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Entry version 130 (29 Sep 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Actin-related protein T3

Gene

ACTRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BYD9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BYD9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-related protein T3
Short name:
ARP-T3
Alternative name(s):
Actin-related protein M1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACTRT3
Synonyms:ARPM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24022, ACTRT3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608534, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYD9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000184378

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84517

Open Targets

More...
OpenTargetsi
ENSG00000184378

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYD9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACTRT3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47116738

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000891421 – 372Actin-related protein T3Add BLAST372

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYD9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYD9

PeptideAtlas

More...
PeptideAtlasi
Q9BYD9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYD9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79622

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184378, Expressed in testis and 129 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYD9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184378, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PFN3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124111, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333037

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYD9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYD9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0676, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162209

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027965_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYD9

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEDMEIM

Database of Orthologous Groups

More...
OrthoDBi
649708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYD9

TreeFam database of animal gene trees

More...
TreeFami
TF337161

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR030068, ARP-T3
IPR043129, ATPase_NBD

The PANTHER Classification System

More...
PANTHERi
PTHR11937, PTHR11937, 1 hit
PTHR11937:SF159, PTHR11937:SF159, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00022, Actin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00190, ACTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00268, ACTIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01132, ACTINS_ACT_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BYD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNHCQLPVVI DNGSGMIKAG VAGCREPQFI YPNIIGRAKG QSRAAQGGLE
60 70 80 90 100
LCVGDQAQDW RSSLFISYPV ERGLITSWED MEIMWKHIYD YNLKLKPCDG
110 120 130 140 150
PVLITEPALN PLANRQQITE MFFEHLGVPA FYMSIQAVLA LFAAGFTTGL
160 170 180 190 200
VLNSGAGVTQ SVPIFEGYCL PHGVQQLDLA GLDLTNYLMV LMKNHGIMLL
210 220 230 240 250
SASDRKIVED IKESFCYVAM NYEEEMAKKP DCLEKVYQLP DGKVIQLHDQ
260 270 280 290 300
LFSCPEALFS PCHMNLEAPG IDKICFSSIM KCDTGLRNSF FSNIILAGGS
310 320 330 340 350
TSFPGLDKRL VKDIAKVAPA NTAVQVIAPP ERKISVWMGG SILASLSAFQ
360 370
DMWITAAEFK EVGPNIVHQR CF
Length:372
Mass (Da):41,008
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56413BCF02AA4794
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78W → C in AAH07289 (PubMed:16641997).Curated1
Sequence conflicti282C → R in BAB70906 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055483234E → K. Corresponds to variant dbSNP:rs2068178Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB049117 mRNA Translation: BAB39481.1
AK055346 mRNA Translation: BAB70906.1
AC078802 Genomic DNA No translation available.
BC007289 mRNA Translation: AAH07289.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3206.1

NCBI Reference Sequences

More...
RefSeqi
NP_115876.3, NM_032487.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330368; ENSP00000333037; ENSG00000184378

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84517

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84517

UCSC genome browser

More...
UCSCi
uc003ffs.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049117 mRNA Translation: BAB39481.1
AK055346 mRNA Translation: BAB70906.1
AC078802 Genomic DNA No translation available.
BC007289 mRNA Translation: AAH07289.1
CCDSiCCDS3206.1
RefSeqiNP_115876.3, NM_032487.4

3D structure databases

SMRiQ9BYD9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124111, 1 interactor
STRINGi9606.ENSP00000333037

Genetic variation databases

BioMutaiACTRT3
DMDMi47116738

Proteomic databases

MassIVEiQ9BYD9
PaxDbiQ9BYD9
PeptideAtlasiQ9BYD9
PRIDEiQ9BYD9
ProteomicsDBi79622

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33699, 135 antibodies

The DNASU plasmid repository

More...
DNASUi
84517

Genome annotation databases

EnsembliENST00000330368; ENSP00000333037; ENSG00000184378
GeneIDi84517
KEGGihsa:84517
UCSCiuc003ffs.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84517
DisGeNETi84517

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACTRT3
HGNCiHGNC:24022, ACTRT3
HPAiENSG00000184378, Tissue enriched (testis)
MIMi608534, gene
neXtProtiNX_Q9BYD9
OpenTargetsiENSG00000184378
VEuPathDBiHostDB:ENSG00000184378

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0676, Eukaryota
GeneTreeiENSGT00940000162209
HOGENOMiCLU_027965_0_2_1
InParanoidiQ9BYD9
OMAiWEDMEIM
OrthoDBi649708at2759
PhylomeDBiQ9BYD9
TreeFamiTF337161

Enzyme and pathway databases

PathwayCommonsiQ9BYD9
SignaLinkiQ9BYD9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84517, 24 hits in 1017 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84517
PharosiQ9BYD9, Tdark

Protein Ontology

More...
PROi
PR:Q9BYD9
RNActiQ9BYD9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184378, Expressed in testis and 129 other tissues
GenevisibleiQ9BYD9, HS

Family and domain databases

InterProiView protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR030068, ARP-T3
IPR043129, ATPase_NBD
PANTHERiPTHR11937, PTHR11937, 1 hit
PTHR11937:SF159, PTHR11937:SF159, 1 hit
PfamiView protein in Pfam
PF00022, Actin, 1 hit
PRINTSiPR00190, ACTIN
SMARTiView protein in SMART
SM00268, ACTIN, 1 hit
SUPFAMiSSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS01132, ACTINS_ACT_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACTT3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYD9
Secondary accession number(s): Q96IS0, Q96NJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: September 29, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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