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UniProtKB - Q9BYJ1 (LOXE3_HUMAN)

Entry version 169 (23 Feb 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Hydroperoxide isomerase ALOXE3

Gene

ALOXE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:12881489, PubMed:17045234, PubMed:20921226, PubMed:20923767).

The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:12881489, PubMed:17045234, PubMed:20923767).

In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides (PubMed:20921226).

In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561).

Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561).

In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (PubMed:21558561).

Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity).

Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity).

By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Lipoxygenase activity is activated by 13(S)-HPODE leading to an active free ferric enzyme (PubMed:20921226). The lipoxygenase and hydroperoxide isomerase activities are in competition and are reciprocally regulated by oxygen (PubMed:20923767). The oxygen reacts with an epoxyallylic radical intermediate leading to an epoxyallylic peroxyl radical, which, due to its limited reactivity within the enzyme active site, it dissociates and leaves the enzyme in the activated free ferric state (PubMed:20923767).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Has a 5 to 10 fold higher activity toward (12R)-HPETE (hydroperoxyeicosatetraenoic acid) compared to (12S)-HPETE and (15S)-HPETE (PubMed:12881489). From (12R)-HPETE produces a stereoisomer of hepoxilin A3 (PubMed:12881489). More active on hydroperoxides with an R configuration than an S one (PubMed:17045234).2 Publications
  1. KM=46 µM for (12R)-HPETE1 Publication
  2. KM=28 µM for (12S)-HPETE1 Publication
  3. KM=32 µM for (15S)-HPETE1 Publication
  4. KM=50 µM for synthetic fatty acid 9E,11Z,14Z-20:3omega6 (at pH 7.5)1 Publication
  1. Vmax=3.256 µmol/min/mg enzyme for (12R)-HPETE (at pH 7.5)1 Publication
  2. Vmax=0.858 µmol/min/mg enzyme for (12S)-HPETE (at pH 7.5)1 Publication
  3. Vmax=0.484 µmol/min/mg enzyme for (15S)-HPETE (at pH 7.5)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hydroperoxy eicosatetraenoic acid biosynthesis

This protein is involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis and in Lipid metabolism.

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi408Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi413Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi588Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi592Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi711Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Isomerase, Lyase, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.2.1.152, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BYJ1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2142712, Synthesis of 12-eicosatetraenoic acid derivatives

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BYJ1

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00222
UPA00881

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000656

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydroperoxide isomerase ALOXE3Curated
Alternative name(s):
Epidermis-type lipoxygenase 3By similarity
Short name:
Epidermal LOX-3
Short name:
e-LOX-3By similarity
Short name:
eLOX-3
Hydroperoxy dehydratase ALOXE3Curated
Hydroperoxy icosatetraenoate dehydratase (EC:4.2.1.1522 Publications)
Hydroperoxy icosatetraenoate isomerase (EC:5.4.4.73 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALOXE3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13743, ALOXE3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607206, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BYJ1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000179148

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ichthyosis, congenital, autosomal recessive 3 (ARCI3)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069561237L → M in ARCI3; no effect on enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434235EnsemblClinVar.1
Natural variantiVAR_069562281G → V in ARCI3; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs786205120EnsemblClinVar.1
Natural variantiVAR_069563344 – 347QYVA → P in ARCI3; complete loss of the enzyme activity. 1 Publication4
Natural variantiVAR_015175396R → S in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434234EnsemblClinVar.1
Natural variantiVAR_069564427L → P in ARCI3. 1 PublicationCorresponds to variant dbSNP:rs1355284797EnsemblClinVar.1
Natural variantiVAR_015176500V → F in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434232EnsemblClinVar.1
Natural variantiVAR_069565630P → L in ARCI3; complete loss of the enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs147149459EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi451A → G: Increases the O2-dependent dioxygenase activity. 2 Publications1

