UniProtKB - Q9BYM8 (HOIL1_HUMAN)
RanBP-type and C3HC4-type zinc finger-containing protein 1
RBCK1
Functioni
Catalytic activityi
- [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.1 Publication EC:2.3.2.31
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 282 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 285 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 300 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 302 | Zinc 2; via pros nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 305 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 308 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 323 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 332 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 371 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 376 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 391 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 394 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 399 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 402 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 406 | Zinc 4; via tele nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 411 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 447 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 450 | Zinc 5PROSITE-ProRule annotation | 1 | |
Active sitei | 460 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 465 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 468 | Zinc 5PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 193 – 222 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 282 – 332 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 351 – 411 | IBR-typePROSITE-ProRule annotationAdd BLAST | 61 | |
Zinc fingeri | 447 – 476 | RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 30 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- protein sequestering activity Source: GO_Central
- transcription coactivator activity Source: GO_Central
- ubiquitin binding Source: UniProtKB
- ubiquitin-protein transferase activity Source: UniProtKB
GO - Biological processi
- cytoplasmic sequestering of protein Source: GO_Central
- I-kappaB kinase/NF-kappaB signaling Source: Reactome
- negative regulation of necroptotic process Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein linear polyubiquitination Source: UniProtKB
- protein polyubiquitination Source: UniProtKB
- regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Host-virus interaction, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BYM8 |
Reactomei | R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q9BYM8 |
Names & Taxonomyi
Protein namesi | Recommended name: RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC:2.3.2.311 Publication)Alternative name(s): HBV-associated factor 4 Heme-oxidized IRP2 ubiquitin ligase 1 Short name: HOIL-1 Hepatitis B virus X-associated protein 4 RING finger protein 54 RING-type E3 ubiquitin transferase HOIL-1Curated Ubiquitin-conjugating enzyme 7-interacting protein 3 |
Gene namesi | Name:RBCK1 Synonyms:C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15864, RBCK1 |
MIMi | 610924, gene |
neXtProti | NX_Q9BYM8 |
VEuPathDBi | HostDB:ENSG00000125826.19 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Other locations
- LUBAC complex Source: UniProtKB
- ubiquitin ligase complex Source: GO_Central
Pathology & Biotechi
Involvement in diseasei
Polyglucosan body myopathy 1 with or without immunodeficiency (PGBM1)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071385 | 18 | A → P in PGBM1. 1 Publication | 1 | |
Natural variantiVAR_071386 | 387 | N → S in PGBM1. 1 PublicationCorresponds to variant dbSNP:rs566912235EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 282 | C → S: Binds to IREB2 in iron-treated cells. Reversed iron-induced down-regulation of IREB2. No ubiquitination of heme-loaded IREB2; when associated with S-285. 1 Publication | 1 | |
Mutagenesisi | 285 | C → S: Binds to IREB2 in iron-treated cells. Reversed iron-induced down-regulation of IREB2. No ubiquitination of heme-loaded IREB2; when associated with S-282. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 10616 |
MalaCardsi | RBCK1 |
MIMi | 615895, phenotype |
OpenTargetsi | ENSG00000125826 |
Orphaneti | 329173, Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis 397937, Polyglucosan body myopathy type 1 |
PharmGKBi | PA25723 |
Miscellaneous databases
Pharosi | Q9BYM8, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4296109 |
Genetic variation databases
BioMutai | RBCK1 |
DMDMi | 166214993 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056295 | 1 – 510 | RanBP-type and C3HC4-type zinc finger-containing protein 1Add BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 50 | PhosphoserineCombined sources | 1 | |
Modified residuei | 330 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BYM8 |
jPOSTi | Q9BYM8 |
MassIVEi | Q9BYM8 |
MaxQBi | Q9BYM8 |
PaxDbi | Q9BYM8 |
PeptideAtlasi | Q9BYM8 |
PRIDEi | Q9BYM8 |
ProteomicsDBi | 79667 [Q9BYM8-1] 79668 [Q9BYM8-3] 79669 [Q9BYM8-4] |
PTM databases
iPTMneti | Q9BYM8 |
MetOSitei | Q9BYM8 |
PhosphoSitePlusi | Q9BYM8 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000125826, Expressed in right hemisphere of cerebellum and 233 other tissues |
ExpressionAtlasi | Q9BYM8, baseline and differential |
Genevisiblei | Q9BYM8, HS |
Organism-specific databases
HPAi | ENSG00000125826, Low tissue specificity |
Interactioni
Subunit structurei
Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits.
Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) and with UBE2L3.
Interacts with PRKCH. Isoform 1 and isoform 2 interact with IREB2 only in iron-rich conditions. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner.
Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1.
Interacts with IRF3.
9 Publications(Microbial infection) Interacts with hepatitis B virus/HBV protein HBx; this interaction is required to activate transcription of the viral genome.
1 PublicationBinary interactionsi
Hide detailsQ9BYM8
Isoform 3 [Q9BYM8-4]
With | #Exp. | IntAct |
---|---|---|
UBE2K [P61086] | 3 | EBI-25867896,EBI-473850 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- ubiquitin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115862, 133 interactors |
CORUMi | Q9BYM8 |
DIPi | DIP-47737N |
IntActi | Q9BYM8, 92 interactors |
MINTi | Q9BYM8 |
STRINGi | 9606.ENSP00000348632 |
Chemistry databases
BindingDBi | Q9BYM8 |
Miscellaneous databases
RNActi | Q9BYM8, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9BYM8 |
SMRi | Q9BYM8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BYM8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 119 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 270 | Interaction with TAB21 PublicationAdd BLAST | 270 | |
Regioni | 1 – 220 | Interaction with IRF31 PublicationAdd BLAST | 220 | |
Regioni | 69 – 131 | Interaction with RNF311 PublicationAdd BLAST | 63 | |
Regioni | 278 – 506 | TRIAD supradomainPROSITE-ProRule annotationAdd BLAST | 229 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 233 – 261 | Sequence analysisAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 193 – 222 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 282 – 332 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 351 – 411 | IBR-typePROSITE-ProRule annotationAdd BLAST | 61 | |
Zinc fingeri | 447 – 476 | RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 30 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1815, Eukaryota |
GeneTreei | ENSGT00940000161130 |
HOGENOMi | CLU_014998_1_0_1 |
InParanoidi | Q9BYM8 |
OMAi | MNCKDYQ |
OrthoDBi | 1086223at2759 |
PhylomeDBi | Q9BYM8 |
TreeFami | TF323486 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR002867, IBR_dom IPR026261, RBCK1/SHARPIN IPR044066, TRIAD_supradom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR027370, Znf-RING_LisH IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR22770:SF35, PTHR22770:SF35, 1 hit |
Pfami | View protein in Pfam PF01485, IBR, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS51873, TRIAD, 1 hit PS50053, UBIQUITIN_2, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDEKTKKAEE MALSLTRAVA GGDEQVAMKC AIWLAEQRVP LSVQLKPEVS
60 70 80 90 100
PTQDIRLWVS VEDAQMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPVLQQ
110 120 130 140 150
WVIGQRLARD QETLHSHGVR QNGDSAYLYL LSARNTSLNP QELQRERQLR
160 170 180 190 200
MLEDLGFKDL TLQPRGPLEP GPPKPGVPQE PGRGQPDAVP EPPPVGWQCP
210 220 230 240 250
GCTFINKPTR PGCEMCCRAR PEAYQVPASY QPDEEERARL AGEEEALRQY
260 270 280 290 300
QQRKQQQQEG NYLQHVQLDQ RSLVLNTEPA ECPVCYSVLA PGEAVVLREC
310 320 330 340 350
LHTFCRECLQ GTIRNSQEAE VSCPFIDNTY SCSGKLLERE IKALLTPEDY
360 370 380 390 400
QRFLDLGISI AENRSAFSYH CKTPDCKGWC FFEDDVNEFT CPVCFHVNCL
410 420 430 440 450
LCKAIHEQMN CKEYQEDLAL RAQNDVAARQ TTEMLKVMLQ QGEAMRCPQC
460 470 480 490 500
QIVVQKKDGC DWIRCTVCHT EICWVTKGPR WGPGGPGDTS GGCRCRVNGI
510
PCHPSCQNCH
The sequence of this isoform differs from the canonical sequence as follows:
1-55: MDEKTKKAEEMALSLTRAVAGGDEQVAMKCAIWLAEQRVPLSVQLKPEVSPTQDI → MGTATPDGREDQE
253-272: RKQQQQEGNYLQHVQLDQRS → GVPAGHHPQQPGGGGLLPLH
273-510: Missing.
