GSDMC

Functionⁱ

The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).Curated1 Publication

Caution

Despite its name, it is unclear if this protein contains a functional leucine zipper.Curated

GO - Molecular functionⁱ

phosphatidylinositol-4,5-bisphosphate binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylinositol-4-phosphate binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylserine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

pyroptosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Necrosis

Biological process

Necrosis

Protein family/group databases

TCDBⁱ	1.C.123.1.4 the pore-forming gasdermin (gasdermin) family

TCDBⁱ

1.C.123.1.4 the pore-forming gasdermin (gasdermin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gasdermin-C Alternative name(s): Melanoma-derived leucine zipper-containing extranuclear factor
Gene namesⁱ	Name:GSDMC Synonyms:MLZE
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147697.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7151 GSDMC
MIMⁱ	608384 gene
neXtProtⁱ	NX_Q9BYG8

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	319	L → D: Low spontaneous pyroptosis-inducing activity. 1 Publication	1
Mutagenesisⁱ	398	Y → D: Low spontaneous pyroptosis-inducing activity. 1 Publication	1
Mutagenesisⁱ	402	A → D: Spontaneous pyroptosis-inducing activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56169
Open Targets More...OpenTargetsⁱ	ENSG00000147697
PharmGKBⁱ	PA162390324

Polymorphism and mutation databases

BioMutaⁱ	GSDMC
DMDMⁱ	311033444

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000148180	1 – 508	Gasdermin-CAdd BLAST		508

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	Q9BYG8
PaxDbⁱ	Q9BYG8
PeptideAtlas More...PeptideAtlasⁱ	Q9BYG8
PRIDEⁱ	Q9BYG8
ProteomicsDBⁱ	79642

PTM databases

iPTMnetⁱ	Q9BYG8
PhosphoSitePlusⁱ	Q9BYG8

Expressionⁱ

Tissue specificityⁱ

Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000147697 Expressed in 107 organ(s), highest expression level in esophagus mucosa
CleanExⁱ	HS_GSDMC
Genevisibleⁱ	Q9BYG8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023670 HPA024767 HPA026317

HPAⁱ

HPA023670
HPA024767
HPA026317

Interactionⁱ

Subunit structureⁱ

The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.By similarity

Protein-protein interaction databases

BioGridⁱ	121101, 1 interactor

BioGridⁱ

121101, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BYG8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 257	Triggers pyroptosis1 PublicationAdd BLAST		257

Domainⁱ

Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.By similarity

Sequence similaritiesⁱ

Belongs to the gasdermin family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IVCF Eukaryota ENOG4111AD5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063218
HOGENOMⁱ	HOG000082450
HOVERGENⁱ	HBG107969
InParanoidⁱ	Q9BYG8
KEGG Orthology (KO) More...KOⁱ	K22143
OMAⁱ	PWSIPFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MAU
PhylomeDBⁱ	Q9BYG8
TreeFamⁱ	TF331886

Family and domain databases

InterProⁱ	View protein in InterPro IPR007677 Gasdermin
PANTHERⁱ	PTHR16399 PTHR16399, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04598 Gasdermin, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9BYG8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSMLERISK NLVKEIGSKD LTPVKYLLSA TKLRQFVILR KKKDSRSSFW 
        60         70         80         90        100
EQSDYVPVEF SLNDILEPSS SVLETVVTGP FHFSDIMIQK HKADMGVNVG 
       110        120        130        140        150
IEVSVSGEAS VDHGCSLEFQ IVTIPSPNLE DFQKRKLLDP EPSFLKECRR 
       160        170        180        190        200
RGDNLYVVTE AVELINNTVL YDSSSVNILG KIALWITYGK GQGQGESLRV 
       210        220        230        240        250
KKKALTLQKG MVMAYKRKQL VIKEKAILIS DDDEQRTFQD EYEISEMVGY 
       260        270        280        290        300
CAARSEGLLP SFHTISPTLF NASSNDMKLK PELFLTQQFL SGHLPKYEQV 
       310        320        330        340        350
HILPVGRIEE PFWQNFKHLQ EEVFQKIKTL AQLSKDVQDV MFYSILAMLR 
       360        370        380        390        400
DRGALQDLMN MLELDSSGHL DGPGGAILKK LQQDSNHAWF NPKDPILYLL 
       410        420        430        440        450
EAIMVLSDFQ HDLLACSMEK RILLQQQELV RSILEPNFRY PWSIPFTLKP 
       460        470        480        490        500
ELLAPLQSEG LAITYGLLEE CGLRMELDNP RSTWDVEAKM PLSALYGTLS 

