UniProtKB - Q9BYN0 (SRXN1_HUMAN)
Protein
Sulfiredoxin-1
Gene
SRXN1
Organism
Homo sapiens (Human)
Status
Functioni
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.2 Publications
Catalytic activityi
- [peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP = [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H+ + phosphateEC:1.8.98.2
Cofactori
Mg2+By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 98 – 101 | ATP | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- oxidoreductase activity, acting on a sulfur group of donors Source: UniProtKB
- sulfiredoxin activity Source: GO_Central
GO - Biological processi
- cellular response to oxidative stress Source: GO_Central
- response to oxidative stress Source: UniProtKB
Keywordsi
Molecular function | Antioxidant, Oxidoreductase |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 1.8.98.2, 2681 |
PathwayCommonsi | Q9BYN0 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SRXN1 Synonyms:C20orf139, SRX, SRX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16132, SRXN1 |
MIMi | 617583, gene |
neXtProti | NX_Q9BYN0 |
VEuPathDBi | HostDB:ENSG00000271303.1 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 99 | C → S: No effect on association with PRDX1, PRDX2, PRDX3 or PRDX4. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 140809 |
OpenTargetsi | ENSG00000271303 |
PharmGKBi | PA25681 |
Miscellaneous databases
Pharosi | Q9BYN0, Tbio |
Genetic variation databases
BioMutai | SRXN1 |
DMDMi | 30315944 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211431 | 1 – 137 | Sulfiredoxin-1Add BLAST | 137 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 16 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 99 | InterchainBy similarity |
Keywords - PTMi
Disulfide bond, Methylation, PhosphoproteinProteomic databases
EPDi | Q9BYN0 |
jPOSTi | Q9BYN0 |
MassIVEi | Q9BYN0 |
MaxQBi | Q9BYN0 |
PaxDbi | Q9BYN0 |
PeptideAtlasi | Q9BYN0 |
PRIDEi | Q9BYN0 |
ProteomicsDBi | 79670 |
PTM databases
iPTMneti | Q9BYN0 |
PhosphoSitePlusi | Q9BYN0 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in kidney, lung, spleen and thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000271303, Expressed in islet of Langerhans and 113 other tissues |
Genevisiblei | Q9BYN0, HS |
Organism-specific databases
HPAi | ENSG00000271303, Low tissue specificity |
Interactioni
Binary interactionsi
Q9BYN0
With | #Exp. | IntAct |
---|---|---|
PRDX1 [Q06830] | 3 | EBI-15678820,EBI-353193 |
Protein-protein interaction databases
BioGRIDi | 126716, 41 interactors |
CORUMi | Q9BYN0 |
DIPi | DIP-59836N |
IntActi | Q9BYN0, 2 interactors |
STRINGi | 9606.ENSP00000371388 |
Miscellaneous databases
RNActi | Q9BYN0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9BYN0 |
SMRi | Q9BYN0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BYN0 |
Family & Domainsi
Sequence similaritiesi
Belongs to the sulfiredoxin family.Curated
Phylogenomic databases
eggNOGi | KOG3388, Eukaryota |
GeneTreei | ENSGT00390000007832 |
HOGENOMi | CLU_124532_1_0_1 |
InParanoidi | Q9BYN0 |
OMAi | CHRFAAY |
OrthoDBi | 1421270at2759 |
PhylomeDBi | Q9BYN0 |
TreeFami | TF300230 |
Family and domain databases
InterProi | View protein in InterPro IPR003115, ParB/Sulfiredoxin_dom IPR036086, ParB/Sulfiredoxin_sf IPR016692, Sulfiredoxin |
PANTHERi | PTHR21348, PTHR21348, 1 hit |
Pfami | View protein in Pfam PF02195, ParBc, 1 hit |
PIRSFi | PIRSF017267, Sulfiredoxin, 1 hit |
SMARTi | View protein in SMART SM00470, ParB, 1 hit |
SUPFAMi | SSF110849, SSF110849, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BYN0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLRAGGTLG RAGAGRGAPE GPGPSGGAQG GSIHSGRIAA VHNVPLSVLI
60 70 80 90 100
RPLPSVLDPA KVQSLVDTIR EDPDSVPPID VLWIKGAQGG DYFYSFGGCH
