ALOXE3

Functionⁱ

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.5 Publications

Catalytic activityⁱ

A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate.5 Publications

A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H₂O.5 Publications

Cofactorⁱ

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit.PROSITE-ProRule annotation

Kineticsⁱ

Has a 5 to 10 fold higher activity toward (12R)-HPETE (hydroperoxyeicosatetraenoic acid) compared to (12S)-HPETE and (15S)-HPETE. From (12R)-HPETE produces a stereoisomer of hepoxilin A3. More active on hydroperoxides with an R configuration than an S one.

Pathwayⁱ: hydroperoxy eicosatetraenoic acid biosynthesis

This protein is involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis and in Lipid metabolism.

Pathwayⁱ: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	408	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	413	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	588	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	592	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	711	Iron; via carboxylate; catalyticPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

hepoxilin A3 synthase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12881489
- 17045234
iron ion binding Source: InterPro
lyase activity Source: UniProtKB-KW
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Source: UniProtKB
Inferred from direct assayⁱ
- 20921226

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arachidonic acid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12881489
- 17045234
ceramide biosynthetic process Source: UniProtKB
establishment of skin barrier Source: UniProtKB
fat cell differentiation Source: UniProtKB
hepoxilin biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12881489
- 17045234
linoleic acid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12881489
- 17045234
lipoxygenase pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 20921226
peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
sensory perception of pain Source: UniProtKB
sphingolipid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 21558561

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Dioxygenase, Isomerase, Lyase, Oxidoreductase
Biological process	Fatty acid metabolism, Lipid metabolism
Ligand	Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
UniPathwayⁱ	UPA00222 UPA00881

Chemistry databases

SwissLipidsⁱ	SLP:000000656

SwissLipidsⁱ

SLP:000000656

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hydroperoxide isomerase ALOXE3 (EC:5.4.4.75 Publications) Alternative name(s): Epidermis-type lipoxygenase 31 Publication Short name: Epidermal LOX-3 Short name: e-LOX-3 Short name: eLOX-3 Hydroperoxy icosatetraenoate dehydratase (EC:4.2.1.1525 Publications)
Gene namesⁱ	Name:ALOXE3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179148.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13743 ALOXE3
MIMⁱ	607206 gene
neXtProtⁱ	NX_Q9BYJ1

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ichthyosis, congenital, autosomal recessive 3 (ARCI3)5 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	451	A → G: Increases the O2-dependent dioxygenase activity. 2 Publications		1

Keywords - Diseaseⁱ

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	59344
GeneReviewsⁱ	ALOXE3
MalaCards human disease database More...MalaCardsⁱ	ALOXE3
MIMⁱ	606545 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000179148
Orphanetⁱ	79394 Congenital non-bullous ichthyosiform erythroderma 313 Lamellar ichthyosis 281122 Self-improving collodion baby
PharmGKBⁱ	PA24727

Polymorphism and mutation databases

BioMutaⁱ	ALOXE3
DMDMⁱ	27923803

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220691	1 – 711	Hydroperoxide isomerase ALOXE3Add BLAST		711

Proteomic databases

EPDⁱ	Q9BYJ1
PaxDbⁱ	Q9BYJ1
PeptideAtlas More...PeptideAtlasⁱ	Q9BYJ1
PRIDEⁱ	Q9BYJ1
ProteomicsDBⁱ	79655 79656 [Q9BYJ1-2]

PTM databases

iPTMnetⁱ	Q9BYJ1
PhosphoSitePlusⁱ	Q9BYJ1

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in skin.

Gene expression databases

Bgeeⁱ	ENSG00000179148 Expressed in 72 organ(s), highest expression level in skin of leg
CleanExⁱ	HS_ALOXE3
ExpressionAtlasⁱ	Q9BYJ1 baseline and differential
Genevisibleⁱ	Q9BYJ1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023120 HPA078597

HPAⁱ

HPA023120
HPA078597

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ALOX12B	O75342	2	EBI-6925949,EBI-6925925

With

Entry

#Exp.