Keywords - Diseasei

Disease variant, Ichthyosis

Organism-specific databases

DisGeNET

More...DisGeNETi		59344

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		ALOXE3

MalaCards human disease database

More...MalaCardsi		ALOXE3
MIMi606545, phenotype

Open Targets

More...OpenTargetsi		ENSG00000179148

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79394, Congenital non-bullous ichthyosiform erythroderma
313, Lamellar ichthyosis
281122, Self-improving collodion baby

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24727

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BYJ1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALOXE3

Domain mapping of disease mutations (DMDM)

More...DMDMi		27923803

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206911 – 711Hydroperoxide isomerase ALOXE3Add BLAST711

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BYJ1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BYJ1

PeptideAtlas

More...PeptideAtlasi		Q9BYJ1

PRoteomics IDEntifications database

More...PRIDEi		Q9BYJ1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79655 [Q9BYJ1-1]
79656 [Q9BYJ1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BYJ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BYJ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in skin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179148, Expressed in skin of leg and 100 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BYJ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BYJ1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000179148, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121886, 49 interactors

Protein interaction database and analysis system

More...IntActi		Q9BYJ1, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000314879

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BYJ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BYJ1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 119PLATPROSITE-ProRule annotationAdd BLAST118
Domaini120 – 711LipoxygenasePROSITE-ProRule annotationAdd BLAST592

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQSP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156796

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004282_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BYJ1

Identification of Orthologs from Complete Genome Data

More...OMAi		LCEAFSM

Database of Orthologous Groups

More...OrthoDBi		385042at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BYJ1

TreeFam database of animal gene trees

More...TreeFami		TF105320

Family and domain databases

Conserved Domains Database

More...CDDi		cd01753, PLAT_LOX, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000907, LipOase
IPR013819, LipOase_C
IPR036226, LipOase_C_sf
IPR020834, LipOase_CS
IPR020833, LipOase_Fe_BS
IPR001885, LipOase_mml
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042062, PLAT_LOX_verte

The PANTHER Classification System

More...PANTHERi		PTHR11771, PTHR11771, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00305, Lipoxygenase, 1 hit
PF01477, PLAT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00087, LIPOXYGENASE
PR00467, MAMLPOXGNASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00308, LH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48484, SSF48484, 1 hit
SSF49723, SSF49723, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00711, LIPOXYGENASE_1, 1 hit
PS00081, LIPOXYGENASE_2, 1 hit
PS51393, LIPOXYGENASE_3, 1 hit
PS50095, PLAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVYRLCVTT GPYLRAGTLD NISVTLVGTC GESPKQRLDR MGRDFAPGSV 
        60         70         80         90        100
QKYKVRCTAE LGELLLLRVH KERYAFFRKD SWYCSRICVT EPDGSVSHFP 
       110        120        130        140        150
CYQWIEGYCT VELRPGTART ICQDSLPLLL DHRTRELRAR QECYRWKIYA 
       160        170        180        190        200
PGFPCMVDVN SFQEMESDKK FALTKTTTCV DQGDSSGNRY LPGFPMKIDI 
       210        220        230        240        250
PSLMYMEPNV RYSATKTISL LFNAIPASLG MKLRGLLDRK GSWKKLDDMQ 
       260        270        280        290        300
NIFWCHKTFT TKYVTEHWCE DHFFGYQYLN GVNPVMLHCI SSLPSKLPVT 
       310        320        330        340        350
NDMVAPLLGQ DTCLQTELER GNIFLADYWI LAEAPTHCLN GRQQYVAAPL 
       360        370        380        390        400
CLLWLSPQGA LVPLAIQLSQ TPGPDSPIFL PTDSEWDWLL AKTWVRNSEF 
       410        420        430        440        450
LVHENNTHFL CTHLLCEAFA MATLRQLPLC HPIYKLLLPH TRYTLQVNTI 
       460        470        480        490        500
ARATLLNPEG LVDQVTSIGR QGLIYLMSTG LAHFTYTNFC LPDSLRARGV 
       510        520        530        540        550
LAIPNYHYRD DGLKIWAAIE SFVSEIVGYY YPSDASVQQD SELQAWTGEI 
       560        570        580        590        600
FAQAFLGRES SGFPSRLCTP GEMVKFLTAI IFNCSAQHAA VNSGQHDFGA 
       610        620        630        640        650
WMPNAPSSMR QPPPQTKGTT TLKTYLDTLP EVNISCNNLL LFWLVSQEPK 
       660        670        680        690        700
DQRPLGTYPD EHFTEEAPRR SIAAFQSRLA QISRDIQERN QGLALPYTYL 
       710 
DPPLIENSVS I
Length:711
Mass (Da):80,543
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDED1E4ED5CF6783
GO
Isoform 2 (identifier: Q9BYJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRGAFRPCL...PGHPFLLPIM