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3XAG9 | G3XAG9_HUMAN | HCG2019817, isoform CRA_d | RBCK1 hCG_2019817 | 336 | Annotation score: | ||
A6PVK0 | A6PVK0_HUMAN | HCG2019817, isoform CRA_b | RBCK1 hCG_2019817 | 340 | Annotation score: | ||
B4DML5 | B4DML5_HUMAN | RanBP-type and C3HC4-type zinc fing... | RBCK1 | 272 | Annotation score: | ||
H0Y4S7 | H0Y4S7_HUMAN | RanBP-type and C3HC4-type zinc fing... | RBCK1 | 255 | Annotation score: | ||
A6PVJ6 | A6PVJ6_HUMAN | RanBP-type and C3HC4-type zinc fing... | RBCK1 | 105 | Annotation score: | ||
A6PVJ7 | A6PVJ7_HUMAN | RanBP-type and C3HC4-type zinc fing... | RBCK1 | 116 | Annotation score: | ||
Q5JWR1 | Q5JWR1_HUMAN | RanBP-type and C3HC4-type zinc fing... | RBCK1 | 117 | Annotation score: | ||
A6PVJ5 | A6PVJ5_HUMAN | RanBP-type and C3HC4-type zinc fing... | RBCK1 | 63 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 236 | E → D in BAC75409 (PubMed:12629548).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071385 | 18 | A → P in PGBM1. 1 Publication | 1 | |
Natural variantiVAR_071386 | 387 | N → S in PGBM1. 1 PublicationCorresponds to variant dbSNP:rs566912235EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005766 | 1 – 55 | MDEKT…PTQDI → MGTATPDGREDQE in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 55 | |
Alternative sequenceiVSP_005767 | 253 – 272 | RKQQQ…LDQRS → GVPAGHHPQQPGGGGLLPLH in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_005768 | 273 – 510 | Missing in isoform 3. 1 PublicationAdd BLAST | 238 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67322 mRNA Translation: AAD00162.1 AB107766 mRNA Translation: BAC75409.1 AL121747 Genomic DNA No translation available. BC000983 mRNA No translation available. BC015219 mRNA Translation: AAH15219.2 Different initiation. |
CCDSi | CCDS12998.1 [Q9BYM8-3] CCDS13000.2 [Q9BYM8-1] |
RefSeqi | NP_006453.1, NM_006462.5 [Q9BYM8-3] NP_112506.2, NM_031229.3 [Q9BYM8-1] |
Genome annotation databases
Ensembli | ENST00000353660; ENSP00000254960; ENSG00000125826 [Q9BYM8-3] ENST00000356286; ENSP00000348632; ENSG00000125826 [Q9BYM8-1] |
GeneIDi | 10616 |
KEGGi | hsa:10616 |
UCSCi | uc002wdp.5, human [Q9BYM8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67322 mRNA Translation: AAD00162.1 AB107766 mRNA Translation: BAC75409.1 AL121747 Genomic DNA No translation available. BC000983 mRNA No translation available. BC015219 mRNA Translation: AAH15219.2 Different initiation. |
CCDSi | CCDS12998.1 [Q9BYM8-3] CCDS13000.2 [Q9BYM8-1] |
RefSeqi | NP_006453.1, NM_006462.5 [Q9BYM8-3] NP_112506.2, NM_031229.3 [Q9BYM8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CRC | NMR | - | A | 194-232 | [»] | |
2LGY | NMR | - | A | 51-139 | [»] | |
4DBG | X-ray | 2.71 | A | 37-137 | [»] | |
BMRBi | Q9BYM8 | |||||
SMRi | Q9BYM8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115862, 133 interactors |
CORUMi | Q9BYM8 |
