UniProtKB - Q9BYK8 (HELZ2_HUMAN)
Helicase with zinc finger domain 2
HELZ2
Functioni
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 40 – 64 | C2H2-type; atypicalAdd BLAST | 25 | |
Nucleotide bindingi | 544 – 551 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 2174 – 2181 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- nuclear receptor transcription coactivator activity Source: GO_Central
- ribonuclease activity Source: InterPro
- RNA binding Source: UniProtKB
- RNA helicase activity Source: GO_Central
GO - Biological processi
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of lipid metabolic process Source: Reactome
Keywordsi
Molecular function | Activator, DNA-binding, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BYK8 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781, PPARA activates gene expression R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock |
Names & Taxonomyi
Protein namesi | Recommended name: Helicase with zinc finger domain 2Alternative name(s): ATP-dependent helicase PRIC285 Helicase with zinc finger 2, transcriptional coactivator PPAR-alpha-interacting complex protein 285 PPAR-gamma DNA-binding domain-interacting protein 1 Short name: PDIP1 Short name: PPAR-gamma DBD-interacting protein 1 Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC:3.6.4.-) |
Gene namesi | Name:HELZ2 Synonyms:KIAA1769, PRIC285 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30021, HELZ2 |
MIMi | 611265, gene |
neXtProti | NX_Q9BYK8 |
VEuPathDBi | HostDB:ENSG00000130589.16 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: Reactome
Other locations
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 85441 |
OpenTargetsi | ENSG00000130589 |
Miscellaneous databases
Pharosi | Q9BYK8, Tdark |
Genetic variation databases
BioMutai | HELZ2 |
DMDMi | 317373591 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058561 | 1 – 2649 | Helicase with zinc finger domain 2Add BLAST | 2649 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1006 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BYK8 |
jPOSTi | Q9BYK8 |
MassIVEi | Q9BYK8 |
MaxQBi | Q9BYK8 |
PaxDbi | Q9BYK8 |
PeptideAtlasi | Q9BYK8 |
PRIDEi | Q9BYK8 |
ProteomicsDBi | 79663 [Q9BYK8-1] 79664 [Q9BYK8-2] 79665 [Q9BYK8-4] |
PTM databases
iPTMneti | Q9BYK8 |
PhosphoSitePlusi | Q9BYK8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130589, Expressed in stomach and 126 other tissues |
Genevisiblei | Q9BYK8, HS |
Organism-specific databases
HPAi | ENSG00000130589, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PPARA (via DNA-binding domain) and PPARG; the interaction stimulates the transcriptional activity of PPARA and PPARG.
Interacts with THRAP3; the interaction is direct and HELZ2 and THRAP3 synergistically enhance the transcriptional activity of PPARG. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC).
2 PublicationsProtein-protein interaction databases
BioGRIDi | 124528, 20 interactors |
IntActi | Q9BYK8, 8 interactors |