110 120 130
RYAAYQQLQR ETIPAKLVQS TLSDLRVYLG ASTPDLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312054 mRNA Translation: BAG34990.1 AL833944 mRNA Translation: CAD38799.1 AL121758 Genomic DNA No translation available. BC017001 mRNA Translation: AAH17001.1 BC032604 mRNA Translation: AAH32604.1 BC047707 mRNA Translation: AAH47707.1 |
CCDSi | CCDS13005.1 |
RefSeqi | NP_542763.1, NM_080725.2 |
Genome annotation databases
Ensembli | ENST00000381962; ENSP00000371388; ENSG00000271303 |
GeneIDi | 140809 |
KEGGi | hsa:140809 |
UCSCi | uc002wea.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312054 mRNA Translation: BAG34990.1 AL833944 mRNA Translation: CAD38799.1 AL121758 Genomic DNA No translation available. BC017001 mRNA Translation: AAH17001.1 BC032604 mRNA Translation: AAH32604.1 BC047707 mRNA Translation: AAH47707.1 |
CCDSi | CCDS13005.1 |
RefSeqi | NP_542763.1, NM_080725.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XW3 | X-ray | 1.65 | A | 32-137 | [»] | |
1XW4 | X-ray | 2.00 | X | 32-137 | [»] | |
1YZS | NMR | - | A | 17-137 | [»] | |
2B6F | NMR | - | A | 17-137 | [»] | |
2RII | X-ray | 2.60 | X/Y | 32-137 | [»] | |
3CYI | X-ray | 1.80 | A | 32-137 | [»] | |
3HY2 | X-ray | 2.10 | X/Y | 32-137 | [»] | |
BMRBi | Q9BYN0 | |||||
SMRi | Q9BYN0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126716, 41 interactors |
CORUMi | Q9BYN0 |
DIPi | DIP-59836N |
IntActi | Q9BYN0, 2 interactors |
STRINGi | 9606.ENSP00000371388 |
PTM databases
iPTMneti | Q9BYN0 |
PhosphoSitePlusi | Q9BYN0 |
Genetic variation databases
BioMutai | SRXN1 |
DMDMi | 30315944 |
Proteomic databases
EPDi | Q9BYN0 |
jPOSTi | Q9BYN0 |
MassIVEi | Q9BYN0 |
MaxQBi | Q9BYN0 |
PaxDbi | Q9BYN0 |
PeptideAtlasi | Q9BYN0 |
PRIDEi | Q9BYN0 |
ProteomicsDBi | 79670 |
Protocols and materials databases
Antibodypediai | 69340, 89 antibodies |
DNASUi | 140809 |
Genome annotation databases
Ensembli | ENST00000381962; ENSP00000371388; ENSG00000271303 |
GeneIDi | 140809 |
KEGGi | hsa:140809 |
UCSCi | uc002wea.5, human |
Organism-specific databases
CTDi | 140809 |
DisGeNETi | 140809 |
GeneCardsi | SRXN1 |
HGNCi | HGNC:16132, SRXN1 |
HPAi | ENSG00000271303, Low tissue specificity |
MIMi | 617583, gene |
neXtProti | NX_Q9BYN0 |
OpenTargetsi | ENSG00000271303 |
PharmGKBi | PA25681 |
VEuPathDBi | HostDB:ENSG00000271303.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3388, Eukaryota |
GeneTreei | ENSGT00390000007832 |
HOGENOMi | CLU_124532_1_0_1 |
InParanoidi | Q9BYN0 |
OMAi | CHRFAAY |
OrthoDBi | 1421270at2759 |
PhylomeDBi | Q9BYN0 |
TreeFami | TF300230 |
Enzyme and pathway databases
BRENDAi | 1.8.98.2, 2681 |
PathwayCommonsi | Q9BYN0 |
Miscellaneous databases
BioGRID-ORCSi | 140809, 6 hits in 874 CRISPR screens |
ChiTaRSi | SRXN1, human |
EvolutionaryTracei | Q9BYN0 |
GeneWikii | SRXN1 |
GenomeRNAii | 140809 |
Pharosi | Q9BYN0, Tbio |
PROi | PR:Q9BYN0 |
RNActi | Q9BYN0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000271303, Expressed in islet of Langerhans and 113 other tissues |
Genevisiblei | Q9BYN0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003115, ParB/Sulfiredoxin_dom IPR036086, ParB/Sulfiredoxin_sf IPR016692, Sulfiredoxin |
PANTHERi | PTHR21348, PTHR21348, 1 hit |
Pfami | View protein in Pfam PF02195, ParBc, 1 hit |
PIRSFi | PIRSF017267, Sulfiredoxin, 1 hit |
SMARTi | View protein in SMART SM00470, ParB, 1 hit |
SUPFAMi | SSF110849, SSF110849, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRXN1_HUMAN | |
Accessioni | Q9BYN0Primary (citable) accession number: Q9BYN0 Secondary accession number(s): B2R543, Q8NDM3, Q96AK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 30, 2003 |
Last sequence update: | April 30, 2003 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families