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Protein

Zinc finger protein 341

Gene

ZNF341

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 76C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri322 – 344C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 497C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri503 – 525C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 564C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 677C2H2-type 11PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri683 – 705C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 341
Gene namesi
Name:ZNF341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000131061.13
HGNCiHGNC:15992 ZNF341
neXtProtiNX_Q9BYN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131061
PharmGKBiPA38076

Polymorphism and mutation databases

BioMutaiZNF341
DMDMi76803837

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475411 – 854Zinc finger protein 341Add BLAST854

Proteomic databases

EPDiQ9BYN7
MaxQBiQ9BYN7
PaxDbiQ9BYN7
PeptideAtlasiQ9BYN7
PRIDEiQ9BYN7
ProteomicsDBi79671
79672 [Q9BYN7-2]

PTM databases

iPTMnetiQ9BYN7
PhosphoSitePlusiQ9BYN7

Expressioni

Gene expression databases

BgeeiENSG00000131061 Expressed in 119 organ(s), highest expression level in blood
CleanExiHS_ZNF341
ExpressionAtlasiQ9BYN7 baseline and differential
GenevisibleiQ9BYN7 HS

Organism-specific databases

HPAiHPA023240
HPA024607
HPA067108

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124344, 7 interactors
IntActiQ9BYN7, 11 interactors
STRINGi9606.ENSP00000344308

Structurei

3D structure databases

ProteinModelPortaliQ9BYN7
SMRiQ9BYN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi143 – 186Pro-richAdd BLAST44

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 76C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri322 – 344C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 497C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri503 – 525C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 564C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 677C2H2-type 11PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri683 – 705C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00390000000546
HOGENOMiHOG000232006
HOVERGENiHBG056415
InParanoidiQ9BYN7
OMAiHTGCSKE
OrthoDBiEOG091G01QZ
PhylomeDBiQ9BYN7
TreeFamiTF333164

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQAIFEALE GMDNQTVLAV QSLLDGQGAV PDPTGQSVNA PPAIQPLDDE
60 70 80 90 100
DVFLCGKCKK QFNSLPAFMT HKREQCQGNA PALATVSLAT NSIYPPSAAP
110 120 130 140 150
TAVQQAPTPA NRQISTYITV PPSPLIQTLV QGNILVSDDV LMSAMSAFTS
160 170 180 190 200
LDQPMPQGPP PVQSSLNMHS VPSYLTQPPP PPPPPPPLPP PPPPQPPPPP
210 220 230 240 250
PQSLGPPGRP NPGGNGVVEV YSAAAPLAGS GTVEIQALGM QPYPPLEVPN
260 270 280 290 300
QCVEPPVYPT PTVYSPGKQG FKPKGPNPAA PMTSATGGTV ATFDSPATLK
310 320 330 340 350
TRRAKGARGL PEAAGKPKAQ KLKCSYCDKS FTKNFDLQQH IRSHTGEKPF
360 370 380 390 400
QCIACGRAFA QKSNVKKHMQ THKVWPPGHS GGTVSRNSVT VQVMALNPSR
410 420 430 440 450
QEDEESTGLG QPLPGAPQPQ ALSTAGEEEG DKPESKQVVL IDSSYLCQFC
460 470 480 490 500
PSKFSTYFQL KSHMTQHKNE QVYKCVVKSC AQTFPKLDTF LEHIKSHQEE
510 520 530 540 550
LSYRCHLCGK DFPSLYDLGV HQYSHSLLPQ HSPKKDNAVY KCVKCVNKYS
560 570 580 590 600
TPEALEHHLQ TATHNFPCPH CQKVFPCERY LRRHLPTHGS GGRFKCQVCK
610 620 630 640 650
KFFRREHYLK LHAHIHSGEK PYKCSVCESA FNRKDKLKRH MLIHEPFKKY
660 670 680 690 700
KCPFSTHTGC SKEFNRPDKL KAHILSHSGM KLHKCALCSK SFSRRAHLAE
710 720 730 740 750
HQRAHTGNYK FRCAGCAKGF SRHKYLKDHR CRLGPQKDKD LQTRRPPQRR
760 770 780 790 800
AAPRSCGSGG RKVLTPLPDP LGLEELKDTG AGLVPEAVPG KPPFAEPDAV
810 820 830 840 850
LSIVVGGAVG AETELVVPGH AEGLGSNLAL AELQAGAEGP CAMLAVPVYI

QASE
Note: No experimental confirmation available.
Length:854
Mass (Da):92,728
Last modified:September 27, 2005 - v2
Checksum:i1198203F2C7ECF07
GO
Isoform 2 (identifier: Q9BYN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-312: Missing.