IntAct

Notes

ALOX12B

O75342

2

EBI-6925949,EBI-6925925

Protein-protein interaction databases

BioGridⁱ	121886, 29 interactors
IntActⁱ	Q9BYJ1, 3 interactors
STRINGⁱ	9606.ENSP00000314879

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BYJ1
SMRⁱ	Q9BYJ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 119	PLATPROSITE-ProRule annotationAdd BLAST		118
Domainⁱ	120 – 711	LipoxygenasePROSITE-ProRule annotationAdd BLAST		592

Sequence similaritiesⁱ

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IF0U Eukaryota ENOG410YN4N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074415
HOGENOMⁱ	HOG000234358
HOVERGENⁱ	HBG005150
InParanoidⁱ	Q9BYJ1
KEGG Orthology (KO) More...KOⁱ	K18684
PhylomeDBⁱ	Q9BYJ1
TreeFamⁱ	TF105320

Family and domain databases

InterProⁱ	View protein in InterPro IPR000907 LipOase IPR013819 LipOase_C IPR036226 LipOase_C_sf IPR020834 LipOase_CS IPR020833 LipOase_Fe_BS IPR001885 LipOase_mml IPR001024 PLAT/LH2_dom IPR036392 PLAT/LH2_dom_sf
PANTHERⁱ	PTHR11771 PTHR11771, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00305 Lipoxygenase, 1 hit PF01477 PLAT, 1 hit
PRINTSⁱ	PR00087 LIPOXYGENASE PR00467 MAMLPOXGNASE
SMARTⁱ	View protein in SMART SM00308 LH2, 1 hit
SUPFAMⁱ	SSF48484 SSF48484, 1 hit SSF49723 SSF49723, 1 hit
PROSITEⁱ	View protein in PROSITE PS00711 LIPOXYGENASE_1, 1 hit PS00081 LIPOXYGENASE_2, 1 hit PS51393 LIPOXYGENASE_3, 1 hit PS50095 PLAT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BYJ1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVYRLCVTT GPYLRAGTLD NISVTLVGTC GESPKQRLDR MGRDFAPGSV 
        60         70         80         90        100
QKYKVRCTAE LGELLLLRVH KERYAFFRKD SWYCSRICVT EPDGSVSHFP 
       110        120        130        140        150
CYQWIEGYCT VELRPGTART ICQDSLPLLL DHRTRELRAR QECYRWKIYA 
       160        170        180        190        200
PGFPCMVDVN SFQEMESDKK FALTKTTTCV DQGDSSGNRY LPGFPMKIDI 
       210        220        230        240        250
PSLMYMEPNV RYSATKTISL LFNAIPASLG MKLRGLLDRK GSWKKLDDMQ 
       260        270        280        290        300
NIFWCHKTFT TKYVTEHWCE DHFFGYQYLN GVNPVMLHCI SSLPSKLPVT 
       310        320        330        340        350
NDMVAPLLGQ DTCLQTELER GNIFLADYWI LAEAPTHCLN GRQQYVAAPL 
       360        370        380        390        400
CLLWLSPQGA LVPLAIQLSQ TPGPDSPIFL PTDSEWDWLL AKTWVRNSEF 
       410        420        430        440        450
LVHENNTHFL CTHLLCEAFA MATLRQLPLC HPIYKLLLPH TRYTLQVNTI 
       460        470        480        490        500
ARATLLNPEG LVDQVTSIGR QGLIYLMSTG LAHFTYTNFC LPDSLRARGV 
       510        520        530        540        550
LAIPNYHYRD DGLKIWAAIE SFVSEIVGYY YPSDASVQQD SELQAWTGEI 
       560        570        580        590        600
FAQAFLGRES SGFPSRLCTP GEMVKFLTAI IFNCSAQHAA VNSGQHDFGA 
       610        620        630        640        650
WMPNAPSSMR QPPPQTKGTT TLKTYLDTLP EVNISCNNLL LFWLVSQEPK 
       660        670        680        690        700
DQRPLGTYPD EHFTEEAPRR SIAAFQSRLA QISRDIQERN QGLALPYTYL 
       710 
DPPLIENSVS I

