
SPRY1 [O43609]3EBI-1044640,EBI-3866665
SPRY2 [O43597]3EBI-1044640,EBI-742487
SUMO1P1 [G2XKQ0]3EBI-1044640,EBI-10175576
TFAP2D [Q7Z6R9]5EBI-1044640,EBI-11952651
TMEM190 [Q8WZ59]3EBI-1044640,EBI-10278423
TMSB10 [P63313]3EBI-1044640,EBI-2688673
TSPAN4 [O14817]3EBI-1044640,EBI-8652667
TYRO3 [Q06418]3EBI-1044640,EBI-3951628
VGLL3 - isoform 2 [A8MV65-2]3EBI-1044640,EBI-11957216
ZDHHC1 [Q8WTX9]3EBI-1044640,EBI-2818796
ZNF20 [P17024]3EBI-1044640,EBI-717634
ZNF575 [Q86XF7]5EBI-1044640,EBI-14069183
ZNF696 [Q9H7X3]3EBI-1044640,EBI-11090299

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123810, 144 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BYQ4, 137 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366950

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYQ4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati8 – 1215
Repeati13 – 1725
Repeati18 – 2235
Repeati37 – 4145
Repeati42 – 4655
Repeati51 – 5565
Repeati61 – 6575
Repeati66 – 7085
Repeati75 – 7995
Repeati80 – 84105
Repeati85 – 89115
Repeati90 – 94125
Repeati95 – 99135
Repeati144 – 148145
Repeati149 – 153155
Repeati154 – 158165
Repeati168 – 172175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni8 – 17217 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]-[TASP]Add BLAST165

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4726, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156135

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_113141_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYQ4

Identification of Orthologs from Complete Genome Data

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OMAi
CYQPACV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYQ4

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494, KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262, PTHR23262, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885, Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BYQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP ACCVSSCCQP
60 70 80 90 100
CCRPTCCQNT CCRTTCCQPT CVTSCCQPSC CSTPCCQPTC CGSSCCGQTS
110 120 130 140 150
CGSSCGQSSS CAPVYCRRTC YYPTTVCLPG CLNQSCGSNC CQPCCRPACC
160 170
ETTCCRTTCF QPTCVSSCCQ PSCC
Length:174
Mass (Da):18,287
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E5A1D598966FE3C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140TA58A0A140TA58_HUMAN
Keratin-associated protein 9-2
KRTAP9-2
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04670236P → S2 PublicationsCorresponds to variant dbSNP:rs9903833Ensembl.1
Natural variantiVAR_04670356C → S2 PublicationsCorresponds to variant dbSNP:rs9902235Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ406946 mRNA Translation: CAC27585.1
CH471152 Genomic DNA Translation: EAW60718.1
BC069560 mRNA Translation: AAH69560.1
BC110619 mRNA Translation: AAI10620.1
BC117287 mRNA Translation: AAI17288.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32651.1

NCBI Reference Sequences

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RefSeqi
NP_114167.2, NM_031961.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000377721; ENSP00000366950; ENSG00000239886
ENST00000572513; ENSP00000458594; ENSG00000263090

Database of genes from NCBI RefSeq genomes

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GeneIDi
83899

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83899

UCSC genome browser

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UCSCi
uc002hwf.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406946 mRNA Translation: CAC27585.1
CH471152 Genomic DNA Translation: EAW60718.1
BC069560 mRNA Translation: AAH69560.1
BC110619 mRNA Translation: AAI10620.1
BC117287 mRNA Translation: AAI17288.1
CCDSiCCDS32651.1
RefSeqiNP_114167.2, NM_031961.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123810, 144 interactors
IntActiQ9BYQ4, 137 interactors
STRINGi9606.ENSP00000366950

PTM databases

iPTMnetiQ9BYQ4
PhosphoSitePlusiQ9BYQ4

Polymorphism and mutation databases

BioMutaiKRTAP9-2
DMDMi209572642

Proteomic databases

MassIVEiQ9BYQ4
PaxDbiQ9BYQ4
PeptideAtlasiQ9BYQ4
PRIDEiQ9BYQ4
ProteomicsDBi79684

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
74944, 8 antibodies

Genome annotation databases

EnsembliENST00000377721; ENSP00000366950; ENSG00000239886
ENST00000572513; ENSP00000458594; ENSG00000263090
GeneIDi83899
KEGGihsa:83899
UCSCiuc002hwf.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83899
EuPathDBiHostDB:ENSG00000239886.5

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP9-2
HGNCiHGNC:16926, KRTAP9-2
HPAiENSG00000239886, Tissue enriched (skin)
neXtProtiNX_Q9BYQ4
PharmGKBiPA38424

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
GeneTreeiENSGT00940000156135
HOGENOMiCLU_113141_0_0_1
InParanoidiQ9BYQ4
OMAiCYQPACV
PhylomeDBiQ9BYQ4
TreeFamiTF351356

Enzyme and pathway databases

PathwayCommonsiQ9BYQ4
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
83899, 119 hits in 832 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83899
PharosiQ9BYQ4, Tdark

Protein Ontology

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PROi
PR:Q9BYQ4
RNActiQ9BYQ4, protein

Gene expression databases

BgeeiENSG00000239886, Expressed in skin of abdomen and 20 other tissues
GenevisibleiQ9BYQ4, HS

Family and domain databases

InterProiView protein in InterPro
IPR002494, KAP
PANTHERiPTHR23262, PTHR23262, 1 hit
PfamiView protein in Pfam
PF13885, Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA92_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYQ4
Secondary accession number(s): Q17RK8, Q2TB15, Q6ISF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 14, 2008
Last modified: October 7, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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