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Entry version 153 (18 Sep 2019)
Sequence version 2 (14 Oct 2008)
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Protein

Cadherin-related family member 2

Gene

CDHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Differentiation
LigandCalcium

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q9BYE9 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-related family member 2Curated
Alternative name(s):
Protocadherin LKC1 Publication
Short name:
PC-LKC1 Publication
Protocadherin-241 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDHR2Imported
Synonyms:PCDH241 Publication, PCLKC1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18231 CDHR2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYE9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1154ExtracellularSequence analysisAdd BLAST1134
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1155 – 1175HelicalSequence analysisAdd BLAST21
Topological domaini1176 – 1310CytoplasmicSequence analysisAdd BLAST135

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1310L → R: Loss of interaction with USH1C. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54825

Open Targets

More...
OpenTargetsi
ENSG00000074276

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660231

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDHR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572658

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000401121 – 1310Cadherin-related family member 2Add BLAST1290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi680N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi775N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi821N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi871N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi877N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi911N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi932N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1107N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1248PhosphoserineCombined sources1
Modified residuei1299PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BYE9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYE9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BYE9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYE9

PeptideAtlas

More...
PeptideAtlasi
Q9BYE9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYE9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79633

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1922

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYE9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers (PubMed:12117771, PubMed:15534908). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074276 Expressed in 120 organ(s), highest expression level in jejunal mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BYE9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYE9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012569
HPA017053

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (PubMed:26812018).

Interacts with MAST2 (PubMed:12117771).

Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR2 to microvilli tips and its function in brush border differentiation (PubMed:24725409, PubMed:26812017).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120179, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BYE9, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000424565

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYE9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 124Cadherin 1PROSITE-ProRule annotationAdd BLAST98
Domaini125 – 241Cadherin 2PROSITE-ProRule annotationAdd BLAST117
Domaini242 – 353Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini368 – 480Cadherin 4PROSITE-ProRule annotationAdd BLAST113
Domaini481 – 586Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini586 – 695Cadherin 6PROSITE-ProRule annotationAdd BLAST110
Domaini696 – 808Cadherin 7PROSITE-ProRule annotationAdd BLAST113
Domaini810 – 928Cadherin 8PROSITE-ProRule annotationAdd BLAST119
Domaini930 – 1058Cadherin 9PROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1180 – 1310Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization1 PublicationAdd BLAST131

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cadherin 1 domain is required for binding to CDHR5.1 Publication

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161160

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115467

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYE9

KEGG Orthology (KO)

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KOi
K16502

Identification of Orthologs from Complete Genome Data

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OMAi
TIQAYDN

Database of Orthologous Groups

More...
OrthoDBi
83119at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYE9

TreeFam database of animal gene trees

More...
TreeFami
TF332908

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030276 CDHR2

The PANTHER Classification System

More...
PANTHERi
PTHR24026:SF75 PTHR24026:SF75, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00028 Cadherin, 6 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BYE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLWLSCFL LPALVVSVAA NVAPKFLANM TSVILPEDLP VGAQAFWLVA
60 70 80 90 100
EDQDNDPLTY GMSGPNAYFF AVTPKTGEVK LASALDYETL YTFKVTISVS
110 120 130 140 150
DPYIQVQREM LVIVEDRNDN APVFQNTAFS TSINETLPVG SVVFSVLAVD
160 170 180 190 200
KDMGSAGMVV YSIEKVIPST GDSEHLFRIL ANGSIVLNGS LSYNNKSAFY
210 220 230 240 250
QLELKACDLG GMYHNTFTIQ CSLPVFLSIS VVDQPDLDPQ FVREFYSASV
260 270 280 290 300
AEDAAKGTSV LTVEAVDGDK GINDPVIYSI SYSTRPGWFD IGADGVIRVN
310 320 330 340 350
GSLDREQLLE ADEEVQLQVT ATETHLNIYG QEAKVSIWVT VRVMDVNDHK
360 370 380 390 400
PEFYNCSLPA CTFTPEEAQV NFTGYVDEHA SPRIPIDDLT MVVYDPDKGS
410 420 430 440 450
NGTFLLSLGG PDAEAFSVSP ERAVGSASVQ VLVRVSALVD YERQTAMAVQ
460 470 480 490 500
VVATDSVSQN FSVAMVTIHL RDINDHRPTF PQSLYVLTVP EHSATGSVVT
510 520 530 540 550
DSIHATDPDT GAWGQITYSL LPGNGADLFQ VDPVSGTVTV RNGELLDRES
560 570 580 590 600
QAVYYLTLQA TDGGNLSSST TLQIHLLDIN DNAPVVSGSY NIFVQEEEGN
610 620 630 640 650
VSVTIQAHDN DEPGTNNSRL LFNLLPGPYS HNFSLDPDTG LLRNLGPLDR
660 670 680 690 700
EAIDPALEGR IVLTVLVSDC GEPVLGTKVN VTITVEDIND NLPIFNQSSY
710 720 730 740 750
NFTVKEEDPG VLVGVVKAWD ADQTEANNRI SFSLSGSGAN YFMIRGLVLG
760 770 780 790 800
AGWAEGYLRL PPDVSLDYET QPVFNLTVSA ENPDPQGGET IVDVCVNVKD
810 820 830 840 850
VNDNPPTLDV ASLRGIRVAE NGSQHGQVAV VVASDVDTSA QLEIQLVNIL
860 870 880 890 900
CTKAGVDVGS LCWGWFSVAA NGSVYINQSK AIDYEACDLV TLVVRACDLA
910 920 930 940 950
TDPGFQAYSN NGSLLITIED VNDNAPYFLP ENKTFVIIPE LVLPNREVAS
960 970 980 990 1000
VRARDDDSGN NGVILFSILR VDFISKDGAT IPFQGVFSIF TSSEADVFAG
1010 1020 1030 1040 1050
SIQPVTSLDS TLQGTYQVTV QARDRPSLGP FLEATTTLNL FTVDQSYRSR
1060 1070 1080 1090 1100
LQFSTPKEEV GANRQAINAA LTQATRTTVY IVDIQDIDSA ARARPHSYLD
1110 1120 1130 1140 1150
AYFVFPNGSA LTLDELSVMI RNDQDSLTQL LQLGLVVLGS QESQESDLSK
1160 1170 1180 1190 1200
QLISVIIGLG VALLLVLVIM TMAFVCVRKS YNRKLQAMKA AKEARKTAAG
1210 1220 1230 1240 1250
VMPSAPAIPG TNMYNTERAN PMLNLPNKDL GLEYLSPSND LDSVSVNSLD
1260 1270 1280 1290 1300
DNSVDVDKNS QEIKEHRPPH TPPEPDPEPL SVVLLGRQAG ASGQLEGPSY
1310
TNAGLDTTDL
Length:1,310
Mass (Da):141,543
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0BC8AEEF8D9E1F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REJ3D6REJ3_HUMAN
Cadherin-related family member 2
CDHR2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90962 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64G → S in BAB40777 (PubMed:12117771).Curated1
Sequence conflicti1229D → G in BAA90962 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046695107Q → H. Corresponds to variant dbSNP:rs6886860Ensembl.1
Natural variantiVAR_046696415A → G. Corresponds to variant dbSNP:rs3762960Ensembl.1
Natural variantiVAR_046697424V → A3 PublicationsCorresponds to variant dbSNP:rs11134982Ensembl.1
Natural variantiVAR_046698766L → P. Corresponds to variant dbSNP:rs752138Ensembl.1
Natural variantiVAR_046699901T → M. Corresponds to variant dbSNP:rs35018750Ensembl.1
Natural variantiVAR_046700948V → M. Corresponds to variant dbSNP:rs3749625Ensembl.1
Natural variantiVAR_0541481004P → L Found in an acute myeloid leukemia sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs371676123Ensembl.1
Natural variantiVAR_0467011128T → M3 PublicationsCorresponds to variant dbSNP:rs2291442Ensembl.1
Natural variantiVAR_0215481164L → M1 PublicationCorresponds to variant dbSNP:rs17078347Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB047004 mRNA Translation: BAB40777.1
AK000131 mRNA Translation: BAA90962.1 Different initiation.
AK315055 mRNA Translation: BAG37531.1
AC091934 Genomic DNA No translation available.
BC130282 mRNA Translation: AAI30283.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34297.1