Length:711

Mass (Da):80,543

Last modified:June 1, 2001 - v1

Checksum:ⁱBDED1E4ED5CF6783

GO

Isoform 2 (identifier: Q9BYJ1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MPRGAFRPCL...PGHPFLLPIM

« Hide

        10         20         30         40         50
MPRGAFRPCL PALYFAFLTC PTPEQRMSGT QAPDIHLGEP ARGTGCVRGK 
        60         70         80         90        100
QTSIRVQDCG RREEARAASR ELRREKAQEH PRESWAHPQP YPAPQPLALR 
       110        120        130        140        150
PETQPCPACR SSPPGRLLLR PALPGHPFLL PIMAVYRLCV TTGPYLRAGT 
       160        170        180        190        200
LDNISVTLVG TCGESPKQRL DRMGRDFAPG SVQKYKVRCT AELGELLLLR 
       210        220        230        240        250
VHKERYAFFR KDSWYCSRIC VTEPDGSVSH FPCYQWIEGY CTVELRPGTA 
       260        270        280        290        300
RTICQDSLPL LLDHRTRELR ARQECYRWKI YAPGFPCMVD VNSFQEMESD 
       310        320        330        340        350
KKFALTKTTT CVDQGDSSGN RYLPGFPMKI DIPSLMYMEP NVRYSATKTI 
       360        370        380        390        400
SLLFNAIPAS LGMKLRGLLD RKGSWKKLDD MQNIFWCHKT FTTKYVTEHW 
       410        420        430        440        450
CEDHFFGYQY LNGVNPVMLH CISSLPSKLP VTNDMVAPLL GQDTCLQTEL 
       460        470        480        490        500
ERGNIFLADY WILAEAPTHC LNGRQQYVAA PLCLLWLSPQ GALVPLAIQL 
       510        520        530        540        550
SQTPGPDSPI FLPTDSEWDW LLAKTWVRNS EFLVHENNTH FLCTHLLCEA 
       560        570        580        590        600
FAMATLRQLP LCHPIYKLLL PHTRYTLQVN TIARATLLNP EGLVDQVTSI 
       610        620        630        640        650
GRQGLIYLMS TGLAHFTYTN FCLPDSLRAR GVLAIPNYHY RDDGLKIWAA 
       660        670        680        690        700
IESFVSEIVG YYYPSDASVQ QDSELQAWTG EIFAQAFLGR ESSGFPSRLC 
       710        720        730        740        750
TPGEMVKFLT AIIFNCSAQH AAVNSGQHDF GAWMPNAPSS MRQPPPQTKG 
       760        770        780        790        800
TTTLKTYLDT LPEVNISCNN LLLFWLVSQE PKDQRPLGTY PDEHFTEEAP 
       810        820        830        840 
RRSIAAFQSR LAQISRDIQE RNQGLALPYT YLDPPLIENS VSI

Note: No experimental confirmation available.

Show »