Note: Gene prediction based on EST data.
Show »
Length:847
Mass (Da):92,047
Checksum:iF386C0D71EDB6936
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PN62E9PN62_HUMAN
Zinc finger protein 341
ZNF341
604Annotation score:
E9PQQ0E9PQQ0_HUMAN
Zinc finger protein 341
ZNF341
72Annotation score:

Sequence cautioni

The sequence BAB55193 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti659G → D in BAB55193 (PubMed:14702039).Curated1
Sequence conflicti706T → M in BAB55193 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027218306 – 312Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050349 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76295.1
BC132873 mRNA Translation: AAI32874.1
BC144188 mRNA Translation: AAI44189.1
BC146811 mRNA Translation: AAI46812.1
BC157823 mRNA Translation: AAI57824.1
AK027550 mRNA Translation: BAB55193.1 Different initiation.
CCDSiCCDS13227.1 [Q9BYN7-2]
CCDS74719.1 [Q9BYN7-1]
RefSeqiNP_001269862.1, NM_001282933.1 [Q9BYN7-1]
NP_001269864.1, NM_001282935.1
NP_116208.3, NM_032819.4 [Q9BYN7-2]
UniGeneiHs.516989

Genome annotation databases

EnsembliENST00000342427; ENSP00000344308; ENSG00000131061 [Q9BYN7-2]
ENST00000375200; ENSP00000364346; ENSG00000131061 [Q9BYN7-1]
GeneIDi84905
KEGGihsa:84905
UCSCiuc002wzx.5 human [Q9BYN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050349 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76295.1
BC132873 mRNA Translation: AAI32874.1
BC144188 mRNA Translation: AAI44189.1
BC146811 mRNA Translation: AAI46812.1
BC157823 mRNA Translation: AAI57824.1
AK027550 mRNA Translation: BAB55193.1 Different initiation.
CCDSiCCDS13227.1 [Q9BYN7-2]
CCDS74719.1 [Q9BYN7-1]
RefSeqiNP_001269862.1, NM_001282933.1 [Q9BYN7-1]
NP_001269864.1, NM_001282935.1
NP_116208.3, NM_032819.4 [Q9BYN7-2]
UniGeneiHs.516989

3D structure databases

ProteinModelPortaliQ9BYN7
SMRiQ9BYN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124344, 7 interactors
IntActiQ9BYN7, 11 interactors
STRINGi9606.ENSP00000344308

PTM databases

iPTMnetiQ9BYN7
PhosphoSitePlusiQ9BYN7

Polymorphism and mutation databases

BioMutaiZNF341
DMDMi76803837

Proteomic databases

EPDiQ9BYN7
MaxQBiQ9BYN7
PaxDbiQ9BYN7
PeptideAtlasiQ9BYN7
PRIDEiQ9BYN7
ProteomicsDBi79671
79672 [Q9BYN7-2]

Protocols and materials databases

DNASUi84905
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342427; ENSP00000344308; ENSG00000131061 [Q9BYN7-2]
ENST00000375200; ENSP00000364346; ENSG00000131061 [Q9BYN7-1]
GeneIDi84905
KEGGihsa:84905
UCSCiuc002wzx.5 human [Q9BYN7-1]

Organism-specific databases

CTDi84905
EuPathDBiHostDB:ENSG00000131061.13
GeneCardsiZNF341
HGNCiHGNC:15992 ZNF341
HPAiHPA023240
HPA024607
HPA067108
neXtProtiNX_Q9BYN7
OpenTargetsiENSG00000131061
PharmGKBiPA38076
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00390000000546
HOGENOMiHOG000232006
HOVERGENiHBG056415
InParanoidiQ9BYN7
OMAiHTGCSKE
OrthoDBiEOG091G01QZ
PhylomeDBiQ9BYN7
TreeFamiTF333164

Miscellaneous databases

ChiTaRSiZNF341 human
GenomeRNAii84905
PROiPR:Q9BYN7

Gene expression databases

BgeeiENSG00000131061 Expressed in 119 organ(s), highest expression level in blood
CleanExiHS_ZNF341
ExpressionAtlasiQ9BYN7 baseline and differential
GenevisibleiQ9BYN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN341_HUMAN
AccessioniPrimary (citable) accession number: Q9BYN7
Secondary accession number(s): A2RUF4
, B2RXE5, B7ZM09, Q5JXM8, Q96ST5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: September 27, 2005
Last modified: October 10, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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