UniProtKB - Q9BYG4 (PAR6G_HUMAN)
Partitioning defective 6 homolog gamma
PARD6G
Functioni
Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).
By similarityGO - Molecular functioni
- protein kinase C binding Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- centrosome cycle Source: GO_Central
- establishment or maintenance of cell polarity Source: GO_Central
- regulation of cellular localization Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
PathwayCommonsi | Q9BYG4 |
Reactomei | R-HSA-420029, Tight junction interactions |
SignaLinki | Q9BYG4 |
Names & Taxonomyi
Protein namesi | Recommended name: Partitioning defective 6 homolog gammaShort name: PAR-6 gamma Alternative name(s): PAR6D |
Gene namesi | Name:PARD6G Synonyms:PAR6G |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16076, PARD6G |
MIMi | 608976, gene |
neXtProti | NX_Q9BYG4 |
VEuPathDBi | HostDB:ENSG00000178184 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Cytoplasm and Cytosol
Other locations
- tight junction By similarity
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- apical plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
- cell cortex Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junctionPathology & Biotechi
Organism-specific databases
DisGeNETi | 84552 |
OpenTargetsi | ENSG00000178184 |
PharmGKBi | PA32939 |
Miscellaneous databases
Pharosi | Q9BYG4, Tbio |
Genetic variation databases
BioMutai | PARD6G |
DMDMi | 30913175 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000112518 | 1 – 376 | Partitioning defective 6 homolog gammaAdd BLAST | 376 |
Proteomic databases
EPDi | Q9BYG4 |
jPOSTi | Q9BYG4 |
MassIVEi | Q9BYG4 |
MaxQBi | Q9BYG4 |
PaxDbi | Q9BYG4 |
PeptideAtlasi | Q9BYG4 |
PRIDEi | Q9BYG4 |
ProteomicsDBi | 79638 [Q9BYG4-1] |
PTM databases
iPTMneti | Q9BYG4 |
PhosphoSitePlusi | Q9BYG4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000178184, Expressed in upper arm skin and 203 other tissues |
ExpressionAtlasi | Q9BYG4, baseline and differential |
Genevisiblei | Q9BYG4, HS |
Organism-specific databases
HPAi | ENSG00000178184, Tissue enhanced (skin) |
Interactioni
Subunit structurei
Interacts with PARD3 (Probable).
Interacts with GTP-bound forms of CDC42, RHOQ/TC10 and RAC1.
Interacts with the N-terminal part of PRKCI and PRKCZ.
Curated2 PublicationsBinary interactionsi
Q9BYG4
GO - Molecular functioni
- protein kinase C binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 124135, 27 interactors |
ComplexPortali | CPX-6194, PAR cell polarity complex, PARD6G-PRKCI variant CPX-6195, PAR cell polarity complex, PARD6G-PRKCZ variant |
IntActi | Q9BYG4, 16 interactors |
MINTi | Q9BYG4 |
STRINGi | 9606.ENSP00000343144 |
Miscellaneous databases
RNActi | Q9BYG4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 98 | PB1PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 134 – 151 | Pseudo-CRIBAdd BLAST | 18 | |
Domaini | 158 – 251 | PDZPROSITE-ProRule annotationAdd BLAST | 94 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 254 | Interaction with PARD3 and CDC42By similarityAdd BLAST | 128 | |
Regioni | 356 – 376 | DisorderedSequence analysisAdd BLAST | 21 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3606, Eukaryota |
GeneTreei | ENSGT00950000183211 |
HOGENOMi | CLU_040653_2_0_1 |
InParanoidi | Q9BYG4 |
OMAi | SKPHDFR |
OrthoDBi | 825211at2759 |
PhylomeDBi | Q9BYG4 |
TreeFami | TF312899 |
Family and domain databases
CDDi | cd06403, PB1_Par6, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR034874, PAR-6_G IPR000270, PB1_dom IPR034868, PB1_Par6 IPR001478, PDZ IPR036034, PDZ_sf |
PANTHERi | PTHR14102:SF3, PTHR14102:SF3, 1 hit |
Pfami | View protein in Pfam PF00564, PB1, 1 hit PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00666, PB1, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51745, PB1, 1 hit PS50106, PDZ, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV
60 70 80 90 100
HTHHISNSDV TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE
110 120 130 140 150
AERGSLGAGS LCRRRRALGA LRDEGPRRRA HLDIGLPRDF RPVSSIIDVD
160 170 180 190 200
LVPETHRRVR LHRHGCEKPL GFYIRDGASV RVTPHGLEKV PGIFISRMVP
210 220 230 240 250
GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS HNLIVTVKPA
260 270 280 290 300