NCBI Reference Sequences

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RefSeqi
NP_001165447.1, NM_001171976.1
NP_060145.3, NM_017675.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261944; ENSP00000261944; ENSG00000074276
ENST00000506348; ENSP00000421078; ENSG00000074276
ENST00000510636; ENSP00000424565; ENSG00000074276

Database of genes from NCBI RefSeq genomes

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GeneIDi
54825

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54825

UCSC genome browser

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UCSCi
uc003mem.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

A tighter mesh - Issue 178 of April 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047004 mRNA Translation: BAB40777.1
AK000131 mRNA Translation: BAA90962.1 Different initiation.
AK315055 mRNA Translation: BAG37531.1
AC091934 Genomic DNA No translation available.
BC130282 mRNA Translation: AAI30283.1
CCDSiCCDS34297.1
RefSeqiNP_001165447.1, NM_001171976.1
NP_060145.3, NM_017675.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CZRX-ray2.30A/B/C/D21-237[»]
SMRiQ9BYE9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120179, 10 interactors
IntActiQ9BYE9, 4 interactors
STRINGi9606.ENSP00000424565

Protein family/group databases

MoonDBiQ9BYE9 Predicted

PTM databases

GlyConnecti1922
iPTMnetiQ9BYE9
PhosphoSitePlusiQ9BYE9

Polymorphism and mutation databases

BioMutaiCDHR2
DMDMi209572658

Proteomic databases

jPOSTiQ9BYE9
MassIVEiQ9BYE9
MaxQBiQ9BYE9
PaxDbiQ9BYE9
PeptideAtlasiQ9BYE9
PRIDEiQ9BYE9
ProteomicsDBi79633

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261944; ENSP00000261944; ENSG00000074276
ENST00000506348; ENSP00000421078; ENSG00000074276
ENST00000510636; ENSP00000424565; ENSG00000074276
GeneIDi54825
KEGGihsa:54825
UCSCiuc003mem.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54825
DisGeNETi54825

GeneCards: human genes, protein and diseases

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GeneCardsi
CDHR2
HGNCiHGNC:18231 CDHR2
HPAiHPA012569
HPA017053
neXtProtiNX_Q9BYE9
OpenTargetsiENSG00000074276
PharmGKBiPA165660231

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000161160
HOGENOMiHOG000115467
InParanoidiQ9BYE9
KOiK16502
OMAiTIQAYDN
OrthoDBi83119at2759
PhylomeDBiQ9BYE9
TreeFamiTF332908

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PCLKC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54825

Pharos

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Pharosi
Q9BYE9

Protein Ontology

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PROi
PR:Q9BYE9

Gene expression databases

BgeeiENSG00000074276 Expressed in 120 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiQ9BYE9 baseline and differential
GenevisibleiQ9BYE9 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030276 CDHR2
PANTHERiPTHR24026:SF75 PTHR24026:SF75, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 6 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SUPFAMiSSF49313 SSF49313, 9 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDHR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYE9
Secondary accession number(s): A1L3U4, A6NC80, Q9NXP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 14, 2008
Last modified: September 18, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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