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Protein

Polycomb group RING finger protein 6

Gene

PCGF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 173RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8953750 Transcriptional Regulation by E2F6
SIGNORiQ9BYE7

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 6
Alternative name(s):
Mel18 and Bmi1-like RING finger
RING finger protein 134
Gene namesi
Name:PCGF6
Synonyms:MBLR, RNF134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000156374.14
HGNCiHGNC:21156 PCGF6
MIMi607816 gene
neXtProtiNX_Q9BYE7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30S → A: Abolishes phosphorylation. 1 Publication1
Mutagenesisi57S → A: Does not abolish phosphorylation. 1 Publication1
Mutagenesisi59S → A: Does not abolish phosphorylation. 1 Publication1
Mutagenesisi69S → A: Does not abolish phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi84108
OpenTargetsiENSG00000156374
PharmGKBiPA134887110

Polymorphism and mutation databases

BioMutaiPCGF6
DMDMi116242703

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559891 – 350Polycomb group RING finger protein 6Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Phosphoserine1 Publication1
Modified residuei115PhosphoserineCombined sources1
Cross-linki223Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki234Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BYE7
MaxQBiQ9BYE7
PaxDbiQ9BYE7
PeptideAtlasiQ9BYE7
PRIDEiQ9BYE7
ProteomicsDBi79631
79632 [Q9BYE7-3]

PTM databases

iPTMnetiQ9BYE7
PhosphoSitePlusiQ9BYE7

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000156374 Expressed in 91 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_PCGF6
GenevisibleiQ9BYE7 HS

Interactioni

Subunit structurei

Component of a PRC1-like complex (PubMed:19636380, PubMed:26151332). Interacts with BMI1/PCGF4, RING1 and RNF2 (PubMed:12167161). Interacts with KDM5D (PubMed:17320162). Interacts with CBX4, CBX6, CBX7 and CBX8 (PubMed:21282530).5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi123896, 78 interactors
CORUMiQ9BYE7
DIPiDIP-50946N
IntActiQ9BYE7, 51 interactors
MINTiQ9BYE7
STRINGi9606.ENSP00000358862

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BYE7
SMRiQ9BYE7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYE7

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 110Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 66Pro-richAdd BLAST45
Compositional biasi63 – 120Glu-richAdd BLAST58

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 173RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231946
HOVERGENiHBG052826
InParanoidiQ9BYE7
KOiK11470
OMAiCIVKHFF
OrthoDBiEOG091G0EC9
PhylomeDBiQ9BYE7
TreeFamiTF324206

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038037 PCGF6
IPR029071 Ubiquitin-like_domsf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825:SF15 PTHR10825:SF15, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BYE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE
60 70 80 90 100
TGAPGCSGSR PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED
110 120 130 140 150
MSHFSLRLEG GRQDSEDEEE RLINLSELTP YILCSICKGY LIDATTITEC
160 170 180 190 200
LHTFCKSCIV RHFYYSNRCP KCNIVVHQTQ PLYNIRLDRQ LQDIVYKLVI
210 220 230 240 250
NLEEREKKQM HDFYKERGLE VPKPAVPQPV PSSKGRSKKV LESVFRIPPE
260 270 280 290 300
LDMSLLLEFI GANEGTGHFK PLEKKFVRVS GEATIGHVEK FLRRKMGLDP
310 320 330 340 350
ACQVDIICGD HLLEQYQTLR EIRRAIGDAA MQDGLLVLHY GLVVSPLKIT
Length:350
Mass (Da):39,047
Last modified:October 17, 2006 - v2
Checksum:i05977FE6F14972DE
GO
Isoform 3 (identifier: Q9BYE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: R → S
     187-261: Missing.

Show »
Length:275
Mass (Da):30,249
Checksum:iFA50B97D5A39281B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257L → P in BAF83368 (PubMed:14702039).Curated1
Sequence conflicti261G → S in AAH07602 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05431223L → LPP2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042007186R → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_042008187 – 261Missing in isoform 3. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047006 mRNA Translation: BAB40779.1
AK027885 mRNA No translation available.
AK290679 mRNA Translation: BAF83368.1
AL591408 Genomic DNA No translation available.
BC007602 mRNA Translation: AAH07602.1
BC010235 mRNA Translation: AAH10235.1
CCDSiCCDS31275.1 [Q9BYE7-1]
CCDS7546.1 [Q9BYE7-3]
RefSeqiNP_001011663.1, NM_001011663.1 [Q9BYE7-1]
NP_115530.2, NM_032154.3 [Q9BYE7-3]
UniGeneiHs.335808

Genome annotation databases

EnsembliENST00000337211; ENSP00000338845; ENSG00000156374 [Q9BYE7-3]
ENST00000369847; ENSP00000358862; ENSG00000156374 [Q9BYE7-1]
GeneIDi84108
KEGGihsa:84108
UCSCiuc001kwt.3 human [Q9BYE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiPCGF6_HUMAN
AccessioniPrimary (citable) accession number: Q9BYE7
Secondary accession number(s): A8K3R4
, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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