Length:843

Mass (Da):95,186

Checksum:ⁱ75C69C336513F82C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	J3KPH2	J3KPH2_HUMAN		Arachidonate lipoxygenase 3, isofor... Arachidonate lipoxygenase 3, isoform CRA_a (Hydroperoxide isomerase ALOXE3)	ALOXE3 hCG_31289	867	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	155	C → R in CAC12843 (PubMed:11350124).Curated		1
Sequence conflictⁱ	194	F → L in AAG16899 (PubMed:12881489).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069561	237	L → M in ARCI3; no effect on enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434235EnsemblClinVar.	1
Natural variantⁱVAR_069562	281	G → V in ARCI3; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs786205120Ensembl.	1
Natural variantⁱVAR_069563	344 – 347	QYVA → P in ARCI3; complete loss of the enzyme activity. 1 Publication	4
Natural variantⁱVAR_015175	396	R → S in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434234Ensembl.	1
Natural variantⁱVAR_069564	427	L → P in ARCI3. 1 Publication	1
Natural variantⁱVAR_015176	500	V → F in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434232Ensembl.	1
Natural variantⁱVAR_069565	630	P → L in ARCI3; complete loss of the enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs147149459EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043287	1	M → MPRGAFRPCLPALYFAFLTC PTPEQRMSGTQAPDIHLGEP ARGTGCVRGKQTSIRVQDCG RREEARAASRELRREKAQEH PRESWAHPQPYPAPQPLALR PETQPCPACRSSPPGRLLLR PALPGHPFLLPIM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ269499 mRNA Translation: CAC12843.1 AJ305020 , AJ305021, AJ305023, AJ305025 Genomic DNA Translation: CAC34518.1 AF182218 mRNA Translation: AAG16899.1 AK296416 mRNA Translation: BAH12346.1 AK313677 mRNA Translation: BAG36428.1 CH471108 Genomic DNA Translation: EAW90094.1 BC101938 mRNA Translation: AAI01939.1 BC101939 mRNA Translation: AAI01940.1 BC103508 mRNA Translation: AAI03509.1 BC104724 mRNA Translation: AAI04725.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11130.1 [Q9BYJ1-1] CCDS54084.1 [Q9BYJ1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001159432.1, NM_001165960.1 [Q9BYJ1-2] NP_067641.2, NM_021628.2 [Q9BYJ1-1]
UniGeneⁱ	Hs.232770

Genome annotation databases

Ensemblⁱ	ENST00000318227; ENSP00000314879; ENSG00000179148 [Q9BYJ1-2] ENST00000448843; ENSP00000400581; ENSG00000179148 [Q9BYJ1-1]
GeneIDⁱ	59344
KEGGⁱ	hsa:59344
UCSC genome browser More...UCSCⁱ	uc010cnr.4 human [Q9BYJ1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BYJ1	Arachidonate lipoxygenase 3, isoform CRA_a		HUMAN		867	UniRef100_Q9BYJ1

Protein	Similar proteins		Species	Score	Length	Source
Q9BYJ1	Arachidonate lipoxygenase 3, isoform CRA_a		HUMAN		867	UniRef90_Q9BYJ1
ALOXE3 isoform 1		PANTR		868
ALOXE3 isoform 3		PONAB		868
Uncharacterized protein		PAPAN		868
Arachidonate lipoxygenase 3		MACMU		711
+58

Protein	Similar proteins		Species	Score	Length	Source
Q9BYJ1	Hydroperoxide isomerase ALOXE3		RAT		711	UniRef50_Q9BYJ1
Hydroperoxide isomerase ALOXE3		MOUSE		711
Arachidonate lipoxygenase 3, isoform CRA_a		HUMAN		867
ALOXE3 isoform 3		PONAB		868
Uncharacterized protein		PAPAN		868
+176

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

about water - Issue 153 of September 2013

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ269499 mRNA Translation: CAC12843.1 AJ305020 , AJ305021, AJ305023, AJ305025 Genomic DNA Translation: CAC34518.1 AF182218 mRNA Translation: AAG16899.1 AK296416 mRNA Translation: BAH12346.1 AK313677 mRNA Translation: BAG36428.1 CH471108 Genomic DNA Translation: EAW90094.1 BC101938 mRNA Translation: AAI01939.1 BC101939 mRNA Translation: AAI01940.1 BC103508 mRNA Translation: AAI03509.1 BC104724 mRNA Translation: AAI04725.1
CCDSⁱ	CCDS11130.1 [Q9BYJ1-1] CCDS54084.1 [Q9BYJ1-2]
RefSeqⁱ	NP_001159432.1, NM_001165960.1 [Q9BYJ1-2] NP_067641.2, NM_021628.2 [Q9BYJ1-1]
UniGeneⁱ	Hs.232770

3D structure databases

ProteinModelPortalⁱ	Q9BYJ1
SMRⁱ	Q9BYJ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121886, 29 interactors
IntActⁱ	Q9BYJ1, 3 interactors
STRINGⁱ	9606.ENSP00000314879