LLQQLAEA

Length:508

Mass (Da):57,692

Last modified:November 2, 2010 - v3

Checksum:ⁱ9CB6054AFA1ED88C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A2R8Y5J4	A0A2R8Y5J4_HUMAN		Gasdermin-C Gasdermin-C	GSDMC	508	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_028138	23	P → S1 PublicationCorresponds to variant dbSNP:rs10090835Ensembl.	1
Natural variantⁱVAR_028139	150	R → K. Corresponds to variant dbSNP:rs16904151Ensembl.	1
Natural variantⁱVAR_028140	475	M → T1 PublicationCorresponds to variant dbSNP:rs4144738Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB042405 mRNA Translation: BAB40331.1 AC022849 Genomic DNA No translation available. BC035321 mRNA Translation: AAH35321.1 BC063595 mRNA Translation: AAH63595.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6360.1
NCBI Reference Sequences More...RefSeqⁱ	NP_113603.1, NM_031415.2
UniGeneⁱ	Hs.133244

Genome annotation databases

Ensemblⁱ	ENST00000276708; ENSP00000276708; ENSG00000147697 ENST00000619643; ENSP00000482343; ENSG00000147697
GeneIDⁱ	56169
KEGGⁱ	hsa:56169
UCSC genome browser More...UCSCⁱ	uc003ysr.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BYG8	Uncharacterized protein		RHIBE		508	UniRef90_Q9BYG8
Gasdermin-C		HUMAN		508
Uncharacterized protein		NOMLE		508
Uncharacterized protein		COLAP		508
Uncharacterized protein		RHIRO		508
+27

Protein	Similar proteins		Species	Score	Length	Source
Q9BYG8	Uncharacterized protein		RHIRO		508	UniRef50_Q9BYG8
GSDMC isoform 1		PONAB		508
Uncharacterized protein		PANPA		508
Uncharacterized protein		RHIBE		508
Uncharacterized protein		COLAP		508
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB042405 mRNA Translation: BAB40331.1 AC022849 Genomic DNA No translation available. BC035321 mRNA Translation: AAH35321.1 BC063595 mRNA Translation: AAH63595.1
CCDSⁱ	CCDS6360.1
RefSeqⁱ	NP_113603.1, NM_031415.2
UniGeneⁱ	Hs.133244

3D structure databases

ProteinModelPortalⁱ	Q9BYG8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121101, 1 interactor

BioGridⁱ

121101, 1 interactor

Protein family/group databases

TCDBⁱ	1.C.123.1.4 the pore-forming gasdermin (gasdermin) family

TCDBⁱ

1.C.123.1.4 the pore-forming gasdermin (gasdermin) family

PTM databases

iPTMnetⁱ	Q9BYG8
PhosphoSitePlusⁱ	Q9BYG8

Polymorphism and mutation databases

BioMutaⁱ	GSDMC
DMDMⁱ	311033444

Proteomic databases

EPDⁱ	Q9BYG8
PaxDbⁱ	Q9BYG8
PeptideAtlasⁱ	Q9BYG8
PRIDEⁱ	Q9BYG8
ProteomicsDBⁱ	79642

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56169
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000276708; ENSP00000276708; ENSG00000147697 ENST00000619643; ENSP00000482343; ENSG00000147697
GeneIDⁱ	56169
KEGGⁱ	hsa:56169
UCSCⁱ	uc003ysr.3 human

Organism-specific databases

CTDⁱ	56169
DisGeNETⁱ	56169
EuPathDBⁱ	HostDB:ENSG00000147697.8
GeneCardsⁱ	GSDMC
H-InvDBⁱ	HIX0034239
HGNCⁱ	HGNC:7151 GSDMC
HPAⁱ	HPA023670 HPA024767 HPA026317
MIMⁱ	608384 gene
neXtProtⁱ	NX_Q9BYG8
OpenTargetsⁱ	ENSG00000147697
PharmGKBⁱ	PA162390324
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVCF Eukaryota ENOG4111AD5 LUCA
GeneTreeⁱ	ENSGT00530000063218
HOGENOMⁱ	HOG000082450
HOVERGENⁱ	HBG107969
InParanoidⁱ	Q9BYG8
KOⁱ	K22143
OMAⁱ	PWSIPFT
OrthoDBⁱ	EOG091G0MAU
PhylomeDBⁱ	Q9BYG8
TreeFamⁱ	TF331886

Miscellaneous databases

GenomeRNAiⁱ	56169
Protein Ontology More...PROⁱ	PR:Q9BYG8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147697 Expressed in 107 organ(s), highest expression level in esophagus mucosa
CleanExⁱ	HS_GSDMC
Genevisibleⁱ	Q9BYG8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007677 Gasdermin
PANTHERⁱ	PTHR16399 PTHR16399, 1 hit
Pfamⁱ	View protein in Pfam PF04598 Gasdermin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GSDMC_HUMAN
Accessionⁱ	Q9BYG8Primary (citable) accession number: Q9BYG8 Secondary accession number(s): Q5XKF3, Q6P494
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniParc

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UniRef

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Supporting data

UniProtKB - Q9BYG8 (GSDMC_HUMAN)

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Gasdermin-C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Cytoskeleton

Cytosol

Mitochondrion

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