UniProtKB - Q9BYJ1 (LOXE3_HUMAN)
Hydroperoxide isomerase ALOXE3
ALOXE3
Functioni
Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:12881489, PubMed:17045234, PubMed:20921226, PubMed:20923767).
The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:12881489, PubMed:17045234, PubMed:20923767).
In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides (PubMed:20921226).
In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561).
Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561).
In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (PubMed:21558561).
Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity).
Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity).
By similarity5 PublicationsCatalytic activityi
- EC:5.4.4.73 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate1 PublicationEC:5.4.4.71 PublicationThis reaction proceeds in the forward1 Publication direction.
- (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate1 PublicationEC:5.4.4.71 PublicationThis reaction proceeds in the forward1 Publication direction.
- (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate1 PublicationEC:5.4.4.71 PublicationThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate1 PublicationEC:5.4.4.71 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- N-[ω-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-β-D-glucosyl-(1↔1)-octadecasphing-4E-enine = N-[ω-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-β-D-glucosyl-(1↔1)-octadecasphing-4E-enine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:4.2.1.1521 PublicationThis reaction proceeds in the forward1 Publication direction.
- (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O2 PublicationsEC:4.2.1.1522 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O1 PublicationEC:4.2.1.1521 PublicationThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateBy similarityEC:5.4.4.7By similarityThis reaction proceeds in the forwardBy similarity direction.
- (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2OBy similarityEC:4.2.1.152By similarityThis reaction proceeds in the forwardBy similarity direction.
- (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2OBy similarityEC:4.2.1.152By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
Activity regulationi
Kineticsi
- KM=46 µM for (12R)-HPETE1 Publication
- KM=28 µM for (12S)-HPETE1 Publication
- KM=32 µM for (15S)-HPETE1 Publication
- KM=50 µM for synthetic fatty acid 9E,11Z,14Z-20:3omega6 (at pH 7.5)1 Publication
- Vmax=3.256 µmol/min/mg enzyme for (12R)-HPETE (at pH 7.5)1 Publication
- Vmax=0.858 µmol/min/mg enzyme for (12S)-HPETE (at pH 7.5)1 Publication
- Vmax=0.484 µmol/min/mg enzyme for (15S)-HPETE (at pH 7.5)1 Publication
: hydroperoxy eicosatetraenoic acid biosynthesis Pathwayi
This protein is involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis and in Lipid metabolism.
Pathwayi: sphingolipid metabolism
This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 408 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 413 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 588 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 592 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 711 | Iron; via carboxylate; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- hepoxilin A3 synthase activity Source: UniProtKB
- hydroperoxy icosatetraenoate dehydratase activity Source: UniProtKB-EC
- hydroperoxy icosatetraenoate isomerase activity Source: UniProtKB-EC
- intramolecular transferase activity, transferring hydroxy groups Source: UniProtKB
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Source: UniProtKB
GO - Biological processi
- arachidonic acid metabolic process Source: UniProtKB
- ceramide biosynthetic process Source: UniProtKB
- establishment of skin barrier Source: UniProtKB
- fat cell differentiation Source: UniProtKB
- hepoxilin biosynthetic process Source: UniProtKB
- linoleic acid metabolic process Source: UniProtKB
- lipoxygenase pathway Source: UniProtKB
- peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