NQRNNVVRGG RALGSSGPPS DGTAGFVGPP APRVLQNFHP DEAESDEDND
310 320 330 340 350
VVIEGTLEPA RPPQTPGAPA GSLSRVNGAG LAQRLQRDLA LDGGLQRLLS
360 370
SLRADPRHSL ALPPGGVEEH GPAVTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7ELH1 | K7ELH1_HUMAN | Partitioning defective 6 homolog ga... | PARD6G | 61 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047586 | 99 – 107 | EEAERGSLG → DDGALRPGT in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_047587 | 108 – 376 | Missing in isoform 2. 1 PublicationAdd BLAST | 269 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB044556 mRNA Translation: BAB40757.1 AB178536 mRNA Translation: BAF92015.1 AC139100 Genomic DNA No translation available. BC060797 mRNA Translation: AAH60797.1 |
CCDSi | CCDS12022.1 [Q9BYG4-1] |
RefSeqi | NP_115899.1, NM_032510.3 [Q9BYG4-1] |
Genome annotation databases
Ensembli | ENST00000353265; ENSP00000343144; ENSG00000178184 ENST00000470488; ENSP00000468735; ENSG00000178184 [Q9BYG4-2] |
GeneIDi | 84552 |
KEGGi | hsa:84552 |
MANE-Selecti | ENST00000353265.8; ENSP00000343144.3; NM_032510.4; NP_115899.1 |
UCSCi | uc002lny.4, human [Q9BYG4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB044556 mRNA Translation: BAB40757.1 AB178536 mRNA Translation: BAF92015.1 AC139100 Genomic DNA No translation available. BC060797 mRNA Translation: AAH60797.1 |
CCDSi | CCDS12022.1 [Q9BYG4-1] |
RefSeqi | NP_115899.1, NM_032510.3 [Q9BYG4-1] |
3D structure databases
SMRi | Q9BYG4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124135, 27 interactors |
ComplexPortali | CPX-6194, PAR cell polarity complex, PARD6G-PRKCI variant CPX-6195, PAR cell polarity complex, PARD6G-PRKCZ variant |
IntActi | Q9BYG4, 16 interactors |
MINTi | Q9BYG4 |
STRINGi | 9606.ENSP00000343144 |
PTM databases
iPTMneti | Q9BYG4 |
PhosphoSitePlusi | Q9BYG4 |
Genetic variation databases
BioMutai | PARD6G |
DMDMi | 30913175 |
Proteomic databases
EPDi | Q9BYG4 |
jPOSTi | Q9BYG4 |
MassIVEi | Q9BYG4 |
MaxQBi | Q9BYG4 |
PaxDbi | Q9BYG4 |
PeptideAtlasi | Q9BYG4 |
PRIDEi | Q9BYG4 |
ProteomicsDBi | 79638 [Q9BYG4-1] |
Protocols and materials databases
Antibodypediai | 23537, 107 antibodies from 18 providers |
DNASUi | 84552 |
Genome annotation databases
Ensembli | ENST00000353265; ENSP00000343144; ENSG00000178184 ENST00000470488; ENSP00000468735; ENSG00000178184 [Q9BYG4-2] |
GeneIDi | 84552 |
KEGGi | hsa:84552 |
MANE-Selecti | ENST00000353265.8; ENSP00000343144.3; NM_032510.4; NP_115899.1 |
UCSCi | uc002lny.4, human [Q9BYG4-1] |
Organism-specific databases
CTDi | 84552 |
DisGeNETi | 84552 |
GeneCardsi | PARD6G |
HGNCi | HGNC:16076, PARD6G |
HPAi | ENSG00000178184, Tissue enhanced (skin) |
MIMi | 608976, gene |
neXtProti | NX_Q9BYG4 |
OpenTargetsi | ENSG00000178184 |
PharmGKBi | PA32939 |
VEuPathDBi | HostDB:ENSG00000178184 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3606, Eukaryota |
GeneTreei | ENSGT00950000183211 |
HOGENOMi | CLU_040653_2_0_1 |
InParanoidi | Q9BYG4 |
OMAi | SKPHDFR |
OrthoDBi | 825211at2759 |
PhylomeDBi | Q9BYG4 |
TreeFami | TF312899 |
Enzyme and pathway databases
PathwayCommonsi | Q9BYG4 |
Reactomei | R-HSA-420029, Tight junction interactions |
SignaLinki | Q9BYG4 |
Miscellaneous databases
BioGRID-ORCSi | 84552, 6 hits in 1043 CRISPR screens |
ChiTaRSi | PARD6G, human |
GenomeRNAii | 84552 |
Pharosi | Q9BYG4, Tbio |
PROi | PR:Q9BYG4 |
RNActi | Q9BYG4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178184, Expressed in upper arm skin and 203 other tissues |
ExpressionAtlasi | Q9BYG4, baseline and differential |
Genevisiblei | Q9BYG4, HS |
Family and domain databases
CDDi | cd06403, PB1_Par6, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR034874, PAR-6_G IPR000270, PB1_dom IPR034868, PB1_Par6 IPR001478, PDZ IPR036034, PDZ_sf |
PANTHERi | PTHR14102:SF3, PTHR14102:SF3, 1 hit |
Pfami | View protein in Pfam PF00564, PB1, 1 hit PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00666, PB1, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51745, PB1, 1 hit PS50106, PDZ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAR6G_HUMAN | |
Accessioni | Q9BYG4Primary (citable) accession number: Q9BYG4 Secondary accession number(s): A8QM57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families