UniProtKB - Q9BYJ9 (YTHD1_HUMAN)

BLAST

>sp|Q9BYJ9|YTHD1_HUMAN YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1
MSATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGQSNQSNSYPSMSDPYLSSYY
PPSIGFPYSLNEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIYQHRF
NFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQPGFHSDTLSKAPGM
NSLEQGMVGLKIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASK
PAKPQPKMKTKSGPVMGGGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQ
VAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAP
SVESHPVLEKLKAAHSYNPKEFEWNLKSGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKR
LDSAFRCMSSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIF
VKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYE
KRQEEEEVVRKERQSRNKQ

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History
Entry version 149 (10 Oct 2018)
Sequence version 1 (01 Jun 2001)
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Protein

YTH domain-containing family protein 1

Gene

YTHDF1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440).3 Publications

Caution

Promotes mRNA translation efficiency (PubMed:26046440). It is however unclear whether it plays a role in cap-independent mRNA translation following heat shock stress, since it has not been identified purified eIF3 preparations that promote cap-independent mRNA translation (PubMed:26593424).2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	401	N6-methyladenosineCombined sources1 Publication	1
Binding siteⁱ	441	N6-methyladenosineBy similarity	1
Binding siteⁱ	465	N6-methyladenosineCombined sources1 Publication	1
Binding siteⁱ	470	N6-methyladenosineCombined sources1 Publication	1

GO - Molecular functionⁱ

N6-methyladenosine-containing RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
ribosome binding
Source: UniProtKB
Inferred from direct assayⁱ
- 26046440
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of translation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28106072
- 28106076
positive regulation of translational initiation
Source: UniProtKB
Inferred from direct assayⁱ
- 26046440

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding

Molecular function

RNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: YTH domain-containing family protein 1Curated Alternative name(s): Dermatomyositis associated with cancer putative autoantigen 11 Publication Short name: DACA-11 Publication
Gene namesⁱ	Name:YTHDF1Imported Synonyms:C20orf21Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149658.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15867 YTHDF1
MIMⁱ	616529 gene
neXtProtⁱ	NX_Q9BYJ9

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	397	Y → A: Strongly reduced binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	401	D → N: Increased binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	411	W → A: Abolished binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	465	W → A: Abolished binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	470	W → A: Abolished binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	506	R → A: Reduced binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000149658
PharmGKBⁱ	PA25737

Polymorphism and mutation databases

BioMutaⁱ	YTHDF1
DMDMⁱ	28380041

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000223073	2 – 559	YTH domain-containing family protein 1Add BLAST		558

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1
Modified residueⁱ	182	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BYJ9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BYJ9
PaxDbⁱ	Q9BYJ9
PeptideAtlas More...PeptideAtlasⁱ	Q9BYJ9
PRIDEⁱ	Q9BYJ9
ProteomicsDBⁱ	79659 79660 [Q9BYJ9-2]

PTM databases

GlyConnectⁱ	1904
iPTMnetⁱ	Q9BYJ9
PhosphoSitePlusⁱ	Q9BYJ9

Miscellaneous databases

PMAP-CutDBⁱ	Q9BYJ9

PMAP-CutDBⁱ

Q9BYJ9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000149658 Expressed in 234 organ(s), highest expression level in female gonad
CleanExⁱ	HS_YTHDF1
ExpressionAtlasⁱ	Q9BYJ9 baseline and differential
Genevisibleⁱ	Q9BYJ9 HS

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

BioGridⁱ	120257, 74 interactors
IntActⁱ	Q9BYJ9, 35 interactors
Molecular INTeraction database More...MINTⁱ	Q9BYJ9
STRINGⁱ	9606.ENSP00000359364

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	366 – 374	Combined sources	9
Beta strandⁱ	390 – 397	Combined sources	8
Helixⁱ	399 – 408	Combined sources	10
Helixⁱ	415 – 428	Combined sources	14
Beta strandⁱ	434 – 440	Combined sources	7
Beta strandⁱ	443 – 452	Combined sources	10
Beta strandⁱ	457 – 459	Combined sources	3
Beta strandⁱ	465 – 467	Combined sources	3
Beta strandⁱ	473 – 485	Combined sources	13
Helixⁱ	486 – 488	Combined sources	3
Turnⁱ	489 – 491	Combined sources	3
Helixⁱ	495 – 497	Combined sources	3
Helixⁱ	502 – 504	Combined sources	3
Helixⁱ	513 – 525	Combined sources	13
Helixⁱ	532 – 535	Combined sources	4
Helixⁱ	536 – 550	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BYJ9
SMRⁱ	Q9BYJ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	389 – 523	YTHPROSITE-ProRule annotationAdd BLAST		135

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	395 – 397	N6-methyladenosine bindingCombined sources1 Publication		3
Regionⁱ	411 – 412	N6-methyladenosine bindingCombined sources1 Publication		2