- sensory perception of pain Source: UniProtKB
- sphingolipid metabolic process Source: UniProtKB
Keywordsi
Molecular function | Dioxygenase, Isomerase, Lyase, Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 4.2.1.152, 2681 |
PathwayCommonsi | Q9BYJ1 |
Reactomei | R-HSA-2142712, Synthesis of 12-eicosatetraenoic acid derivatives |
SignaLinki | Q9BYJ1 |
UniPathwayi | UPA00222 UPA00881 |
Chemistry databases
SwissLipidsi | SLP:000000656 |
Names & Taxonomyi
Protein namesi | Recommended name: Hydroperoxide isomerase ALOXE3CuratedAlternative name(s): |
Gene namesi | Name:ALOXE3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13743, ALOXE3 |
MIMi | 607206, gene |
neXtProti | NX_Q9BYJ1 |
VEuPathDBi | HostDB:ENSG00000179148 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm PROSITE-ProRule annotation
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Ichthyosis, congenital, autosomal recessive 3 (ARCI3)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069561 | 237 | L → M in ARCI3; no effect on enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434235EnsemblClinVar. | 1 | |
Natural variantiVAR_069562 | 281 | G → V in ARCI3; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs786205120EnsemblClinVar. | 1 | |
Natural variantiVAR_069563 | 344 – 347 | QYVA → P in ARCI3; complete loss of the enzyme activity. 1 Publication | 4 | |
Natural variantiVAR_015175 | 396 | R → S in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434234EnsemblClinVar. | 1 | |
Natural variantiVAR_069564 | 427 | L → P in ARCI3. 1 PublicationCorresponds to variant dbSNP:rs1355284797EnsemblClinVar. | 1 | |
Natural variantiVAR_015176 | 500 | V → F in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434232EnsemblClinVar. | 1 | |
Natural variantiVAR_069565 | 630 | P → L in ARCI3; complete loss of the enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs147149459EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 451 | A → G: Increases the O2-dependent dioxygenase activity. 2 Publications | 1 |
Keywords - Diseasei
Disease variant, IchthyosisOrganism-specific databases
DisGeNETi | 59344 |
GeneReviewsi | ALOXE3 |
MalaCardsi | ALOXE3 |
MIMi | 606545, phenotype |
OpenTargetsi | ENSG00000179148 |
Orphaneti | 79394, Congenital non-bullous ichthyosiform erythroderma 313, Lamellar ichthyosis 281122, Self-improving collodion baby |
PharmGKBi | PA24727 |
Miscellaneous databases
Pharosi | Q9BYJ1, Tbio |
Genetic variation databases
BioMutai | ALOXE3 |
DMDMi | 27923803 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220691 | 1 – 711 | Hydroperoxide isomerase ALOXE3Add BLAST | 711 |
Proteomic databases
MassIVEi | Q9BYJ1 |
PaxDbi | Q9BYJ1 |
PeptideAtlasi | Q9BYJ1 |
PRIDEi | Q9BYJ1 |
ProteomicsDBi | 79655 [Q9BYJ1-1] 79656 [Q9BYJ1-2] |
PTM databases
iPTMneti | Q9BYJ1 |
PhosphoSitePlusi | Q9BYJ1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000179148, Expressed in skin of leg and 100 other tissues |
ExpressionAtlasi | Q9BYJ1, baseline and differential |
Genevisiblei | Q9BYJ1, HS |
Organism-specific databases
HPAi | ENSG00000179148, Tissue enriched (skin) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 121886, 49 interactors |
IntActi | Q9BYJ1, 21 interactors |
STRINGi | 9606.ENSP00000314879 |
Miscellaneous databases
RNActi | Q9BYJ1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 119 | PLATPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 120 – 711 | LipoxygenasePROSITE-ProRule annotationAdd BLAST | 592 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QQSP, Eukaryota |
GeneTreei | ENSGT00940000156796 |
HOGENOMi | CLU_004282_3_3_1 |
InParanoidi | Q9BYJ1 |
OMAi | LCEAFSM |
OrthoDBi | 385042at2759 |
PhylomeDBi | Q9BYJ1 |
TreeFami | TF105320 |
Family and domain databases
CDDi | cd01753, PLAT_LOX, 1 hit |
InterProi | View protein in InterPro IPR000907, LipOase IPR013819, LipOase_C IPR036226, LipOase_C_sf IPR020834, LipOase_CS IPR020833, LipOase_Fe_BS IPR001885, LipOase_mml IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR042062, PLAT_LOX_verte |