Show »
Length:843
Mass (Da):95,186
Checksum:i75C69C336513F82C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPH2J3KPH2_HUMAN
Arachidonate lipoxygenase 3, isofor...
ALOXE3 hCG_31289
867Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155C → R in CAC12843 (PubMed:11350124).Curated1
Sequence conflicti194F → L in AAG16899 (PubMed:12881489).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069561237L → M in ARCI3; no effect on enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434235EnsemblClinVar.1
Natural variantiVAR_069562281G → V in ARCI3; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs786205120EnsemblClinVar.1
Natural variantiVAR_069563344 – 347QYVA → P in ARCI3; complete loss of the enzyme activity. 1 Publication4
Natural variantiVAR_015175396R → S in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434234EnsemblClinVar.1
Natural variantiVAR_069564427L → P in ARCI3. 1 PublicationCorresponds to variant dbSNP:rs1355284797EnsemblClinVar.1
Natural variantiVAR_015176500V → F in ARCI3; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121434232EnsemblClinVar.1
Natural variantiVAR_069565630P → L in ARCI3; complete loss of the enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs147149459EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0432871M → MPRGAFRPCLPALYFAFLTC PTPEQRMSGTQAPDIHLGEP ARGTGCVRGKQTSIRVQDCG RREEARAASRELRREKAQEH PRESWAHPQPYPAPQPLALR PETQPCPACRSSPPGRLLLR PALPGHPFLLPIM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ269499 mRNA Translation: CAC12843.1
AJ305020 AJ305025 Genomic DNA Translation: CAC34518.1
AF182218 mRNA Translation: AAG16899.1
AK296416 mRNA Translation: BAH12346.1
AK313677 mRNA Translation: BAG36428.1
CH471108 Genomic DNA Translation: EAW90094.1
BC101938 mRNA Translation: AAI01939.1
BC101939 mRNA Translation: AAI01940.1
BC103508 mRNA Translation: AAI03509.1
BC104724 mRNA Translation: AAI04725.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11130.1 [Q9BYJ1-1]
CCDS54084.1 [Q9BYJ1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001159432.1, NM_001165960.1 [Q9BYJ1-2]
NP_067641.2, NM_021628.2 [Q9BYJ1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000318227; ENSP00000314879; ENSG00000179148
ENST00000380149; ENSP00000369494; ENSG00000179148
ENST00000448843; ENSP00000400581; ENSG00000179148

Database of genes from NCBI RefSeq genomes

More...GeneIDi		59344

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:59344

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000448843.7; ENSP00000400581.2; NM_021628.3; NP_067641.2

UCSC genome browser

More...UCSCi		uc010cnr.4, human [Q9BYJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

about water - Issue 153 of September 2013

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ269499 mRNA Translation: CAC12843.1
AJ305020 AJ305025 Genomic DNA Translation: CAC34518.1
AF182218 mRNA Translation: AAG16899.1
AK296416 mRNA Translation: BAH12346.1
AK313677 mRNA Translation: BAG36428.1
CH471108 Genomic DNA Translation: EAW90094.1
BC101938 mRNA Translation: AAI01939.1
BC101939 mRNA Translation: AAI01940.1
BC103508 mRNA Translation: AAI03509.1
BC104724 mRNA Translation: AAI04725.1
CCDSiCCDS11130.1 [Q9BYJ1-1]
CCDS54084.1 [Q9BYJ1-2]
RefSeqiNP_001159432.1, NM_001165960.1 [Q9BYJ1-2]
NP_067641.2, NM_021628.2 [Q9BYJ1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6VB2X-ray1.41C136-144[»]
SMRiQ9BYJ1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121886, 49 interactors
IntActiQ9BYJ1, 21 interactors
STRINGi9606.ENSP00000314879