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	241 – 331	Gln/Pro-richAdd BLAST		91

Phylogenomic databases

eggNOGⁱ	KOG1901 Eukaryota ENOG410YABQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017549
HOVERGENⁱ	HBG060315
InParanoidⁱ	Q9BYJ9
KEGG Orthology (KO) More...KOⁱ	K20102
OMAⁱ	QPKMKAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D17
PhylomeDBⁱ	Q9BYJ9
TreeFamⁱ	TF323736

Family and domain databases

InterProⁱ	View protein in InterPro IPR007275 YTH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04146 YTH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50882 YTH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BYJ9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSATSVDTQR TKGQDNKVQN GSLHQKDTVH DNDFEPYLTG QSNQSNSYPS 
        60         70         80         90        100
MSDPYLSSYY PPSIGFPYSL NEAPWSTAGD PPIPYLTTYG QLSNGDHHFM 
       110        120        130        140        150
HDAVFGQPGG LGNNIYQHRF NFFPENPAFS AWGTSGSQGQ QTQSSAYGSS 
       160        170        180        190        200
YTYPPSSLGG TVVDGQPGFH SDTLSKAPGM NSLEQGMVGL KIGDVSSSAV 
       210        220        230        240        250
KTVGSVVSSV ALTGVLSGNG GTNVNMPVSK PTSWAAIASK PAKPQPKMKT 
       260        270        280        290        300
KSGPVMGGGL PPPPIKHNMD IGTWDNKGPV PKAPVPQQAP SPQAAPQPQQ 
       310        320        330        340        350
VAQPLPAQPP ALAQPQYQSP QQPPQTRWVA PRNRNAAFGQ SGGAGSDSNS 
       360        370        380        390        400
PGNVQPNSAP SVESHPVLEK LKAAHSYNPK EFEWNLKSGR VFIIKSYSED 
       410        420        430        440        450
DIHRSIKYSI WCSTEHGNKR LDSAFRCMSS KGPVYLLFSV NGSGHFCGVA 
       460        470        480        490        500
EMKSPVDYGT SAGVWSQDKW KGKFDVQWIF VKDVPNNQLR HIRLENNDNK 
       510        520        530        540        550
PVTNSRDTQE VPLEKAKQVL KIISSYKHTT SIFDDFAHYE KRQEEEEVVR 

KERQSRNKQ

Length:559

Mass (Da):60,874

Last modified:June 1, 2001 - v1

Checksum:ⁱDB8AA15636130E18

Isoform 2 (identifier: Q9BYJ9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.
     191-260: KIGDVSSSAV...KSGPVMGGGL → MLFLGSLGAW...QAFTATPSAR
     383-559: Missing.

« Hide

        10         20         30         40         50
MLFLGSLGAW GTTSISTGSI FSLKTLRSQH GGQVGLKVSR PRAPRMGAAT 
        60         70         80         90        100
PTPRAPWVAR WLMGSQAFTA TPSARPPPPI KHNMDIGTWD NKGPVPKAPV 
       110        120        130        140        150
PQQAPSPQAA PQPQQVAQPL PAQPPALAQP QYQSPQQPPQ TRWVAPRNRN 
       160        170        180        190 
AAFGQSGGAG SDSNSPGNVQ PNSAPSVESH PVLEKLKAAH SYNPKEF

Note: No experimental confirmation available.

Show »

Length:197

Mass (Da):20,833

Checksum:ⁱDD50829544FE6119

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5JXC6	Q5JXC6_HUMAN		YTH domain-containing family protei... YTH domain-containing family protein 1	YTHDF1	52	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	123 – 124	FP → AR in BAB62751 (Ref. 4) Curated		2
Sequence conflictⁱ	283 – 284	AP → PH in CAD39029 (PubMed:17974005).Curated		2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_006815	1 – 190	Missing in isoform 2. 1 PublicationAdd BLAST	190
Alternative sequenceⁱVSP_006816	191 – 260	KIGDV…MGGGL → MLFLGSLGAWGTTSISTGSI FSLKTLRSQHGGQVGLKVSR PRAPRMGAATPTPRAPWVAR WLMGSQAFTATPSAR in isoform 2. 1 PublicationAdd BLAST	70
Alternative sequenceⁱVSP_006817	383 – 559	Missing in isoform 2. 1 PublicationAdd BLAST	177

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000398 mRNA Translation: BAA91138.1 AL096828 Genomic DNA No translation available. BC003681 mRNA Translation: AAH03681.1 BC016920 mRNA Translation: AAH16920.2 BC025264 mRNA Translation: AAH25264.1 BC050284 mRNA Translation: AAH50284.1 AB055518 mRNA Translation: BAB62751.1 AL834366 mRNA Translation: CAD39029.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13511.1 [Q9BYJ9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_060268.2, NM_017798.3 [Q9BYJ9-1]
UniGeneⁱ	Hs.744852