STRINGi | 9606.ENSP00000417401 |
Miscellaneous databases
RNActi | Q9BYK8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 563 – 1059 | Interaction with THRAP31 PublicationAdd BLAST | 497 | |
Regioni | 2135 – 2649 | Interaction with THRAP31 PublicationAdd BLAST | 515 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 667 – 670 | DEAA box | 4 | |
Motifi | 1075 – 1079 | LXXLL motif 1 | 5 | |
Motifi | 1118 – 1122 | LXXLL motif 2 | 5 | |
Motifi | 1173 – 1177 | LXXLL motif 3 | 5 | |
Motifi | 2012 – 2016 | LXXLL motif 4 | 5 | |
Motifi | 2229 – 2233 | LXXLL motif 5 | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 968 – 1059 | Ala-richAdd BLAST | 92 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 40 – 64 | C2H2-type; atypicalAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1804, Eukaryota KOG2102, Eukaryota |
GeneTreei | ENSGT00940000160694 |
HOGENOMi | CLU_000407_0_0_1 |
InParanoidi | Q9BYK8 |
OMAi | LGPIWEH |
OrthoDBi | 5044at2759 |
PhylomeDBi | Q9BYK8 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 2 hits |
InterProi | View protein in InterPro IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR031191, HELZ2 IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase IPR001900, RNase_II/R IPR022966, RNase_II/R_CS IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR10887:SF428, PTHR10887:SF428, 1 hit |
Pfami | View protein in Pfam PF13086, AAA_11, 2 hits PF13087, AAA_12, 2 hits PF00773, RNB, 1 hit |
SMARTi | View protein in SMART SM00955, RNB, 1 hit |
SUPFAMi | SSF50249, SSF50249, 2 hits SSF52540, SSF52540, 2 hits SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVWEAEQLG GLQRGDLLTP PAPDGDGRTA PLGQPPGAQL YCPACLVTCH
60 70 80 90 100
SQEAFENHCA SSEHAQMVAF DQALPWEHRS PPPGLSKFEL CPKPDLCEYG
110 120 130 140 150
DACTKAHSAQ ELQEWVRRTQ AVELRGQAAW QDGLVPYQER LLAEYQRSSS
160 170 180 190 200
EVLVLAETLD GVRVTCNQPL MYQAQERKTQ YSWTFAVHSE EPLLHVALLK
210 220 230 240 250
QEPGADFSLV APGLPPGRLY ARGERFRVPS STADFQVGVR VQAASFGTFE
260 270 280 290 300
QWVVFDFGRR PVLLQKLGLQ LGQGRRPGPC RNLALGHPEE MERWHTGNRH
310 320 330 340 350
VVPGVERTAE QTALMAKYKG PALALEFNRS SVASGPISPT NYRQRMHQFL
360 370 380 390 400
YEEEAAQQQL VAKLTLRGQV FLKTALQTPA LNMLFAPPGA LYAEVPVPSS
410 420 430 440 450
LMPDTDQGFL LGRAVSTALV APVPAPDNTV FEVRLERRAS SEQALWLLLP
460 470 480 490 500
ARCCLALGLQ PEARLVLEVQ FQIDPMTFRL WHQAVDTLPE EQLVVPDLPT
510 520 530 540 550
CALPRPWSVP PLRRGNRKQE LAVALIAGWG PGDGRRVPPL LIYGPFGTGK
560 570 580 590 600
TYTLAMASLE VIRRPETKVL ICTHTNSAAD IYIREYFHSH VSGGHPEATP
610 620 630 640 650
LRVMYTDRPL SQTDPVTLQY CCLTDDRQAF RPPTRAELAR HRVVVTTTSQ
660 670 680 690 700
ARELRVPVGF FSHILIDEAA QMLECEALTP LAYASHGTRL VLAGDHMQVT
710 720 730 740 750
PRLFSVARAR AAEHTLLHRL FLCYQQETHE VARQSRLVFH ENYRCTDAIV
760 770 780 790 800
SFISRHFYVA KGNPIHARGK VPPHPRHYPL MFCHVAGSPD RDMSMASWLN
810 820 830 840 850
LAEIAQVVEK VQEAYNTWPS CWGGREQRCI CVVSHGAQVS ALRQELRRRD
860 870 880 890 900
LGQVSVGSFE ILPGRQFRVV VLSTVHTCQS LLSPGALAPE FFTDARVLNT
910 920 930 940 950
