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Protein

Tripartite motif-containing protein 34

Gene

TRIM34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as antiviral protein and may contribute to the defense against retroviral infections.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 60RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri92 – 134B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 34
Alternative name(s):
Interferon-responsive finger protein 1
RING finger protein 21
Gene namesi
Name:TRIM34
Synonyms:IFP1, RNF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000258659.6
HGNCiHGNC:10063 TRIM34
MIMi605684 gene
neXtProtiNX_Q9BYJ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi121R → E: Reduced association with TRIM5. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000258659
PharmGKBiPA35533

Polymorphism and mutation databases

BioMutaiTRIM34
DMDMi55976584

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562481 – 488Tripartite motif-containing protein 34Add BLAST488

Proteomic databases

MaxQBiQ9BYJ4
PaxDbiQ9BYJ4
PeptideAtlasiQ9BYJ4
PRIDEiQ9BYJ4
ProteomicsDBi79657
79658 [Q9BYJ4-2]

PTM databases

iPTMnetiQ9BYJ4
PhosphoSitePlusiQ9BYJ4

Expressioni

Tissue specificityi

Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.1 Publication

Inductioni

Isoform 1 is up-regulated by interferons.1 Publication

Gene expression databases

BgeeiENSG00000258659
CleanExiHS_TRIM34
GenevisibleiQ9BYJ4 HS

Organism-specific databases

HPAiHPA077996

Interactioni

Subunit structurei

Homotrimer. Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811). Interacts (via B-box and SPRY domain) with TRIM5 (PubMed:21680743, PubMed:17156811).2 Publications

Protein-protein interaction databases

BioGridi119809, 9 interactors
IntActiQ9BYJ4, 6 interactors
STRINGi9606.ENSP00000402595

Structurei

Secondary structure

1488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni16 – 19Combined sources4
Beta strandi29 – 31Combined sources3
Helixi36 – 39Combined sources4
Beta strandi47 – 49Combined sources3
Beta strandi57 – 59Combined sources3
Helixi67 – 69Combined sources3
Beta strandi72 – 74Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGPNMR-A8-79[»]
ProteinModelPortaliQ9BYJ4
SMRiQ9BYJ4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYJ4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 488B30.2/SPRYPROSITE-ProRule annotationAdd BLAST206

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 239Sequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 159Poly-Glu6
Compositional biasi206 – 209Poly-Glu4

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 60RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri92 – 134B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234134
HOVERGENiHBG001357
InParanoidiQ9BYJ4
KOiK11999
OrthoDBiEOG091G04O8
PhylomeDBiQ9BYJ4

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15825 SPRY_PRY_TRIM34, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR035826 TRIM34_PRY/SPRY
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYJ4-1) [UniParc]FASTAAdd to basket
Also known as: Medium

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM
60 70 80 90 100
GGKSSCPVCG ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH
110 120 130 140 150
GEKLLLFCKE DRKVICWLCE RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR
160 170 180 190 200
LKKEEEEAEK LEADIREEKT SWKYQVQTER QRIQTEFDQL RSILNNEEQR
210 220 230 240 250
ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR SQWSTMELLQ
260 270 280 290 300
DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW
310 320 330 340 350
VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY
360 370 380 390 400
WEVDVSKKTA WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI
410 420 430 440 450
GLQNKCKYGV FEESLSSDPE VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT
460 470 480
SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP MTLCPPSS
Length:488
Mass (Da):56,864
Last modified:November 23, 2004 - v2
Checksum:iF2D60A16576187A0
GO
Isoform 2 (identifier: Q9BYJ4-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     259-270: SEIWRLKKPKMV → CVWVATSGACEL
     271-488: Missing.

Show »
Length:270
Mass (Da):31,338
Checksum:i7802B9B749E5111F
GO

Sequence cautioni

The sequence AAG53517 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB17050 differs from that shown. The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349H → Y (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019825276T → S. Corresponds to variant dbSNP:rs6578670Ensembl.1
Natural variantiVAR_019826282D → H. Corresponds to variant dbSNP:rs3740997Ensembl.1
Natural variantiVAR_052141404N → K. Corresponds to variant dbSNP:rs16933844Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011921259 – 270SEIWR…KPKMV → CVWVATSGACEL in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_011922271 – 488Missing in isoform 2. 1 PublicationAdd BLAST218

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039902 mRNA Translation: BAB17049.1
AB039903 mRNA Translation: BAB17050.1 Sequence problems.
AB039904 mRNA Translation: BAB17051.1
AF220143 mRNA Translation: AAG53516.1
AF220144 mRNA Translation: AAG53517.1 Different initiation.
AK027876 mRNA Translation: BAB55424.1
CH471064 Genomic DNA Translation: EAW68778.1
CH471064 Genomic DNA Translation: EAW68780.1
AL583914 mRNA Translation: CAC29498.1
CCDSiCCDS31391.1 [Q9BYJ4-1]
RefSeqiNP_001003827.1, NM_001003827.1 [Q9BYJ4-1]
NP_067629.2, NM_021616.5 [Q9BYJ4-1]
NP_569074.2, NM_130390.2
UniGeneiHs.729048

Genome annotation databases

EnsembliENST00000429814; ENSP00000402595; ENSG00000258659 [Q9BYJ4-1]
ENST00000514226; ENSP00000422947; ENSG00000258659 [Q9BYJ4-1]
GeneIDi53840
KEGGihsa:53840
UCSCiuc001mbh.4 human [Q9BYJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI34_HUMAN
AccessioniPrimary (citable) accession number: Q9BYJ4
Secondary accession number(s): D3DQS7
, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: June 20, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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