Chemistry databases

SwissLipidsⁱ	SLP:000000656

SwissLipidsⁱ

SLP:000000656

PTM databases

iPTMnetⁱ	Q9BYJ1
PhosphoSitePlusⁱ	Q9BYJ1

Polymorphism and mutation databases

BioMutaⁱ	ALOXE3
DMDMⁱ	27923803

Proteomic databases

EPDⁱ	Q9BYJ1
PaxDbⁱ	Q9BYJ1
PeptideAtlasⁱ	Q9BYJ1
PRIDEⁱ	Q9BYJ1
ProteomicsDBⁱ	79655 79656 [Q9BYJ1-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000318227; ENSP00000314879; ENSG00000179148 [Q9BYJ1-2] ENST00000448843; ENSP00000400581; ENSG00000179148 [Q9BYJ1-1]
GeneIDⁱ	59344
KEGGⁱ	hsa:59344
UCSCⁱ	uc010cnr.4 human [Q9BYJ1-1]

Organism-specific databases

CTDⁱ	59344
DisGeNETⁱ	59344
EuPathDBⁱ	HostDB:ENSG00000179148.9
GeneCardsⁱ	ALOXE3
GeneReviewsⁱ	ALOXE3
HGNCⁱ	HGNC:13743 ALOXE3
HPAⁱ	HPA023120 HPA078597
MalaCardsⁱ	ALOXE3
MIMⁱ	606545 phenotype 607206 gene
neXtProtⁱ	NX_Q9BYJ1
OpenTargetsⁱ	ENSG00000179148
Orphanetⁱ	79394 Congenital non-bullous ichthyosiform erythroderma 313 Lamellar ichthyosis 281122 Self-improving collodion baby
PharmGKBⁱ	PA24727
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF0U Eukaryota ENOG410YN4N LUCA
GeneTreeⁱ	ENSGT00550000074415
HOGENOMⁱ	HOG000234358
HOVERGENⁱ	HBG005150
InParanoidⁱ	Q9BYJ1
KOⁱ	K18684
PhylomeDBⁱ	Q9BYJ1
TreeFamⁱ	TF105320

Enzyme and pathway databases

UniPathwayⁱ	UPA00222 UPA00881
Reactomeⁱ	R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives

Miscellaneous databases

ChiTaRSⁱ	ALOXE3 human
GeneWikiⁱ	ALOXE3
GenomeRNAiⁱ	59344
Protein Ontology More...PROⁱ	PR:Q9BYJ1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179148 Expressed in 72 organ(s), highest expression level in skin of leg
CleanExⁱ	HS_ALOXE3
ExpressionAtlasⁱ	Q9BYJ1 baseline and differential
Genevisibleⁱ	Q9BYJ1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000907 LipOase IPR013819 LipOase_C IPR036226 LipOase_C_sf IPR020834 LipOase_CS IPR020833 LipOase_Fe_BS IPR001885 LipOase_mml IPR001024 PLAT/LH2_dom IPR036392 PLAT/LH2_dom_sf
PANTHERⁱ	PTHR11771 PTHR11771, 1 hit
Pfamⁱ	View protein in Pfam PF00305 Lipoxygenase, 1 hit PF01477 PLAT, 1 hit
PRINTSⁱ	PR00087 LIPOXYGENASE PR00467 MAMLPOXGNASE
SMARTⁱ	View protein in SMART SM00308 LH2, 1 hit
SUPFAMⁱ	SSF48484 SSF48484, 1 hit SSF49723 SSF49723, 1 hit
PROSITEⁱ	View protein in PROSITE PS00711 LIPOXYGENASE_1, 1 hit PS00081 LIPOXYGENASE_2, 1 hit PS51393 LIPOXYGENASE_3, 1 hit PS50095 PLAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LOXE3_HUMAN
Accessionⁱ	Q9BYJ1Primary (citable) accession number: Q9BYJ1 Secondary accession number(s): B2R981 , B7Z3W0, Q3ZB74, Q9H4F2, Q9HC22
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - Q9BYJ1 (LOXE3_HUMAN)

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Hydroperoxide isomerase ALOXE3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hydroperoxy eicosatetraenoic acid biosynthesis

Pathwayi: sphingolipid metabolism

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: hydroperoxy eicosatetraenoic acid biosynthesis

Pathwayⁱ: sphingolipid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