VLTRAQSQLV VVGDAVALCS FGACGKLWES FIRECVERHS VCPEGLSMEQ
960 970 980 990 1000
VEQGVAQRRR WPPRGTQAGA AGNWEAAPEP VGDLAEEQAA VVTAMVKAEP
1010 1020 1030 1040 1050
GDEALSPASR DITATTAQTE AAAAPAGDAV KEDVVPGACA AGAAAAAGVE
1060 1070 1080 1090 1100
STEAEDAEAD FWPWDGELNA DDAILRELLD ESQKVMVTVG EDGLLDTVAR
1110 1120 1130 1140 1150
PESLQQARLY ENLPPAALRK LLHAEPERYR HCSFVPETFE RASAIPLDDA
1160 1170 1180 1190 1200
SSGPIQVRGR LDCGMAFAGD EVLVQLLSGD KAPEGRLRGR VLGVLKRKRH
1210 1220 1230 1240 1250
ELAFVCRMDT WDPRIMVPIN GSVTKIFVAE LKDPSQVPIY SLRKGRLQRV
1260 1270 1280 1290 1300
GLERLTAEAR HSRLFWVQIV LWRQGFYYPL GIVREVLPEA STWEQGLRIL
1310 1320 1330 1340 1350
GLEYSLRVPP SDQATITKVL QKYHTELGRV AGRREDCRAF LTFTVDPQGA
1360 1370 1380 1390 1400
CNLDDALSVR DLGPRCEVAV HITDVASFVP RDGVLDVEAR RQGAAFYAPG
1410 1420 1430 1440 1450
REPVPMLPAS LCQDVLSLLP GRDRLAISLF LTMEKASGQL KSLRFAPSVV
1460 1470 1480 1490 1500
QSDRQLSYEE AEEVIRQHPG AGRELPARLD SVDACVVAAC YFSRLLRRHR
1510 1520 1530 1540 1550
LRSDCFYEQP DEDGTLGFRA AHIMVKEYMI QFNRLVAEFL VGSECTRTVT
1560 1570 1580 1590 1600
PLRWQPAPRS QQLKALCEKH GDRVPLSLHL GHHLHGGGGS PPDTRLHLLA
1610 1620 1630 1640 1650
SLWKQVQFAA RTQDYEQMVD LVTTDDMHPF LAPAGRDLRK ALERSAFGRC
1660 1670 1680 1690 1700
ARGHQQQGGH YSLQVDWYTW ATSPIRRYLD VVLQRQILLA LGHGGSAYSA
1710 1720 1730 1740 1750
RDIDGLCQAF SLQHALAQSY QRRARSLHLA VQLKAQPLDK LGFVVDVEAG
1760 1770 1780 1790 1800
SRCFRLLFPS NRETLPDPCP VPYGSLQLAE HPHALAGRPG LRLLWRRRVY
1810 1820 1830 1840 1850
SAQGSSPPLP LPGTVPDPHT LAVETALWKQ LLELVELQRW PEAAALIQEK
1860 1870 1880 1890 1900
GEASQRRELV QVQRSHCGHF LEVARELGSG DTLQVQLGTS LQHGFLVPSP
1910 1920 1930 1940 1950
QLWTVAPGFS LCLEHVERPG DCFSGRVYRA PRDRYRDVDE YACVWEPFCA
1960 1970 1980 1990 2000
LESATGAVAE NDSVTLQHLS VSWEASRTPQ GQLQGAFRLE AAFLEENCAD
2010 2020 2030 2040 2050
INFSCCYLCI RLEGLPAPTA SPRPGPSSLG PGLNVDPGTY TWVAHGQTQD
2060 2070 2080 2090 2100
WDQERRADRQ EAPRRVHLFV HHMGMEKVPE EVLRPGTLFT VELLPKQLPD
2110 2120 2130 2140 2150
LRKEEAVRGL EEASPLVTSI ALGRPVPQPL CRVIPSRFLE RQTYNIPGGR
2160 2170 2180 2190 2200
HKLNPSQNVA VREALEKPFT VIQGPPGTGK TIVGLHIVFW FHKSNQEQVQ
2210 2220 2230 2240 2250
PGGPPRGEKR LGGPCILYCG PSNKSVDVLA GLLLRRMELK PLRVYSEQAE
2260 2270 2280 2290 2300
ASEFPVPRVG SRKLLRKSPR EGRPNQSLRS ITLHHRIRQA PNPYSSEIKA
2310 2320 2330 2340 2350
FDTRLQRGEL FSREDLVWYK KVLWEARKFE LDRHEVILCT CSCAASASLK
2360 2370 2380 2390 2400
ILDVRQILVD EAGMATEPET LIPLVQFPQA EKVVLLGDHK QLRPVVKNER
2410 2420 2430 2440 2450
LQNLGLDRSL FERYHEDAHM LDTQYRMHEG ICAFPSVAFY KSKLKTWQGL
2460 2470 2480 2490 2500
RRPPSVLGHA GKESCPVIFG HVQGHERSLL VSTDEGNENS KANLEEVAEV
2510 2520 2530 2540 2550
VRITKQLTLG RTVEPQDIAV LTPYNAQASE ISKALRREGI AGVAVSSITK
2560 2570 2580 2590 2600
SQGSEWRYVL VSTVRTCAKS DLDQRPTKSW LKKFLGFVVD PNQVNVAVTR
2610 2620 2630 2640
AQEGLCLIGD HLLLRCCPLW RSLLDFCEAQ QTLVPAGQVR VCRRPTMPS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 196 | V → A in BAE46995 (PubMed:16239304).Curated | 1 | |
Sequence conflicti | 327 – 329 | FNR → SNH in BAE46995 (PubMed:16239304).Curated | 3 | |
Sequence conflicti | 442 | E → G in BAE46995 (PubMed:16239304).Curated | 1 | |
Sequence conflicti | 836 | G → D in BAE46995 (PubMed:16239304).Curated | 1 | |
Sequence conflicti | 1873 | V → A in BAE46995 (PubMed:16239304).Curated | 1 | |
Sequence conflicti | 2203 | G → S in BAE46995 (PubMed:16239304).Curated | 1 | |
Sequence conflicti | 2383 | V → A in BAE46995 (PubMed:16239304).Curated | 1 | |
Sequence conflicti | 2626 | F → L in BAE46995 (PubMed:16239304).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015597 | 788 | S → N3 PublicationsCorresponds to variant dbSNP:rs438363Ensembl. | 1 | |
Natural variantiVAR_015598 | 1123 | H → R3 PublicationsCorresponds to variant dbSNP:rs310632Ensembl. | 1 | |
Natural variantiVAR_047038 | 1152 | S → L. Corresponds to variant dbSNP:rs35817585EnsemblClinVar. | 1 | |
Natural variantiVAR_047039 | 1308 | V → L. Corresponds to variant dbSNP:rs310631Ensembl. | 1 | |
Natural variantiVAR_047040 | 1381 | R → K. Corresponds to variant dbSNP:rs3810487Ensembl. | 1 | |
Natural variantiVAR_047041 | 1821 | L → R. Corresponds to variant dbSNP:rs3810486Ensembl. | 1 | |
Natural variantiVAR_047042 | 1889 | T → A. Corresponds to variant dbSNP:rs34980032Ensembl. | 1 | |
Natural variantiVAR_015599 | 2016 | P → L3 PublicationsCorresponds to variant dbSNP:rs3810485Ensembl. | 1 | |
Natural variantiVAR_015600 | 2049 | Q → E3 PublicationsCorresponds to variant dbSNP:rs3810483Ensembl. | 1 | |
Natural variantiVAR_047043 | 2170 | T → M. Corresponds to variant dbSNP:rs3810481Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007297 | 1 – 569 | Missing in isoform 2. 2 PublicationsAdd BLAST | 569 | |
Alternative sequenceiVSP_017377 | 1 – 535 | Missing in isoform 3. CuratedAdd BLAST | 535 | |
Alternative sequenceiVSP_017378 | 536 – 576 | RVPPL…CTHTN → LTSDSQTRAVLRGSSAGHTV GALADSTEAPSKKPMSSSPS R in isoform 3. CuratedAdd BLAST | 41 | |
Alternative sequenceiVSP_007298 | 570 – 576 | LICTHTN → MSSSPSR in isoform 2. 2 Publications | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF517673 mRNA Translation: AAM74197.1 AB201715 mRNA Translation: BAE46995.1 AB051556 mRNA Translation: BAB21860.2 AL121829 Genomic DNA No translation available. AK074171 mRNA Translation: BAB84997.1 AK055611 mRNA Translation: BAB70969.1 Frameshift. |
CCDSi | CCDS13527.1 [Q9BYK8-2] CCDS33508.1 [Q9BYK8-1] |
RefSeqi | NP_001032412.2, NM_001037335.2 [Q9BYK8-1] NP_208384.3, NM_033405.3 [Q9BYK8-2] |
Genome annotation databases
Ensembli | ENST00000427522; ENSP00000393257; ENSG00000130589 [Q9BYK8-2] ENST00000467148; ENSP00000417401; ENSG00000130589 [Q9BYK8-1] |
GeneIDi | 85441 |
KEGGi | hsa:85441 |
UCSCi | uc002yfl.2, human [Q9BYK8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF517673 mRNA Translation: AAM74197.1 AB201715 mRNA Translation: BAE46995.1 AB051556 mRNA Translation: BAB21860.2 AL121829 Genomic DNA No translation available. AK074171 mRNA Translation: BAB84997.1 AK055611 mRNA Translation: BAB70969.1 Frameshift. |
CCDSi | CCDS13527.1 [Q9BYK8-2] CCDS33508.1 [Q9BYK8-1] |
RefSeqi | NP_001032412.2, NM_001037335.2 [Q9BYK8-1] NP_208384.3, NM_033405.3 [Q9BYK8-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124528, 20 interactors |
IntActi | Q9BYK8, 8 interactors |
STRINGi | 9606.ENSP00000417401 |
PTM databases
iPTMneti | Q9BYK8 |
PhosphoSitePlusi | Q9BYK8 |
Genetic variation databases
BioMutai | HELZ2 |
DMDMi | 317373591 |
Proteomic databases
EPDi | Q9BYK8 |
jPOSTi | Q9BYK8 |
MassIVEi | Q9BYK8 |
MaxQBi | Q9BYK8 |
PaxDbi | Q9BYK8 |
PeptideAtlasi | Q9BYK8 |
PRIDEi | Q9BYK8 |
ProteomicsDBi | 79663 [Q9BYK8-1] 79664 [Q9BYK8-2] 79665 [Q9BYK8-4] |
Protocols and materials databases
Antibodypediai | 63897, 40 antibodies |
Genome annotation databases
Ensembli | ENST00000427522; ENSP00000393257; ENSG00000130589 [Q9BYK8-2] ENST00000467148; ENSP00000417401; ENSG00000130589 [Q9BYK8-1] |
GeneIDi | 85441 |
KEGGi | hsa:85441 |
UCSCi | uc002yfl.2, human [Q9BYK8-1] |
Organism-specific databases
CTDi | 85441 |
DisGeNETi | 85441 |
GeneCardsi | HELZ2 |
HGNCi | HGNC:30021, HELZ2 |
HPAi | ENSG00000130589, Low tissue specificity |
MIMi | 611265, gene |
neXtProti | NX_Q9BYK8 |
OpenTargetsi | ENSG00000130589 |
VEuPathDBi | HostDB:ENSG00000130589.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1804, Eukaryota KOG2102, Eukaryota |
GeneTreei | ENSGT00940000160694 |
HOGENOMi | CLU_000407_0_0_1 |
InParanoidi | Q9BYK8 |
OMAi | LGPIWEH |
OrthoDBi | 5044at2759 |
PhylomeDBi | Q9BYK8 |
Enzyme and pathway databases
PathwayCommonsi | Q9BYK8 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781, PPARA activates gene expression R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock |
Miscellaneous databases
BioGRID-ORCSi | 85441, 9 hits in 873 CRISPR screens |
ChiTaRSi | HELZ2, human |
GeneWikii | PRIC285 |
GenomeRNAii | 85441 |
Pharosi | Q9BYK8, Tdark |
PROi | PR:Q9BYK8 |
RNActi | Q9BYK8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130589, Expressed in stomach and 126 other tissues |
Genevisiblei | Q9BYK8, HS |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 2 hits |
InterProi | View protein in InterPro IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR031191, HELZ2 IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase IPR001900, RNase_II/R IPR022966, RNase_II/R_CS IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR10887:SF428, PTHR10887:SF428, 1 hit |
Pfami | View protein in Pfam PF13086, AAA_11, 2 hits PF13087, AAA_12, 2 hits PF00773, RNB, 1 hit |
SMARTi | View protein in SMART SM00955, RNB, 1 hit |
SUPFAMi | SSF50249, SSF50249, 2 hits SSF52540, SSF52540, 2 hits SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HELZ2_HUMAN | |
Accessioni | Q9BYK8Primary (citable) accession number: Q9BYK8 Secondary accession number(s): Q3C2G2 Q9C094 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 30, 2003 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 10, 2021 | |
This is version 192 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families