Genome annotation databases

Ensemblⁱ	ENST00000370339; ENSP00000359364; ENSG00000149658 [Q9BYJ9-1]
GeneIDⁱ	54915
KEGGⁱ	hsa:54915
UCSC genome browser More...UCSCⁱ	uc002yeh.4 human [Q9BYJ9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9BYJ9	YTH domain-containing family protein 1		MOUSE		559	UniRef90_Q9BYJ9
Uncharacterized protein		MANLE		567
Uncharacterized protein		COLAP		561
Uncharacterized protein		RHIBE		561
Uncharacterized protein		RHIRO		561
+70

Protein	Similar proteins		Species	Score	Length	Source
Q9BYJ9	YTH domain-containing family protein 1		MOUSE		559	UniRef50_Q9BYJ9
Uncharacterized protein		MANLE		567
Uncharacterized protein		COLAP		561
Uncharacterized protein		RHIBE		561
Uncharacterized protein		RHIRO		561
+191

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000398 mRNA Translation: BAA91138.1 AL096828 Genomic DNA No translation available. BC003681 mRNA Translation: AAH03681.1 BC016920 mRNA Translation: AAH16920.2 BC025264 mRNA Translation: AAH25264.1 BC050284 mRNA Translation: AAH50284.1 AB055518 mRNA Translation: BAB62751.1 AL834366 mRNA Translation: CAD39029.1
CCDSⁱ	CCDS13511.1 [Q9BYJ9-1]
RefSeqⁱ	NP_060268.2, NM_017798.3 [Q9BYJ9-1]
UniGeneⁱ	Hs.744852

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4RCI	X-ray	1.97	A/B/C/D	361-559	[»]
	4RCJ	X-ray	1.60	A	365-554	[»]
ProteinModelPortalⁱ	Q9BYJ9
SMRⁱ	Q9BYJ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120257, 74 interactors
IntActⁱ	Q9BYJ9, 35 interactors
MINTⁱ	Q9BYJ9
STRINGⁱ	9606.ENSP00000359364

PTM databases

GlyConnectⁱ	1904
iPTMnetⁱ	Q9BYJ9
PhosphoSitePlusⁱ	Q9BYJ9

Polymorphism and mutation databases

BioMutaⁱ	YTHDF1
DMDMⁱ	28380041

Proteomic databases

EPDⁱ	Q9BYJ9
MaxQBⁱ	Q9BYJ9
PaxDbⁱ	Q9BYJ9
PeptideAtlasⁱ	Q9BYJ9
PRIDEⁱ	Q9BYJ9
ProteomicsDBⁱ	79659 79660 [Q9BYJ9-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000370339; ENSP00000359364; ENSG00000149658 [Q9BYJ9-1]
GeneIDⁱ	54915
KEGGⁱ	hsa:54915
UCSCⁱ	uc002yeh.4 human [Q9BYJ9-1]

Organism-specific databases

CTDⁱ	54915
EuPathDBⁱ	HostDB:ENSG00000149658.17
GeneCardsⁱ	YTHDF1
HGNCⁱ	HGNC:15867 YTHDF1
MIMⁱ	616529 gene
neXtProtⁱ	NX_Q9BYJ9
OpenTargetsⁱ	ENSG00000149658
PharmGKBⁱ	PA25737
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1901 Eukaryota ENOG410YABQ LUCA
GeneTreeⁱ	ENSGT00390000017549
HOVERGENⁱ	HBG060315
InParanoidⁱ	Q9BYJ9
KOⁱ	K20102
OMAⁱ	QPKMKAK
OrthoDBⁱ	EOG091G0D17
PhylomeDBⁱ	Q9BYJ9
TreeFamⁱ	TF323736

Miscellaneous databases

ChiTaRSⁱ	YTHDF1 human
GenomeRNAiⁱ	54915
PMAP-CutDBⁱ	Q9BYJ9
Protein Ontology More...PROⁱ	PR:Q9BYJ9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149658 Expressed in 234 organ(s), highest expression level in female gonad
CleanExⁱ	HS_YTHDF1
ExpressionAtlasⁱ	Q9BYJ9 baseline and differential
Genevisibleⁱ	Q9BYJ9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007275 YTH_domain
Pfamⁱ	View protein in Pfam PF04146 YTH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50882 YTH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YTHD1_HUMAN
Accessionⁱ	Q9BYJ9Primary (citable) accession number: Q9BYJ9 Secondary accession number(s): Q8N3G5 , Q8TBT1, Q96AN4, Q96S57, Q9BTI7, Q9NX79
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
	Last sequence update:	June 1, 2001
	Last modified:	October 10, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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Supporting data

UniProtKB - Q9BYJ9 (YTHD1_HUMAN)

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YTH domain-containing family protein 1

YTHDF1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