UniProtKB - Q9BYE3 (LCE3D_HUMAN)
Protein
Late cornified envelope protein 3D
Gene
LCE3D
Organism
Homo sapiens (Human)
Status
Functioni
Precursors of the cornified envelope of the stratum corneum.
Miscellaneous
Belongs to the LCE cluster present on 1q21.
GO - Biological processi
- cornification Source: Reactome
Keywordsi
Biological process | Keratinization |
Enzyme and pathway databases
PathwayCommonsi | Q9BYE3 |
Reactomei | R-HSA-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Late cornified envelope protein 3DAlternative name(s): Late envelope protein 16 Small proline-rich-like epidermal differentiation complex protein 6A Small proline-rich-like epidermal differentiation complex protein 6B |
Gene namesi | Name:LCE3D Synonyms:LEP16, SPRL6A, SPRL6B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163202.4 |
HGNCi | HGNC:16615, LCE3D |
MIMi | 612616, gene |
neXtProti | NX_Q9BYE3 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84648 |
OpenTargetsi | ENSG00000163202 |
PharmGKBi | PA38174 |
Miscellaneous databases
Pharosi | Q9BYE3, Tdark |
Polymorphism and mutation databases
BioMutai | LCE3D |
DMDMi | 74752448 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000235336 | 1 – 92 | Late cornified envelope protein 3DAdd BLAST | 92 |
Proteomic databases
MassIVEi | Q9BYE3 |
PaxDbi | Q9BYE3 |
PeptideAtlasi | Q9BYE3 |
PRIDEi | Q9BYE3 |
ProteomicsDBi | 79629 |
Expressioni
Tissue specificityi
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000163202, Expressed in ectocervix and 92 other tissues |
Genevisiblei | Q9BYE3, HS |
Organism-specific databases
HPAi | ENSG00000163202, Tissue enhanced (cervix, uterine, lymphoid tissue, tongue, vagina) |
Interactioni
Binary interactionsi
Hide detailsQ9BYE3
Protein-protein interaction databases
BioGRIDi | 124171, 55 interactors |
IntActi | Q9BYE3, 50 interactors |
STRINGi | 9606.ENSP00000357776 |
Miscellaneous databases
RNActi | Q9BYE3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the LCE family.Curated
Phylogenomic databases
eggNOGi | ENOG502TDZ9, Eukaryota |
GeneTreei | ENSGT00940000163905 |
HOGENOMi | CLU_152038_1_0_1 |
InParanoidi | Q9BYE3 |
OMAi | GCCLGHH |
TreeFami | TF338709 |
Family and domain databases
InterProi | View protein in InterPro IPR028205, LCE IPR026075, SPRR/LCE |
PANTHERi | PTHR23263, PTHR23263, 1 hit |
Pfami | View protein in Pfam PF14672, LCE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BYE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSCQQNQQQC QPPPKCPSPK CPPKSPVQCL PPASSGCAPS SGGCGPSSEG
60 70 80 90
GCFLNHHRRH HRCRRQRPNS CDRGSGQQGG GSGCGHGSGG CC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053485 | 43 | G → V1 PublicationCorresponds to variant dbSNP:rs512208Ensembl. | 1 | |
Natural variantiVAR_062120 | 81 | G → V. Corresponds to variant dbSNP:rs57201979Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB048288 mRNA Translation: BAB40643.1 AL356426 Genomic DNA No translation available. BC069291 mRNA Translation: AAH69291.1 BC101784 mRNA Translation: AAI01785.1 |
CCDSi | CCDS1014.1 |
RefSeqi | NP_115952.1, NM_032563.1 |
Genome annotation databases
Ensembli | ENST00000368787; ENSP00000357776; ENSG00000163202 |
GeneIDi | 84648 |
KEGGi | hsa:84648 |
UCSCi | uc001fab.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB048288 mRNA Translation: BAB40643.1 AL356426 Genomic DNA No translation available. BC069291 mRNA Translation: AAH69291.1 BC101784 mRNA Translation: AAI01785.1 |
CCDSi | CCDS1014.1 |
RefSeqi | NP_115952.1, NM_032563.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124171, 55 interactors |
IntActi | Q9BYE3, 50 interactors |
STRINGi | 9606.ENSP00000357776 |
Polymorphism and mutation databases
BioMutai | LCE3D |
DMDMi | 74752448 |
Proteomic databases
MassIVEi | Q9BYE3 |
PaxDbi | Q9BYE3 |
PeptideAtlasi | Q9BYE3 |
PRIDEi | Q9BYE3 |
ProteomicsDBi | 79629 |
Genome annotation databases
Ensembli | ENST00000368787; ENSP00000357776; ENSG00000163202 |
GeneIDi | 84648 |
KEGGi | hsa:84648 |
UCSCi | uc001fab.4, human |
Organism-specific databases
CTDi | 84648 |
DisGeNETi | 84648 |
EuPathDBi | HostDB:ENSG00000163202.4 |
GeneCardsi | LCE3D |
HGNCi | HGNC:16615, LCE3D |
HPAi | ENSG00000163202, Tissue enhanced (cervix, uterine, lymphoid tissue, tongue, vagina) |
MIMi | 612616, gene |
neXtProti | NX_Q9BYE3 |
OpenTargetsi | ENSG00000163202 |
PharmGKBi | PA38174 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDZ9, Eukaryota |
GeneTreei | ENSGT00940000163905 |
HOGENOMi | CLU_152038_1_0_1 |
InParanoidi | Q9BYE3 |
OMAi | GCCLGHH |
TreeFami | TF338709 |
Enzyme and pathway databases
PathwayCommonsi | Q9BYE3 |
Reactomei | R-HSA-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 84648, 78 hits in 810 CRISPR screens |
GenomeRNAii | 84648 |
Pharosi | Q9BYE3, Tdark |
PROi | PR:Q9BYE3 |
RNActi | Q9BYE3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163202, Expressed in ectocervix and 92 other tissues |
Genevisiblei | Q9BYE3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028205, LCE IPR026075, SPRR/LCE |
PANTHERi | PTHR23263, PTHR23263, 1 hit |
Pfami | View protein in Pfam PF14672, LCE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LCE3D_HUMAN | |
Accessioni | Q9BYE3Primary (citable) accession number: Q9BYE3 Secondary accession number(s): Q3MIL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations