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Entry version 172 (22 Apr 2020)
Sequence version 3 (19 Oct 2011)
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Protein

Serine/threonine-protein kinase WNK3

Gene

WNK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca2+ influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.7 Publications
Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.2 Publications

Caution

Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activation requires autophosphorylation of Ser-308. Phosphorylation of Ser-304 also promotes increased activity (By similarity). Kinase activity is inhibited by WNK4.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei277ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei294Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi227 – 230ATPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BYP7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase WNK3Curated (EC:2.7.11.11 Publication)
Alternative name(s):
Protein kinase lysine-deficient 3Imported
Protein kinase with no lysine 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK3Imported
Synonyms:KIAA1566Imported, PRKWNK3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14543 WNK3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300358 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYP7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi294D → A: Catalytically inactive form. Inhibits sodium-coupled chloride cotransporters and activates potassium-coupled chloride cotransporters. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
65267

Open Targets

More...
OpenTargetsi
ENSG00000196632

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYP7 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6055

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2282

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WNK3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
353526307

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000868231 – 1800Serine/threonine-protein kinase WNK3Add BLAST1800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei62PhosphoserineCombined sources1
Modified residuei304Phosphoserine; by autocatalysisBy similarity1
Modified residuei308Phosphoserine; by autocatalysisBy similarity1
Modified residuei1070PhosphoserineBy similarity1
Modified residuei1585PhosphoserineBy similarity1
Modified residuei1638PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by the BCR(KLHL2) complex, leading to its degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BYP7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BYP7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BYP7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BYP7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYP7

PeptideAtlas

More...
PeptideAtlasi
Q9BYP7

PRoteomics IDEntifications database

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PRIDEi
Q9BYP7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79674 [Q9BYP7-1]
79675 [Q9BYP7-2]
79676 [Q9BYP7-3]
79677 [Q9BYP7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3 is kidney-specific.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196632 Expressed in caput epididymis and 130 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BYP7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BYP7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196632 Tissue enhanced (epididymis, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WNK1 and WNK4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122422, 8 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9BYP7

Protein interaction database and analysis system

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IntActi
Q9BYP7, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000346667

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BYP7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYP7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11800
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYP7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 405Protein kinasePROSITE-ProRule annotationAdd BLAST259

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0584 Eukaryota
ENOG410XQWZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160145

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000550_1_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BYP7

KEGG Orthology (KO)

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KOi
K08867

Identification of Orthologs from Complete Genome Data

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OMAi
ENNPCQH

Database of Orthologous Groups

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OrthoDBi
27514at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BYP7

TreeFam database of animal gene trees

More...
TreeFami
TF315363

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDSGDPAS TEDSEKPDGI SFENRVPQVA ATLTVEARLK EKNSTFSASG
60 70 80 90 100
ETVERKRFFR KSVEMTEDDK VAESSPKDER IKAAMNIPRV DKLPSNVLRG
110 120 130 140 150
GQEVKYEQCS KSTSEISKDC FKEKNEKEME EEAEMKAVAT SPSGRFLKFD
160 170 180 190 200
IELGRGAFKT VYKGLDTETW VEVAWCELQD RKLTKAEQQR FKEEAEMLKG
210 220 230 240 250
LQHPNIVRFY DSWESILKGK KCIVLVTELM TSGTLKTYLK RFKVMKPKVL
260 270 280 290 300
RSWCRQILKG LQFLHTRTPP IIHRDLKCDN IFITGPTGSV KIGDLGLATL
310 320 330 340 350
MRTSFAKSVI GTPEFMAPEM YEEHYDESVD VYAFGMCMLE MATSEYPYSE
360 370 380 390 400
CQNAAQIYRK VTSGIKPASF NKVTDPEVKE IIEGCIRQNK SERLSIRDLL
410 420 430 440 450
NHAFFAEDTG LRVELAEEDD CSNSSLALRL WVEDPKKLKG KHKDNEAIEF
460 470 480 490 500
SFNLETDTPE EVAYEMVKSG FFHESDSKAV AKSIRDRVTP IKKTREKKPA
510 520 530 540 550
GCLEERRDSQ CKSMGNVFPQ PQNTTLPLAP AQQTGAECEE TEVDQHVRQQ
560 570 580 590 600
LLQRKPQQHC SSVTGDNLSE AGAASVIHSD TSSQPSVAYS SNQTMGSQMV
610 620 630 640 650
SNIPQAEVNV PGQIYSSQQL VGHYQQVSGL QKHSKLTQPQ ILPLVQGQST
660 670 680 690 700
VLPVHVLGPT VVSQPQVSPL TVQKVPQIKP VSQPVGAEQQ AALLKPDLVR
710 720 730 740 750
SLNQDVATTK ENVSSPDNPS GNGKQDRIKQ RRASCPRPEK GTKFQLTVLQ
760 770 780 790 800
VSTSGDNMVE CQLETHNNKM VTFKFDVDGD APEDIADYMV EDNFVLESEK
810 820 830 840 850
EKFVEELRAI VGQAQEILHV HFATERATGV DSITVDSNSS QTGSSEQVQI
860 870 880 890 900
NSTSTQTSNE SAPQSSPVGR WRFCINQTIR NRETQSPPSL QHSMSAVPGR
910 920 930 940 950
HPLPSPKNTS NKEISRDTLL TIENNPCHRA LFTSKSEHKD VVDGKISECA
960 970 980 990 1000
SVETKQPAIL YQVEDNRQIM APVTNSSSYS TTSVRAVPAE CEGLTKQASI
1010 1020 1030 1040 1050
FIPVYPCHQT ASQADALMSH PGESTQTSGN SLTTLAFDQK PQTLSVQQPA
1060 1070 1080 1090 1100
MDAEFISQEG ETTVNTEASS PKTVIPTQTP GLEPTTLQPT TVLESDGERP
1110 1120 1130 1140 1150
PKLEFADNRI KTLDEKLRNL LYQEHSISSI YPESQKDTQS IDSPFSSSAE
1160 1170 1180 1190 1200
DTLSCPVTEV IAISHCGIKD SPVQSPNFQQ TGSKLLSNVA ASQPANISVF
1210 1220 1230 1240 1250
KRDLNVITSV PSELCLHEMS SDASLPGDPE AYPAAVSSGG AIHLQTGGGY
1260 1270 1280 1290 1300
FGLSFTCPSL KNPISKKSWT RKLKSWAYRL RQSTSFFKRS KVRQVETEEM
1310 1320 1330 1340 1350
RSAIAPDPIP LTRESTADTR ALNRCKAMSG SFQRGRFQVI TIPQQQSAKM
1360 1370 1380 1390 1400
TSFGIEHISV FSETNHSSEE AFIKTAKSQL VEIEPATQNP KTSFSYEKLQ
1410 1420 1430 1440 1450
ALQETCKENK GVPKQGDNFL SFSAACETDV SSVTPEKEFE ETSATGSSMQ
1460 1470 1480 1490 1500
SGSELLLKER EILTAGKQPS SDSEFSASLA GSGKSVAKTG PESNQCLPHH
1510 1520 1530 1540 1550
EEQAYAQTQS SLFYSPSSPM SSDDESEIED EDLKVELQRL REKHIQEVVN
1560 1570 1580 1590 1600
LQTQQNKELQ ELYERLRSIK DSKTQSTEIP LPPASPRRPR SFKSKLRSRP
1610 1620 1630 1640 1650
QSLTHVDNGI VATGKSCLIN ELENPLCVES NAASCQQSPA SKKGMFTDDL
1660 1670 1680 1690 1700
HKLVDDWTKE AVGNSLIKPS LNQLKQSQHK LETENWNKVS ENTPSTMGYT
1710 1720 1730 1740 1750
STWISSLSQI RGAVPTSLPQ GLSLPSFPGP LSSYGMPHVC QYNAVAGAGY
1760 1770 1780 1790 1800
PVQWVGISGT TQQSVVIPAQ SGGPFQPGMN MQAFPTSSVQ NPATIPPGPK
Length:1,800
Mass (Da):198,416
Last modified:October 19, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1766D6AC8C7DE864
GO
Isoform 2 (identifier: Q9BYP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1614-1624: GKSCLINELEN → D

Show »
Length:1,790
Mass (Da):197,329
Checksum:iF49E2D171D308FE3
GO
Isoform 3 (identifier: Q9BYP7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1248-1294: Missing.
     1614-1624: GKSCLINELEN → D

Show »
Length:1,743
Mass (Da):191,789
Checksum:i7B06CC8C7E8E4D67
GO
Isoform 4 (identifier: Q9BYP7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1248-1294: Missing.

Show »
Length:1,753
Mass (Da):192,875
Checksum:iD08B93F28F01E049
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYK2A0A087WYK2_HUMAN
Serine/threonine-protein kinase WNK...
WNK3
1,799Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AQN8B1AQN8_HUMAN
Serine/threonine-protein kinase WNK...
WNK3
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10S → N in AAL99253 (PubMed:15194194).Curated1
Sequence conflicti431 – 432WV → RD in BAB13392 (PubMed:10997877).Curated2
Sequence conflicti1211P → S in BAB13392 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041323704Q → H1 PublicationCorresponds to variant dbSNP:rs56077971Ensembl.1
Natural variantiVAR_041324854S → C in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041325998A → T1 PublicationCorresponds to variant dbSNP:rs56404148Ensembl.1
Natural variantiVAR_0413261169K → E1 PublicationCorresponds to variant dbSNP:rs55903619Ensembl.1
Natural variantiVAR_0413271375T → I1 PublicationCorresponds to variant dbSNP:rs55879434Ensembl.1
Natural variantiVAR_0413281533L → F in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0413291634S → P in a renal clear cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0419321248 – 1294Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_0419331614 – 1624GKSCLINELEN → D in isoform 3 and isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ409088 mRNA Translation: CAC32455.2
AY082340 mRNA Translation: AAL99253.1
AY352048 mRNA Translation: AAR89465.1
AL049793 Genomic DNA No translation available.
AL591766 Genomic DNA No translation available.
Z84469 Genomic DNA No translation available.
AB046786 mRNA Translation: BAB13392.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14357.1 [Q9BYP7-1]
CCDS35302.1 [Q9BYP7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001002838.1, NM_001002838.3 [Q9BYP7-3]
NP_065973.2, NM_020922.4 [Q9BYP7-1]
XP_006724656.1, XM_006724593.3 [Q9BYP7-3]
XP_011529104.1, XM_011530802.2 [Q9BYP7-4]
XP_016885230.1, XM_017029741.1 [Q9BYP7-1]
XP_016885231.1, XM_017029742.1 [Q9BYP7-1]
XP_016885232.1, XM_017029743.1 [Q9BYP7-1]
XP_016885233.1, XM_017029744.1 [Q9BYP7-1]
XP_016885234.1, XM_017029745.1 [Q9BYP7-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65267

UCSC genome browser

More...
UCSCi
uc004dtc.3 human [Q9BYP7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409088 mRNA Translation: CAC32455.2
AY082340 mRNA Translation: AAL99253.1
AY352048 mRNA Translation: AAR89465.1
AL049793 Genomic DNA No translation available.
AL591766 Genomic DNA No translation available.
Z84469 Genomic DNA No translation available.
AB046786 mRNA Translation: BAB13392.1
CCDSiCCDS14357.1 [Q9BYP7-1]
CCDS35302.1 [Q9BYP7-3]
RefSeqiNP_001002838.1, NM_001002838.3 [Q9BYP7-3]
NP_065973.2, NM_020922.4 [Q9BYP7-1]
XP_006724656.1, XM_006724593.3 [Q9BYP7-3]
XP_011529104.1, XM_011530802.2 [Q9BYP7-4]
XP_016885230.1, XM_017029741.1 [Q9BYP7-1]
XP_016885231.1, XM_017029742.1 [Q9BYP7-1]
XP_016885232.1, XM_017029743.1 [Q9BYP7-1]
XP_016885233.1, XM_017029744.1 [Q9BYP7-1]
XP_016885234.1, XM_017029745.1 [Q9BYP7-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NKPX-ray2.80C/D537-547[»]
5O1VX-ray1.72A/B132-414[»]
5O21X-ray2.06A/B132-414[»]
5O23X-ray2.25A/B132-414[»]
5O26X-ray2.38A/B133-414[»]
5O2BX-ray2.04A/B132-414[»]
5O2CX-ray2.40A123-500[»]
SMRiQ9BYP7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122422, 8 interactors
ELMiQ9BYP7
IntActiQ9BYP7, 9 interactors
STRINGi9606.ENSP00000346667

Chemistry databases

BindingDBiQ9BYP7
ChEMBLiCHEMBL6055
GuidetoPHARMACOLOGYi2282

PTM databases

iPTMnetiQ9BYP7
PhosphoSitePlusiQ9BYP7

Polymorphism and mutation databases

BioMutaiWNK3
DMDMi353526307

Proteomic databases

EPDiQ9BYP7
jPOSTiQ9BYP7
MassIVEiQ9BYP7
MaxQBiQ9BYP7
PaxDbiQ9BYP7
PeptideAtlasiQ9BYP7
PRIDEiQ9BYP7
ProteomicsDBi79674 [Q9BYP7-1]
79675 [Q9BYP7-2]
79676 [Q9BYP7-3]
79677 [Q9BYP7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26766 251 antibodies

Genome annotation databases

GeneIDi65267
KEGGihsa:65267
UCSCiuc004dtc.3 human [Q9BYP7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65267
DisGeNETi65267

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WNK3
HGNCiHGNC:14543 WNK3
HPAiENSG00000196632 Tissue enhanced (epididymis, testis)
MIMi300358 gene
neXtProtiNX_Q9BYP7
OpenTargetsiENSG00000196632
PharmGKBiPA33784

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0584 Eukaryota
ENOG410XQWZ LUCA
GeneTreeiENSGT00940000160145
HOGENOMiCLU_000550_1_2_1
InParanoidiQ9BYP7
KOiK08867
OMAiENNPCQH
OrthoDBi27514at2759
PhylomeDBiQ9BYP7
TreeFamiTF315363

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
SignaLinkiQ9BYP7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WNK3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WNK3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65267
PharosiQ9BYP7 Tchem

Protein Ontology

More...
PROi
PR:Q9BYP7
RNActiQ9BYP7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196632 Expressed in caput epididymis and 130 other tissues
ExpressionAtlasiQ9BYP7 baseline and differential
GenevisibleiQ9BYP7 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWNK3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYP7
Secondary accession number(s): B1AKG2
, Q5JRC1, Q6JP76, Q8TCX6, Q9HCK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 19, 2011
Last modified: April 22, 2020
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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