DIPi | DIP-47737N |
IntActi | Q9BYM8, 92 interactors |
MINTi | Q9BYM8 |
STRINGi | 9606.ENSP00000348632 |
Chemistry databases
BindingDBi | Q9BYM8 |
ChEMBLi | CHEMBL4296109 |
PTM databases
iPTMneti | Q9BYM8 |
MetOSitei | Q9BYM8 |
PhosphoSitePlusi | Q9BYM8 |
Genetic variation databases
BioMutai | RBCK1 |
DMDMi | 166214993 |
Proteomic databases
EPDi | Q9BYM8 |
jPOSTi | Q9BYM8 |
MassIVEi | Q9BYM8 |
MaxQBi | Q9BYM8 |
PaxDbi | Q9BYM8 |
PeptideAtlasi | Q9BYM8 |
PRIDEi | Q9BYM8 |
ProteomicsDBi | 79667 [Q9BYM8-1] 79668 [Q9BYM8-3] 79669 [Q9BYM8-4] |
Protocols and materials databases
Antibodypediai | 6164, 288 antibodies |
DNASUi | 10616 |
Genome annotation databases
Ensembli | ENST00000353660; ENSP00000254960; ENSG00000125826 [Q9BYM8-3] ENST00000356286; ENSP00000348632; ENSG00000125826 [Q9BYM8-1] |
GeneIDi | 10616 |
KEGGi | hsa:10616 |
UCSCi | uc002wdp.5, human [Q9BYM8-1] |
Organism-specific databases
CTDi | 10616 |
DisGeNETi | 10616 |
GeneCardsi | RBCK1 |
HGNCi | HGNC:15864, RBCK1 |
HPAi | ENSG00000125826, Low tissue specificity |
MalaCardsi | RBCK1 |
MIMi | 610924, gene 615895, phenotype |
neXtProti | NX_Q9BYM8 |
OpenTargetsi | ENSG00000125826 |
Orphaneti | 329173, Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis 397937, Polyglucosan body myopathy type 1 |
PharmGKBi | PA25723 |
VEuPathDBi | HostDB:ENSG00000125826.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1815, Eukaryota |
GeneTreei | ENSGT00940000161130 |
HOGENOMi | CLU_014998_1_0_1 |
InParanoidi | Q9BYM8 |
OMAi | MNCKDYQ |
OrthoDBi | 1086223at2759 |
PhylomeDBi | Q9BYM8 |
TreeFami | TF323486 |
Enzyme and pathway databases
PathwayCommonsi | Q9BYM8 |
Reactomei | R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q9BYM8 |
Miscellaneous databases
BioGRID-ORCSi | 10616, 7 hits in 874 CRISPR screens |
ChiTaRSi | RBCK1, human |
EvolutionaryTracei | Q9BYM8 |
GeneWikii | RBCK1 |
GenomeRNAii | 10616 |
Pharosi | Q9BYM8, Tbio |
PROi | PR:Q9BYM8 |
RNActi | Q9BYM8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125826, Expressed in right hemisphere of cerebellum and 233 other tissues |
ExpressionAtlasi | Q9BYM8, baseline and differential |
Genevisiblei | Q9BYM8, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR002867, IBR_dom IPR026261, RBCK1/SHARPIN IPR044066, TRIAD_supradom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR027370, Znf-RING_LisH IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR22770:SF35, PTHR22770:SF35, 1 hit |
Pfami | View protein in Pfam PF01485, IBR, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS51873, TRIAD, 1 hit PS50053, UBIQUITIN_2, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HOIL1_HUMAN | |
Accessioni | Q9BYM8Primary (citable) accession number: Q9BYM8 Secondary accession number(s): O95623 Q9BYM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 10, 2021 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families