Chemistry databases

SwissLipidsiSLP:000000656

PTM databases

iPTMnetiQ9BYJ1
PhosphoSitePlusiQ9BYJ1

Genetic variation databases

BioMutaiALOXE3
DMDMi27923803

Proteomic databases

MassIVEiQ9BYJ1
PaxDbiQ9BYJ1
PeptideAtlasiQ9BYJ1
PRIDEiQ9BYJ1
ProteomicsDBi79655 [Q9BYJ1-1]
79656 [Q9BYJ1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24534, 163 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		59344

Genome annotation databases

EnsembliENST00000318227; ENSP00000314879; ENSG00000179148
ENST00000380149; ENSP00000369494; ENSG00000179148
ENST00000448843; ENSP00000400581; ENSG00000179148
GeneIDi59344
KEGGihsa:59344
MANE-SelectiENST00000448843.7; ENSP00000400581.2; NM_021628.3; NP_067641.2
UCSCiuc010cnr.4, human [Q9BYJ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		59344
DisGeNETi59344

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALOXE3
GeneReviewsiALOXE3
HGNCiHGNC:13743, ALOXE3
HPAiENSG00000179148, Tissue enriched (skin)
MalaCardsiALOXE3
MIMi606545, phenotype
607206, gene
neXtProtiNX_Q9BYJ1
OpenTargetsiENSG00000179148
Orphaneti79394, Congenital non-bullous ichthyosiform erythroderma
313, Lamellar ichthyosis
281122, Self-improving collodion baby
PharmGKBiPA24727
VEuPathDBiHostDB:ENSG00000179148

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQSP, Eukaryota
GeneTreeiENSGT00940000156796
HOGENOMiCLU_004282_3_3_1
InParanoidiQ9BYJ1
OMAiLCEAFSM
OrthoDBi385042at2759
PhylomeDBiQ9BYJ1
TreeFamiTF105320

Enzyme and pathway databases

UniPathwayiUPA00222
UPA00881
BRENDAi4.2.1.152, 2681
PathwayCommonsiQ9BYJ1
ReactomeiR-HSA-2142712, Synthesis of 12-eicosatetraenoic acid derivatives
SignaLinkiQ9BYJ1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		59344, 2 hits in 1030 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALOXE3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ALOXE3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		59344
PharosiQ9BYJ1, Tbio

Protein Ontology

More...PROi		PR:Q9BYJ1
RNActiQ9BYJ1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000179148, Expressed in skin of leg and 100 other tissues
ExpressionAtlasiQ9BYJ1, baseline and differential
GenevisibleiQ9BYJ1, HS

Family and domain databases

CDDicd01753, PLAT_LOX, 1 hit
InterProiView protein in InterPro
IPR000907, LipOase
IPR013819, LipOase_C
IPR036226, LipOase_C_sf
IPR020834, LipOase_CS
IPR020833, LipOase_Fe_BS
IPR001885, LipOase_mml
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042062, PLAT_LOX_verte
PANTHERiPTHR11771, PTHR11771, 2 hits
PfamiView protein in Pfam
PF00305, Lipoxygenase, 1 hit
PF01477, PLAT, 1 hit
PRINTSiPR00087, LIPOXYGENASE
PR00467, MAMLPOXGNASE
SMARTiView protein in SMART
SM00308, LH2, 1 hit
SUPFAMiSSF48484, SSF48484, 1 hit
SSF49723, SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711, LIPOXYGENASE_1, 1 hit
PS00081, LIPOXYGENASE_2, 1 hit
PS51393, LIPOXYGENASE_3, 1 hit
PS50095, PLAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLOXE3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYJ1
Secondary accession number(s): B2R981
, B7Z3W0, Q3ZB74, Q9H4F2, Q9HC22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
  8. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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