PANTHERi | PTHR11771, PTHR11771, 2 hits |
Pfami | View protein in Pfam PF00305, Lipoxygenase, 1 hit PF01477, PLAT, 1 hit |
PRINTSi | PR00087, LIPOXYGENASE PR00467, MAMLPOXGNASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF48484, SSF48484, 1 hit SSF49723, SSF49723, 1 hit |
PROSITEi | View protein in PROSITE PS00711, LIPOXYGENASE_1, 1 hit PS00081, LIPOXYGENASE_2, 1 hit PS51393, LIPOXYGENASE_3, 1 hit PS50095, PLAT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVYRLCVTT GPYLRAGTLD NISVTLVGTC GESPKQRLDR MGRDFAPGSV
60 70 80 90 100
QKYKVRCTAE LGELLLLRVH KERYAFFRKD SWYCSRICVT EPDGSVSHFP
110 120 130 140 150
CYQWIEGYCT VELRPGTART ICQDSLPLLL DHRTRELRAR QECYRWKIYA
160 170 180 190 200
PGFPCMVDVN SFQEMESDKK FALTKTTTCV DQGDSSGNRY LPGFPMKIDI
210 220 230 240 250
PSLMYMEPNV RYSATKTISL LFNAIPASLG MKLRGLLDRK GSWKKLDDMQ
260 270 280 290 300
NIFWCHKTFT TKYVTEHWCE DHFFGYQYLN GVNPVMLHCI SSLPSKLPVT
310 320 330 340 350
NDMVAPLLGQ DTCLQTELER GNIFLADYWI LAEAPTHCLN GRQQYVAAPL
360 370 380 390 400
CLLWLSPQGA LVPLAIQLSQ TPGPDSPIFL PTDSEWDWLL AKTWVRNSEF
410 420 430 440 450
LVHENNTHFL CTHLLCEAFA MATLRQLPLC HPIYKLLLPH TRYTLQVNTI
460 470 480 490 500
ARATLLNPEG LVDQVTSIGR QGLIYLMSTG LAHFTYTNFC LPDSLRARGV
510 520 530 540 550
LAIPNYHYRD DGLKIWAAIE SFVSEIVGYY YPSDASVQQD SELQAWTGEI
560 570 580 590 600
FAQAFLGRES SGFPSRLCTP GEMVKFLTAI IFNCSAQHAA VNSGQHDFGA
610 620 630 640 650
WMPNAPSSMR QPPPQTKGTT TLKTYLDTLP EVNISCNNLL LFWLVSQEPK
660 670 680 690 700
DQRPLGTYPD EHFTEEAPRR SIAAFQSRLA QISRDIQERN QGLALPYTYL
710
DPPLIENSVS I
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3KPH2 | J3KPH2_HUMAN | Arachidonate lipoxygenase 3, isofor... | ALOXE3 hCG_31289 | 867 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 155 | C → R in CAC12843 (PubMed:11350124).Curated | 1 | |
Sequence conflicti | 194 | F → L in AAG16899 (PubMed:12881489).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069561 | 237 | L → M in ARCI3; no effect on enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434235EnsemblClinVar. | 1 | |
Natural variantiVAR_069562 | 281 | G → V in ARCI3; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs786205120EnsemblClinVar. | 1 | |
Natural variantiVAR_069563 | 344 – 347 | QYVA → P in ARCI3; complete loss of the enzyme activity. 1 Publication | 4 | |
Natural variantiVAR_015175 | 396 | R → S in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434234EnsemblClinVar. | 1 | |
Natural variantiVAR_069564 | 427 | L → P in ARCI3. 1 PublicationCorresponds to variant dbSNP:rs1355284797EnsemblClinVar. | 1 | |
Natural variantiVAR_015176 | 500 | V → F in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434232EnsemblClinVar. | 1 | |
Natural variantiVAR_069565 | 630 | P → L in ARCI3; complete loss of the enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs147149459EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043287 | 1 | M → MPRGAFRPCLPALYFAFLTC PTPEQRMSGTQAPDIHLGEP ARGTGCVRGKQTSIRVQDCG RREEARAASRELRREKAQEH PRESWAHPQPYPAPQPLALR PETQPCPACRSSPPGRLLLR PALPGHPFLLPIM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ269499 mRNA Translation: CAC12843.1 AJ305020 , AJ305021, AJ305023, AJ305025 Genomic DNA Translation: CAC34518.1 AF182218 mRNA Translation: AAG16899.1 AK296416 mRNA Translation: BAH12346.1 AK313677 mRNA Translation: BAG36428.1 CH471108 Genomic DNA Translation: EAW90094.1 BC101938 mRNA Translation: AAI01939.1 BC101939 mRNA Translation: AAI01940.1 BC103508 mRNA Translation: AAI03509.1 BC104724 mRNA Translation: AAI04725.1 |
CCDSi | CCDS11130.1 [Q9BYJ1-1] CCDS54084.1 [Q9BYJ1-2] |
RefSeqi | NP_001159432.1, NM_001165960.1 [Q9BYJ1-2] NP_067641.2, NM_021628.2 [Q9BYJ1-1] |
Genome annotation databases
Ensembli | ENST00000318227; ENSP00000314879; ENSG00000179148 ENST00000380149; ENSP00000369494; ENSG00000179148 ENST00000448843; ENSP00000400581; ENSG00000179148 |
GeneIDi | 59344 |
KEGGi | hsa:59344 |
MANE-Selecti | ENST00000448843.7; ENSP00000400581.2; NM_021628.3; NP_067641.2 |
UCSCi | uc010cnr.4, human [Q9BYJ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight about water - Issue 153 of September 2013 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ269499 mRNA Translation: CAC12843.1 AJ305020 , AJ305021, AJ305023, AJ305025 Genomic DNA Translation: CAC34518.1 AF182218 mRNA Translation: AAG16899.1 AK296416 mRNA Translation: BAH12346.1 AK313677 mRNA Translation: BAG36428.1 CH471108 Genomic DNA Translation: EAW90094.1 BC101938 mRNA Translation: AAI01939.1 BC101939 mRNA Translation: AAI01940.1 BC103508 mRNA Translation: AAI03509.1 BC104724 mRNA Translation: AAI04725.1 |
CCDSi | CCDS11130.1 [Q9BYJ1-1] CCDS54084.1 [Q9BYJ1-2] |
RefSeqi | NP_001159432.1, NM_001165960.1 [Q9BYJ1-2] NP_067641.2, NM_021628.2 [Q9BYJ1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6VB2 | X-ray | 1.41 | C | 136-144 | [»] | |
SMRi | Q9BYJ1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121886, 49 interactors |
IntActi | Q9BYJ1, 21 interactors |
STRINGi | 9606.ENSP00000314879 |
Chemistry databases
SwissLipidsi | SLP:000000656 |
PTM databases
iPTMneti | Q9BYJ1 |
PhosphoSitePlusi | Q9BYJ1 |
Genetic variation databases
BioMutai | ALOXE3 |
DMDMi | 27923803 |
Proteomic databases
MassIVEi | Q9BYJ1 |
PaxDbi | Q9BYJ1 |
PeptideAtlasi | Q9BYJ1 |
PRIDEi | Q9BYJ1 |
ProteomicsDBi | 79655 [Q9BYJ1-1] 79656 [Q9BYJ1-2] |
Protocols and materials databases
Antibodypediai | 24534, 163 antibodies from 21 providers |
DNASUi | 59344 |
Genome annotation databases
Ensembli | ENST00000318227; ENSP00000314879; ENSG00000179148 ENST00000380149; ENSP00000369494; ENSG00000179148 ENST00000448843; ENSP00000400581; ENSG00000179148 |
GeneIDi | 59344 |
KEGGi | hsa:59344 |
MANE-Selecti | ENST00000448843.7; ENSP00000400581.2; NM_021628.3; NP_067641.2 |
UCSCi | uc010cnr.4, human [Q9BYJ1-1] |
Organism-specific databases
CTDi | 59344 |
DisGeNETi | 59344 |
GeneCardsi | ALOXE3 |
GeneReviewsi | ALOXE3 |
HGNCi | HGNC:13743, ALOXE3 |
HPAi | ENSG00000179148, Tissue enriched (skin) |
MalaCardsi | ALOXE3 |
MIMi | 606545, phenotype 607206, gene |
neXtProti | NX_Q9BYJ1 |
OpenTargetsi | ENSG00000179148 |
Orphaneti | 79394, Congenital non-bullous ichthyosiform erythroderma 313, Lamellar ichthyosis 281122, Self-improving collodion baby |
PharmGKBi | PA24727 |
VEuPathDBi | HostDB:ENSG00000179148 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQSP, Eukaryota |
GeneTreei | ENSGT00940000156796 |
HOGENOMi | CLU_004282_3_3_1 |
InParanoidi | Q9BYJ1 |
OMAi | LCEAFSM |
OrthoDBi | 385042at2759 |
PhylomeDBi | Q9BYJ1 |
TreeFami | TF105320 |
Enzyme and pathway databases
UniPathwayi | UPA00222 UPA00881 |
BRENDAi | 4.2.1.152, 2681 |
PathwayCommonsi | Q9BYJ1 |
Reactomei | R-HSA-2142712, Synthesis of 12-eicosatetraenoic acid derivatives |
SignaLinki | Q9BYJ1 |
Miscellaneous databases
BioGRID-ORCSi | 59344, 2 hits in 1030 CRISPR screens |
ChiTaRSi | ALOXE3, human |
GeneWikii | ALOXE3 |
GenomeRNAii | 59344 |
Pharosi | Q9BYJ1, Tbio |
PROi | PR:Q9BYJ1 |
RNActi | Q9BYJ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179148, Expressed in skin of leg and 100 other tissues |
ExpressionAtlasi | Q9BYJ1, baseline and differential |
Genevisiblei | Q9BYJ1, HS |
Family and domain databases
CDDi | cd01753, PLAT_LOX, 1 hit |
InterProi | View protein in InterPro IPR000907, LipOase IPR013819, LipOase_C IPR036226, LipOase_C_sf IPR020834, LipOase_CS IPR020833, LipOase_Fe_BS IPR001885, LipOase_mml IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR042062, PLAT_LOX_verte |
PANTHERi | PTHR11771, PTHR11771, 2 hits |
Pfami | View protein in Pfam PF00305, Lipoxygenase, 1 hit PF01477, PLAT, 1 hit |
PRINTSi | PR00087, LIPOXYGENASE PR00467, MAMLPOXGNASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF48484, SSF48484, 1 hit SSF49723, SSF49723, 1 hit |
PROSITEi | View protein in PROSITE PS00711, LIPOXYGENASE_1, 1 hit PS00081, LIPOXYGENASE_2, 1 hit PS51393, LIPOXYGENASE_3, 1 hit PS50095, PLAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LOXE3_HUMAN | |
Accessioni | Q9BYJ1Primary (citable) accession number: Q9BYJ1 Secondary accession number(s): B2R981 Q9HC22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 27, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries